Abstract: The present invention relates to a method and a device for monitoring the process for a welding seam formed by means of collision welding, in which a first joining partner (1) and a second joining partner (2) are moved toward one another by an introduction of energy and are welded to one another to form the welding seam. A light flash between the first joining partner (1) and the second joining partner (2) is detected during the welding by an optical capture unit (6), which measures in a time-resolved manner, having at least one detector (19, 20, 24) and an actual value of a beginning of the light flash, a duration of the light flash, an intensity of the light flash, and/or an intensity distribution over time of the light flash is determined by an analysis unit (16) and compared to a respective target value of the beginning of the light flash, the duration of the light flash, the intensity of the light flash, and/or the intensity distribution over time of the light flash.

Abstract: The invention relates to a method for obtaining a visual field map of an observer, particularly a perimetry method, wherein a plurality of test locations in front of the observer is provided, at each test location of a subset of said plurality a respective perceived sensitivity threshold is measured, wherein at least one light signal is provided at the respective test location, and wherein it is monitored whether said observer observes said at least one light signal, and wherein for each test location a respective estimate of the perceived sensitivity threshold is derived from the previously measured perceived sensitivity thresholds of said subset, and wherein said light signal is provided at a light intensity value derived from the estimate of the perceived sensitivity threshold of said respective test location.

Abstract: Methods are provided of optimizing a tree-structured distributed-index with tree-nodes including data-elements and parent-child relations between tree-nodes. The distributed-index is stored in distributed system including computer-nodes each storing tree-nodes and a tree-map structurally describing the distributed-index. The methods include: inspecting the tree-map in first computer-node to determine whether the distributed-index is imbalanced due to a first tree-node in first computer-node and, in said case: notifying to other computer-nodes that first tree-node is replicable, to provoke that any request from other computer-nodes of inserting a data-element in first-tree-node includes inserting the data-element in corresponding child-node of first-tree-node; and verifying whether the other computer-nodes have been notified and, in said case, replicating data-elements stored in first tree-node into children-nodes thereof.

Abstract: Method of making BTX compounds including benzene, toluene, and xylene, including feeding heavy reformate to a reactor containing a composite zeolite catalyst. The composite zeolite catalyst includes a mixture of layered mordenite (MOR-L) comprising a layered or rod-type morphology with a layer thickness less than 30 nm and ZSM-5. The MOR-L, the ZSM-5, or both include one or more impregnated metals. The method further includes producing the BTX compounds by simultaneously performing transalkylation and dealkylation of the heavy reformate in the reactor. The composite zeolite catalyst is able to simultaneously catalyze both the transalkylation and dealkylation reactions.

Abstract: The present invention concerns a novel method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from naturally available NRPSs. The artificial NRPSs are of predetermined length and amino acid composition and sequence. Via fusion of well-defined NRPS units (so-called “exchange units”) in a certain manner, using a specific sequence motif in the linker areas it is possible to construct artificial and/or modified NRPS assembly lines, which have the ability of synthesizing peptides of a desired structure.

Abstract: The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.

Abstract: The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.

Abstract: The invention relates to an optical waveguide with two or more light-guiding cores (1a-1e) extending continuously along the longitudinal extension of the optical waveguide, parallel to one another and spaced apart from one another, from one end of the optical waveguide to the other, and with a first cladding (2) enclosing the cores (1a-1e). It is an object of the invention to provide a multicore optical waveguide for high-power operation with reduced system complexity compared to the prior art.

Abstract: The present invention relates to a method for the synthesis of a two-dimensional or quasi-two-dimensional polymer comprising a surfactant, the two-dimensional or quasi-two-dimensional polymer film and the use for the production of membranes, electronic devices or catalysts.

Abstract: The present invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) nitrate as a metal cation ligand and (ii) a metal cation chelating domain comprising a chelating ligand and a label and/or carrier. This complex can be used for attaching a label and/or a carrier to a target molecule, preferably a protein. The attachment of the label or carrier via the complex of the invention involves the replacement of the metal cation ligand with a coordinating group of the target molecule so that a product complex with the target molecule as primary ligand in the coordination sphere of the metal cation is formed. Accordingly, the present invention also provides for uses and methods involving the attachment of a label and/or carrier to a target molecule.

Abstract: Multilingual translators are provided with a plurality of input languages, a plurality of output languages, and a plurality of translation directions each of which from one of the input languages to one of the output languages. Multilingual translators include an encoder for each of the input languages and a decoder for each of the output languages. Each of the encoders is trained or trainable to translate from its input language to an arbitrary intermediate representation shared by all the translation directions and, furthermore, has its own encoding parameters or weights that are independent from the other encoders. Each of the decoders is trained or trainable to translate from the arbitrary intermediate representation to its output language and, besides, has its own decoding parameters or weights that are independent from the other decoders. Methods, computing systems, and computers programs for training such multilingual translators are also provided.

Abstract: A method for producing an aluminum layer is provided. The method includes depositing a metallic seed layer on a substrate, the seed layer having a thickness of not more than 5 nm, and also includes applying the aluminum layer to the seed layer, wherein the aluminum layer has a thickness of more than 30 nm. Further, an optical element, which can be a mirror layer, is provided including the metallic seed layer and the aluminum layer.

Abstract: The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.

Abstract: A container for menstrual collection and emptying thereof, in the shape of a cup or of a flat cup, with a drainage tube composed of at least one very flexible thin-walled portion, and a wall portion of greater thickness. By applying an upward force on the portion, the tube is folded by its portion closing off the liquid passageway, and the tube end remaining directly anchored to the vaginal wall or below a hollow formed in the container. For a mid-day emptying, a downward force is applied on the portion to unfold the drainage tube. The horizontal rim of the cup has a number of notches to aid the folding and can have a sloped shape, or double-ringed.

Abstract: The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6?, C2? and/or C5?. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasion of resistance traits and increased selectivity, enabling systemic use of the compounds.

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.

Abstract: An apparatus for determining a disease parameter describing a type of cardiac disease includes a unit for reading input parameters representing 3D myocardial velocity fields with voxel wise 3D velocity information. The velocity vectors represent velocity of a voxel of a region of the heart at a predefined time point or time interval; a velocity vector depicts a voxel wise 3D velocity of the myocardium with different magnitude. A processor applies an algorithm to obtain a rotation parameter and/or strain-rate-tensor representing local curl of the input parameters and local rate of strain at a certain spatial point, at a certain time point or time interval. A processor calculates the disease parameter on the basis of the rotation parameter and strain-rate-tensor, dividing an absolute value of the rotation parameter by an eigenvalue. The disease parameter reflects a proportion to overall deformation of local layer shearing with regard to local pure deformation.