Patents Assigned to Universite Claude Bernard Lyon 1
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Patent number: 10987435Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.Type: GrantFiled: August 15, 2017Date of Patent: April 27, 2021Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, NANOHInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Patent number: 10982110Abstract: The present invention relates to a process for preparing a vinylidene chloride polymer composite comprising a vinylidene chloride polymer and clay materials. The process comprises polymerising vinylidene chloride and clay materials and the resulting vinylidene chloride polymer particle is surrounded by a plurality of clay platelets. The clay materials according to the present invention function as a solid stabilizer in the process for preparing a vinylidene chloride polymer composite of the present invention. The present invention further relates to the vinylidene chloride polymer composite obtainable from the process, to use of the vinylidene chloride polymer composite for the preparation of films, and to films prepared therefrom.Type: GrantFiled: November 25, 2016Date of Patent: April 20, 2021Assignees: Solvay SA, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Ecole Supérieure de Chimie Physique Electronique de Lyon, Ezus LyonInventors: Pierre-Emmanuel Dufils, Isabelle Chaduc, Laura Delafresnaye, Elodie Bourgeat-Lami, Muriel Lansalot, Jérôme Vinas, Yves Vanderveken
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Patent number: 10975318Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.Type: GrantFiled: January 12, 2017Date of Patent: April 13, 2021Assignees: INOVENTEAM, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Arthur Marais, Mahmoud Ould-Metidji, Florian Lepoivre, Anatole Collet, Matteo Martini, Fabien Rossetti, Olivier Tillement, Antoine Vanlaer, François Ghillebaert
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Patent number: 10968253Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: October 20, 2016Date of Patent: April 6, 2021Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Patent number: 10961351Abstract: An object of the present invention is the use of iron compounds as hydrosilylation and dehydrogenative silylation catalysts.Type: GrantFiled: July 5, 2018Date of Patent: March 30, 2021Assignees: ELKEM SILICONES FRANCE SAS, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-Inventors: Vincent Monteil, Jean Raynaud, Magali Puillet, Magali Bousquie
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Publication number: 20210072431Abstract: A liquid lens that includes a first window, a second window, and a cavity disposed between the first window and the second window; a first and second liquid disposed within the cavity, the first and second liquid substantially immiscible with each other and having different refractive indices such that an interface between the first and second liquid defines a variable lens, at least a portion of the first liquid disposed within a first portion of the cavity, the second liquid disposed within a second portion of the cavity; a common electrode in electrical communication with the first liquid; and a driving electrode disposed on a sidewall of the cavity and insulated from the first liquid and the second liquid by an insulating element, wherein the insulating element comprises an insulating outer layer in contact with the liquids, the insulating outer layer comprising a lanthanide series oxide.Type: ApplicationFiled: December 13, 2018Publication date: March 11, 2021Applicants: CORNING INCORPORATED, UNIVERSITE CLAUDE BERNARD LYON 1, Centre National De La Recherche Scientifique-CNRSInventors: Bruno Berge, Gwenael Bonfante, Benjamin Burger, Stéphanie Chevalliot, Mathieu Maillard, Bérangère Toury-Pierre
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Patent number: 10934343Abstract: The present invention provides a tropoelastin-derived polypeptide and an elastic composite biocompatible material comprising the polypeptide. The object of the invention is also a method for the synthesis of such a biocompatible material, a cell culture support comprising such a biocompatible material and the use of this material, in particular in the biological and medical field, in particular for cell culture and tissue regeneration.Type: GrantFiled: May 12, 2017Date of Patent: March 2, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ CLAUDE BERNARD LYON 1Inventors: Romain Debret, Clément Faye, Jérôme Sohier, Pascal Sommer
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Publication number: 20210047479Abstract: The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant.Type: ApplicationFiled: March 13, 2019Publication date: February 18, 2021Applicants: Albert-Ludwigs-Universitaet Freiburg, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique - CNRS, Institut Enseignement Supérieur et Recherche en Alimentation Santé Animals Sciences Agronomiques etInventors: Anayancy OSORIO MADRAZO, Laurent DAVID, Alexandra MONTEMBAULT, Eric VIGUIER, Thibaut CACHON
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Publication number: 20210017180Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NORMALE SUPÉRIEURE DE LYON, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1), UNIVERSITÉ DE BRETAGNE OCCIDENTALEInventors: Nadège HAMON, Maryline BEYLER, Raphaël TRIPIER, Olivier MAURY, Janah SHAYA
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Patent number: 10837335Abstract: Disclosed is a reactive filter, that is a selective catalytic reduction filter or an oxidative reaction filter, including a porous substrate including internal pores having their inner surface, totally or partially, directly coated with a catalytic zeolite material resulting from an in situ hydrothermal synthesis. Also disclosed is a process for preparing such a reactive filter and the use thereof in an engine exhaust depolluting system.Type: GrantFiled: October 29, 2015Date of Patent: November 17, 2020Assignees: VOLVO TRUCK CORPORATION, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Anne Giroir-Fendler, Sonia Gil Villarino, Eduard Emil Iojoiu
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Patent number: 10832801Abstract: The present invention concerns a method for sequencing oligosaccharides, which makes it possible to identify the primary sequence of an oligosaccharide of unknown structure, including its monosaccharide composition, the position (regiochemistry) and configuration (stereochemistry) of glycosidic bonds, the nature and position of functional modifications, and its branched structure, particularly including the identification of the reducing end.Type: GrantFiled: April 14, 2017Date of Patent: November 10, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ CLAUDE BERNARD LYON 1Inventors: Isabelle Compagnon, Baptiste Schindler
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Publication number: 20200320768Abstract: This method for acquiring a spatial map of auditory perception of a subject comprises a plurality of successive test sequences, each test sequence comprising steps of: a) calibration (1002) of the subject's position, by displaying instructions to the subject, using a head-mounted visual display system worn by the subject, in order to acquire a reference position of the subject, the subject's position being measured using a video motion capture system by measuring the spatial coordinates of a first optical marker worn by the subject, b) choosing (1004) spatial coordinates of a target location of a sound source, said target cation being located around the subject, c) emitting (1006) a predefined sound, using a sound source placed at said target location, d) in response to acquisition instructions generated by the subject using an acquisition interface, acquiring (1008) an estimated location of said sound source, by using the video motion capture system to measure the spatial coordinates of a second optical markType: ApplicationFiled: May 26, 2017Publication date: October 8, 2020Applicants: Institut National De LA Santge Et de La Recherche Medicale(Inserm), Universite Claude Bernard Lyon 1, Universite Jean Monnet Saint Etienne, Centre National De La Recherche ScientifiqueInventors: Romeo SALEMME, Alessandro FARNE, Valérie GAVEAU, Anaël BELLE, Eric KOUN, Francesco PAVANI
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Patent number: 10793970Abstract: A method of fabricating a turbine engine part, the method including fabricating an ingot out of ceramic material of eutectic composition by performing the Czochralski process including putting a seed of the ingot that is to be obtained into contact with a molten bath of a mixture of eutectic composition in order to initiate the formation of the ingot on the seed, the mixture including at least two ceramic compounds; drawing the ingot from the molten bath while imposing on the ingot that is being formed a drawing speed less than or equal to 10 mm/h together with rotation at a speed of rotation less than or equal to 50 rpm; and machining the ingot as fabricated in this way in order to obtain the turbine engine part.Type: GrantFiled: June 14, 2017Date of Patent: October 6, 2020Assignees: SAFRAN AIRCRAFT ENGINES, SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Amélie Potelle, Omar Benamara, Kheirreddine Lebbou, Michaël Podgorski
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Patent number: 10779726Abstract: An eye-movement determination method includes providing an a touch display and a memory that stores an image that includes a point of interest, wherein the image is a stored image, and repeatedly executing a set of steps. The steps include determining a position of a contact point, locating a corresponding position in an image that is displayed on the touch display, generating a degraded image from the stored image, displaying the degraded image on the touch display, and recording successive positions of the contact point. The contact point is a point at which a user contacts the touch display. The degraded image is substantially identical to the stored image with a clear zone but degrades beyond the clear zone.Type: GrantFiled: December 27, 2016Date of Patent: September 22, 2020Assignees: Centre National de la Recherche Scientifique, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Angela Sirigu, Jean-René Duhamel, Guillaume Lio
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Publication number: 20200289049Abstract: The present invention relates to a non-implantable medical device (1, 1?) intended to cover wounds and skin lesions, comprising a biosensor (3E, 3E?), characterised in that said biosensor (3E, 3E?) comprises a piece made of absorbent, hydrophilic material fixing, on the surface and/or within the thickness thereof, a composition of agglomerated powders comprising particles of ethylene vinyl acetate (EVA) having a surface in part covered with at least one orthophosphoric acid salt and a visual indicator of microbiological growth. In particular, the medical device (1, 1?) may comprise several layers in order to enable the guiding of a liquid. The present invention relates to a method for preparing such a medical device (1, 1?).Type: ApplicationFiled: November 29, 2018Publication date: September 17, 2020Applicants: Biomerieux, Elkem Silicones France SAS, F.D.S., Fibroline, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM), Ecole Normale Superieure De Lyon, Centre National de la Recherche Scientifique (CNRS)Inventors: Christine Rozand, Aline Dardy, Fanny Berrat, Caroline Moine, Philippe Serre
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Patent number: 10745520Abstract: The invention relates to a process for producing aromatic polyimides, comprising the following steps: (a) preparation of one or more solid salt(s) by reacting one or more aromatic tetracarboxylic acid(s) and one or more diamine(s) according to a mole ratio ranging from 0.95 to 1.05; (b) drying of the solid salt(s), (c) addition, to the dry salt resulting from step (b), of one or more compound(s) (C) comprising one or more group(s) chosen from a carboxylic acid group, an anhydride group, an ester group and an acyl chloride group; (d) solid-state polymerization of said solid salt(s) in the presence of the compound(s) (C).Type: GrantFiled: December 17, 2015Date of Patent: August 18, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON1, UNIVERSITE JEAN MONNET SAINT-ETIENNE, Rhodia Operations, Institut National Des Sciences Appliquees De LyonInventors: Stéphane Jeol, René Rossin, Vincent Mollet, Benjamin Paci, Françoise Fenouillot-Rimlinger, Alain Rousseau
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Publication number: 20200248144Abstract: The present invention concerns a method for obtaining an implantable cartilage gel for tissue repair of hyaline cartilage, comprising particles of chitosan hydrogel and cells that are capable of forming hyaline cartilage, said method comprising a step for amplification of primary cells in a three-dimensional structure comprising particles of physical hydrogel of chitosan or a chitosan derivative, then a step for re-differentiation and induction of the synthesis of extracellular matrix by said amplified cells, in the same three-dimensional structure, wherein said cells are primary articular chondrocytes and/or mesenchymal stem cells differentiated into chondrocytes. The present invention also concerns the cartilage gel obtained thereby, and its various uses for cartilage repair following a traumatic lesion or an osteoarticular disease such as osteoarthritis.Type: ApplicationFiled: March 25, 2020Publication date: August 6, 2020Applicants: ADVANCED CHITOSAN SOLUTIONS BIOTECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Pascale HAZOT, Frédéric MALLEIN GERIN
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Publication number: 20200246400Abstract: The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.Type: ApplicationFiled: August 17, 2018Publication date: August 6, 2020Applicants: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Universite Claude Bernard Lyon 1Inventors: François Leulier, Maria Elena Martino
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Patent number: 10723999Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.Type: GrantFiled: December 19, 2014Date of Patent: July 28, 2020Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYONInventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
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Patent number: 10718697Abstract: A method for estimating a stiffness of a deformable part of a system including a four-photodiode detector for analyzing at least one characteristic of a sample. The method includes receiving the signals recorded by the four photodiodes, calculating the resultant signals from the recorded signals, calculating a cross-correlation of the resultant signals calculated for obtaining an intercorrelated signal, estimating the stiffness of the deformable part depending on the intercorrelated signal.Type: GrantFiled: December 29, 2016Date of Patent: July 21, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventor: Ludovic Bellon