Abstract: The invention relates to the use of melanin, complexed with an antigen, as a immunostimulatory composition.

Abstract: The present invention relates to improved clot retrieval devices, wherein at least the part of the device intended to be in contact with a clot is coated with at least one chromatin binding agent selected from the group consisting of digoxigenin, a digoxigenin derivative, distamycin and a distamycin derivative. The present invention also relates to a method of producing said improved clot retrieval device. The present invention also relates to a method of prevention and/or treatment of stroke in a subject, comprising removing at least one clot using the clot retrieval device coated with said least one chromatin binding agent.

Abstract: The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.

Abstract: The invention relates to the use of melanin, complexed with an antigen, as a immunostimulatory composition.

Abstract: Disclosed are CD31shed agonists for use in the prevention and/or treatment of reperfusion injury. These CD31shed agonists are peptides or peptidomimetics thereof that are able to restore CD31 signaling in cells bearing a truncated form of CD31 called CD31shed. The CD31shed agonists particularly protect from organ damages caused by reperfusion used to treat ischemia.

Abstract: This catheter comprises a tubular catheter body defining a longitudinal channel, the distal end of the catheter body being closed, and the channel opening out through a single side orifice onto an external surface of a side wall of the catheter body at a distance from this distal end. The channel includes a curved distal end segment and has a substantially constant diameter along the entire length thereof.

Abstract: The invention relates to a cyclic peptide increasing the fusiogenic capacity of the oocyte arising from the disintegrin loop of fertilin beta, to a pharmaceutical composition comprising said cyclic peptide and to the use thereof, particularly in order to supplement culture media used to carry out in vitro fertilization.

Abstract: The invention concerns methods for grafting bioactive polymers on a prosthetic material, the materials obtainable by said method and applications thereof. More specifically, the invention concerns a method for directly grafting polymers on the surface of prosthetic materials.

Abstract: A process for calculating an indice of arterial stiffness, including the step of extracting pulse wave analysis data from a recorded pressure of an artery, the recorded pressure is recorded as a function of time, the indice being calculated as a function of the extracted data, and the extracted pulse wave analysis data including at least one time interval.

Abstract: This analog electronic circuit (2) for processing a light signal (4), of the type comprising: a photodetector (6) adapted for producing an electric signal (8) from the light signal (4); a multiplier (12) adapted for multiplying the electric signal (8) with a reference signal (14) for obtaining a multiplied signal (16); and an integrator (18) adapted for integrating the multiplied signal (16) over at least one time interval, in order to obtain one integrated signal, is characterized in that it further comprises: an analog memory (24) adapted for storing the integrated signal in memory; and a computing unit adapted for estimating a time correlation of the light signal (4) from the integrated signal stored in memory.

Abstract: The invention relates to a cyclic peptide increasing the fusiogenic capacity of the oocyte arising from the disintegrin loop of fertilin beta, to a pharmaceutical composition comprising said cyclic peptide and to the use thereof, particularly in order to supplement culture media used to carry out in vitro fertilization.

Abstract: An image segmenting method includes: reading (202) an image, determining (232) a solution to the problem of maximum flow in a graph including, on the one hand, as vertices, a source, a sink and image points, with each point being assigned a capacity, called a through-capacity, assigning (234), on the basis of the determined solution, a label to each of at least some of the points of the image, and recording the image with the assigned labels in a computer memory. In addition, before determining a solution to the problem of maximum flow, the method includes: determining (212) critical points, for each of which, the points of the image located in a predetermined window applied around the critical point verify a predetermined condition on their through-capacities. The points of the graph include the determined critical points and the inter-point arcs link the neighboring critical points to one another.

Abstract: A system for information retrieval within a database of large size includes a first module for extracting the descriptors associated with each object in the database, and for constructing a table containing the objects and the value of a descriptor associated with an object. The system also includes a second module for applying a number of classification algorithms, for each of the tables obtained from the module, a third module to fusion the results obtained from the module in order to determine, for each type of descriptor, a class number associated with an object, a fourth module for finding which column of a table is closest to the column obtained during the first fusion of the step, and for selecting the map that is closest contained in the table, or best map, and a fifth module to fusion the aggregate “best maps”, and applying an algorithm for searching for the best map to be transmitted to a display means.

Abstract: The method comprises, for each cross-section image, determining the position of the object (O) in relation to the cross-section plane at the moment the cross-section image is captured, and determining a three-dimensional representation (V) of the object (O) using cross-section images (X0 . . . Xm) and positions of the object (O) in relation to the cross-section plane at each moment of image capture. The positions of the object (O) in relation to the cross-section plane are determined using the cross-section images (X0 . . . Xm).

Abstract: The method of the invention includes: determining a set of points of a space and a value of each of these points at a given moment, the set of points including the points of the object in the position thereof at the given moment; selecting a three-dimensional representation function that can be parameterized with parameters and an operation that gives, using the three-dimensional representation function, a function for estimating the value of each point in the space; and determining parameters, such that, for each point in the set, the estimation of the value of the point substantially gives the value of the point.

Abstract: The updating method comprises selecting the best winning neuron and second best winning neuron, modifying the prototype vectors of the best winning neuron and the neurons located around the best winning neuron in the direction of the vector of the learning point (x(k)), determining the neighboring neurons (N(u*)) of the best winning neuron (u*) and, if the second best winning neuron (u**) is part of the neighboring neurons (N(u*)), increasing the valuation of the connection between the first and second best winning neurons. The updating method further involves reducing the valuation of each connection between the first best winning neuron and the direct neighboring neurons (N(u*)) other than the second best winning neuron (u**).

Abstract: An image segmenting method includes: reading (202) an image, determining (232) a solution to the problem of maximum flow in a graph including, on the one hand, as vertices, a source, a sink and image points, with each point being assigned a capacity, called a through-capacity, assigning (234), on the basis of the determined solution, a label to each of at least some of the points of the image, and recording the image with the assigned labels in a computer memory. In addition, before determining a solution to the problem of maximum flow, the method includes: determining (212) critical points, for each of which, the points of the image located in a predetermined window applied around the critical point verify a predetermined condition on their through-capacities. The points of the graph include the determined critical points and the inter-point arcs link the neighboring critical points to one another.

Abstract: This analog electronic circuit (2) for processing a light signal (4), of the type comprising: a photodetector (6) adapted for producing an electric signal (8) from the light signal (4); a multiplier (12) adapted for multiplying the electric signal (8) with a reference signal (14) for obtaining a multiplied signal (16); and an integrator (18) adapted for integrating the multiplied signal (16) over at least one time interval, in order to obtain one integrated signal, is characterized in that it further comprises: an analog memory (24) adapted for storing the integrated signal in memory; and a computing unit adapted for estimating a time correlation of the light signal (4) from the integrated signal stored in memory.

Abstract: A system for information retrieval within a database of large size includes a first module for extracting the descriptors associated with each object in the database, and for constructing a table containing the objects and the value of a descriptor associated with an object. The system also includes a second module for applying a number of classification algorithms, for each of the tables obtained from the module, a third module to fusion the results obtained from the module in order to determine, for each type of descriptor, a class number associated with an object, a fourth module for finding which column of a table is closest to the column obtained during the first fusion of the step, and for selecting the map that is closest contained in the table, or best map, and a fifth module to fusion the aggregate “best maps”, and applying an algorithm for searching for the best map to be transmitted to a display means.

Abstract: The updating method comprises selecting the best winning neuron and second best winning neuron, modifying the prototype vectors of the best winning neuron and the neurons located around the best winning neuron in the direction of the vector of the learning point (x(k)), determining the neighbouring neurons (N(u*)) of the best winning neuron (u*) and, if the second best winning neuron (u**) is part of the neighbouring neurons (N(u*)), increasing the valuation of the connection between the first and second best winning neurons. The updating method further involves reducing the valuation of each connection between the first best winning neuron and the direct neighbouring neurons (N(u*)) other than the second best winning neuron (u**).