Abstract: The present invention describes the determination of the prognostic impact of hERG1 potassium channels along with other hypoxia-related biomolecular parameters, in patients who underwent radical surgery with curative intent for non metastatic CRC.

Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases. (I, II).

Abstract: The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.

Abstract: A helmet (1, 100, 200) for protecting a user's head (90), comprising a cap (2) for protecting the user's cranium (92) and a chin guard (3) for protecting the user's chin (93), wherein the chin guard (3) is adapted to move between a first protecting position (31) and a second protecting position (32) under the action of a force (50) acting in the direction of the chin (93) of a user wearing on said helmet (1), the chin guard (3) in said second protecting position (32) being nearer to the user's chin (93) with respect to the chin guard (3) in said first protecting position (31).

Abstract: A method for referencing and interconnecting contents, applications and metadata to an audiovisual content is described, especially for iTV of for distribution on DVD, which comprises the step of inserting a digital watermark into the audiovisual content during an audiovisual content encoding step, the digital watermark being possibly used for allowing a user to reproduce or exploit additional contents supplementing those provided by the audiovisual content, wherein the digital watermark is inserted into the audiovisual content as data frame with header and body by subdividing it into a plurality of consecutive ‘I’ frames and forcing the parity of LSBs of mid-frequency providing an auxiliary watermark channel, e.g. in an MPEG2 transport stream.

Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases.(I, II).

Abstract: The present invention refers to 3-aza-bicyclo [3.2.1] octane derivatives of general formula (I) their preparation, use and pharmaceutical compositions useful in the treatment of pathologies associated with microbial pathogens expressing aspartylprotease activity.

Abstract: The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.

Abstract: Novel hydroxamate histone deacetylase inhibitors of formula (I) wherein X is C?O or CH2 used as antineoplastic agent.

Abstract: The light capsule object of the present invention is an ingestible device designed to illuminate the gastric cavity of the stomach for therapeutic purposes directed against Helicobacter pylori (H. pylori) bacteria. It comprises: a casing transparent to visible light, in turn containing punctiform light sources, preferably constituted by LEDs, positioned immediately under said casing and capable of emitting light at appropriate wavelength bands (preferably 405 nm and 630 nm); a battery, adapted to power the LED sources for approximately 20-30 minutes (the average transit time in the stomach); a switch which allows a delayed power on and allows the tablet to be still “off” when it is swallowed. The light emitted by the capsule strikes the H. pylori bacteria anchored on the gastric wall. The light radiation is preferentially absorbed by molecules of porphyrin produced by the bacterium which works as photosensitizing agent by inducing the formation of cytotoxic molecular species.

Abstract: A method for referencing and interconnecting contents, applications and metadata to an audiovisual content is described, especially for iTV of for distribution on DVD, which comprises the step of inserting a digital watermark into the audiovisual content during an audiovisual content encoding step, the digital watermark being possibly used for allowing a user to reproduce or exploit additional contents supplementing those provided by the audiovisual content, wherein the digital watermark is inserted into the audiovisual content as data frame with header and body by subdividing it into a plurality of consecutive ‘I’ frames and forcing the parity of LSBs of mid-frequency providing an auxiliary watermark channel, e.g. in an MPEG2 transport stream.

Abstract: The present invention relates to a method and kits thereof for detecting the presence and/or the specific serogroup of a prokaryote selected from the group consisting of & pneumionae, N. meningitidis, H. influenzae, Adenovirus, Klebsiella Pneumonite, Lysteria monocytogenes, Escherichia coli and Streptococcus agalactiae in a sample taken from a human being, through amplification of specific target regions.

Abstract: Glycopeptides capable of identifying multiple sclerosis antibodies, and therefore useful as diagnostic tools or for the treatment of said pathology are described.

Abstract: Polypeptides with sequence corresponding or homologous to that of endostatin, having inhibiting activity on angiogenesis, are useful in the treatment of angiogenesis-dependent tumors.