Abstract: Magnetic stir bar (1) for use with a magnetic stirrer, said magnetic stir bar (1) comprising at least one permanent magnet (2) for spinning said magnetic stir bar (1) when said magnetic stir bar (1) is subjected to a rotating magnetic field; and a chamber (3) for storing a product inside said magnetic stir bar (1), wherein said magnetic stir bar (1) has a closed configuration in which said chamber (3) is closed, said magnetic stir bar (1) being maintained in said closed configuration under the effect of a first force (f), and an open configuration in which said chamber (3) is open, said magnetic stir bar (1) being maintained in said open configuration under the effect of a second force (F); and wherein said magnetic stir bar (1) is adapted to automatically reconfigure itself from said closed configuration to said open configuration when said magnetic stir bar (1) is spun at or above a threshold rotational speed (?t).

Abstract: The invention is directed to a Quantum Random Number Generator comprising an emitting device (110) triggered by a signal representing an input bit x and adapted to generate and send a physical system (130) characterized by one of two possible quantum states determined by said input bit x, a measurement device (120) adapted to detect said physical system, to identify the quantum state of said physical system through an unambiguous state discrimination measurement and to generate an output b first representing whether the quantum state has been identified or not and, if it has been identified, which quantum state among the two possible quantum states was detected by the unambiguous state discrimination measurement to a processing device (140), the processing device (140) being adapted to estimate the entropy of the output b given the probabilities p(b|x) representing the probability of observing output b for a state preparation x, and a randomness extraction device (150) adapted to extract final random bit stre

Abstract: A device for random number generation based on an optical process of quantum nature, including a light source emitting photons randomly, a light detector adapted to absorb the randomly emitted photons and to measure a number n of photons produced by the light source in a time interval T, and a randomness extractor. The detector includes a photon sensor acting as a photon-to-electron converter, an amplifier for converting the electron signal received from the photon sensor into a voltage and amplifying the voltage signal, as well as an analog-to-digital converter for processing the amplified signal received from the amplifier by encoding the amplified signal into digital values and sending these digital values to the randomness extractor for further processing such as to produce quantum random numbers (QRNs) based on the number of photons produced by the light source in a time interval T.

Abstract: The present invention relates to the use of cyanoglucoside according to formula (I) and formulations thereof in the prevention and/or treatment of diabetes and/or metabolic syndrome; wherein R1, R2 and R3 are independently selected from an optionally substituted mono- or di-saccharide, —O—C(O)—R4 and halogen, such as Cl, F or Br, wherein R4 is selected from H, alkyl, such as methyl, as well as tautomers, geometrical isomers, optically active forms, pharmaceutically acceptable salts and pharmaceutically active derivative thereof.

Abstract: The present invention is directed to new 5-ALA derivatives, particles and formulation thereof, related methods of preparation and methods of use thereof. In particular, the invention relates to compounds of the invention, particles and formulation thereof useful in the treatment of a cancer and/or the diagnosis of a cancer cell such as in photodynamic therapy or photodynamic diagnosis.

Abstract: System and methods for synchronizing and aligning quantum channel for Quantum Key Distribution. The primary object of the invention is to allow a Quantum Key Distribution (QKD) apparatus to work continuously with only two communication channels, a quantum communication channel and a service channel. This is achieved by linking the clock frequencies of both channels and completed by an over-sampling method for phase synchronization tracking. Clock signal carry is done through data using a clock data recovery encoding techniques. Having a continuous operating QKD system is not possible without a tracking system that enables phase alignment. This synchronization and alignment system and method for QKD has multiple benefits as it allows real-time synchronization with continuous data flow and is not dedicated to a specific quantum protocol.

Abstract: The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.

Abstract: A data compression method wherein said data comprises noise and information, comprising a data acquisition step, a pre-compression parameter selection step, wherein said pre-compression parameters are linked to an information loss, a compression step, and a storage step, the compression step being characterized in that it comprises a lossy pre-compression for removing some noise of the data, carried out using the pre-compression parameters selected in the selection step followed by lossless compression for compressing the remaining data.

Abstract: A method for recognition and/or verification of authenticity of digital, and/or physical objects, comprising the steps of codebook training, object enrollment, and object verification, the latter consisting in object recognition and/or object authentication. The method uses two types of features, of codebooks, and of databases, which are specifically designed for identification, respectively authentication, the identification database and authentication database having different organizations. The invention is also directed to corresponding computer program means adapted to implement the proposed method, devices adapted for implementation of a method, as well as to applications which are particularly adapted for use of the proposed method.

Abstract: Provided herein are genetically modified arenaviruses suitable as vaccines against mycobacterial infections. The invention also relates to pharmaceutical compositions and methods for the prevention and treatment of mycobacterial infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing and treating infections in Mycobacterium tuberculosis.

Abstract: A method of providing robust and secure fingerprints including, at an enrollment stage, the steps of providing a content x for which a fingerprint is to be provided, assigning an ID number to the content x, providing a secret key k, generating a fingerprint bx based on content x and secret key k, storing the generated fingerprint bx together with the assigned ID in a database, as well as, at an identification stage, the steps of extracting, for a given query content y which might result either from the enrolled content x or an unrelated content x?, an estimate fingerprint by based on content y, and secret key k, producing an estimated I{hacek over (D)} number based on the estimate fingerprint by for identifying the content x using said ID number stored in the database, or else rejecting the query.

Abstract: Apparatus for real-time in vivo bioluminescence monitoring in a conscious small animal, comprising a light-tight enclosure (4) with a base (16), side wall (19) and cover (20) configured for housing the small animal such that it may move freely, a bioluminescence detector system (6) comprising a light detector (22) for detecting the light emitted by said small animal connected to a data processing system, and a life-sustaining system (8) configured for maintaining the small animal alive for a prolonged period of time spanning from a few days to a few weeks.

Abstract: A device for random number generation based on an optical process of quantum nature, including a light source emitting photons randomly, a light detector adapted to absorb the randomly emitted photons and to measure a number n of photons produced by the light source in a time interval T, and a randomness extractor. The detector includes a photon sensor acting as a photon-to-electron converter, an amplifier for converting the electron signal received from the photon sensor into a voltage and amplifying the voltage signal, as well as an analog-to-digital converter for processing the amplified signal received from the amplifier by encoding the amplified signal into digital values and sending these digital values to the randomness extractor for further processing such as to produce quantum random numbers (QRNs) based on the number of photons produced by the light source in a time interval T.

Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

Abstract: The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

Abstract: The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I): as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

Abstract: The present invention relates to a short cell penetrating peptide derived from the Epstein-Barr virus basic leucine zipper transcriptional activator (ZEBRA), optionally linked to a cargo molecule. It also relates to a complex comprising the cell penetrating peptide and a cargo molecule, as well as cells loaded with the complex and the use thereof in therapy and diagnosis.

Abstract: The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

Abstract: Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided.

Abstract: Described herein are compositions comprising polymers prepared by melt polycondensation of 2-hydroxyalkyl acids. Methods of making and using the compositions are also disclosed.