Abstract: The invention provides an isolated peptide containing a motif that binds antiphospholipid antibodies (aPLA) and that is recognized by CD4+ T cells that are able to induce production of antiphospholipid antibodies (aPLA). The present invention further provides methods for detection of aPLA and CD4+ T cells able to induce production of aPLA. The present invention also provides methods for treating the antiphospholipid syndrome (APS).

Abstract: The present invention relates to new profluorophores and conjugates thereof and their use for the detection of target molecule in a sample, in particular nucleic acid target molecules. The invention relates to new profluorophores and new fluorophores and methods of use thereof particularly useful in the fields of diagnostics and quality control.

Abstract: The present relates to a multi-junction photon detector comprising a semiconductor substrate, a plurality of n+ pixels on the top surface and a p+ uniform doping implant on the backside and at least one n-doped layer on the backside, deeper in the substrate bulk than the p+ implant, such that the detector presents a first PN junction corresponding to a drift and signal induction region and comprising the pixels on the substrate, and a second PN junction corresponding to a gain region and comprising the n-doped layer disposed on the backside of the detector active area deeper in the substrate bulk. These two junctions are operated in inverse polarization. The area between them contains a PN junction in direct polarization and it is fully depleted from the free charges.

Abstract: The invention is directed to a Quantum Random Number Generator comprising an emitting device (110) triggered by a signal representing an input bit x and adapted to generate and send a physical system (130) characterized by one of two possible quantum states determined by said input bit x, a measurement device (120) adapted to detect said physical system, to identify the quantum state of said physical system through an unambiguous state discrimination measurement and to generate an output b first representing whether the quantum state has been identified or not and, if it has been identified, which quantum state among the two possible quantum states was detected by the unambiguous state discrimination measurement to a processing device (140), the processing device (140) being adapted to estimate the entropy of the output b given the probabilities p(b|x) representing the probability of observing output b for a state preparation x, and a randomness extraction device (150) adapted to extract final random bit stre

Abstract: A multiplexed and encapsulated 3D cell co-culture drug testing or screening method which discloses an in vitro drug testing kit suitable for testing the effect of one or more drugs of interest on multiple biological processes in one or more target cell types.

Abstract: The present invention relates to a system for detecting and predicting the presence of pathogens in a predetermined area of a field comprising a network of measurement stations, each measurement station comprising a first type of sensor adapted to measure environmental data, and a second type of sensor adapted to detect airborne pathogens, the system further comprising a computer processing unit adapted to collect the data to the two types of sensors and treat them by artificial intelligence to provide real-time spatially and temporally resolved data about the early detection of the pathogens as well as environmental data that are correlated to the spread and development of the pathogens and the plant disease and identify specific patterns representative of situations where treatment is required and a communication device able to send a signal to said field user indicating in which area treatment is required.

Abstract: The invention relates to a Quantum Key Distribution system comprising a transmitter 300 and a receiver 400 for exchanging a quantum key via a quantum channel 600 through a decoy-state three state protocol wherein the transmitter comprises a transmitter processing unit 340 adapted to use random numbers from a quantum random generator to select a quantum state to encode from different states of intensity and basis, a Pulsed light source 310 adapted to generate an optical pulse, a time-bin interferometer 320 through which the generated optical pulse passes and which transforms generated optical pulse into two coherent pulses separated by the time bin duration, a single intensity modulator 360 adapted to change the intensity of the two pulses individually according to the choice made by the transmitter processing unit 340, and a variable optical attenuator 370 adapted to reduce the overall signal intensity to the optimum photon number per pulse.

Abstract: Magnetic stir bar having at least one permanent magnet to spin the magnetic stir bar when the magnetic stir bar is subjected to a rotating magnetic field. The magnetic stir bar has a chamber to store a product within the magnetic stir bar. The magnetic stir bar has a closed configuration in which the chamber is closed and an open configuration in which the chamber is open. The magnetic stir bar automatically reconfigures itself from the closed configuration to the open configuration when said magnetic stir bar is spun at or above a threshold rotational speed.

Abstract: The present invention relates to the use of cyanoglucoside according to formula (I) and formulations thereof in the prevention and/or treatment of diabetes and/or metabolic syndrome; wherein R1, R2 and R3 are independently selected from an optionally substituted mono- or di-saccharide, —O—R4, —O—C(O)—R4 and halogen, such as Cl, F or Br, wherein R4 is selected from H, alkyl, such as methyl, as well as tautomers, geometrical isomers, optically active forms, pharmaceutically acceptable salts and pharmaceutically active derivative thereof.

Abstract: The present application relates to methods for producing structurally variant polypeptide molecules in parallel using column-free techniques by polypeptide ligation, separation of ligated polypeptides from ligation reactions, folding of polypeptides, and desalting of polypeptides. Further described are methods for determining the effects and properties of structurally variant polypeptide molecules produced in parallel using column-free techniques.

Abstract: A method of sampling and decoding of a signal of interest x comprising, at a training stage: acquiring a set of training signals {xi}i=1M, providing a sampling operator P? and a decoder g?g(.), training operator P? on signals {xi}i=1M to obtain a learned sampling operator P{circumflex over (?)}; and, at a sampling stage: applying P{circumflex over (?)} in a transform domain ? to signal x, resulting in observation signal y; applying the decoder g?g(.) to y, to produce an estimate {circumflex over (x)} of signal x to decode and/or, decide about, the signal. Decoder g?g(.) is trained jointly with P? on signals {xi}i=1M, to obtain a learned decoder g{circumflex over (?)}g, by jointly determining, during a cost minimization step, sampling parameters ? and decoding parameters ?g according to a cost function, and wherein the step of applying the decoder g?g(.) uses decoding parameters ?g, such that estimate {circumflex over (x)} is produced by the learned decoder g{circumflex over (?)}g.

Abstract: The present relates to a multi-junction photon detector comprising a semiconductor substrate, a plurality of n+ pixels on the top surface and a p+ uniform doping implant on the backside and at least one n-doped layer on the backside, deeper in the substrate bulk than the p+ implant, such that the detector presents a first PN junction corresponding to a drift and signal induction region and comprising the pixels on the substrate, and a second PN junction corresponding to a gain region and comprising the n-doped layer disposed on the backside of the detector active area deeper in the substrate bulk. These two junctions are operated in inverse polarization. The area between them contains a PN junction in direct polarization and it is fully depleted from the free charges.

Abstract: The present invention relates to biological markers of metabolic bone diseases or disorders such as osteoporosis and related methods using thereof. The invention further relates to the use of those biomarkers and related material and assays in the diagnosis of subjects at risk of developing such disorders or monitoring the effects of a treatment thereof.

Abstract: The present invention provides methods of inhibiting cerebral inflammation comprising administering a CCR5 inhibitor to a subject.

Abstract: The present invention is directed to new 5-ALA derivatives, particles and formulation thereof, related methods of preparation and methods of use thereof. In particular, the invention relates to compounds of the invention, particles and formulation thereof useful in the treatment of a cancer and/or the diagnosis of a cancer cell such as in photodynamic therapy or photodynamic diagnosis.

Abstract: The present invention is directed to N-desmethylclobazam or any suitable pharmaceutically acceptable thereof useful for the prevention and/or treatment of a chronic pain disorder and related methods and pharmaceutical formulations.

Abstract: The present invention is directed to new graft polymer of a hyaluronic acid polymer and N-isopropylacrylamide based polymer, preparations, compositions and uses thereof. In particular, the invention relates to pH and/or thermo-sensitive compositions able to form spontaneously nanoparticles useful as active and agents and delivery systems for at least one bioactive agent.

Abstract: The present application relates to arenaviruses with rearrangements of their open reading frames (“ORF”) in their genomes. In particular, described herein is a modified arenavirus genomic segment, wherein the arenavirus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented arenavirus particles comprising one L segment and two S segments or two L segments and one S segment. The arenavirus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.

Abstract: The present invention relates to a novel method for identifying pairs of receptors/ligands, transgenic animals useful for carrying out said method, and the use of ligands and/or modulators of the interaction between a ligand and its receptor in the food industry, fragrance industry, and health industry, for instance.

Abstract: Magnetic stir bar (1) for use with a magnetic stirrer, said magnetic stir bar (1) comprising at least one permanent magnet (2) for spinning said magnetic stir bar (1) when said magnetic stir bar (1) is subjected to a rotating magnetic field; and a chamber (3) for storing a product inside said magnetic stir bar (1), wherein said magnetic stir bar (1) has a closed configuration in which said chamber (3) is closed, said magnetic stir bar (1) being maintained in said closed configuration under the effect of a first force (f), and an open configuration in which said chamber (3) is open, said magnetic stir bar (1) being maintained in said open configuration under the effect of a second force (F); and wherein said magnetic stir bar (1) is adapted to automatically reconfigure itself from said closed configuration to said open configuration when said magnetic stir bar (1) is spun at or above a threshold rotational speed (?t).