Patents Assigned to Universita' Degli Studi di Milano
  • Publication number: 20120316212
    Abstract: The present invention relates to amino alcohol derivatives of general formula I: These derivatives possess an interesting activity in that they block the secondary products of lipid oxidative stress, and are consequently suitable for therapeutic use in all disorders related with the presence of reactive carbonyl compounds.
    Type: Application
    Filed: December 20, 2010
    Publication date: December 13, 2012
    Applicants: UNIVERSITA DEGLI STUDI DI MILANO, FLAMMA S.P.A.
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, Massimo Previtali, Giancarlo Aldini, Marina Carini, Marica Orioli, Giulio Vistoli
  • Publication number: 20120253043
    Abstract: The present invention provides new bi- and polypyridine ligands of ruthenium dyes. The invention also provides solar cells, in particular dye-sensitized solar cells comprising the dyes.
    Type: Application
    Filed: September 29, 2010
    Publication date: October 4, 2012
    Applicants: Ecole Polytechnique Federale De Lausanne (EPFL), Consiglio Nazionale Delle Ricerche, Universita Degli Studi Di Milano-Bicocca
    Inventors: Mohammad Khaja Nazeeruddin, Michael Graetzel, Alessandro Abbotto, Chiara Marinzi, Norberto Manfredi, Filippo De Angelis
  • Publication number: 20120174954
    Abstract: The disclosure relates to Seebeck/Peltier effect thermoelectric conversion devices and in particular devices made of stack of dielectric layers alternated to treated semiconducting layers even of large size, not requiring lithographic patterning in a nano-micrometric scale.
    Type: Application
    Filed: July 14, 2010
    Publication date: July 12, 2012
    Applicant: Universita degli Studi di Milano - Biococca
    Inventors: Dario Narducci, Gianfranco Cerofolini
  • Publication number: 20120104375
    Abstract: A method for producing electrical contacts on organic semiconductors is described. The method, which involves low energy impact and can be carried out under ambient conditions, comprises covering the relevant surface of the semiconductor with a layer of an appropriate solvent: a metal leaf having an appropriate thickness and work function containing metal oxide impurities is deposited onto the area treated in this manner. Electrical contacts with elevated conductivity are obtained by evaporating the solvent. One embodiment of the invention describes a family of crystalline semiconductors, preferably based on perylene or ?-quaterthiophene, provided with the electrical contacts according to the method described herein and provided with particular structural characteristics. The use of metal leaf satisfying the above-stated requirements (for example imitation gold leaf, gold leaf etc.). in the above-described method is furthermore described.
    Type: Application
    Filed: May 6, 2010
    Publication date: May 3, 2012
    Applicant: UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Marcello Campione, Adele Sassella, Massimo Moret, Daniele Braga
  • Patent number: 8158593
    Abstract: The invention provides GPR17 modulators, methods of screening and use thereof for diagnosis and therapy of diseases or dysfunctions involving GPR17 activation, particularly ischemic brain damage.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: April 17, 2012
    Assignees: Universita' degli Studi di Milano, Universita' degli Studi di Pisa, Consiglio Nazionale delle Ricerche
    Inventors: Maria Pia Abbracchio, Paolo Ciana, Gianenrico Rovati, Claudia Martini, Maria Letizia Trincavelli, Claudia Verderio
  • Publication number: 20120040007
    Abstract: The method for preventing and delaying inherited retinal degenerations using serine palmitoyltransferase inhibitors, and compositions which contain them.
    Type: Application
    Filed: February 23, 2010
    Publication date: February 16, 2012
    Applicants: UNIVERSITA' DEGLI STUDI DI MILANO, NANOVECTOR S.R.L., UNIVERSITA' DEGLI STUDI DL PISA, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Riccardo Ghidoni, Enrica Strettoi, Maria Claudia Gargini, Paolo Gasco
  • Publication number: 20110281862
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumours (IMT) and non-small cell lung cancer (NSCLC).
    Type: Application
    Filed: August 27, 2009
    Publication date: November 17, 2011
    Applicants: Universita' Degli Studi di Milano - Bicocca, Universite' Claude Bernard de Lyon 1, Universite' de Geneve
    Inventors: Carlo Gambacorti Passerini, Luca Mologni, Leonardo Scapozza, Shaheen Ahmed, Peter G. Goekjian, David Gueyrard, Florence Popowycz, Benoit Joseph, Cedric Schneider, Pierre Garcia
  • Publication number: 20110177158
    Abstract: Novel liposomes are described which are capable of effectively binding beta amyloid peptide and are useful for the treatment, prevention and diagnosis of Alzheimer's disease. Binding ability is provided by the presence in the formulation of particular natural lipids identified by the Applicant. These comprise a constant component, made up of cholesterol and sphingomyelin, and an additional variable component, made up of selected lipids.
    Type: Application
    Filed: June 10, 2009
    Publication date: July 21, 2011
    Applicant: Universita degli Studi di Milano-Bicocca
    Inventors: Massimo Masserini, Francesca Re, Maria Silvia Sesana
  • Publication number: 20110104769
    Abstract: The present invention relates to the production of organic acids with yeasts that overexpress at least one sugar transporter. The yeast might express further genes related to the production of the desired organic acid. The organic acid is produced by cultivation of the yeast overexpressing a sugar transporter in an adequate culture medium, whereupon the desired organic acid is accumulated in the culture medium and subsequently purified to the desired degree by techniques known in the art.
    Type: Application
    Filed: May 27, 2009
    Publication date: May 5, 2011
    Applicant: UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Danilo Porro, Paola Branduardi, Michael Sauer
  • Publication number: 20110083713
    Abstract: The invention relates to Seebeck/Peltier bidirectional thermoelectric conversion devices and in particular to devices employing nanowires of conductive or semiconductive material defined on a substrate by common planar technologies.
    Type: Application
    Filed: April 2, 2009
    Publication date: April 14, 2011
    Applicant: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA
    Inventor: Dario Narducci
  • Patent number: 7924431
    Abstract: A method of measuring properties of particles includes generating a beam of radiation (IW); illuminating with the beam (IW) an observation region (MR) which is transited by a particle (B). A portion of the beam (IW) gives rise to radiation (SW) which is scattered by scattering interaction with the particle (B), and another portion (TW) is transmitted substantially undisturbed through the observation region (MR). In a detection plane (M), a plurality of radiation intensity values are detected which are determined by the interference between the scattered radiation (SW) and the transmitted radiation (TW). The detection of the radiation intensity values in the detection plane (M) is carried out according to a time sequence of acquisitions corresponding to successive transit positions of the particle through the observation region (MR).
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: April 12, 2011
    Assignee: Universita' Degli Studi Di Milano
    Inventors: Marzio Giglio, Marco Alberto Carlo Potenza
  • Publication number: 20100267836
    Abstract: Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C8 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which the
    Type: Application
    Filed: January 12, 2007
    Publication date: October 21, 2010
    Applicants: UNIVERSITA DEGLI STUDI DI MILANO, UNIVERSITA DEGLI STUDI DI URBINO, MCGILL UNIVERSITY, UNIVERSITA DEGLI STUDI DI PARMA
    Inventors: Gabriella Gobbi, Marco Mor, Silvia Rivara, Franco Fraschini, Giorgio Tarzia, Annalida Bedini, Gilberto Spadoni, Valeria Lucini
  • Publication number: 20100227336
    Abstract: Procedure for the quantitative determination of interactions of ligands with receptors adsorbed or immobilized on the surface of a solid material which can be functionalized, transparent and with low refractive index, by direct measure of the reflection of light.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 9, 2010
    Applicant: UNIVERSITA' DEGLI STUDI DI MILANO
    Inventors: Tommaso Bellini, Marco Buscaglia, Stefano Pezzati
  • Publication number: 20100198132
    Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
    Type: Application
    Filed: May 7, 2008
    Publication date: August 5, 2010
    Applicant: UNIVERSITÁ DEGLI STUDI DI MILANO-BICOCCA
    Inventor: Antonio Maria Pesenti
  • Publication number: 20100189918
    Abstract: The present invention relates to a method for the preparation of a novel hybrid electrochromic coating material with superior performance in terms of transparency, electrochromic contrast, colouration efficiency, and adhesion, for a use in electrochromic devices for applications where a high transparency is required in the bleached state.
    Type: Application
    Filed: November 28, 2007
    Publication date: July 29, 2010
    Applicants: Fraunhofer-Gesellschaft Zur Forderung der Angewandten Forschung e.V., Universita Degli Studi di Milano-Bicocca
    Inventors: Ayse Cochet, Uwe Posset, Gerhard Schottner, Giorgio Pagani, Ricardo Ruffo, Luca Beverina, Claudio Maria Mari, Giorgio Patriarca, Alessandro Abbotto
  • Publication number: 20100141945
    Abstract: A method of measuring properties of particles comprises the steps of generating a beam of radiation (IW); illuminating with the beam (IW) an observation region (MR) which is transited by a particle (B), a portion of the beam (IW) giving rise to radiation (SW) which is scattered by scattering interaction with the particle (B), and another portion (TW) being transmitted substantially undisturbed through the observation region (MR); and detecting, in a detection plane (M), a plurality of radiation intensity values which are determined by the interference between the scattered radiation (SW) and the transmitted radiation (TW). The detection of the radiation intensity values in the detection plane (M) is carried out according to a time sequence of acquisitions corresponding to successive transit positions of the particle through the observation region (MR).
    Type: Application
    Filed: June 22, 2005
    Publication date: June 10, 2010
    Applicant: Universita' Degli Studi Di Milano
    Inventors: Marzio Giglio, Marco Alberto Carlo Potenza
  • Publication number: 20100081704
    Abstract: The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumour pathologies. Also described is a method for the determination of the drug resistance in tumour cells, as well as a method for the identification of tumour stem cells.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 1, 2010
    Applicant: UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
    Inventors: Marialuisa Lavitrano, Emanuela Grassilli, Kristian Helin
  • Patent number: 7662947
    Abstract: The present invention relates to the expression of recombinant nucleic acids in plants. More specifically, the invention provides an Arabidopsis stomatal-specific promoter (AtMYB60 promoter—SEQ ID NO: l)for the selective expression of nucleic acids in stomatal guard cells, gene constructs containing the promoter, expression vectors carrying such and plants transfected therewith. The selective expression of nucleic acids in plant guard cells allows the regulation of stomatal opening/closing states thereby modulating, e. g. increasing, the plant ability to resist to adverse environmental or climatic conditions.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: February 16, 2010
    Assignee: Universita' degli Studi di Milano
    Inventors: Chiara Tonelli, Massimo Galbiati
  • Publication number: 20090312356
    Abstract: The invention discloses compounds of formula I endowed with agonistic activity at the alpha7 nicotinic acetylcholine receptors (?7 nAChRs), a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric disorders as well as inflammatory diseases.
    Type: Application
    Filed: June 28, 2007
    Publication date: December 17, 2009
    Applicants: UNIVERSITA DEGLI STUDI DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Carlo De Micheli, Marco De Amici, Clelia Dallanoce, Francesco Clementi, Cecilla Gotti
  • Patent number: 7579171
    Abstract: Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic acid precursor. In a second embodiment the yeast is a recombinant yeast growing in a medium comprising an ascorbic acid precursor. Preferably the recombinant yeast is transformed with a coding region encoding an enzyme selected from L-galactose dehydrogenase (LGDH), L-galactono-1,4-lactone dehydrogenase (AGD), D-arabinose dehydrogenase (ARA), D-arabinono-1,4-lactone oxidase (ALO) or L-gulono-1,4-lactone oxidase (RGLO). The ascorbic acid precursor is preferably D-glucose, L-galactose, L-galactono-1,4-lactone, or L-gulono-1,4-lactone. In another preferred embodiment the ascorbic acid is accumulated in the medium at levels greater than background. Preferably, the yield of the conversion of the precursor to ascorbic acid is preferably at least about 35%.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: August 25, 2009
    Assignee: Universita Degli Studi Di Milano, Bicocca
    Inventors: Danilo Porro, Michael Sauer