Abstract: A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.

Abstract: The present disclosure provides efficient and precise programmable gene delivery technology based on a composition comprising (i) a first protein comprising or consisting of a site-specific DNA binding protein capable of binding and cleaving a target nucleic acid sequence; or a nucleic acid construct encoding said first protein; and (ii) a second protein comprising or consisting of a transposase; or a nucleic acid construct encoding said second protein; wherein said transposase is a modified hyperactive PiggyBac.

Abstract: A device for attaching a primary implant as a fixation point for a vascular prosthesis on a vessel wall of a blood vessel, the device at least including a carrier element, which is designed to drive a plurality of penetration elements, for penetrating the vessel wall, radially outwards in relation to a longitudinal axis of the carrier element. In the device, a limiting element is formed on the carrier element as a radial stop for the penetration elements.

Abstract: The present invention relates to a coated membrane containing: a membrane with a front and a rear face, a catalyst-containing coating which is provided on the front face of the membrane, the catalyst containing a support material which has a BET surface area of maximally 80 m2/g, an iridium-containing coating which is provided on the support material and contains an iridium oxide, an iridium hydroxide or an iridium hydroxide oxide or a mixture of at least two of these iridium compounds, wherein the catalyst contains iridium in a quantity of maximally 60 wt. %, and the coating provided on the membrane front face has an iridium content of maximally 0.4 mg iridium/cm2.

Abstract: A process for producing articles with an extrusion-based additive manufacturing system using a consumable filament made from or containing a propylene polymer composition made from or containing: A) from 20% to 60% by weight of a heterophasic propylene copolymer; B) from 5% to 33% by weight of a propylene homopolymer or copolymer, wherein the copolymer contains up to 5% by weight of an alpha olefin; C) from 2% to 15% by weight of an elastomeric block copolymer made from or containing styrene; D) from 4% to 32% by weight of an elastomeric ethylene copolymer; E) from 5% to 50% by weight of a glass material as filler; and F) from 0.1% to 5% by weight of compatibilizer.

Abstract: The present invention relates to the use of plant extracts from the genus Daphne for the cosmetic treatment of the skin and to cosmetic preparations which comprise extracts of Daphne giraldii and/or Daphne gnidium or other members of the genus Daphne containing daphnetoxin and/or other daphnane diterpenoids for skin treatment. The plant extracts and cosmetic preparations are particularly useful for stimulation of the lymphatic system.

Abstract: The invention relates to a method for coaxially extruding an extruded product. Hereby, an extruding device comprises the following: a receiver (7); a first receiver bore (5) which is formed in the receiver (7) and in which a first punch (10) is arranged; a second receiver bore (6) which is formed in the receiver (7) inside the first receiver bore (5) and coaxially therewith and in which a second punch (11) is arranged; and a mold (15) having a mold cavity (14) which is connected to the first and the second receiver bore (5, 6). In the method, the following is provided: arranging a first material billet (8) of a first material (2) in the first receiver bore (5); arranging a second material billet (9) of a second material (3) in the second receiver bore (6); and extruding an extruded product (1) in which the first and the second material (2, 3) are connected in a form-fitting and integrally bonded manner.

Abstract: The present invention relates to a device for the dynamic emulation of forced induction systems of propulsion sources, which comprises an inlet tube (2), an outlet tube (4), a turbine set (12), one or more electric compressors (14), a cooling means (20), a heating means (24), and a heat regulation means. The present invention also relates to a method comprising one or more of the following actions: regulating supply air pressure by controlling the rotation regime of the one or more electric compressors (14); controlling the operating conditions of the one or more electric compressors (14), using a safety means; regulating supply air temperature, using the heat regulation means; regulating the counterpressure of the outlet gases of the propulsion source (10), by modifying the geometry of the turbine of the turbine set (12).

Abstract: A method for measurement of a sequence of recurring electronic signals (10) is proposed, wherein the sequence to be measured consists of n recurring electronic signals, wherein a time-to-digital converter (2) and a memory (5) are provided.

Abstract: It is provided a method for generating a supercontinuum, the method comprising the following steps: a) radiating a carrier laser pulse having a first temporal width onto a first non-linear material; b) at the same time, radiating a second shorter laser pulse having a second temporal width onto the first non-linear material, thereby changing the non-linear properties of the first non-linear material and imprinting a ghost pulse having a third temporal width into the carrier pulse; the second temporal width being at least two times shorter than the first temporal width, and c) radiating the carrier pulse with imprinted ghost pulse onto the first non-linear material or a second non-linear material and generating, by self-phase modulating, a supercontinuum around the center frequency of the carrier pulse.

Abstract: The present invention relates to novel monoclonal anti-human-GDF-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human GDF-15 capable of inhibiting cancer growth.

Abstract: In a method and an apparatus for detecting electrically conductive foreign bodies during inductive energy transmission between a primary coil (1) and a secondary coil (2), at least one sensor coil (5) is arranged between the primary coil (1) and the secondary coil (2), and a current flowing in the sensor coil (5) due to the induced voltage during the energy transmission is detected and evaluated. In this case, the sensor coil (5) is connected to at least one capacitor to form a resonant circuit which is matched to the excitation frequency of the primary coil (1). The phase position of the current in the resonant circuit in relation to a reference signal is then used to determine whether there are electrically conductive foreign bodies (4) between the primary coil (1) and the secondary coil (2). A high degree of sensitivity, also in relation to small electrically conductive foreign bodies within the energy transmission path, is achieved by means of the method and the apparatus.

Abstract: The present invention relates to peptides, in particular amyloid inhibitory peptides, and to pharmaceutical compositions comprising such peptides. Furthermore, the present invention relates to such peptides, in particular such amyloid inhibitory peptides, for use in methods of treating or diagnosing neurodegenerative diseases such as Alzheimer's disease, or for use in a method of treating or diagnosing type 2 diabetes. Furthermore, the present invention also relates to a kit for the in-vitro or in-vivo detection and, optionally, quantification of amyloidogenic polypeptides, amyloid fibrils or amyloid aggregates, and/or for the diagnosis of Alzheimer's disease or type 2 diabetes in a patient.

Abstract: Method for applying a nanolaminate to a metal workpiece, wherein a coating made of a nanolaminate is applied in a region that is subjected to a notch effect, for example, a weld seam, which nanolaminate consists of a series of at least two metal layers, wherein each metal layer consists of a metal or a metal alloy that differs from the metal or the metal alloy in the adjacent layer. According to the invention, the method can take place with a batching tank locally and/or in situ.

Abstract: The invention relates to a device comprising: at least one tool module (4) having a quick-coupling interface (19); at least one support having a quick-coupling interface (19) and designed to hold the at least one tool module; and at least one data processing unit designed for computer-assisted tool management. The support for holding the tool module (4) comprises at least one support frame (16), at least one interface (21) for computer-assisted tool module identification, and at least one sensor unit. The support frame comprises at least one quick-coupling interface (19) for a tool module. The tool module comprises at least one implement (18) for use outdoors, at least one suspension that is compatible with the quick-coupling point on the support frame, at least one computer-readable storage medium (22) for computer-readable data, and at least one interface for transmission of computer-readable data.

Abstract: In a dynamic memory allocator, a method of allocating memory to a process, the method comprising executing on a processor the steps of: creating one or more arenas within the memory, each arena comprising one or more memory blocks and each arena having an n-byte aligned arena address; upon receiving a memory request from the process, returning a pointer to the process, the pointer having as its value an address of a memory block selected from one of the arenas; upon determining that the memory block is no longer needed by the process, retrieving the address of said memory block from the pointer and releasing the memory block; and, upon a new arena being created, shifting forward the n-byte aligned address of said new arena according to a stored variable such that each memory block of said new arena is also shifted by the stored variable, the stored variable having n bytes and the stored variable having a random value.

Abstract: The present invention relates to a permanently polarized hydroxyapatite and a composition or material comprising thereof. The present invention further relates to a process for obtaining a permanently polarized hydroxyapatite and to different uses of the permanently polarized hydroxyapatite or the composition or material comprising thereof.

Abstract: A computer-implemented method for tracking a mobile device based on a series of motion measurements of said device comprises retrieving a topological map providing a graph of topological paths, wherein each topological path is associated with a corresponding path direction; statistically generating, on a virtual map, a plurality of particles around an estimated initial position of the mobile device, representing an initial uncertainty of said estimated initial position of the mobile device; determining, from said series of motion measurements, a measured displacement vector of the mobile device representing an estimated displacement direction and an estimated displacement distance of the mobile device; displacing each of said particles on the virtual map according to a randomized particle displacement vector which is derived from said measured displacement vector based on an uncertainty of the measured displacement vector and recording said particle displacement vector for each displaced particle; determining

Abstract: The application describes a T-cell expressing a chimeric antigen receptor (‘CAR T-cell’) containing superparamagnetic iron-based particles (‘loaded CAR T-cell’) for use in treating a tumor. Said loaded CAR T-cell exhibits a reduced cytokine release upon binding to a cell of the tumor expressing an antigen being recognized by the CAR of the CAR T-cell, compared to a CAR T-cell not containing superparamagnetic iron-based particles (‘unloaded CAR T-cell’) under the same conditions. Furthermore, an in vitro method of generating a CAR T-cell containing superparamagnetic iron-based particles is described, whereby such loaded CAR T-cells are generated.

Abstract: The present invention relates to a compound of formula (I) wherein E1 to E6 are independently Si or Ge; X1 to X4 are independently selected from the group consisting of H, SiH3, halogen and Si(Y)3; Y is independently selected from C1 to C20 alkyl and halogen; R1 to R12 are independently selected from the group consisting of C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, C3 to C20 cycloalkyl, C6 to C20 aryl, C7 to C20 arylalkyl, C7 to C20 alkylaryl and Z; and Z is independently selected from the group consisting of H, halogen and C1 to C20 alkyl; a process for their preparation; and the use of the compound for preparing the Si- and Ge-containing solid.