Abstract: The present invention is directed to N-desmethylclobazam or any suitable pharmaceutically acceptable thereof useful for the prevention and/or treatment of a chronic pain disorder and related methods and pharmaceutical formulations.

Abstract: A compound for use in the treatment of itch is provided, wherein the compound comprises the general formula (1a), general formula (1b) or general formula (1c). The compounds of the invention are positive allosteric ?2 and/or ?3 GABAA receptor modulators.

Abstract: The invention relates to an osteoconductive graft comprising a biocompatible material that is interspersed with a network of non-overlapping pores connected by channels, and wherein the pores are characterized by a pore diameter of 0.6 mm to 1.4 mm, the channels are characterized by a channel diameter of 0.5 mm to 1.3 mm, the channel diameter is smaller than the pore diameter and the pores are aligned in one, two or three spatial axes at regularly spaced intervals.

Abstract: An occluder device (20) for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue comprises:—a compliant balloon (5) defining a fluid-tight balloon chamber and provided with a balloon channel (7) forming a longitudinal passage from a proximal side (B2) to a distal side (B1) of the balloon; —a tip element (10) disposed at the distal side of the balloon, a base element (4) disposed at the proximal side of the balloon, and connecting means comprising at least one connecting stmt (9) attached to the tip element and to the base element, the tip element and the base element each having a guide opening (105a, 105b) substantially coaxial to the balloon channel (7) for slidingly receiving therein a guidewire (106) for the device; —elongated actuating means disposed longitudinally slidable in the balloon channel (7), releasably connectable to the tip element (10), and longitudinally slidable with respect to the base element (4); —locking means (2, 13) for maintaining a predetermin

Abstract: Novel backbone-cyclized peptidomimetics of the general formula cyclo[-P1-P2-P3-P4-P5-P6-P7-P8-T1-T2-]?? (I) wherein the single elements T or P are ?-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to modulate the GLP-1 receptor. They can be used as medicaments to treat, prevent, or delay the onset of diseases, disorders or conditions in which modulation of the human GLP-1 receptor is beneficial, such as type 2 diabetes. These backbone-cyclized peptidomimetics can be manufactured by a process which is based on a mixed solid—and solution phase synthetic strategy.

Abstract: A differential memristive circuit includes a normaliser; a first memristor connected between first top and bottom nodes, the first memristive element having a first adjustable resistance value; a first switch connected between the first bottom node and the normaliser; a second memristor connected between a second top node and a second bottom node the second memristor having a second adjustable resistance value; a second switch connected between the second bottom node and the normaliser; and a set of voltage sources that generate voltages greater than 0V. The set of voltage sources generate a first voltage value across the first memristor and a second voltage value across the second memristor. A first output signal depends on the first adjustable resistance value, while a second output signal depends on the second adjustable resistance value. A memristive circuit net output signal is obtained as the difference between the first and second output signals.

Abstract: The invention relates a method for generating a motion-corrected image for visual-inertial odometry comprising an event camera rigidly connected to an inertial measurement unit (IMU), wherein the event camera comprises pixels arranged in an image plane that are configured to output events in presence of brightness changes in a scene at the time they occur, wherein each event comprises the time at which it is recorded and a position of the respective pixel that detected the brightness change, the method comprising the steps of: Acquiring at least one set of events (S), wherein the at least one set (S) comprises a plurality of subsequent events (e); Acquiring IMU data (D) for the duration of the at least one set (S); Generating a motion-corrected image from the at least one set (S) of events (e), wherein the motion-corrected image is obtained by assigning the position (xj) of each event (ej) recorded at its corresponding event time (tj) at an estimated event camera pose (Ttj) to an adjusted event position (x?j)

Abstract: A method for monitoring and visualizing a patient's medical condition, wherein a graphical representation of the patient comprising a body having at least a torso and a head, as well as particularly two legs and two arms, is displayed using a display device, wherein said displayed graphical representation comprises at least one region which is allocated to at least one or several provided (e.g. measured and/or determined) patient monitoring quantities, and wherein the appearance of the at least one region is altered in real-time when the at least one patient monitoring quantity to which said at least one region is allocated changes.

Abstract: The Invention relates to a medical device (1) for oral procedures, particularly for use in oral intubation and fixation procedures, comprising at least one protective device (2) for teeth, the protective device (2) comprising the a rigid support component (3), and at least one push button (4), arranged at the support component (3), wherein each of the at least one the push button (4) comprises a rigid surface (42) that is facing towards the teeth, when the medical device (1) is applied orally, wherein the support component (3) is configured such that each of the at least one push button (4) is displaceable separately relative to the support component (3) between a first position and a second position.

Abstract: The invention relates to a device for determining a parameter for the diagnostics of hydrocephalus and other disorders of intracranial pressure, wherein information about the volume elasticity is obtained from a pressure signal or another characteristic signal which contains information about the pressure or the volume composition in the skull. The characteristic parameter determined according to the invention is the ratio of the amplitude of a modulating wave in the processed characteristic signal to the amplitude of the modulated wave in the course of the pulse amplitude of the modulated wave of the processed characteristic signal.

Abstract: An implantable pump system can deliver blood within the body of a patient, with a blood pump which delivers a fluid in an axial direction. The blood pump can include a rotatingly drivable rotor as well as a pump casing surrounding the rotor, as well as a support tube, in which the pump casing is arranged and held, wherein an annular gap is formed between the support tube and the pump casing. An almost physiological blood flow is rendered possible in this manner, by way of the combination of a flow through the pump casing on the one hand, and the annular gap on the other hand.

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: The invention relates to computation of optical flow using event-based vision sensors.

Abstract: The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.

Abstract: The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.

Abstract: Template-fixed ?-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These ?-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

Abstract: A magnetic field probe, particularly for magnetic resonance applications, comprises: —a detector liquid that exhibits a nuclear magnetic resonance (NMR) line characterized by a chemical shift ?; —an electrically conductive structure surrounding the detector liquid for receiving therefrom a magnetic resonance signal; and —a container containing the detector liquid; —the detector liquid containing paramagnetic dopant means dissolved therein; —said NMR transition having an observable resonance frequency ? when the field probe is placed in an external magnetic field; and has orientation means for orienting the field probe in relation to a reference direction of said external magnetic field.

Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of insect bite hypersensitivity of equine mammals, preferably of horses. Furthermore, the invention provides methods for preventing or treating insect bite hypersensitivity of equine mammals, preferably of horses.

Abstract: The invention relates to a sleeve (1) for providing a dental implant (2) with a disinfectable surface (100b), wherein the sleeve (1) is configured to be attached to an end or coronal region (20) of a dental implant (2), wherein the sleeve (1) comprises a through hole (101) encompassed by the sleeve (2) which through hole (101) is adapted to receive said end region (20) of the dental implant (2), wherein said through hole (101) is delimited by an inside (100a) of the sleeve which faces said through hole (101), and wherein the sleeve (1) comprises an outside (100b) facing away from said inside (100a), which outside (100b) forms said disinfectable or sterilizable surface (100b). Further, the invention relates to an arrangement of the sleeve on a dental implant as well as to a method for arranging the sleeve on a dental implant.

Abstract: A band-pass filter is described comprising a first first-order filter stage comprising a first resistor characterized by a first impedance and connected to a first node, referred to as a filter input node, and, through a second node to a first reactive component connected to a third node, the first impedance being such that a first current therethrough is dependent on the difference between the voltages at the first and second nodes; and a second first-order filter stage comprising a second resistor characterized by a second impedance and connected to the second node, and, through a fourth node, to a second reactive component connected to a fifth node. The second impedance is such that a second current therethrough is dependent on the negative of the sum of the voltages at the second and fourth nodes. The band-pass filter further comprises summing means for summing the voltages at the second and fourth nodes to output a voltage at a sixth node.