Abstract: The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.

Abstract: The invention relates to nucleic acid products that interfere with or inhibit PROS1 gene expression. It further relates to therapeutic uses of PROS1 inhibition for the treatment of bleeding disorders.

Abstract: The invention relates to a method to indicate the clinical outcome of a cancer patient by labelling a cancer sample with labelled molecular probes, assaying the expression of a plurality of biomolecules at the resolution of a single cell and assigning a cellular identity (CI) to each single cell in the sample based on their expression pattern; then assigning a single cell pathology (SCP) patient group according to the proportion of each CI the sample contains. The invention in other aspects relates to methods of treatment of a patient with anticancer drugs according to the patient's assignment to particular SCPs. Alternatively, this aspect may be formulated as the provision of certain drugs for treatment of cancer in patients characterized by tumours assigned to certain SCPs.

Abstract: The invention relates to a method for operating a memory assembly. A physical address is received. The physical address is associated with a first memory segment of a memory assembly. The physical address is modified to a modified physical address. The modified physical address is associated with a second memory segment of the memory assembly.

Abstract: The present invention relates to pharmaceutical compositions with isolated and treated whole blood cells or Peripheral Blood Mononuclear Cells (PBMCs) as well as such pharmaceutical compositions for use in the prevention and/or treatment of organ or cell graft rejection in a human graft recipient.

Abstract: The invention relates to a locating method for localizing at least one object using wave-based signals, wherein a wave field emanates from the object to be localized and the wave field emanating from the object is received by a number N of receivers, at least one measurement signal is formed in every receiver, said measurement signal being dependent on the spatial and temporal distribution of the wave field and the phase progression of said measurement signal being characteristically influenced by the signal propagation time from the object to the receiver, wherein, for position locating, phase values for each of the at least two measurement signals are taken as measured phase values, and wherein the current position (P(k)) of the object to be located at the time k is determined by a comparison of at least one linear combination of the measured phase values with at least one linear combination of the associated hypothetical phase values, which result from the transmitter-receiver distance(s), and using a recu

Abstract: A method of operating a storage means, wherein for writing and storing a storage item to the storage means the storage item to be written and stored—in particular by using the concept and theory of identification—is provided, a encoding process by means of randomization is applied to the storage item to generate and to provide a randomized encoded storage item, and the randomized encoded storage item is written and stored to the storage means. At least a first randomization process is underlying the encoding process and is a randomization process dedicated and assigned to the underlying storage means. The present disclosure further refers to a unit for operating a storage means, to a storage means and to a system for processing data. By having two randomization processes underlying the encoding process, a distinction can be made between a secrecy insuring and secrecy non-ensuring randomization processes.

Abstract: The present invention relates to a binding polypeptide specifically binding to an epitope comprised in an amino acid sequence corresponding to amino acids 250 to 300 of the norovirus genotype II.10 capsid polypeptide, and to a polynucleotide encoding the same. The present invention further relates to a composition comprising the binding polypeptide according to the present invention and a carrier, and to the binding polypeptide or the composition comprising the same use in diagnosis and/or for use in medicine. Further more, the present invention relates to kits, devices, vaccines, methods, and uses related to the binding polypeptide of the present invention.

Abstract: An accessory kit is provided for interventional procedures using a magnetic resonance imaging scanner. The accessory kit includes a patient support and an electrical connection adapter. The patient support has a first end proximal and a second end distal to the scanner. The distal end is configured to create a space to accommodate a clinician, such as narrowing of the distal end or at least one cutout on a side of the distal end. The electrical connection adapter interfaces with the scanner and a scanner table. The accessory kit is configured so that when the proximal end is extended into the scanner bore, the distal end extends outside the bore. The narrowed width and/or cutout(s) of the exposed distal end and the extended gap between the scanner and scanner table create space on at least one side of the patient support that a clinician may use to access a patient.

Abstract: 6-[18F]Fluoro-2-alkoxynicotinoyl substituted Lys-C(O)-Glu derivatives were identified as efficient imaging probes for PSMA expressing tissues in comparison to other known PSMA specific ligands like [18F]DCFPyL, [68Ga]HBED-CC-PSMA, [18F]PSMA-1007 and [Al18F]HBED-CC-PSMA. Unexpectedly, the 6-[18F]fluoro-2-alkoxy and 6-[18F]fluoro-4-alkoxy substituted analogs showed significant differences in accumulation in PSMA expressing prostate tumor cells. Whereas the 2-alkoxy derivative showed cellular uptake values higher than [18F]DCFPyL, the cellular uptake of the corresponding 4-alkoxy substituted derivative was significantly lower. Furthermore, in vivo PET studies with 2-alkoxy-substituted probes demonstrated excellent visualization of PSMA positive ganglia with extremely high target to background ratio. In contrast, the 4-alkoxy substituted derivatives showed less favorable biodistribution with significantly lower uptake in PSMA positive tissues.

Abstract: The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

Abstract: The invention relates to a device for conducting radiation, a photodetector arrangement, and a method for spatially resolved spectral analysis.

Abstract: The present invention relates to a method for producing a substrate (2) which is coated with an alkali metal (1), in which method a promoter layer (3) which is composed of a material which reacts with the alkali metal (1) by at least partial chemical reduction of the promoter layer (3) is applied to a surface of the substrate (2) and a surface of the promoter layer (3) is acted on by an alkali metal (1) and then the alkali metal (1) is converted into the solid phase and a coating containing the alkali metal is formed.

Abstract: The present invention relates to two-dimensional and three-dimensional shaped parts and composite materials made of popcorn and synthetic and/or natural binding agents which are cured in automatic moulding machines or similar pressing installations by means of radio wave technology or microwaves. By means of these technologies, light-weight, two-dimensional and three-dimensional shaped parts and composite materials can be produced for packaging, as interior and exterior parts (for example in automobile and mobile-home construction), shock absorbers, space-dividing elements, furniture, consumer goods, for the building trade of for heat insulation.

Abstract: The present invention discloses an extracellular matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid.

Abstract: To determine the sex of a bird egg, a hole is produced at the blunt end of the bird egg, wherein the hole affects the calcareous shell and the outer shell membrane, whereas the inner shell membrane remains intact. In the region of the hole at the blunt end, beneath the intact inner shell membrane, at least one blood vessel is registered and the blood therein is excited by means of a preset incident radiation, the back-scattered radiation of which blood is measured, detected and evaluated for the sex determination.

Abstract: A device for mounting an object holder on a carrier that can be inserted into a cryostat includes at least one clamping element may be provided for non-positive connection of the object holder with the carrier. The at least one clamping element is arranged to enable damage-free mounting of the object holder on the carrier even in the case of large temperature changes, so that reproducible measuring conditions are created at large temperature changes. The at least one clamping element may be drive-connected via a lever to a piezoelectric element, which may be subjected to voltage by a control device as a function of temperature and of a bearing specification and is supported against the object holder or the carrier.

Abstract: A particulate matter sensor system for sensing particulate matter in a fluid includes a substrate and a cover disposed on the substrate. The cover defines at least a portion of a flow path through the microfluidic system. The sensor system includes a particulate matter sensor disposed in an interior space between the cover and the substrate. The particulate matter sensor includes an integrated sensor device electrically connected to the substrate. The flow path is defined through the particulate matter sensor. The sensor system includes a fluid circulation device disposed in the interior space between the cover and the substrate and configured to cause fluid to flow along the flow path through the microfluidic system.

Abstract: It is provided a method of treatment of a human or animal patient in need thereof to achieve a reduction of the viscosity of mucus of the patient which is carried out by administering a polyglycerol derivative having a linear or dendritic polyglycerol backbone and carrying at least one thiol group covalently bound to the polyglycerol backbone. It is further provided a method of treatment of a human or animal patient suffering from chronic sinusitis, asthma, chronic bronchitis, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, bronchiectasis, chronic inflammatory bowel diseases, constipation, gastrointestinal malabsorption syndrome, irritable bowel syndrome, steatorrhea or diarrhea by administering a polyglycerol derivative. Further specific thiol-functionalized polyglycerol derivatives and a corresponding manufacturing method are provided.

Abstract: A device for control and closed-loop control of an actuating system of an aircraft is disclosed. The device has a first input interface, which is configured to receive first input data indicating a reference variable, a second input interface, which is configured to receive second input data indicating a controlled variable, and a control output, which is configured to output a control signal. The control signal indicates a manipulated variable for an actuating system of an aircraft, which is to be controlled by means of the actuating system. The reference variable indicates a target acceleration at a point of the aircraft that is to be controlled by means of the actuating system, and the controlled variable indicates an actual acceleration of the aircraft at the point.