Patents Assigned to Universita' Degli Studi di Milano
  • Patent number: 10336707
    Abstract: The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: July 2, 2019
    Assignees: EUDENDRON S.R.L., UNIVERSITA' DEGLI STUDI DI MILANO
    Inventors: Mauro Angiolini, Fabio Zuccotto, Anna Bernardi, Francesco Airaghi
  • Patent number: 10143969
    Abstract: The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: December 4, 2018
    Assignee: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Maurizio Filippo Acciarri, Simona Olga Binetti, Bruno Vodopivec, Maurilio Giuseppe Meschia
  • Patent number: 10010505
    Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 3, 2018
    Assignee: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona
  • Patent number: 9925160
    Abstract: The inventors have made the surprising discovery that when ceramide production is upregulated in the infarct and at-risk areas upon reperfusion injury in the heart, such upregulation is effected through the de novo ceramide synthesis pathway. Upon treatment of cardiac tissues subject to reperfusion injury with a specific inhibitor of the novo ceramide synthesis pathway (myriocin), the inventors have determined that the inhibition of such pathway not only reduces the inflammation of the interested area, but most surprisingly reduces infarct size, ameliorates cardiac contractility and activates cell detoxification and survival programs. There is thus provided an inhibitor of de novo ceramide synthesis pathway, particularly myriocin, for the treatment of cardiac reperfusion injury.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: March 27, 2018
    Assignees: UNIVERSITA' DEGLI STUDI DI MILANO, POLICLINICO SAN DONATO S.P.A.
    Inventors: Riccardo Ghidoni, Paola Signorelli, Luigi Anastasia
  • Patent number: 9879030
    Abstract: Chemical compounds are provided which act on GPR17 receptors and are useful in the treatment or amelioration of chronic and/or acute neurodegenerative diseases, such as multiple sclerosis, inflammatory diseases, pathologies involving the immune system, cardiovascular diseases, and renal diseases.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: January 30, 2018
    Assignees: UNIVERSITA′ DEGLI STUDI DI MILANO, FONDAZIONE ITALIANA SCLEROSI MULTIPLA—FISM ONLUS
    Inventors: Maria Pia Abbracchio, Mario Alberto Battaglia, Ivano Eberini, Marta Fumagalli, Chiara Parravicini, Cristina Sensi, Paola Zaratin
  • Patent number: 9822308
    Abstract: Disclosed are polymers with a complex branched structure (star- or tree-shaped) obtainable by polymerizing a bifunctional type AB monomer and/or type AA+BB monomers in the presence of: a) one or more polyamine and/or a polyacid and/or a polyalcohol and/or more generally a compound (such as POSS) having at least three functional groups such as amino, carboxylic acid or hydroxyl functions; b) one or more phosphorus containing molecules reacting with only one reactive group during the polymerization; c) optionally one or more organic acid and/or an amine and/or an alcohol having one or two functional groups.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: November 21, 2017
    Assignee: UNIVERSITA' DEGLI STUDI DI MILANO
    Inventors: Giuseppe Di Silvestro, Yuan Cuiming, Marco Ortenzi, Hermes Farina, Tommaso Lugato, Luca Basilissi
  • Patent number: 9795730
    Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: October 24, 2017
    Assignee: Universitá Degli Studi di Milano-Bicocco
    Inventors: Antonio Maria Pesenti, Nicolo Antonino Patroniti
  • Publication number: 20170224898
    Abstract: The present invention relates to an extracorporeal circuit for CO2 removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.
    Type: Application
    Filed: July 31, 2015
    Publication date: August 10, 2017
    Applicant: UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
    Inventors: Antonio Maria Pesenti, Alberto Zanella, Domenico Salerno, Nicolò Antonino Patroniti, Francesco Mantegazza
  • Publication number: 20170218264
    Abstract: Disclosed herein are embodiments of a composition comprising a polymer or sol-gel matrix and one or more nanocrystals. The composition is useful for making various products, including a luminescent solar concentrator. The nanocrystals are dispersed in the polymer or sol-gel matrix to reduce or substantially prevent nanocrystal-to-nanocrystal energy transfer and a subsequent reduction in the emission efficiency of the composition. The nanocrystals may comprise an antenna portion and an emitter portion, and in some embodiments the materials for the antenna and emitter portions are selected to produce a large Stokes shift between the absorption and emission wavelengths. In some embodiments, the polymer matrix comprises an acrylate polymer. Also disclosed herein is a method for making the composition, which may comprise a pre-polymerization step before the nanocrystals are introduced. Devices comprising the composition and a photovoltaic cell also are disclosed. In some examples, the device is a window.
    Type: Application
    Filed: October 13, 2014
    Publication date: August 3, 2017
    Applicants: Los Alamos National Security, LLC, Universita Degli Studi Di Milano-Bicocca
    Inventors: Victor I. Klimov, Hunter McDANIEL, Sergio BROVELLI, Francesco MEINARDI
  • Patent number: 9609875
    Abstract: The invention relates to a probiotic mixture of the protection of bees' health, and more specifically for the protection from microbial pathologies, such as those caused by Paenibacillus larvae, etiological agent of the American Foulbrood Disease (AFD).
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: April 4, 2017
    Assignee: UNIVERSITA' DEGLI STUDI DI MILANO
    Inventors: Chadlia Hamdi, Daniele Daffonchio
  • Publication number: 20160346734
    Abstract: The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.
    Type: Application
    Filed: January 16, 2015
    Publication date: December 1, 2016
    Applicant: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Maurizio Filippo ACCIARRI, Simona Olga BINETTI, Bruno VODOPIVEC, Maurilio Giuseppe MESCHIA
  • Publication number: 20160203385
    Abstract: An image processing system includes a first processor that acquires frames of image data. For each frame of data, the first processor generates a Gaussian pyramid for the frame of data, extract histogram of oriented gradient (HOG) descriptors for each level of the Gaussian pyramid, compresses the HOG descriptors, and sends the compressed HOG descriptors. A second processor is coupled to the first processor and is configured to receive the compressed HOG descriptors, aggregate the compressed HOG descriptors into windows, compare data of each window to at least one stored model, and generate output based upon the comparison.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 14, 2016
    Applicants: STMICROELECTRONICS S.R.L., UNIVERSITA DEGLI STUDI DI MILANO - BICOCCA
    Inventors: Alberto Margari, Danilo Pietro Pau, Raimondo Schettini
  • Patent number: 9346034
    Abstract: The invention concerns new catalysts for the reduction of oxygen suitable for PEM fuel cells, the process for their preparation and their use in other electrolytic processes.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: May 24, 2016
    Assignees: UNIVERSITA' DEGLI STUDI DI MILANO, FONDAZIONE CASSA DI RESPARMIO DELLE PROVINCE LOMBARDE
    Inventors: Leonardo Formaro, Mariangela Longhi, Pierluca Messina, Ivano Galbiati
  • Patent number: 9249353
    Abstract: A flexible transparent electrochromic device, which includes the following components, each of which is a flexible film: a working electrode comprising a transparent conducting substrate supporting an working electrode active material; a counter electrode including a transparent conducting substrate supporting a counter electrode active material; a solid polymer electrolyte (SPE) including a solution of a lithium salt in a polymer solvent. A method for preparing an electrochromic device includes the steps of: preparing a working electrode film, preparing a counter electrode film, preparing a polymer electrolyte film, and assembling the electrodes and the electrolyte, the method being implemented continuously.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: February 2, 2016
    Assignees: HYDRO-QUEBEC, FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V., CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI INSTM, UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Uwe Posset, Bettina Herbig, Gerhard Schottner, Karim Zaghib, Jean-François Labrecque, Abdelbast Guerfi, Michel Perrier, Riccardo Ruffo, Matteo Marco Salamone, Claudio Maria Mari, Luca Beverina, Giorgio Pagani, Martin Dontigny
  • Patent number: 9169995
    Abstract: The present invention relates to a device to convert the blue light from solid-state sources into white light, and includes a transparent polymer matrix with a laminar structure, diffusing particles and phosphors.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: October 27, 2015
    Assignee: UNIVERSITA' DEGLI STUDI DI MILANO BICOCCA
    Inventors: Leonida Miglio, Francesco Tassone, Franco Fattorini, Raffaello Nemni, Pierangelo Pasquettin, Sonia Pasquettin, Loretta Pasquettin, Elisa Pasquettin, Irene Pasquettin
  • Patent number: 9114119
    Abstract: The method for preventing and delaying inherited retinal degenerations using serine palmitoyltransferase inhibitors, and compositions which contain them.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: August 25, 2015
    Assignees: Universita' degli Studi di Milano, Consiglio Nazionale delle Ricerche, Universita' degli Studi de Pisa, Nanovactor S.R.L.
    Inventors: Riccardo Ghidoni, Enrica Strettoi, Maria Claudia Gargini, Paolo Gasco
  • Publication number: 20150141410
    Abstract: Chemical compounds are provided which act on GPR17 receptors and are useful in the treatment or amelioration of chronic and/or acute neurodegenerative diseases, such as multiple sclerosis, inflammatory diseases, pathologies involving the immune system, cardiovascular diseases, and renal diseases.
    Type: Application
    Filed: May 9, 2012
    Publication date: May 21, 2015
    Applicants: UNIVERSITA' DEGLI STUDI DI MILANO, FONDAZIONE ITALIANA SCLEROSI MULTIPLA - FISH ONLUS
    Inventors: Maria Pia Abbracchio, Mario Alberto Battaglia, Ivano Eberini, Marta Fumagalli, Chiara Parravicini, Cristina Sensi, Paola Zaratin
  • Publication number: 20150119342
    Abstract: The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
    Type: Application
    Filed: February 20, 2012
    Publication date: April 30, 2015
    Applicants: Universita' Degli Studi Di Milano, Fondazione Cariplo, CISI Scrl, Fondazione IRCCS Istituto Nazionale dei Tumori
    Inventors: Pierfausto Seneci, Laura Belvisi, Federica Cossu, Domenico Delia, Carmelo Drago, Daniele Lecis, Stefano Maiorana, Leonardo Pierpaolo Manzoni, Eloise Mastrangelo, Mario Milani de Mayo de Mari, Paola Maria Chiara Perego, Francesca Vasile
  • Patent number: 8999655
    Abstract: The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of myeloid derived microvesicles in a cerebrospinal fluid sample obtained from the subject. The invention further relates to a method for predicting and/or monitoring the efficacy of a treatment for a neurological pathology or for monitoring a neurological disease progression.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: April 7, 2015
    Assignees: Consiglio Nazionale delle Ricerche, Universita degli Studi di Milano, Ospedale San Raffaele S.r.l.
    Inventors: Claudia Verderio, Michela Matteoli, Roberto Furlan
  • Publication number: 20150094218
    Abstract: An in vitro method and a kit for the quantification of antibodies anti-beta amyloid protein in a sample of cerebrospinal fluid comprising the following steps a) concentrating the quantity of said antibodies of said sample with magnetic micro beads coated with macromolecules capable of binding said antibodies b) analysing the concentrated sample obtained in step a) by immunoenzyme assay or by radioimmunoassay; c) analysing a sample comprising antibodies anti-beta amyloid protein having a known titre with the same assay used in step b) and elaborating the related calibration curve, wherein said antibody having a known titre is a murine antibody belonging to the IgG2a or IgG2b class or a human or humanized antibody belonging to the IgG2b or IgGi class.
    Type: Application
    Filed: March 20, 2013
    Publication date: April 2, 2015
    Applicant: UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA
    Inventors: Fabrizio Piazza, Carlo Ferrarese