Abstract: An optical element includes a transparent substrate and an intermediate coating extending over at least one main surface of the substrate. The intermediate coating has a plurality of dense thin layers which alternate in having a first index refractive index and a second refractive index, the first refractive index being greater than the second refractive index. The optical element further includes at least one porous layer extending over the intermediate coating, opposite the substrate. The porous layer has a third refractive index that is lower than the first and second refractive indices.

Abstract: Inflammation is a prominent feature of ischemia-reperfusion injury (IRI) characterized by leukocyte infiltration and renal tubular injury. However, the signals that initiate these events remain poorly understood. The inventors identify the nuclear alarmin interleukin (IL)-33 as an initiation factor of tissue injury and also as a major amplification factor of the innate immune response triggered by experimental kidney ischemia-reperfusion in mice. In mice lacking IL-33, IRI is reduced, as attested by early decreased tubular cell injury, and by subsequent decreased infiltration of IFN-?/IL-17A-producing neutrophils and preservation of renal functions. These findings led the inventors to propose that endogenous IFN-33 contributes to kidney IRI by promoting iNKT cell recruitment and cytokine production, resulting in neutrophil infiltration and activation at the injury site. Accordingly, the present invention relates to antagonists of IL-33 for use in methods for preventing ischemia reperfusion injury in an organ.

Abstract: The invention relates to a nickel-based superalloy comprising in weight percentages: 5.0 to 6.0% of aluminium, 6.0 to 9.0% of tantalum, 1.0 to 5.0% of cobalt, 5.0 to 7.5% of chromium, 0 to 1.0% of molybdenum, 4.0 to 6.0% of tungsten, 0.50 to 3.5% of rhenium, 1.0 to 4.0% of platinum, 0.05 to 0.25% of hafnium, 0 to 0.15% of silicon, the remainder consisting of nickel and unavoidable impurities. The invention also relates to a single-crystal blade comprising such an alloy and to a turbomachine comprising such a blade.

Abstract: A sleep analyzer, method and system with reduced invasiveness and limited human intervention to monitor sleep in an intensive healthcare unit.

Abstract: The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Abstract: The present invention relates to the production of benzene derivatives from furfural and its derivatives. The present invention also relates to the preparation of novel intermediates derived from furfural and its derivatives. The present invention describes new routes for converting furfural and its derivatives into benzene derivatives including novel intermediates.

Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.

Abstract: The invention relates to a nickel-based superalloy comprising, in percentages by mass, 5.0 to 6.0% aluminum, 6.0 to 9.5% tantalum, 0 to 1.50% titanium, 8.0 to 10.0% cobalt, 6.0 to 7.0% chromium, 0.30 to 0.90% molybdenum, 5.5 to 6.5% tungsten, 0 to 2.50% rhenium, 0.05 to 0.15% hafnium, 0.70 to 4.30% platinum, 0 to 0.15% silicon, the remainder being nickel and unavoidable impurities. The invention also relates to a single-crystal blade comprising such an alloy and a turbomachine comprising such a blade.

Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

Abstract: The present invention relates to a method and a device for the electrostatic separation of granular mixtures of millimetric or sub-millimetric size, which are composed of non-conductive particles, non-conductive and conductive particles and conductive particles, simultaneously using the electric field E, aerodynamic force and gravity. Said forces are exerted on the particles which are previously charged in an intense electric field E generated by a DC voltage applied to two coaxial cylinders, that constitute electrodes. A mechanical cleaning system detaches the particles from the surface of the electrodes, and facilitates the recovery thereof in a collection system, under the action of cyclone vacuums, in such a way that the cleaning of the electrodes and the collection of the separated particles is continuously performed.

Abstract: The present invention relates to a compound of the following general formula (I); or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Abstract: The invention relates to a nickel-based superalloy comprising, in percentages by mass, 5.0 to 6.0% aluminum, 6.0 to 9.5% tantalum, 0 to 1.50% titanium, 8.0 to 10.0% cobalt, 6.0 to 7.0% chromium, 0.30 to 0.90% molybdenum, 5.5 to 6.5% tungsten, 0 to 2.50% rhenium, 0.05 to 0.15% hafnium, 0.70 to 4.30% platinum, 0 to 0.15% silicon, the remainder being nickel and unavoidable impurities. The invention also relates to a single-crystal blade comprising such an alloy and a turbomachine comprising such a blade.

Abstract: Some embodiments are directed to a method for detecting harmonic pollution in an electrical distribution network carrying a three-phase current, including a step of measuring the voltages and strengths of the current, for each of said phases, at a counting point of the network; a step of calculating a first quaternion impedance corresponding to the fundamental frequency of the current; a step of calculating at least one second quaternion impedance corresponding to a harmonic frequency of the current, these impedances being calculated by converting the voltages and strengths in a two-dimensional frame of reference defined according to an angle that is dependent on said frequency in order to provide a system of two vectors of three quantities, ud, uq, uo and id, iq, io, respectively.

Abstract: Disclosed is a medico-surgical simulator and to a corresponding method. The medico-surgical simulator includes a vascularization device and/or a ventilation device, as well as a regulation device. The medico-surgical simulator is arranged so as to be connected to a cadaver and to vascularize an arterial system of the cadaver via the vascularization device and/or to ventilate a respiratory system of the cadaver via the ventilation device. The regulation device controls the vascularization and ventilation devices in such a way as to simulate cardiorespiratory functions for providing surgical training carried out on the cadaver with a very high degree of realism.

Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

Abstract: The invention relates to a plastic compound comprising at least one polyolefin and a biological entity that degrades said polyolefin. The invention further relates to a process for preparing a plastic article wherein at least one polyolefin and one biological entity that degrades said polyolefin are mixed at a temperature at which the polyolefin is in a partially or totally molten state.

Abstract: A process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol being present in a quantity of at least 5% by weight, based on the total weight of the alcohols, and said catalyst comprising at least one triflate ligand and at least one metal selected from bismuth, gallium, aluminum, tin and iron.

Abstract: The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 75%, 80%, 85%, 90%, 95%, 99% or 100% identity to the full length amino acid sequence set forth in SEQ ID NO:1, and having a polyester degrading activity, and uses thereof.

Abstract: The invention relates to a system for generating electric power, comprising: an alternator (1) for coupling with a drive system (7), supplying an AC voltage to an output bus (10); a reversible AC/DC converter (2) in which the AC bus (6) is connected to the output bus (10) of the alternator (1); an electricity-storage element (3) connected to the DC bus (9) of the converter (2); a controller (4) arranged to react to a transient state of load-shedding or charging impact by controlling the converter (2) so as to collect energy on the output bus (10) of the alternator (2) and to store same in the storage element (3) in the case of load-shedding, and to collect energy in the storage element (3) and to inject same into the output bus (10) in the case of charging impact, the converter (2) being controlled so as to inject currents to compensate for harmonic currents into the AC bus (10) of the alternator (1).

Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.