Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Abstract: The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair. In particular, the invention concerns compositions comprising at least IL-17, TNF? and OSM that can be formulated for topical administration for cosmetic or dermatologic use.

Abstract: The invention relates to a process for preparing nanoparticles of a catalyst for cathodic reduction and which is tolerant to methanol, these nanoparticles comprising a metallic center and a submonolayer of a chalcogen.

Abstract: The invention relates to a system for generating electric power, comprising: an alternator (1) for coupling with a drive system (7), supplying an AC voltage to an output bus (10); a reversible AC/DC converter (2) in which the AC bus (6) is connected to the output bus (10) of the alternator (1); an electricity-storage element (3) connected to the DC bus (9) of the converter (2); a controller (4) arranged to react to a transient state of load-shedding or charging impact by controlling the converter (2) so as to collect energy on the output bus (10) of the alternator (2) and to store same in the storage element (3) in the case of load-shedding, and to collect energy in the storage element (3) and to inject same into the output bus (10) in the case of charging impact, the converter (2) being controlled so as to inject currents to compensate for harmonic currents into the AC bus (10) of the alternator (1).

Abstract: The invention relates to a rear casing for a turbine engine comprising a primary body generating a primary flow (10) to be ejected through a primary nozzle (6), said rear casing (7) being shaped so as to be positioned downstream from the primary body and to define, on the inside of the turbine engine, the path followed by the primary flow downstream from the primary nozzle (6). The tail cone is characterised in that it comprises a connection to a system for supplying a pressurised gas and at least one perforation (8) for injecting the pressurised gas through the perforation and into the primary flow. The casing preferably comprises at least one means for rotating same about the axis of rotation of the mobile elements of the primary body.

Abstract: The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.

Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

Abstract: A conductive composite wire includes at least one external jacket made of copper, a first tube including a first metallic material (M1) contacting and located inside the copper jacket; a second tube including a second metallic material (M2) contacting and located inside the first tube; and a fiber including a third metallic material (M3) contacting and located inside the second tube. The copper and the first metallic material are immiscible with each other, the first and second metallic materials are immiscible with each other, and the second and third metallic materials are immiscible with each other. A copper-based coaxial microstructure includes a copper sheath containing an array of nanotubes and nanofibers according to a process for manufacturing the microstructure.

Abstract: A spray device includes a nozzle that forms a channel for supplying liquid to at least one opening for spraying the liquid outside the device, and, close to the opening, a first and a second electrode arranged in such a way as to inject electric charges into the liquid. The edge of the opening includes, on one side of the channel, at least one projecting end of the first electrode that projects into the channel and is to be brought into contact with the liquid, and on the other side of the channel, an electrically insulating nozzle body in which the second electrode is embedded adjacently to the first electrode, in such a way that the intensity of the electrostatic field in the or each projecting end is maximized.

Abstract: An aircraft jet engine comprising a nozzle to eject a gas stream, and a system for reducing the noise generated by the ejection of the gas stream. This system comprises several ducts which each are connected upstream to a recess divided into several chambers and open, downstream, at the outlet of nozzle. In this way, each duct ejects a fluid jet deriving from the recess and which interacts with the gas stream of the engine. The system also comprises a pulsation means for the fluid jet which brings about its ejection at the nozzle outlet and/or modulates its speed by varying the volume contained in the recess.

Abstract: The invention relates to a method and device for controlling the mass flow rate of a sonic gas stream in a pipe. To carry out the above operation, an electric discharge is applied inside the pipe so as to create a plasma in the pipe. The electric discharge allows for an increase in the temperature of the gas stream and thus a variation in the mass flow rate or the pressure of the gas stream. By periodically emitting the electric discharge, a pulsed or adjustable gas jet is obtained at the outlet of the device. The gas jet can then be used to control a main stream.

Abstract: A process for the production of middle distillates comprising at least one hydrocracking stage that oligomerizes a paraffinic feedstock produced by Fischer-Tropsch synthesis, the process using a catalyst that comprises at least one hydrogenating-dehydrogenating metal that is selected from the group that is formed by the metals of group VIB and group VIII of the periodic table, by themselves or in a mixture, and a substrate that comprises a beta zeolite in the form of crystallites with a mean size that is less than 100 nm dispersed in at least one porous mineral matrix, whereby the beta zeolite has a mesopore volume of less than 0.4 ml/g.

Abstract: The present invention relates to a compound of general formula (I): in which: X is OH, NH2, NHOH or RNH, where R may be a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, Y is H, or an electron-withdrawing group, in particular selected from NO2, CF3 or a halogen, R1 and R2 are H or a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, F is a reactive functional group that can be activated by click chemistry.

Abstract: A current reversible DC/DC double-boost quadratic converter, capable of performing high transformation ratios.

Abstract: The invention relates to a rear casing for a turbine engine comprising a primary body generating a primary flow (10) to be ejected through a primary nozzle (6), said rear casing (7) being shaped so as to be positioned downstream from the primary body and to define, on the inside of the turbine engine, the path followed by the primary flow downstream from the primary nozzle (6). The tail cone is characterised in that it comprises a connection to a system for supplying a pressurised gas and at least one perforation (8) for injecting the pressurised gas through the perforation and into the primary flow. The casing preferably comprises at least one means for rotating same about the axis of rotation of the mobile elements of the primary body.

Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.

Abstract: A method and apparatus for reducing a selected tonal noise generated by a fan operating in a non-uniform flow by locating at least one obstruction in the non-uniform flow such that the at least one obstruction generates a noise that is out of phase with the selected tonal noise. The noise generated by the at least one obstruction interferes with the selected tonal noise, thus reducing the selected tonal noise. It is also contemplated to use additional obstructions to reduce other tonal noises generated by the fan.

Abstract: An aircraft jet engine with a longitudinal axis, including a wall enclosing a gas flow ejected from a downstream end of the wall in the longitudinal axis, plural ducts being distributed around the periphery of the downstream end of the wall each including a terminal section, including an outlet opening. Each duct can eject a fluid jet through the outlet opening thereof. The ducts are configured to eject the fluid jets essentially parallel to each other, each fluid jet ejected through the corresponding outlet opening forming a lateral angle with the longitudinal axis in a projection view in a plane with the longitudinal axis.

Abstract: The present invention concerns a method for the synthesis of glycerol dithiocarbamates or bis-dithiocarbamates (GDTCs) in which a reaction medium comprising (1) a carbonate selected from diethyl carbonate, dimethyl carbonate and ethylene or propylene carbonate associated with a glycerol type polyol in the presence of a basic catalyst or (2) a cyclic carbonate comprising five ring members, in a solvent medium, is supplemented with a primary or secondary amine in the presence of carbon disulphide, and the GDTC formed is recovered. In particular, a glycerol type polyol is brought into the presence of diethyl carbonate in the presence of a catalyst, then a primary or secondary amine is added to the reaction medium in the presence of carbon disulphide, and the GDTC formed is recovered. The invention can be used for one-step synthesis of glycerol dithiocarbamates directly from glycerol as the starting material and solvent.

Abstract: The invention relates to strains of bacteria of the genus Ochrobactrum, that can degrade polylactic acid. The invention also relates to an enzyme that can degrade polylactic acid, characterized in that it is produced by said bacteria strains according to the invention. The invention also relates to the applications of said bacteria strains and said enzyme that can degrade polylactic acid.