Patents Assigned to Universite de Reims Champagne-Ardenne
-
Patent number: 9644033Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.Type: GrantFiled: October 21, 2014Date of Patent: May 9, 2017Assignee: Universite De Reims Champagne ArdenneInventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
-
Patent number: 9605025Abstract: Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.Type: GrantFiled: July 6, 2012Date of Patent: March 28, 2017Assignee: Universite de Reims Champagne ArdenneInventors: Stéphane Dedieu, Nicolas Floquet, Laurent Martiny, Christophe Schneider, Albin Jeanne, Emilie Sick, Manuel Dauchez
-
Patent number: 9551829Abstract: A photoacoustic detection device including a nanophotonic circuit including a first chip on which is formed at least one optical waveguide and in which is formed a set of cavities defining a Helmholtz resonator; at least one optical source capable of emitting an optical signal in a given wavelength range, capable of being modulated at an acoustic modulation frequency, this source being attached to the first chip; a second chip forming a cap for said cavities and including acoustic sensors; and electronic circuits for processing the output of the acoustic sensors formed in the first or the second chip.Type: GrantFiled: April 19, 2012Date of Patent: January 24, 2017Assignees: Commissariat a l'energie atomique et aux energies alternatives, Universite De Reims Champagne ArdenneInventors: Mickaël Brun, Sergio Nicoletti, Bertrand Parvitte, Virginie Zeninari
-
Publication number: 20170014544Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.Type: ApplicationFiled: December 12, 2014Publication date: January 19, 2017Applicants: Laboratoires Urgo, Universite de Reims Champagne-Ardenne, Centre National de la Recherche ScientifiqueInventors: Xavier Coqueret, Sadananda Das, Stéphane Auguste
-
Patent number: 9447093Abstract: The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as medications in the treatment of cognitive disorders associated with dysfunction of DYRK1A protein, with Down's syndrome and with Alzheimer's disease.Type: GrantFiled: December 18, 2013Date of Patent: September 20, 2016Assignees: Centre National De La Recherche Scientifique (CNRS), Universite de Reims Champagne-Ardenne, Universite Paris Diderot Paris 7Inventors: Robert Dobb, Kevin Cariou, Stephanie Gourdain, Jean Maurice Delabar, Nathalie Janel, Fernando Rodrigues Lima, Julien Dairou, Clement Denhez
-
Publication number: 20160263858Abstract: A structural part (10) for a motor vehicle includes first (12A) and second (12B) mats, each mat comprising fibers and a resin bonding the fibers, and a separator (14) inserted between the first (12A) and second (12B) mats, the first (12A) and second (12B) mats being fixed on opposite faces of the separator (14). At least one of the first (12A) and second (12B) mats includes at least one continuous web of fibers (16), said web (16) comprising a plurality of parallel fibers bonded together by a thermosetting resin, at least part of the fibers of each web (16) having a length greater than 20 cm, in particular greater than 50 cm.Type: ApplicationFiled: October 17, 2014Publication date: September 15, 2016Applicants: Faurecia Automotive Industrie, Lineo NV, Peugeot Citroen Automobiles SA, Universite de Reim Champagne-ArdenneInventors: Frédéric ROUSSEAU, Moussa KHALFALLAH, François VANFLETEREN, Boussad ABBES, Valérie MARCEL
-
Publication number: 20160200676Abstract: The invention relates to new ?-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2, R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceutically acceptable base. The invention also relates to a method for producing said compounds (I). It further relates to the use of said compounds (I) as selective metalloprotease inhibitors, especially matrix metalloproteases 12 (MMP-12) and/or 9 (MMP-9). The compounds (I) are particularly useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema induced by cigarette smoke.Type: ApplicationFiled: September 2, 2014Publication date: July 14, 2016Applicant: Universite de Reims Champagne-ArdenneInventors: Samir Bouzbouz, Xavier Pannecoucke, Azzaq Belaaouaj, Laurette Malleret, Clement Denhez, Dominique Guillaume
-
Publication number: 20160038569Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.Type: ApplicationFiled: October 21, 2015Publication date: February 11, 2016Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE ROUEN, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNEInventors: Ebba BRAKENHIELM, Sébastien BANQUET, Florence EDWARDS-LEVY, Christian THUILLEZ
-
Patent number: 9238008Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.Type: GrantFiled: March 5, 2012Date of Patent: January 19, 2016Assignees: Institut National de la Sante et da la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Universite de Rouen, Universite de Reims Champagne-Ardennes, Centre Hospitalier Universitaire de RouenInventors: Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
-
Patent number: 9115212Abstract: The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.Type: GrantFiled: January 31, 2013Date of Patent: August 25, 2015Assignees: REGENTIS INTERNATIONAL, UNIVERSITE DE REIMS CHAMPAGNE ARDENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: William Hornebeck, Joan Attia, Sandrine Lorimier, Frank Antonicelli
-
Patent number: 9051408Abstract: A curable composition, and a material obtained by curing the composition, in which the curable composition includes a vinylester polymerisable compound, jointly with a sulphonated polyaromatic thermoplastic polymer, and an N-vinyl lactam, and which is characterised in that it further includes, a first non-vinylester polymerisable compound which includes at least one isocyanurate group bearing at least two (meth)acrylate groups; and a second non-vinylester polymerisable compound which includes at least one carbopolycyclic or heteropolycyclic group bearing at least two (meth)acrylate groups.Type: GrantFiled: December 4, 2012Date of Patent: June 9, 2015Assignees: Astrium SAS, Universite De Reims Champagne-Ardenne, Centre National De La Recherche ScientifiqueInventors: Xavier Coqueret, Mickael Krzeminski, Brigitte Defoort
-
Patent number: 8900592Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.Type: GrantFiled: November 23, 2006Date of Patent: December 2, 2014Assignee: Universite de Reims Champagne ArdenneInventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
-
Patent number: 8618186Abstract: A method increases the toughness of a material obtained by curing a composition that includes at least one vinyl ester monomer. The method includes the incorporation into the composition of a sulfonated polyaromatic thermoplastic polymer, which is achieved by dissolving the vinyl ester monomer and the thermoplastic polymer in a reactive diluent in which they are both soluble. The resulting curable composition includes at least one vinyl ester monomer, and very high toughness materials can be made from it. A curable composition can include at least one vinyl ester monomer, a sulfonated polyaromatic thermoplastic polymer and a N-vinyl lactam. The compositions can be used in the aeronautical, space, railway, nautical, automotive industries, arms and other industries.Type: GrantFiled: October 8, 2010Date of Patent: December 31, 2013Assignees: Astrium SAS, Universite de Reims Champagne-Ardenne, Centre National de la Recherche ScientifiqueInventors: Mickael Krzeminski, Brigitte Defoort, Xavier Coqueret
-
Publication number: 20130337076Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.Type: ApplicationFiled: March 5, 2012Publication date: December 19, 2013Applicants: UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITE DE ROUENInventors: Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
-
Publication number: 20130287053Abstract: A device for emitting a laser beam comprises, in a housing, a laser-emitting component emitting a laser beam and mounted on a base, a heat-dissipating component, at least one collimating lens, and a lens mounting. The heat-dissipating component dissipates the heat produced by the laser of the laser-emitting component and secures the base of the laser-emitting component. The heat-dissipating component has a positioning mark and at least three holes for centering pins machined together with the positioning mark. The lens mounting secures the lens opposite the laser-emitting component and is positioned relative to the heat-dissipating component by at least three centering pins positioned in the holes of the heat-dissipating component.Type: ApplicationFiled: December 13, 2011Publication date: October 31, 2013Applicant: UNIVERSITE DE REIMS CHAMPAGNE ARDENNEInventors: Virgine Zeninari, Bertrand Parvitte, Lilian Joly, Vincent Lecocq, Georges Durry, Regis Hamelin, Ronan Le Loarer
-
Publication number: 20130230426Abstract: The cold plasma sterilization device for the sterilization of at least one object is placed in a container enclosing at least a gas or a gas mixture suitable for generating a cold plasma. The device includes a closed vessel in which a support for receiving the container is arranged. There is a device for subjecting the vessel to a secondary vacuum of the order of 10?3 to 10?7 millibar. There is an electron cyclotron resonance generator for generating, in the vessel, a flow of microwaves coupled to a magnetic field at least in a phase of initialization of the cold plasma. There is also a device for polarization of the support of the container.Type: ApplicationFiled: September 23, 2011Publication date: September 5, 2013Applicant: Universite de Reims Champagne ArdenneInventors: Jean-Marc Popot, Marie-Paule Gelle
-
Publication number: 20130205871Abstract: The photoacoustic device for measuring the quantity of at least one gas. The Helmholtz-type esonant container comprises at least two tubes closed at their ends and linked together, close to each of their respective ends, by capillary tubes of diameter lower than the diameter of the parallel tubes. Each of the two radiant laser energy sources is physically separated and adapted to supply an excitation energy to the gas in the container at a different emission wavelength. The modulation means modulates the excitation energy supplied by each laser energy source with a modulation frequency corresponding to the acoustic resonance frequency of the container. At least one acoustoelectric transducer disposed on one of the tubes detects the produced acoustic signals produced and supplies an electric signal representative of the gas concentration in the container.Type: ApplicationFiled: July 21, 2011Publication date: August 15, 2013Applicants: AEROVIA, UNIVERSITE DE REIMS CHAMPAGNE ARDENNEInventors: Virginie Zeninari, Bertrand Parvitte, Lilian Joly, Georges Durry, Ronan Le Loarer, Jean Charles Garcia, Regis Hamelin
-
Patent number: 8492445Abstract: An emulsifying composition, characterised in that it contains by weight, excluding impurities, (i) 1 to 98% by weight of a mixture of alkyl glycosides R1O(G1)g1(G2)g2(G3)g3(G4)g4(G5)g5, (ii) 1 to 90% by weight of a mixture of alcohol esters R2OZ, (iii) 1 to 90% of an alcohol R3OH, and (iv) 4 to 90% of a mixture of alkyl glycoside esters R4O(X1)x1(Z)z1(X2)x2(Z)z2(X3)x3(Z)z3(X4)x4(Z)z4(X5)x5(Z)z5, is disclosed In accordance with the composition, R1 is a hydrocarbon radical, linear or branched, saturated or unsaturated, having 10 to 22 carbon atoms. G1, G2, G3, G4, G5 are identical or different residues of -oses selected from glucose, galactose, mannose, fructose, ribose, xylose and arabinose, g1, g2, g3, g4 and g5 being equal to 0 or 1, the sum of g1, g2, g3, g4 and g5 being at least equal to 1. The composition has emulsifying capacity in the presence of electrolytes or in the case of paraffin-based emulsions.Type: GrantFiled: March 4, 2010Date of Patent: July 23, 2013Assignees: Bioamber SAS, Universite de Reims Champagne Ardenne (U.R.C.A.), Centre National de Recherche Scientifique (C.N.R.S.)Inventors: Benjamin Renault, Boris Estrine, Charles Portella, Cedric Ernenwein, Fabien Massicot, Sinisa Marinkovic
-
Patent number: 8383410Abstract: The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.Type: GrantFiled: March 30, 2007Date of Patent: February 26, 2013Assignee: Universite de Reims Champagne-ArdenneInventors: Jacques Henri Max Cohen, Brigitte Reveil, Aymric Kisserli, Fadi Haidar, Béatrice Donvito
-
Publication number: 20120277383Abstract: A method increases the toughness of a material obtained by curing a composition that includes at least one vinyl ester monomer. The method includes the incorporation into the composition of a sulfonated polyaromatic thermoplastic polymer, which is achieved by dissolving the vinyl ester monomer and the thermoplastic polymer in a reactive diluent in which they are both soluble. The resulting curable composition includes at least one vinyl ester monomer, and very high toughness materials can be made from it. A curable composition can include at least one vinyl ester monomer, a sulfonated polyaromatic thermoplastic polymer and a N-vinyl lactam. The compositions can be used in the aeronautical, space, railway, nautical, automotive industries, arms and other industries.Type: ApplicationFiled: October 8, 2010Publication date: November 1, 2012Applicants: ASTRIUM SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNEInventors: Mickael Krzeminski, Brigitte Defoort, Xavier Coqueret