Abstract: The present invention relates to phenyl diamides according to the general formula (1) and their use as a medicament and a pharmaceutical preparation comprising as an active ingredient a phenyl diamide according to the general formula (1). Further, the present invention relates to phenyl diamides according to the formulas (16), (17) and (18) for use in the treatment of gliomas.

Abstract: A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.

Abstract: The invention relates to the use of an L-ribozyme, which is capable of splitting an L-RNA in the region of a target sequence of the L-RNA, in order to produce a pharmaceutical composition for trating undesired physiological adverse reactions due to the administration of a therapeautic modecule containing the L-RNA. Alternatively, an endogeneous target RNA may also be split by the L-ribozyme.

Abstract: The invention relates to an optical amplifier arrangement for amplifying ultra-short pulsed laser radiation comprising a mode-locked laser (1) and two or more optical amplifiers (3) arranged downstream of the laser (1) in the propagation direction of the laser radiation. Optical amplifier arrangements of this type are known in the prior art. Here the intention is to present an alternative to the known amplifier arrangements. The invention proposes arranging between the laser (1) and the optical amplifiers (3) at least one splitting element (2) which splits the pulsed laser radiation between a plurality of amplifier channels (4), wherein each amplifier channel (4) has at least one optical amplifier (3), and wherein at least one common combination element (5) is disposed downstream of the amplifier channels (4) and coherently superimposes the pulsed laser radiation amplified in the amplifier channels (4).

Abstract: Monocyclometalated Au(III) complexes, cis-[(N?C)AuL1L2] and cis-[(N?C)Au L1?L2] represented by generic chemical formulae 1a and 1b respectively with ligands L1 and L2 being either similar (L1=L2) or dissimilar (L1?L2) but with at least one of either (L1 or L2) comprising a ?-donating carbanionic group is described here. Also described are Au(III) complexes of formula in which L3 denotes a neutral donor ligand bound in a tridentate fashion. The complexes depicted by the formulae 1a, 1b and 1c in the present invention are suitable as emissive phosphorescent organometallic materials in OLEDs.

Abstract: The invention relates to a heavy-wire bond arrangement, having a substrate (2), a heavy wire (1) and a high-voltage heavy-wire bond connection, in which an end bond section (4) of the heavy wire (1), which extends towards the end (7) of the heavy wire (1), is bonded to the substrate (2), such that in the area of the bond section (4) a bond contact (5) between the heavy wire (1) and the substrate (2) is formed, the heavy wire (1) having a tapering section (6) which adjoins the end of the wire (7) and in which the wire cross-section tapers towards the end of the wire (7). The application additionally relates to a method for producing a heavy-wire bond arrangement.

Abstract: The invention relates to a gasification reactor (1) and associated method for the entrained-flow gasification of solid fuels under pressure. The reactor essentially consists of a pressure vessel (4) that can be cooled and an inner jacket (7) that is equipped with a heat shield. At least one crude gas outflow (8) is located at the upper end of the cylindrical pressure vessel and at least one bottoms withdrawal outlet (30) is located at the lower end, the pressure vessel having at least enough space for a moving bed (13), an entrained flow (11) that circulates internally above the surface of the moving bed and a buffer zone (3) situated above said entrained bed.

Abstract: The present invention relates to a headlight for a motor vehicle having a light source, which is arranged in a reflector, for emission of light beams in a light outlet direction, having a masking apparatus (1) which has a mask (2) which can be moved to a first position in order to mask out at least a portion of the light beams, and which can be moved to a second position in which the mask (2) is moved at least partially out of the light beams, wherein the movement of the mask (2) can be produced by an actuator unit (3) which has at least one magnet coil (4) and a magnet yoke (5) in order to form a magnetic flux circuit. According to the invention, a hinged armature (6) is provided, is held in an articulated manner on at least a part of the magnet yoke (5) and is in the form of part of the mask (2), such that the hinged armature (6) carries out a folding movement, and produces the movement of the mask (2), when current is passed through the magnet coil (4).

Abstract: The present invention describes tripodal catechol derivatives with an adamantyl basic framework for the functionalisation of surfaces, and methods for their production and use. A fourth remaining position of the adamantane skeleton is suitable to be optionally functionalised by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents.

Abstract: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.

Abstract: A method of generating intra-resonator laser light (1) comprises the steps of coupling input laser light (2), e.g.

Abstract: The present invention provides aqueous stable suspensions of biodegradable diblock copolyesters and a method for their production. The diblock copolyesters comprise one block of an aliphatic polyester and one block of a polyethylene oxide. Suspensions according to the present invention are suitable to be used as biodegradable viscosity modifiers, compatibilizers in blends, as glues, varnishes, paper additives, flame retardants, impact modifiers and hazers of transparent plastics, and for the production of biodegradable sheets, films, fibers, plates, vessels, tubes and capillaries for transport or packaging purposes. Furthermore, the suspensions according to the present invention are suitable to be used for the production of nano- and microfibers and nano- and microfiber nonwovens with non-oriented or oriented fibers by means of electrospinning.

Abstract: The invention relates to an integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids and monitoring the condition of the cell-spheroids in real time, comprising a) a mounting device for a cultivation chamber plate, b) an amplifier board linked with the contacts for the microelectrodes in the mounting device, c) a rotary shaker, on which the amplifier board and the mounting device for the cultivation chamber plate are placed, and d) a control unit, that is linked with the amplifier board and the rotary shaker, wherein the control unit allows recording, analyzing of data and controlling of the movement of the rotary shaker. The cultivation chamber plate has several culture reservoirs, wherein the bottom of each culture reservoir forms a microcavity and each microcavity features microelectrodes on the microcavity walls. The mounting device has contacts for the microelectrodes.

Abstract: The invention relates to antibodies against the human La protein and to their use in immunotargeting, in particular the immunotargeting of tumour cells. The object of the invention is to provide improved antibodies which bind universal target structures on the surface of tumour cells, and to provide novel anti-La antibodies, in particular with a high affinity for La, a universal target structure on tumour cells, which make it possible to use the antibodies as recombinant fragments for immunotargeting. The invention comprises recombinant antibodies comprising: i. a binding unit of an antibody which specifically binds to an epitope of a human nuclear antigen, preferably human La protein, and ii. a binding unit of an antibody which specifically binds to an effector cell or of a ligand which specifically binds to an effector cell. The invention furthermore comprises novel antibodies which specifically bind the human La protein.

Abstract: The invention relates to a method for operating a multiprocessor computer system which has at least two microprocessors (102) and resources (103, 104, 105, 106, 107, 108) which are jointly used by the microprocessors, programs (403) being able to be executed on the computer system, characterized by at least one resource manager (101) with the following features: a) the resource manager (101) manages resources (103, 104, 105, 106, 107, 108) which are assigned to said manager and can be adjusted at least in terms of their time response, b) the resource manager (101) receives and processes reservation requests (401) for reserving desired resources (103, 104, 105, 106, 107, 108), which reservation requests are transmitted by programs (403), c) the reservation requests (401) describe at least the type, scope and time response of the desired resources (103, 104, 105, 106, 107, 108), d) the resource manager (101) allocates the respectively desired resources (103, 104, 105, 106, 107, 108) to the requesting program

Abstract: The invention relates to a device and to a method for the detection of hydrogen in a gas mixture, wherein the device comprises a catalyst unit which is connected to a source and a supply device for CO and/or CO2, respectively, or comprises these and wherein the catalyst unit is connected to a flame ionization detector by a feed line, such that the gas mixture, especially containing an inert carrier gas after passing through the catalyst unit is conducted to the FID. The FID is operated with hydrogen as fuel gas.

Abstract: The invention relates to a method for recovering volatile components from a solid (10), characterized by the following method steps: drying (12) the solid (10) by means of superheated steam, withdrawing excess steam (14) from a closed circuit (23), and recovering (18) the volatile components from the excess steam (14).

Abstract: The invention relates to Phospholipase A2 (hereinafter also referred to as PLA2) inhibitors for use in the treatment or prevention of flavivirus infection, in particular an infection with a flavivirus of the genus Flavi or the genus Hepaci. The invention also provides a pharmaceutical formulation for use in the treatment or prevention of an infection with a flavivirus of the genus Flavi or the genus Hepaci and a method of preventing or treating an infection with a flavivirus of the genus Flavi or the genus Hepaci.

Abstract: The present invention is based on two important experimental observations: The first observation is that increased extracellular concentrations of ionized calcium are found in erosive arthritis and stimulate monocytic IL-1? release via the CaSR and GPRC6A. Simultaneous stimulation of monocytes with calcium ions and selected TLR ligands results in a 20-fold increased IL1? response compared to lipopolysaccharide (LPS) alone. During the crosstalk between GPCR and TLR signaling, phospholipase C is activated, which triggers calcium dependent potassium channels, resulting in potassium efflux, caspase-1 activation and IL-1? release. The amplification of IL1? secretion at sites of locally increased calcium ion concentrations aggravates rheumatoid arthritis. The second important observation is that both CaSR and GPRC6A, are highly expressed in the synovial membrane of patients with rheumatoid arthritis, but expression of GPRC6A, but not of CaSR, is lower in patients with osteoarthritis (s. FIG. 1).

Abstract: A solar element with increased efficiency and also a method for increasing the efficiency of a solar cell are provided. The solar cell comprises a luminescent element, an upconverter, and also at least one selectively reflecting structure.