Abstract: The invention relates to an in vitro process for determining the functional IL-17 pro-inflammatory dependent level (IPDL) of a biological sample, comprising the following steps: a) measuring the level of an inflammatory marker produced by IL-17-sensitive cells incubated in the presence of a biological sample, b) measuring the level of said inflammatory marker produced by said cells incubated in the presence of a biological sample, in the presence of antibodies which neutralize the biological activity of IL-17, and c) determining the IPDL level, which is the difference between the level of said inflammatory marker measured in step a) and the level of said inflammatory marker measured in step b).
Type:
Grant
Filed:
June 5, 2015
Date of Patent:
August 3, 2021
Assignees:
Hospices Civils de Lyon, Universite Claude Bernard Lyon 1
Abstract: A method for producing a porous silicone material including the following steps: 1) implementing a direct emulsion E of silicone in water including: A) a silicone base A crosslinkable by polyaddition or polycondensation; B) at least one nonionic silicone surfactant B having a cloud point between 10 and 50° C.; C) optionally, at least one catalyst C; and D) water; 2) heating the emulsion E to a temperature greater than or equal to 60° C. to obtain a porous silicone material; and 3) optionally, drying the porous silicone material.
Type:
Application
Filed:
May 17, 2019
Publication date:
July 8, 2021
Applicants:
Elkem Silicones France SAS, Institut National des Sciences Appliquees de Lyon, Universite Claude Bernard Lyon I, Centre National de la Recherche Scientifique - CNRS, Universite Jean Monnet Saint Etienne
Inventors:
Francois GANACHAUD, Etienne FLEURY, Gabriel LARRIBE, David MARIOT, Frederic MARCHAL
Abstract: A power electronic module (1) including at least one semiconductor (5) that is connected to connection conductors (6, 7), and including a dielectric carrier (10) having both a fixed layer (9), on which at least one of said connection conductors (6) is mounted, and a movable layer (11), the fixed layer (9) and the movable layer (11) exhibiting similar dielectric permittivities and being superposed along at least one surface facing the at least one connection conductor (6).
Type:
Grant
Filed:
January 29, 2018
Date of Patent:
June 29, 2021
Assignees:
Supergrid Institute, Universite Claude Bernard Lyon 1, Ecole Centrale De Lyon, Institut National Des Sciences Appliquees De Lyon, Centre National De La Recherche Scientifique
Abstract: The present invention relates to a pharmaceutical combination product comprising: a liposomal formulation exclusively containing a LPS; and at least one cytotoxic compound. It also relates to its use as an anti-tumour therapy.
Type:
Application
Filed:
October 30, 2018
Publication date:
June 17, 2021
Applicants:
Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Hospices Civils de Lyon, Centre Léon Bérard
Abstract: The present invention relates to the technical field of composite materials comprising a thermosetting polymer matrix in which thermoplastic polymer and/or elastomer particles are dispersed. More precisely, the invention relates to a novel type of polymeric material obtained by using a particular ionic liquid as cross-linking agent for an epoxy resin mixed with a thermoplastic polymer and/or an elastomer. The invention also relates to a process for manufacturing said composite material and uses thereof, notably in the aeronautical, aerospace, automotive, maritime, wind power, electronics, or sports and leisure sectors.
Type:
Grant
Filed:
May 22, 2017
Date of Patent:
June 15, 2021
Assignees:
UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITÉ JEAN MONNET SAINT ETIENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
Abstract: The invention concerns a gallinacean embryo in which cancer cells have been grafted within the embryo tissue, characterised in that the embryo is at a developmental stage between the HH10 and HH25 stages at the time of the grafting, wherein said cancer cells are not neuroblastoma cells and said cells form tumors inside the embryo.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
May 18, 2021
Assignees:
UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
Abstract: The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing an aqueous solution of biological membrane-associated membrane proteins into contact with at least one compound of the invention. The present invention also relates to a method for stabilizing membrane proteins in solution in an aqueous solution, comprising a step (i) consisting in bringing an aqueous solution of a membrane protein in solution into contact with at least one compound of the invention.
Type:
Application
Filed:
December 27, 2017
Publication date:
May 6, 2021
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE GRENOBLE ALPES
Inventors:
Pierre FALSON, Julien DAUVERGNE, Ahcène BOUMENDJEL, Marine PEUCHMAUR, Kim Anh NGUYEN, Sandrine MAGNARD
Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
Type:
Grant
Filed:
August 15, 2017
Date of Patent:
April 27, 2021
Assignees:
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, NANOH
Inventors:
François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
Abstract: A method for detecting and quantifying additives in a complex aqueous fluid, and a method for detecting an inhibitor of mineral deposition or corrosion, injected in a gas or oil well. The invention also relates to a developer solution including a lanthanide and a chelating agent for detecting said additives or inhibitors.
Type:
Grant
Filed:
June 17, 2015
Date of Patent:
April 27, 2021
Assignees:
TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Christian Hurtevent, Salima Baraka-Lokmane, Olivier Tillement, Arthur Marais, Mattéo Martini, Mahmoud Ould-Metidji, Francisco Vasquez Velado, Florian Lepoivre
Abstract: The present invention relates to a process for preparing a vinylidene chloride polymer composite comprising a vinylidene chloride polymer and clay materials. The process comprises polymerising vinylidene chloride and clay materials and the resulting vinylidene chloride polymer particle is surrounded by a plurality of clay platelets. The clay materials according to the present invention function as a solid stabilizer in the process for preparing a vinylidene chloride polymer composite of the present invention. The present invention further relates to the vinylidene chloride polymer composite obtainable from the process, to use of the vinylidene chloride polymer composite for the preparation of films, and to films prepared therefrom.
Type:
Grant
Filed:
November 25, 2016
Date of Patent:
April 20, 2021
Assignees:
Solvay SA, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Ecole Supérieure de Chimie Physique Electronique de Lyon, Ezus Lyon
Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
April 13, 2021
Assignees:
INOVENTEAM, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Arthur Marais, Mahmoud Ould-Metidji, Florian Lepoivre, Anatole Collet, Matteo Martini, Fabien Rossetti, Olivier Tillement, Antoine Vanlaer, François Ghillebaert
Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
Type:
Grant
Filed:
October 20, 2016
Date of Patent:
April 6, 2021
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
Inventors:
Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
Abstract: A liquid lens that includes a first window, a second window, and a cavity disposed between the first window and the second window; a first and second liquid disposed within the cavity, the first and second liquid substantially immiscible with each other and having different refractive indices such that an interface between the first and second liquid defines a variable lens, at least a portion of the first liquid disposed within a first portion of the cavity, the second liquid disposed within a second portion of the cavity; a common electrode in electrical communication with the first liquid; and a driving electrode disposed on a sidewall of the cavity and insulated from the first liquid and the second liquid by an insulating element, wherein the insulating element comprises an insulating outer layer in contact with the liquids, the insulating outer layer comprising a lanthanide series oxide.
Type:
Application
Filed:
December 13, 2018
Publication date:
March 11, 2021
Applicants:
CORNING INCORPORATED, UNIVERSITE CLAUDE BERNARD LYON 1, Centre National De La Recherche Scientifique-CNRS
Inventors:
Bruno Berge, Gwenael Bonfante, Benjamin Burger, Stéphanie Chevalliot, Mathieu Maillard, Bérangère Toury-Pierre
Abstract: The present invention provides a tropoelastin-derived polypeptide and an elastic composite biocompatible material comprising the polypeptide. The object of the invention is also a method for the synthesis of such a biocompatible material, a cell culture support comprising such a biocompatible material and the use of this material, in particular in the biological and medical field, in particular for cell culture and tissue regeneration.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
March 2, 2021
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ CLAUDE BERNARD LYON 1
Inventors:
Romain Debret, Clément Faye, Jérôme Sohier, Pascal Sommer
Abstract: The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant.
Type:
Application
Filed:
March 13, 2019
Publication date:
February 18, 2021
Applicants:
Albert-Ludwigs-Universitaet Freiburg, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique - CNRS, Institut Enseignement Supérieur et Recherche en Alimentation Santé Animals Sciences Agronomiques et
Inventors:
Anayancy OSORIO MADRAZO, Laurent DAVID, Alexandra MONTEMBAULT, Eric VIGUIER, Thibaut CACHON
Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
Type:
Application
Filed:
March 29, 2019
Publication date:
January 21, 2021
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NORMALE SUPÉRIEURE DE LYON, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1), UNIVERSITÉ DE BRETAGNE OCCIDENTALE
Abstract: Disclosed is a reactive filter, that is a selective catalytic reduction filter or an oxidative reaction filter, including a porous substrate including internal pores having their inner surface, totally or partially, directly coated with a catalytic zeolite material resulting from an in situ hydrothermal synthesis. Also disclosed is a process for preparing such a reactive filter and the use thereof in an engine exhaust depolluting system.
Type:
Grant
Filed:
October 29, 2015
Date of Patent:
November 17, 2020
Assignees:
VOLVO TRUCK CORPORATION, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
Inventors:
Anne Giroir-Fendler, Sonia Gil Villarino, Eduard Emil Iojoiu
Abstract: Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.
Type:
Application
Filed:
January 11, 2019
Publication date:
November 12, 2020
Applicants:
Elkem Silicones France SAS, Universite Claude Bernard Lyon I, CPE Lyon Formation Continue et Recherche - CPE Lyon FCR, Centre National de la Recherche Scientifique - CNRS
Abstract: The present invention concerns a method for sequencing oligosaccharides, which makes it possible to identify the primary sequence of an oligosaccharide of unknown structure, including its monosaccharide composition, the position (regiochemistry) and configuration (stereochemistry) of glycosidic bonds, the nature and position of functional modifications, and its branched structure, particularly including the identification of the reducing end.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
November 10, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ CLAUDE BERNARD LYON 1