Abstract: Described herein is a genetically modified plant or non-human animal having reduced expression of an endogenous target gene.

Abstract: A method for demodulation including the following steps: exciting a vibrationally mounted, at least sectionally bar-shaped oscillating element for oscillating in the range of a resonance frequency of the oscillating element, wherein a temporally varying, in particular periodic, excitation signal is used for excitation, and wherein at least the temporal variation of the excitation signal is known or determined; detecting a modulated oscillation of the oscillating element by means of at least one sensor, wherein the sensor supplies a sensor measurement variable that varies versus time as a function of an amplitude and a phase of the modulated oscillation of the oscillating element. According to the present teaching, it is provided that the method includes the following step: generate a first comparison signal by amplitude modulating a known temporally varying, in particular periodic, demodulation signal by means of the temporally varying sensor measurement variable.

Abstract: An occlusion device (210) is provided for occluding a left atrial appendage (LAA), including a compliant balloon (230) defining a fluid-tight balloon chamber (232), and an actuating shaft (234), which is disposed at least partially within the balloon chamber (232) for setting a distance between distal and proximal end portions (236, 238) of the balloon (230). A proximal LAA-orifice cover (70) includes a frame (72) and a covering (74) fixed to the frame (72). An orifice-support stent (290) is fixed to and extends distally from the proximal LAA-orifice cover (70), and is generally cylindrical when in a radially-expanded state. Other embodiments are also described.

Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.

Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.

Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.

Abstract: A transparent multi-layer assembly includes a transparent carrier structure comprising a polymer material and an electrically conductive transparent layer comprising an electrically conductive oxide. A silicon carbide layer is arranged as an adhesion promoter between the transparent carrier structure and the electrically conductive transparent layer.

Abstract: A heat exchanger comprises a base, and a plurality of deformable fins connected to a surface of the base. Some deformable fins have a free end configured to move away from the surface of the base as a function of a local temperature increase of the base. The deformable fins are distributed on the surface of the base to be exposed to a coolant flowing over the surface of the base, wherein a distribution of the deformable fins on the surface of the base is non-uniform.

Abstract: A method for transferring objects includes providing a medium in a reservoir, the medium containing objects; providing a substrate having an acceptor surface, the acceptor surface facing an opening of the reservoir; determining a first target focus point in the medium; and generating a first laser pulse or first laser pulse train focused onto the first target focus point. Pulse intensity of the first laser pulse or pulse train at the first target focus point and/or pulse duration of the first laser pulse or pulse train is/are chosen to generate a droplet of the medium ejected towards the acceptor surface. A center wavelength of the first laser pulse or pulse train is larger than 500 nm, larger than 650 nm, or between 0.9 ?m and 1.35 ?m. The first target focus point is determined relative to the position of at least one object of the objects.

Abstract: A shaped article, a method for making it, and its use. The shaped article is formed from flat fiber material and has a bottom (2), a body (4), and an opening, which is surrounded by a circumferential flange (6). The shaped article (1) comprises a flange stabilizer (10) attached to the second flat side (18) of the flange (6) facing the bottom (2). The flange stabilizer (10) is disc-shaped and has an inner contour (12) corresponding to the desired cross-sectional shape of the shaped article (1) in the region of the opening and can be slipped over the body (4) in the region of the bottom (2) and up to the flange (6). The flat sides (16, 18) of the flange stabilizer (10) extend essentially parallel to the flange (6), defining and stabilizing the cross-sectional shape of the body (4) in the region of the opening and the flange.

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

Abstract: 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof.

Abstract: The present invention relates to a method for producing a sport beverage, comprising the steps of providing malt and/or unmalted grains, providing mashing liquor produced from spent grains, processing the malt and the mashing liquor to obtain a wort, fermenting the wort by using a yeast and optionally, blending with flavour(s) and/or vitamin(s); and/or adding of sugar(s). The present invention further relates to a sport beverage obtained by said method, wherein said sport beverage is non-alcoholic or has an alcohol content of less than about 1.2 vol-%, preferably less than about 0.5 vol-%. The present invention also relates to the use of the sport beverage before and/or after physical activities.

Abstract: An apparatus and a method using no switching elements for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured are proposed. Sensor elements are arranged in groups and columns where each column is fed with a continuous voltage waveform of different amplitude, frequency and phase characteristics which then produce current signals that are modulated by the variable resistance signals to be measured. Modulated currents are summed row-wise and collected at the read-out circuits, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output voltage signals. The read-out circuits de-multiplex each individual sensor signal to be measured by lock-in demodulation according to the frequencies and phases employed for the stimulation of each column.

Abstract: The present invention relates to an electrolyte for use in metal-air batteries comprising at least one polyalkylene glycol containing ethylene oxide or propylene oxide units or mixtures thereof in an alkaline solution. Further, the invention relates to a metal-air battery comprising an anode, a cathode and an ion-conducting electrolyte interposed therebetween, wherein the anode contains a metal selected from the group of aluminum (Al), iron (Fe), lithium (Li), zinc (Zn), magnesium (Mg) or silicon (Si) and the cathode is an air electrode and the electrolyte comprises at least one polyalkylene glycol containing ethylene oxide or propylene oxide units or mixtures thereof in an alkaline solution.

Abstract: The present invention relates to a quantum computing unit comprising a superconducting substrate or other superconducting component, at least three outer Majorana modes, and at least one inner Majorana mode, wherein the at least three outer Majorana modes are located along an outer perimeter, and wherein the at least one inner Majorana mode is located within the outer perimeter. This spatial configuration of the four participating Majorana modes allows to control the time-dependent coupling between the respective Majorana modes. The related quantum gates can be performed perfectly in a finite time, preferably with a frequency of up to several GHz. These include the braiding gate, the ?/8 magic phase gate, the ?/12 phase gate, and, for multi-qubit systems, the CNOT gate. The robustness of the mechanism guarantees that for special times the quantum gate is conducted the quantum gate is perfectly realized. This property is independent of material specific parameters.

Abstract: The present invention relates to a microscope for quantitative measurements of the wavefront, comprising: means for the illumination of a sample (T); an objective lens (2); an ordered two-dimensional arrangement of lenses (3), with a spacing p? greater than 500 ?m and a relative aperture of less than 10; an image sensor (4) located in a capture space (Ec) to receive the light scattered by the sample (T), and to acquire spatial and angular information on the object wavefront associated therewith; and a computational entity to perform a computational reconstruction of the object wavefront from the spatial and angular information. Other aspects of the invention relate to a method, a computer program and a product incorporating the same, adapted for the performance of the functions of the computational entity of the microscope, as well as to a module and a kit for a microscope.

Abstract: A method of producing a test body for diffusion tensor imaging, which comprises a plurality of channels in a structuring material, the channels preferably having a maximum cross-section of 625 ?m2, wherein a virtual model of the test body is created and the virtual model is fed to a structuring device which produces the test body by means of a 3D printing-based, in particular lithography-based, structuring process, the structuring process being designed as a multiphoton lithography process, in particular as a multiphoton absorption process, in which the structuring material containing a photosensitizer or photoinitiator is irradiated in a location-selective manner, wherein the radiation is successively focused on focal points lying within the structuring material, resulting in that in each case a volume element of the material located in the focal point is subjected to a change in state by means of a photochemical reaction as a result of multiphoton absorption.

Abstract: The invention relates to a device for taking up oil from a water surface, comprising a container for receiving the oil and an oil-transporting means, wherein a portion of the oil-transporting means can be brought into fluid communication with the water surface and another portion of the oil-transporting means is disposed within the container, wherein the oil can be transported into the container via the oil-transporting means, wherein the oil-transporting means is formed from a hydrophobic fabric, the surface of which comprises filament-shaped and/or grid-like structures which are designed in such a way that they retain a gas layer on the surface of the hydrophobic fabric under water. The invention further relates to a corresponding method for taking up oil from a water surface.

Abstract: A system for one-sided measuring a presence of magnetic particles in a probe volume comprises a one-sided coil assembly and a current controller, wherein the one-sided coil assembly is arranged around a central coil assembly axis for generating a rotating magnetic field distribution and comprises at least 3, preferably at least 4, circumferentially distributed coil assembly sectors, wherein the current controller is configured to generate a time varying current in each of said coil assembly sectors, said time varying current comprising a periodic modulation with a rotation frequency and phase shifted between adjacent coil assembly sectors to generate a magnetic field rotating in a plane perpendicular to the coil assembly axis, said magnetic field rotating with a rotation frequency associated with a frequency of said periodic modulation, and wherein the system is configured for measuring said presence of magnetic particles in said probe volume with said one-sided coil assembly.