Abstract: The invention relates to a method for identifying and quantifying a polypeptide from a library of polypeptides. The method comprises the steps of: 1—providing a polypeptide library and a detection tag library, 2—generating a nested library comprising the polypeptides and the detection tags, 3—sequencing the nested library, 4—selecting a member of the nested library in one or several selection steps that are independent of a physical genotype-phenotype linkage, 5—isolating the detection tag from the selected polypeptide, 6—identifying and quantifying the detection tag by mass spectrometry, 7—obtaining the sequence of the selected polypeptide. The invention also relates to a collection of polypeptides, a collection of detection tags, and a collection of plasmid vectors.

Abstract: Described herein is the use of a non-agonist ligand, particularly an antibody, specifically binding to GM-CSF or one of CD116, CD131 and the GM-CSF receptor composed of CD116 and CD131 for use in treatment of leukemia in a patient having undergone allo-HCT or in treatment of other complications arising as a consequence of hematopoietic cell transplantation from an immunologically non-identical donor.

Abstract: The invention relates to a method, a device and a system for producing particularly a hydrogel (200) and for controlling an enzymatically catalyzed formation of a covalent bond in a solution, wherein said covalent bond is formed between a first compound (20) comprising a first moiety (21) and a second compound (22) comprising a second moiety (23), wherein the first and the second moiety (21, 23) are a substrate of an enzyme wherein said enzyme catalyzes the formation of a covalent bond between the first and the second moiety (21, 23), and wherein a voltage is applied to the solution for spatially controlling said formation, wherein said voltage is adjusted such that it induces electrolysis of said solution.

Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

Abstract: The invention relates to a method to predict a patient's risk of developing prostate cancer, or to distinguish indolent vs. aggressive cancers among patients suspected of bearing PCa and therefore selected for biopsy, and/or predict the risk of progression of prostate cancer in a patient having undergone prostate cancer treatment, particularly by radical prostatectomy, brachytherapy, and/or external beam radiation therapy, wherein said method comprises detecting/quantifying the level of indoleamine-2,3-dioxygenase (IDO) mRNA or protein in a urine sample obtained from said patient.

Abstract: A method is for providing a medical image of a patient, acquired via a computed tomography apparatus. An embodiment of the method includes acquiring first projection data of a first measurement region; acquiring second projection data of a second measurement region; registering a reference image to the at least one respiration-correlated image of the patient, wherein the reference image corresponds to the at least one functional image of the patient or is reconstructed under a second reconstruction rule from the second projection data, to produce a deformation model; applying the deformation model to the at least one functional image of the patient; combining the at least one functional image of the patient, deformed by the applying of the deformation model, with the at least one respiration-correlated image of the patient, to produce the medical image of the patient; and providing the medical image of the patient.

Abstract: The invention relates to a combination medicament for treatment of malignant neoplastic disease. The combination medicament comprises an IL-12 polypeptide having a biological activity of IL-12 or a nucleic acid expression vector comprising a sequence encoding such IL-12 polypeptide, and a non-agonist blockade of T-cell inhibitory molecules, including non -agonist LAG-3 ligand, non-agonist TIM-3 ligand, non-agonist BLTA ligand, non-agonist TIGIT ligand, non-agonist VISTA ligand, non-agonist B7/H3 ligand, non-agonist CTLA-4 ligand or non-agonist PD-1 ligand, particularly an anti-CTLA-4 or anti-PD-1 immunoglobulin G.

Abstract: The invention relates to a method for 3D reconstruction of a scene, wherein an event camera (1) is moved on a trajectory (T) along the scene, wherein the event camera (1) comprises a plurality of pixels that are configured to only output events (ek) in presence of brightness changes in the scene at the time (tk) they occur, wherein each event comprises the time (tk) at which it occurred, an address (xk,yk) of the respective pixel that detected the brightness change, as well as a polarity value (pk) indicating the sign of the brightness change, wherein a plurality of successive events generated by the event camera (1) along said trajectory (T) are back-projected according to the viewpoint (P) of the event camera (1) as viewing rays (R) through a discretized volume (DSI) at a reference viewpoint (RV) of a virtual event camera associated to said plurality of events, wherein said discretized volume (DSI) comprises voxels (V?), and wherein a score function ƒ(X) associated to the discretized volume (DSI) is determi

Abstract: The invention relates to a method for monitoring touchscreen events (3) of a handheld device (6), wherein —a monitoring application (1) is provided, —at least one touchscreen event (3) on a display screen (61) of said handheld device (6) is detected by means of said monitoring application (1), wherein the touchscreen event (3) is directed to a foreground application (2), —event data (4) is generated for said at least one touchscreen event (3) by means of said monitoring application (1), wherein said event data (4) comprises a time stamp (41) of said at least one touchscreen event (3) and an identification (42) of said foreground application (2), —said event data (4) is stored by means of said monitoring application (1). The invention further relates to a computer program for executing the steps of the method according to the invention.

Abstract: The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors. Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

Abstract: The present invention relates to a method for detecting and reconstructing a surface illuminated with spatially structured light such that the light illuminates an area of the surface from which the light is reflected back. The light includes a temporarily varying intensity in the form of successive light modulation patterns. The back-reflected light is detected by an optical sensor including a plurality of pixels. A pixel coordinate is associated to each pixel and each pixel generated a photocurrent proportional to the intensity of the light impinging on a respective pixel, computes a signal related to a photocurrent, and each pixel outputs an address-event merely when a respective signal due to the light impinging on the respective pixel increases by an amount larger than a first threshold or decreases by an amount larger than a second threshold since a last address-event from the respective pixel.

Abstract: The invention relates to a medical implant, comprising an expandable structure (100) which is designed to be expanded from a crimped state into an expanded state, wherein the structure (100) forms a tubular scaffolding in the expanded state, and wherein the structure (100) comprises a plurality of first struts (101) arranged along a periphery of the structure in said expanded state. According to the invention, the first struts (101) each comprise a recess (O), wherein the medical implant (1) further comprises a sealing member (200) arranged in said recesses (O), wherein said sealing member (200) is formed annularly in said expanded state.

Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.

Abstract: The invention relates to a medical implant device for attaching or re-attaching a flexible graft to a bone, comprising: at least a first insert comprising a synthetic osteoconductive and/or osteoinductive material, and a flexible graft, wherein the flexible graft is connected to the at least one insert, particularly prior to surgical implantation of the medical implant device.

Abstract: The invention provides for a method for the detection of FeLV infection in a patient, wherein a sample obtained from the patient is contacted in-vitro with a recombinant transmembrane p15E protein in a p15 (E) antibody binding step.

Abstract: The present invention relates to a method for tracking a position of at least one keypoint in an image of an object moving relative to an optical sensor, wherein light reflected from the object (12) is detected so as to generate an image of the object, and wherein a position of at least one keypoint (Kj) in said image is detected and updated using temporal contrast events (Ev) of the optical sensor. The invention also relates to a corresponding computer program and device.

Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.

Abstract: The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III.

Abstract: The present invention concerns a method of programming an analogue electronic neural network comprising a plurality of layers of somas. Any two consecutive layers of somas are connected by a matrix of synapses. The method comprises: applying test signals to inputs of the neural network; measuring at a plurality of measurement locations in the neural network responses of at least some somas and synapses to the test signals; extracting from the neural network, based on the responses, a first parameter set characterising the behaviour of the at least some somas; carrying out a training of the neural network by applying to a training algorithm the first parameter set and training data for obtaining a second parameter set; and programming the neural network by using the second parameter set. The invention also relates to the neural network and to a method of operating it.

Abstract: The invention relates to a device and a method for compressing a hydrogel layer (H), wherein a separate piston (600) that is designed to be connected to a second component (400) of the device in a releasable manner in an operating mode of the device, particularly by means of a latching connection, presses along a compression direction (C) against said hydrogel layer (H) residing on a membrane bottom (501) of a graft frame (500) so as to compress the hydrogel layer (H) between the piston (600) and the membrane bottom (501).