Abstract: The present invention relates to a device for the dynamic emulation of forced induction systems of propulsion sources, which comprises an inlet tube (2), an outlet tube (4), a turbine set (12), one or more electric compressors (14), a cooling means (20), a heating means (24), and a heat regulation means. The present invention also relates to a method comprising one or more of the following actions: regulating supply air pressure by controlling the rotation regime of the one or more electric compressors (14); controlling the operating conditions of the one or more electric compressors (14), using a safety means; regulating supply air temperature, using the heat regulation means; regulating the counterpressure of the outlet gases of the propulsion source (10), by modifying the geometry of the turbine of the turbine set (12).

Abstract: It is provided a method for generating a supercontinuum, the method comprising the following steps: a) radiating a carrier laser pulse having a first temporal width onto a first non-linear material; b) at the same time, radiating a second shorter laser pulse having a second temporal width onto the first non-linear material, thereby changing the non-linear properties of the first non-linear material and imprinting a ghost pulse having a third temporal width into the carrier pulse; the second temporal width being at least two times shorter than the first temporal width, and c) radiating the carrier pulse with imprinted ghost pulse onto the first non-linear material or a second non-linear material and generating, by self-phase modulating, a supercontinuum around the center frequency of the carrier pulse.

Abstract: A method for measurement of a sequence of recurring electronic signals (10) is proposed, wherein the sequence to be measured consists of n recurring electronic signals, wherein a time-to-digital converter (2) and a memory (5) are provided.

Abstract: The invention relates to a method for coaxially extruding an extruded product. Hereby, an extruding device comprises the following: a receiver (7); a first receiver bore (5) which is formed in the receiver (7) and in which a first punch (10) is arranged; a second receiver bore (6) which is formed in the receiver (7) inside the first receiver bore (5) and coaxially therewith and in which a second punch (11) is arranged; and a mold (15) having a mold cavity (14) which is connected to the first and the second receiver bore (5, 6). In the method, the following is provided: arranging a first material billet (8) of a first material (2) in the first receiver bore (5); arranging a second material billet (9) of a second material (3) in the second receiver bore (6); and extruding an extruded product (1) in which the first and the second material (2, 3) are connected in a form-fitting and integrally bonded manner.

Abstract: The present invention relates to peptides, in particular amyloid inhibitory peptides, and to pharmaceutical compositions comprising such peptides. Furthermore, the present invention relates to such peptides, in particular such amyloid inhibitory peptides, for use in methods of treating or diagnosing neurodegenerative diseases such as Alzheimer's disease, or for use in a method of treating or diagnosing type 2 diabetes. Furthermore, the present invention also relates to a kit for the in-vitro or in-vivo detection and, optionally, quantification of amyloidogenic polypeptides, amyloid fibrils or amyloid aggregates, and/or for the diagnosis of Alzheimer's disease or type 2 diabetes in a patient.

Abstract: The present invention relates to novel monoclonal anti-human-GDF-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human GDF-15 capable of inhibiting cancer growth.

Abstract: In a method and an apparatus for detecting electrically conductive foreign bodies during inductive energy transmission between a primary coil (1) and a secondary coil (2), at least one sensor coil (5) is arranged between the primary coil (1) and the secondary coil (2), and a current flowing in the sensor coil (5) due to the induced voltage during the energy transmission is detected and evaluated. In this case, the sensor coil (5) is connected to at least one capacitor to form a resonant circuit which is matched to the excitation frequency of the primary coil (1). The phase position of the current in the resonant circuit in relation to a reference signal is then used to determine whether there are electrically conductive foreign bodies (4) between the primary coil (1) and the secondary coil (2). A high degree of sensitivity, also in relation to small electrically conductive foreign bodies within the energy transmission path, is achieved by means of the method and the apparatus.

Abstract: The invention relates to a device comprising: at least one tool module (4) having a quick-coupling interface (19); at least one support having a quick-coupling interface (19) and designed to hold the at least one tool module; and at least one data processing unit designed for computer-assisted tool management. The support for holding the tool module (4) comprises at least one support frame (16), at least one interface (21) for computer-assisted tool module identification, and at least one sensor unit. The support frame comprises at least one quick-coupling interface (19) for a tool module. The tool module comprises at least one implement (18) for use outdoors, at least one suspension that is compatible with the quick-coupling point on the support frame, at least one computer-readable storage medium (22) for computer-readable data, and at least one interface for transmission of computer-readable data.

Abstract: Method for applying a nanolaminate to a metal workpiece, wherein a coating made of a nanolaminate is applied in a region that is subjected to a notch effect, for example, a weld seam, which nanolaminate consists of a series of at least two metal layers, wherein each metal layer consists of a metal or a metal alloy that differs from the metal or the metal alloy in the adjacent layer. According to the invention, the method can take place with a batching tank locally and/or in situ.

Abstract: In a dynamic memory allocator, a method of allocating memory to a process, the method comprising executing on a processor the steps of: creating one or more arenas within the memory, each arena comprising one or more memory blocks and each arena having an n-byte aligned arena address; upon receiving a memory request from the process, returning a pointer to the process, the pointer having as its value an address of a memory block selected from one of the arenas; upon determining that the memory block is no longer needed by the process, retrieving the address of said memory block from the pointer and releasing the memory block; and, upon a new arena being created, shifting forward the n-byte aligned address of said new arena according to a stored variable such that each memory block of said new arena is also shifted by the stored variable, the stored variable having n bytes and the stored variable having a random value.

Abstract: The present invention relates to a permanently polarized hydroxyapatite and a composition or material comprising thereof. The present invention further relates to a process for obtaining a permanently polarized hydroxyapatite and to different uses of the permanently polarized hydroxyapatite or the composition or material comprising thereof.

Abstract: A computer-implemented method for tracking a mobile device based on a series of motion measurements of said device comprises retrieving a topological map providing a graph of topological paths, wherein each topological path is associated with a corresponding path direction; statistically generating, on a virtual map, a plurality of particles around an estimated initial position of the mobile device, representing an initial uncertainty of said estimated initial position of the mobile device; determining, from said series of motion measurements, a measured displacement vector of the mobile device representing an estimated displacement direction and an estimated displacement distance of the mobile device; displacing each of said particles on the virtual map according to a randomized particle displacement vector which is derived from said measured displacement vector based on an uncertainty of the measured displacement vector and recording said particle displacement vector for each displaced particle; determining

Abstract: The application describes a T-cell expressing a chimeric antigen receptor (‘CAR T-cell’) containing superparamagnetic iron-based particles (‘loaded CAR T-cell’) for use in treating a tumor. Said loaded CAR T-cell exhibits a reduced cytokine release upon binding to a cell of the tumor expressing an antigen being recognized by the CAR of the CAR T-cell, compared to a CAR T-cell not containing superparamagnetic iron-based particles (‘unloaded CAR T-cell’) under the same conditions. Furthermore, an in vitro method of generating a CAR T-cell containing superparamagnetic iron-based particles is described, whereby such loaded CAR T-cells are generated.

Abstract: The present invention relates to a compound of formula (I) wherein E1 to E6 are independently Si or Ge; X1 to X4 are independently selected from the group consisting of H, SiH3, halogen and Si(Y)3; Y is independently selected from C1 to C20 alkyl and halogen; R1 to R12 are independently selected from the group consisting of C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, C3 to C20 cycloalkyl, C6 to C20 aryl, C7 to C20 arylalkyl, C7 to C20 alkylaryl and Z; and Z is independently selected from the group consisting of H, halogen and C1 to C20 alkyl; a process for their preparation; and the use of the compound for preparing the Si- and Ge-containing solid.

Abstract: The invention relates to a method and a device for producing an extruded product. In the method an extrusion device is provided comprising: a container (7); a first container bore (5), formed in the container (7) and in which a first extrusion punch (10) is arranged; a second container bore (6), formed in the container (7) separately from the first container bore (5) and in which a second extrusion punch (11) is arranged; and a moulding tool (15) with a moulding cavity (14), which are connected to the first and the second container bore (5, 6).

Abstract: The present invention is relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH; R1 and R2 are independently of each other (iii) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1-C2alkoxyC1-C3alkyl, CN, or C(O)O—C1-C2alkyl; or R3 and R4 form together a bivalent residue —R5R6— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2—, —CH2—NH—CH2—, or any of the structures wherein the arrows denote the bonds in formula (II); or (iv) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalk

Abstract: The proposed morphable sheet structure comprises a succession of adjacent flexible elongated rods (10) laterally connected to each other defining a sheet structure (1), each rod (10) defining a longitudinal axis (A); wherein the rods (10) are grouped in pairs, each pair of adjacent rods (10) are connected to each other through a first connector (11) tightly connected to a second connector (12) complementary with the first connector (11), being the first connector (11) part of one rod (10) of said pair of adjacent rods (10) and being the second connector (12) part of the other rod (10) of said pair of adjacent rods (10); being the first connector (11) and the second connector (12) slidably movable to each other in the direction of the longitudinal axis (A); the first connector (11) and/or the second connector (12) extending along the entire longitude of the rod (10).

Abstract: An organometallic compound represented by Formula 1: wherein M1 and M2 are each independently a first row transition metal, a second row transition metal, or a third row transition metal in the Periodic Table of Elements; and wherein L1, L2, a1, a2, Ar1, Ar2, R1 to R4, and LK in Formula 1 are as described in the present disclosure.

Abstract: The invention relates to a method for classifying spectra of objects having complex information content after recording of the spectra involving the use of a method for preprocessing data and of a method, associated with the data preprocessing, for classification with the calculation of a classifier. After the recording of the spectra and the preprocessing of the spectra, a multiple classification method is thereby performed with at least two different methods for the data preprocessing of the spectra and the method, assigned to the respective data preprocessing, for classification.

Abstract: There are disclosed techniques (e.g., apparatus, methods) for estimating an impulse response of a linear system. An apparatus is configured to generate a transmit signal on the basis of a first sequence. The apparatus is configured to obtain a receive signal and to multiply the receive signal with a second sequence, to obtain a modified receive signal, wherein the second sequence is different from the first sequence. The apparatus is configured to analog-to-digital, ADC, convert an integration result in order to obtain a sample value, the integration result being based on an integration of the modified receive signal over a period of time. The apparatus is configured to obtain an estimate of the impulse response on the basis of a plurality of sample values.