Patents Assigned to UNIVERSITE GRENOBLE ALPES
  • Publication number: 20190276316
    Abstract: The invention relates to an exfoliation method according to which a fluid loaded with particles flows at a first flow rate into a first (2), and then into a second, section of a pipe (1), the first flow rate being suitable for generating shear stresses and cavitation bubbles in the fluid as it passes through the first section (2) of the pipe (1), the second section (3) having a hydraulic diameter suitable for bringing about an implosion of cavitation bubbles as soon as the fluid exits the first section (2) and flows into the second section (3), so that an exfoliation of the particles is brought about under the combined action of the shear stresses and a shock wave generated by the implosion of the cavitation bubbles, the first section (2) having a hydraulic diameter less than 300 ?m.
    Type: Application
    Filed: May 16, 2017
    Publication date: September 12, 2019
    Applicant: UNIVERSITE GRENOBLE ALPES
    Inventors: Frédéric AYELA, Damien COLOMBET
  • Publication number: 20190240232
    Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.
    Type: Application
    Filed: July 26, 2017
    Publication date: August 8, 2019
    Applicants: University of Southern California, CNRS, Universite Grenoble Alpes, INSERM
    Inventors: Charles E. MCKENNA, Carlo PETOSA, Jerome GOVIN, Boris A. KASHEMIROV, Elena FERRI, Flore MIETTON
  • Patent number: 10316284
    Abstract: The invention concerns a bioreactor obtained by compressing a mixture of an enzyme, a conductor and chitosan. The conductor can consist of carbon nanotubes. This bioreactor can be produced according to the following steps: preparing a mixture of powders in which the proportion of enzyme powder relative to a carbon nanotube powder is of the order of 50/50 by weight; preparing a viscous solution of chitosan in a ratio of 5 to 15 (in mg) of chitosan to 0.75 to 1.25 (in ml) of acetic acid diluted to 0.4 to 0.6% by volume in water; adding the viscous chitosan to the mixture of powders in a proportion be weight of 3 to 5 of powder to 5 to 10 of chitosan; carrying out a first compression followed by light grinding; carrying out a second compression to produce a pellet; and drying at ambient temperature.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: June 11, 2019
    Assignee: Universite Grenoble Alpes
    Inventors: Sarra El Ichi, Donald K. Martin, Philippe Cinquin, Abdelkader Zebda
  • Publication number: 20190169136
    Abstract: The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.
    Type: Application
    Filed: August 7, 2017
    Publication date: June 6, 2019
    Applicants: Commissariat a l'Energie Atomique et aux Energies Alternatives, Universite Grenoble Alpes, Universite d'Aix Marseille
    Inventors: Marie-Odile Fauvarque, Magda Mortier, Catherine Pillet, Carmen Aguilar, Emmanuelle Soleilhac, Caroline Barette, Vincent Remusat, Thierry Terme, Patrice Vanelle
  • Publication number: 20190170576
    Abstract: A spectral imager, including: a photodetector including a plurality of photosensitive sites exposed on a photosensitive surface; a collimating lens including an intermediate focal plane; an array of interferometers including two main waves, each including a cavity defined by two faces; an array of microlenses arranged in a plane parallel to the photosensitive surface, each microlens paired with an interferometer to form an optical pair, including an image focal plane coinciding with the photosensitive surface and facing a section of the photosensitive surface.
    Type: Application
    Filed: June 30, 2017
    Publication date: June 6, 2019
    Applicants: OFFICE NATIONAL D'ETUDES ET DE RECHERCHES AEROSPATIALES, UNIVERSITE GRENOBLE ALPES
    Inventors: Nicolas GUERINEAU, Etienne LE COARER, Yann FERREC, Florence DE LA BARRIERE
  • Patent number: 10301658
    Abstract: The present invention relates to a method for in vivo production of glycosaminoglycans (GAG), by metabolic engineering in a genetically modified cell. In a method according to the invention, said cell is genetically modified in order to express the genes coding for the enzymes that are suitable for synthesizing GAG from an exogenous precursor, preferably internalized by the cell. According to one specific feature, the present invention relates to a method for producing chondroitin or heparosan in a genetically modified bacterial cell, from an exogenous beta-galactoside precursor, preferably internalized by the cell. According to another specific feature, the present invention relates to the use of an Escherichia coli cell comprising at least the genes glcA-T, kfoC, kfiD and wbpP for the production of chondroitin.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 28, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventor: Bernard Priem
  • Patent number: 10266569
    Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 23, 2019
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de le Recherche Scientifique (CNRS), Université Claude Bernard—Lyon 1, Ecole Normale Superieure de Lyon (ENS de Lyon), Université Grenobles Alpes
    Inventors: Viktor Volchkov, Marc Jamin, Philip Lawrence, Filip Yabukarski
  • Patent number: 10234706
    Abstract: Photonic devices for generating linearly frequency modulated arbitrary microwave signals comprise a laser, and assembly for forming the emitted signal and a photoreceiver the passband of which is in the domain of the microwave frequencies. The forming assembly comprises: a first beam splitter; a first optical channel including a frequency-shifting loop comprising a beam splitter, a first optical amplifier, an optical isolator, a first spectral optical filter and an acousto-optical frequency shifter; a second optical channel including an electro-optical frequency shifter; a second beam splitter; a second optical amplifier; and a second optical filter; the acousto-optical frequency shift, the electro-optical frequency shift and the amplification gain of the first optical amplifier being adjustable.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: March 19, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPES, INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Hugues Guillet De Chatellus, José Azana
  • Publication number: 20190033324
    Abstract: Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A(SEQ ID NO.1) is determined.
    Type: Application
    Filed: January 16, 2017
    Publication date: January 31, 2019
    Applicants: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Hospitalier Universitaire, Universite Grenoble Alpes, INSERM, Universite Paris Sud
    Inventors: Virginie Brun, Jérôme Garin, Christophe Bruley, Jamila Faivre, Jean-Pierre Zarski, Vincent Leroy
  • Patent number: 10180427
    Abstract: Novel grafted dinuclear metal complexes having formula (I) or of formula (II) wherein M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterising cellular microparticles.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 15, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN BASSE-NORMANDIE, UNIVERSITE GRENOBLE ALPES
    Inventors: Catherine Belle, Gisele Gellon, Laurent Plawinski, Loic Doeuvre, Eduardo Angles Cano
  • Patent number: 10175181
    Abstract: The invention relates to an X-ray imaging system wherein images are obtained using an X-ray blocking element, the system comprising means for determining a position of the detector (40) on the basis of coordinates of projected patterns of the blocker (20, 220) in an image in order to especially be able to perform a calibration and/or correct the contribution of the scatter radiation in a radiographic image obtained by the system.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 8, 2019
    Assignees: UNIVERSITE GRENOBLE ALPES, SURGIQUAL INSTITUTE
    Inventors: Philippe Cinquin, Laurent Desbat, Yannick Grondin
  • Patent number: 10168206
    Abstract: The detection device comprises a cold finger which performs thermal connection between a detector fitted on a cooling plate and a cooling system. The cold finger comprises at least one side wall at least partially formed by an area made from the hafnium-based amorphous metal alloy. Advantageously, the whole of the cold finger is made from the hafnium-based amorphous metal alloy.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: January 1, 2019
    Assignees: SOCIÉTÉ FRANÇAISE DE DÉTECTEURS INFRAROUGES—SOFRADIR, UNIVERSITÉ GRENOBLE ALPES
    Inventors: Pierre Cassaigne, Alexis Lenain, Sébastien Gravier
  • Patent number: 10120051
    Abstract: The invention is a method for estimating a product of convolution of a measurement function, representing measurements, defined according to first coordinates, with a convolution kernel. The convolution product is estimated at second coordinates, different from said first coordinates. The measurement function represents measurements performed on the basis of a detector, in particular a detector of physical quantities. An exemplary application of the method relates to Magnetic Resonance Imaging, the method allowing a redistributing of measured data, not uniformly distributed, according to a uniform mesh, prior to the application of a fast Fourier transform algorithm.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: November 6, 2018
    Assignee: UNIVERSITE GRENOBLE ALPES
    Inventor: Laurent Lamalle
  • Publication number: 20180303338
    Abstract: The invention relates to a device for measuring the speed of blood in a blood vessel of the eye. Said device includes: a light source (5), two detectors provided with input diaphragms (36, 46) for receiving two light beams backscattered by a blood vessel, an optical system including a Dove prism (70) through which the source beam and backscattered beams pass and which is rotatably adjustable about an axis parallel to the source beam passing therethrough, and a focusing system (62) capable of forming the image of a blood vessel on the input diaphragms, a processor capable of processing the signals from the detectors, and an opitcal element (52) that can be inserted during the device adjustment phase so as to convert the light spot, provided by the light source, into a line coplanar with the source beam and the backscattered beams.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Applicant: UNIVERSITE GRENOBLE ALPES
    Inventors: Martial Henri GEISER, Frédéric TRUFFER, Helene STRESE, Christophe CHIQUET
  • Patent number: 10106858
    Abstract: Disclosed is a method for the in vitro detection of strains of Legionella pneumophila, resistant to antibiotics, in particular to the fluoroquinolones. Also disclosed are nucleotide probes and a kit of reagents allowing the detection of Legionella pneumophila bacterial strains that are resistant to antibiotics, in particular of the fluoroquinolone type.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: October 23, 2018
    Assignees: UNIVERSITE GRENOBLE ALPES, CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE ALPES
    Inventors: Max Maurice Louis Maurin, Dominique Schneider, Lubana Shadoud, Sophie Jarraud, Jean Francois Timsit, Jerome Etienne
  • Patent number: 10093988
    Abstract: The invention relates to oligonucleotides and to the use thereof as universal primers for the detection and identification of amphibia/fish species, especially in complex and deteriorated substrates. The invention also relates to a method for detecting and identifying amphibia/fish species in samples collected from the environment (ground, water, faeces) or from industry (especially transformed products). The invention further relates to a kit for said detection.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: October 9, 2018
    Assignees: UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre Taberlet, Eric Coissac, Tiayyba Riaz
  • Publication number: 20180279887
    Abstract: A device non-invasively measures aortic flow in the subdiaphragmatic region in a small laboratory mammal. The device includes a device for plethysmography of the thorax by inductance measurement, having two electrically conducting, extendible coils rigidly attached to an elastic garment that is adjustable to the torso of the mammal, a device for acquiring the signal from variation in the cross-section of each coil, and a processor configured to calculate the instantaneous subdiaphragmatic aortic flow of the mammal from the signals from the variation in cross-section of each coil and from a functional model of the cardiorespiratory system. The exchanges of blood between the thorax and the rest of the body of the mammal include an output of blood via the abdominal aorta in the subdiaphragmatic region and an input of blood via the inferior vena cava.
    Type: Application
    Filed: August 26, 2016
    Publication date: October 4, 2018
    Applicant: UNIVERSITE GRENOBLE ALPES
    Inventors: Pierre BACONNIER, François BOUCHER, Pierre-Yves GUMERY
  • Publication number: 20180287166
    Abstract: An electrochemical reactor block including at least two pellets cut out of a flexible conductive film including chains of a linear polymer, carbon nanotubes being bound to each of the chains by pi-pi interaction, a catalyst agent selected from the group including enzymes, metal catalysts, macrocyclic catalysts, and redox mediators being trapped between the pellets.
    Type: Application
    Filed: September 14, 2016
    Publication date: October 4, 2018
    Applicant: Universite Grenoble-Alpes
    Inventors: Serge Cosnier, Raoudha Haddad
  • Patent number: 10056266
    Abstract: A method for manufacturing a resistive device, includes depositing a first electrically conductive layer on a substrate; forming an etching mask on the first conductive layer; etching the first conductive layer through the mask, such as to obtain a plurality of electrically conductive pillars separated from one another; and forming storage elements with variable electrical resistance at the tops of the electrically conductive pillars, such that each storage element is supported by one of the electrically conductive pillars, the step of forming the storage elements including the following operations depositing a first layer by non-collimated cathode sputtering at normal incidence relative to the substrate; and depositing a second layer on the first layer by cathode sputtering, the second layer including a first chemical species sputtered at an oblique incidence.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: August 21, 2018
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventors: Bernard Dieny, Maxime Darnon, Gabriele Navarro, Olivier Joubert
  • Patent number: 10039568
    Abstract: The invention relates to a device for guiding a medical needle, including said medical needle (1) and an insert (2) that is rotatably, translatably, and slidably arranged in the needle (1), wherein said device is characterized in that the insert (2) has, in the free state thereof, a curved distal portion (21), and in that the needle has at least two regions (11, 12), the mechanical behaviors of which are different, wherein the mechanical behaviors of each region (11, 12) and of the curved distal portion (21) of the insert are selected such that a movement of the insert (2) into the needle (1) causes a local deformation of the needle and/or of the insert. The invention also relates to a method for manufacturing said device.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: August 7, 2018
    Assignee: UNIVERSITE GRENOBLE ALPES
    Inventors: Denis Favier, Thierry Alonso, Gregory Chagnon, Yinong Liu, Alexandre Moreau-Gaudry