Patents Assigned to UNIVERSITE GRENOBLE ALPES
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Patent number: 11268961Abstract: An in vitro method for diagnosing a urological cancer comprising the comparison of a secretome of isolated cells from a urine sample from a patient to be diagnosed with respect: either to a reference secretome obtained from secretions of healthy isolated cells from a urine sample from a healthy person, or to a reference secretome obtained from secretions of healthy cells which are derivatives of standard cell line cultures, characteristic of a determined urological organ, the secretome and the reference secretome being constituted of all the components forming the respective secretions thereof.Type: GrantFiled: May 11, 2017Date of Patent: March 8, 2022Assignees: UNIVERSITE GRENOBLE ALPES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Donald Keith Martin, Nathalie Picollet-D'Hahan
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Patent number: 11264688Abstract: An interposer (16) and a substrate (10) incorporating the interposer (16) are provided. The interposer (16) includes one or more layers (18) and a cavity (20) defined in the one or more layers (18), the cavity (20) being configured as a waveguide for propagation of electromagnetic waves.Type: GrantFiled: May 23, 2018Date of Patent: March 1, 2022Assignees: THALES SOLUTIONS ASIA PTE LTD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLES ALPES, L'INSTITUT POLYTECHNIQUE DE GRENOBLE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE 1, UNIVERSITÉ DE LIMOGES, NANYANG TECHNOLOGICAL UNIVERSITYInventors: Philippe Coquet, Beng Kang Tay, Mathieu Cometto, Dominique Baillargeat, Stéphane Bila, Kamel Frigui, Philippe Ferrari, Emmanuel Pistono, Florence Podevin
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Patent number: 11221341Abstract: Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A (SEQ ID NO.1) is determined.Type: GrantFiled: January 16, 2017Date of Patent: January 11, 2022Assignees: Commissariat a 1'Energie Atomique et aux Energies Alternatives, Centre Hospitalier Universitaire, Universite Grenoble Alpes, Institut National de la Sante et de la Recherche Medicale, Universite Paris SudInventors: Virginie Brun, Jérôme Garin, Christophe Bruley, Jamila Faivre, Jean-Pierre Zarski, Vincent Leroy
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Publication number: 20210401618Abstract: A probe intended to be at least partially implanted in a living being, with a view to locally cooling at least one region of the living being, this probe notably including a cooling member present at its distal end, which member is intended to make contact with the region to be cooled, and a thermoelectric cooling module including a cold region making contact with the cooling member.Type: ApplicationFiled: June 25, 2021Publication date: December 30, 2021Applicants: Commissariat à l'Energie Atomique et aux Energies Alternatives, UNIVERSITE GRENOBLE ALPES, CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE ALPESInventors: Quentin BORNTRAGER, Claude CHABROL, Stephan CHABARDES
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Patent number: 11179599Abstract: A device for acclimatising at altitude comprising a breathing mask defining a confined air space when it is placed on the face of a user. The mask comprising a suction valve to let the surrounding air enter inside the confined space when breathing in; an expiration valve to let air exit with a determined resistance, so as to create an overpressurisation of air in the confined space, when breathing out; and a sensor to establish information about the pressure of the confined space behind. The acclimatisation device in addition comprises a unit for processing the pressure information configured to establish a breathing characteristic of the user and compare it to at least one target value, in view of recommending to them an adjustment of the breathing mode thereof. A method for functioning this device is also provided.Type: GrantFiled: January 24, 2017Date of Patent: November 23, 2021Assignees: UNIVERSITE GRENOBLE ALPES, CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE, UNIVERSITE DE CHAMBERY-UNIVERSITE SAVOIE MONT BLANCInventors: Samuel Verges, Bernard Wuyam, Thomas Rupp
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Patent number: 11174568Abstract: A microfluidic chip comprising at least one dialysis crystallisation cell. The cell includes: a substrate made of PMMA; a first level including a tank defined at least partially by the substrate and by an outer wall of the cell, the tank being in fluid communication with a channel for inlet and a channel for outlet of a solution allowing the crystallisation method to be implemented; and a second level including a dialysis chamber defined at least partially by an inner wall of the cell without contact with the substrate and by a dialysis membrane forming an interface between the tank and the dialysis chamber, the inner wall including at least one one-piece portion in which the periphery of the membrane is kept sealed.Type: GrantFiled: December 2, 2016Date of Patent: November 16, 2021Assignees: UNIVERSITE GRENOBLE ALPES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES, LTERNATIVES CENTRE NATIONAL DE LA RECHERCHE, SCIENTIFIQUE RHODIA OPERATIONS, RHODIA LABORATOIRE DU FUTUR, UNIVERSITE DE BORDEAUXInventors: Monika Spano, Jean-Baptiste Salmon, Niels Heinz Junius
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Publication number: 20210296699Abstract: The present invention relates to a solid polymer electrolyte comprising: at least one comb polymer comprising a main chain formed from 1-ethenyl- and/or 1-allyl-2,3,4,5,6-pentafluorobenzene monomers, some of the monomer units of the main chain bearing polymeric side chains based on polymers that are solvents for alkali metal or alkaline-earth metal salts; said chains being grafted in the para position of the pentafluorophenyl groups; and at least one alkali metal or alkaline-earth metal salt, in particular a lithium salt. The invention also relates to a process for preparing a solid polymer electrolyte film and to the use thereof in an electrochemical system, in particular a lithium battery.Type: ApplicationFiled: February 12, 2021Publication date: September 23, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Lionel PICARD, Thomas CLEMENT, Patrice RANNOU
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Publication number: 20210282963Abstract: The invention relates to a device for cooling an organ locally, that includes an elongate stem including a far end intended to make contact with an organ to be cooled and comprising including a cooling element having a cold finger, a crystal that has a capacity to cool via excitation at a set excitation wavelength, said crystal being positioned adjacent to said cooling element, an optical guide that is able to convey a light signal at said excitation wavelength and that opens onto said crystal, and an illuminating system including at least one light source, which light source is arranged to emit said light signal.Type: ApplicationFiled: September 12, 2017Publication date: September 16, 2021Applicants: COMMISSARIAT A L'ENEGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE ALPESInventors: Nicolas AUBERT, Claude CHARBROL, Stephan CHABARDES, Luarent DURAFFOURG
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Publication number: 20210269883Abstract: The present disclosure relates to the identification of a biomarker, consisting in a circulating miRNA, suitable for use in the diagnosis and prognosis of high-grade serous ovarian carcinoma (HGSOC), and to diagnostic kits for use in such diagnosis.Type: ApplicationFiled: July 4, 2019Publication date: September 2, 2021Applicants: UNIVERSITE DE CAEN NORMANDIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE REGIONAL FRANCOIS BACLESSE, UNIVERSITE GRENOBLE ALPESInventors: Nicolas VIGNERON, Christophe DENOYELLE, Laurent POULAIN, Jean-Paul ISSARTEL, Bernard LAMBERT, Matthieu MERYET-FIGUIERE, Mégane VERNON, Audrey GUTTIN
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Patent number: 11104578Abstract: The invention relates to an exfoliation method according to which a fluid loaded with particles flows at a first flow rate into a first (2), and then into a second, section of a pipe (1), the first flow rate being suitable for generating shear stresses and cavitation bubbles in the fluid as it passes through the first section (2) of the pipe (1), the second section (3) having a hydraulic diameter suitable for bringing about an implosion of cavitation bubbles as soon as the fluid exits the first section (2) and flows into the second section (3), so that an exfoliation of the particles is brought about under the combined action of the shear stresses and a shock wave generated by the implosion of the cavitation bubbles, the first section (2) having a hydraulic diameter less than 300 ?m.Type: GrantFiled: May 16, 2017Date of Patent: August 31, 2021Assignee: UNIVERSITE GRENOBLE ALPESInventors: Frédéric Ayela, Damien Colombet
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Patent number: 11097336Abstract: A device and method for producing metal slugs, in which: a movable support has a plurality of cavities separated by partition walls, such that the cavities travel over a path, a feeding means is positioned above a location on said path and is capable of forming a stream of molten metal, flowing under the effect of gravity, such that, during the continuous movement of the movable support, the continuous stream of molten metal from the feeding means is divided or fragmented into slugs formed successively in said cavities, under the effect of said partition walls.Type: GrantFiled: July 9, 2018Date of Patent: August 24, 2021Assignees: UNIVERSITE GRENOBLE ALPES, INSTITUT POLYTECHNIQUE DE GRENOBLEInventors: Sébastien Gravier, Georges Kapelski
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Publication number: 20210253760Abstract: The present invention relates to a comb polymer comprising a main chain formed from 1-ethenyl- and/or 1-allyl-2,3,4,5,6-pentafluorobenzene monomers and polymeric side chains grafted in the para position of the pentafluorophenyl groups, in which said polymeric side chains are linked to said main chain by an oxygen atom, the molar grafting rate of polymeric side chains being greater than or equal to 50%. It also relates to a method for the preparation of such a comb polymer.Type: ApplicationFiled: February 12, 2021Publication date: August 19, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Lionel PICARD, Thomas CLEMENT, Patrice RANNOU
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Publication number: 20210245613Abstract: An electrical power converter unit (2) includes: a first connection interface (10) comprising two leads (12, 14) forming a DC input/output interface for connecting a first electrical device to the power converter unit, a three-phase rectifier power converter circuit (16) and a second connection interface (30) for connecting a second electrical device to the power converter unit. The second connection interface includes a switching unit (46) adapted to switch between:—a DC input/output mode, in which first, second and third arms of the power converter circuit (16) are electrically connected together, forming one DC input/output; and—an AC input/output mode, in which the arms are disconnected from each other, forming separate input/outputs for a three-phase AC voltage.Type: ApplicationFiled: July 25, 2018Publication date: August 12, 2021Applicants: VOLVO TRUCK CORPORATION, UNIVERSITE GRENOBLE ALPESInventors: Michael MILLET, Christophe MAGNET, David FREY, Julien RICHER, Philippe LE BRUSQ
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Publication number: 20210219955Abstract: The invention relates to a sheath (10) for an endoscopic ultrasound probe, comprising: a first flexible portion (10a) suited to surrounding a catheter (4) of the ultrasound probe, made of a material suited to allowing ultrasounds to pass, having a closed distal end, a second portion (10b) suited to surrounding a handle (2) and a cable (3) for electrically connecting the probe to an ultrasound station, and a fitting (11) arranged between the first and the second portion (10a, 10b), said fitting (11) being suited to being removably attached to the handle (2).Type: ApplicationFiled: June 3, 2019Publication date: July 22, 2021Applicant: Universite Grenoble AlpesInventors: Guillaume Custillon, Nicolas Dubois
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Publication number: 20210212570Abstract: The invention relates to a photoacoustic ultrasound probe (100), comprising: a catheter (4), an ultrasound sensor (5) arranged at a distal end (40) of the catheter, at least one optical fibre (50) suited to being connected to a laser source, said optical fibre extending into the catheter up to the distal end (40), said probe being characterised in that the catheter has an inclined distal portion (42) and/or a bevelled distal end (40).Type: ApplicationFiled: June 3, 2019Publication date: July 15, 2021Applicant: Universite Grenoble AlpesInventors: Guillaume Custillon, Nicolas Dubois
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Patent number: 11061325Abstract: A photosensitive composition activatable by multiphoton absorption usable for the fabrication of a three-dimensional structure which is biodegradable and/or biocompatible and/or bioresorbable. This structure is usable as a matrix for cell culture. The photosensitive composition comprises: gelatin, collagen, a water-soluble photoinitiator, able to be excited by several photons and capable of generating singlet oxygen, optionally a cell adhesion promoter, and water. A process for preparing the photosensitive composition, a process for preparing a three-dimensional structure from the photosensitive composition, the three-dimensional structure obtained by this preparation process and a matrix for cell culture comprising this structure.Type: GrantFiled: March 29, 2017Date of Patent: July 13, 2021Assignee: UNIVERSITE GRENOBLE ALPESInventors: Olivier Stephan, Laetitia Gredy
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Publication number: 20210196172Abstract: A method for determining a membership function, the membership functions allowing a stress level of a user to be determined on the basis of a physiological parameter measured on the user, the membership function varying, depending on the physiological parameter, between: a first value, representative of a rest state; and a second value, representative of a stressed state; the membership function taking into account a distribution function, which is defined beforehand, the distribution function being a continuous and monotonic function, the distribution function being applied to a normalized parameter established on the basis of a measured physiological parameter, the method comprising determining a normalization function, and optionally a standardization function, the normalization function and the optional standardization function being determined on the basis of physiological parameters measured on a plurality of test individuals, in various calibration periods.Type: ApplicationFiled: December 23, 2020Publication date: July 1, 2021Applicants: Commissariat à l'Energie Atomique et aux Energies Alternatives, UNIVERSITE GRENOBLE ALPESInventors: Gaël VILA, Christelle GODIN
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Patent number: 11045539Abstract: The present disclosure is related to a live-attenuated strain of Pseudomonas for its use as a vaccine, and for use in a method for preventive immunizing and for treating Pseudomonas infection, in particular in patients suffering from cystic fibrosis. Preferably, the live-attenuated strain of Pseudomonas is furthermore treated to become ‘killed but metabolically active’.Type: GrantFiled: February 15, 2018Date of Patent: June 29, 2021Assignees: Universite Grenoble Alpes, Centre Hospitalier Universitaire Grenoble Alpes, Establissement Francais Du SangInventors: Audrey Le Gouellec, Bertrand Toussaint, Jean-Luc Lenormand, David Laurin, Elodie Meynet
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Patent number: 11040191Abstract: The invention concerns a method of forming a medical device, the method comprising: forming a graphene film (100) over a substrate (204); depositing, by gas phase deposition, a polymer material covering a surface of the graphene film (100); and removing the substrate (204) from the graphene film (100), wherein the polymer material forms a support (102) for the graphene film (100).Type: GrantFiled: March 9, 2016Date of Patent: June 22, 2021Assignees: Centre National de la Recherche Scientifique, UNIVERSITE GRENOBLE ALPESInventors: Dipankar Kalita, Vincent Bouchiat, Laetitia Marty, Nedjma Bendiab
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Publication number: 20210147899Abstract: Method for determining the sensitivity of a bacterial strain of interest to a viral strain of bacteriophages, the method comprising: a) preparing a sample, this comprising bringing bacteria, belonging to the bacterial strain of interest, into contact with bacteriophages, each bacteriophage belonging to the same viral strain, the bacteria being either in a liquid medium, or in an agar medium; b) placing the sample between a light source and an image sensor, the light source emitting a light wave in an emission spectral band comprised between 500 nm and 600 nm; c) illuminating the sample using the light source and acquiring at least one image of the sample, with the image sensor, in the emission spectral band, no image-forming optic being placed between the sample and the image sensor; d) on the basis of the acquired images, determining a sensitivity of the bacterial strain of interest to the viral strain.Type: ApplicationFiled: November 13, 2020Publication date: May 20, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPESInventors: Prisca PERLEMOINE, Thomas BORDY, Pierre MARCOUX, Emmanuel PICARD, Rémi TOUTAIN, Marc ZELSMANN, Alexis MAIRE