Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.

Abstract: A scanning dynamic collimator device (SDD) for minibeam production. The SDD includes a single slit collimator being mounted on a support. The SDD is arranged to translate the collimator in a plane perpendicular to a plane whereby the single slit extends and/or in a direction parallel to the plane whereby the single slit extends and/or to rotate the collimator relative to a rotation axis parallel to the plane whereby the single slit extends and to tilt the collimator relative to a predefined reference axis and/or relative to a point comprised in the single slit.

Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.

Abstract: The invention relates to a device forming a DC voltage bus for a polyphase electrical system (M), comprising voltage legs (A1, A2, A3) each having a plurality of battery cell modules (C1, C2, C3), each module comprising a battery cell or a cluster of battery cells (c1), connected to a DC-to-AC converter (DCAC); said battery cell modules (C1, C2, C3) being connected together in series via the DC-to-AC converter (DCAC); said voltage legs (A1, A2, A3) each being connected to a specific phase leg (B1, B2, B3) for said polyphase electrical system (M), at least one phase leg (B1, B2, B3) having a branch (D1, D2, D3) connected to a rectifier module (R1). The invention also relates to a motor vehicle, a renewable energy generator and a method based on such a system.

Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.

Abstract: A device for supplying an ultrasonic transducer including a power interface configured to provide an analog power signal, called supply signal, to the ultrasonic transducer, and further including a delta-sigma modulator configured to produce a delta-sigma modulator of a sinusoidal signal, called drive signal, and provide a digital signal, called control signal, to control said power interface. Also an ultrasonic device powered by such a supply device, an ultrasonic head including such ultrasonic devices and an ultrasonic system including such an ultrasonic head.

Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.

Abstract: A method for processing a signal from a lidar including digitizing the amplified electrical signal (s0e(t)), applying at least one time correction function, referred to as the correcting filter (Ce(t)), to the digitizing amplified electrical signal in order to generate a processed signal (sf(t)), the correcting filter (Ce(t)) being determined based on the impulse response and a predetermined time analysis function, the analysis function having at least one non-zero value, referred to as the discontinuity, at a given time referred to as the discontinuity time, with a return to substantially zero values around the discontinuity; and determining a distance (di) of the at least one element (Ei) based on the processed signal.

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula I or of formula II: wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.

Abstract: The present invention pertains to the field of nanoimprint lithography (NIL) processes and more specifically to a soft NIL process used for providing a sol-gel patterned layer on a substrate. Specifically, this process comprises a step of adjusting the solvent uptake of the sol-gel film to 10 to 50% vol., preferably between 15 and 40% vol., by varying the relative pressure of the solvent while a soft mould is applied onto the substrate coated with the sol-gel film.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: The invention is a method for processing a calibration spectrum acquired by a spectrometric detector of X or gamma photons. The method comprises a taking into account of a parametric form of a calibration function, the calibration function linking the rank of an energy channel to an energy value. The method comprises a confrontation between the channels of the peaks of the calibration spectrum and emission energies of calibration isotopes. The confrontation makes it possible to define the values of the parameters of the calibration function.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: A lidar system based on measuring a time-of-flight, including: an emission device configured to emit light pulses towards a scene at an angle greater than or equal to 5°; a reception device including: o a photodetector configured to receive pulses reflected or backscattered by at least one element of the scene and to convert the pulses into an electrical signal, an amplification circuit configured to amplify the electrical signal, a processing unit for processing the amplified electrical signal, configured to digitize the amplified electrical signal and determine a distance from the at least one element based on the digitized amplified electrical signal, the amplification circuit including a transimpedance amplifier, a transformer including a primary and a secondary, a capacitor and an inductor arranged in series with the capacitor.

Abstract: Disclosed are novel polymers that are grafted onto a substrate. These polymers contain monomer units derived from 4-vinylpyridine and monomer units derived from a co-monomer. The polymers may be complexed with a metal, and linear or crosslinked. Also disclosed are methods for preparing these polymers by radical polymerisation, as well as to their use for metal capture in aqueous media, particularly uranium capture in seawater or in final nuclear waste from nuclear power plants.

Abstract: An integrable, non-reciprocal optical component, with guidance, between two magneto-plasmonic interfaces each formed between a dielectric and a metal. An optical port and an input signal passes through a selection region providing a selected signal whose energy is concentrated in a single plasmonic mode, LRSPP or SRSPP, by a selection aperture of a width for which these modes have optical impedances that differ significantly from each other, one of which (z1eff) is close to, or equal to, the input optical impedance (z0eff). The selected signal passes through a differentiation region, which enhances the asymmetry between the two magneto-plasmonic interfaces, to concentrate its energy on a single magneto-plasmonic interface. The differentiated signal passes through a non-reciprocal treatment region formed by two magneto-plasmonic interfaces of non-equivalent geometries. The input signal will thus undergo different treatment from a reverse signal.

Abstract: The present invention relates to the fields of medicine and in particular cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cells, in particular cancer cells, or changing the immunopeptidome, in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a therapy in a subject in need thereof. The invention also discloses methods for treating a disease, in particular cancer, for preventing or treating cancer metastasis and/or cancer recurrence, in a subject.

Abstract: The invention relates to a method for attaching nucleic acids to a platinum electrode, comprising the following steps: —a step (S1) of attaching an ethylenediamine molecule to the electrode, step (S1) comprising electro-oxidation of a primary amine from the ethylenediamine molecule by cyclic voltammetry, —a step (S2) of attaching a sulfo SMCC molecule of 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester to the ethylenediamine molecule, —a step (S3) of attaching a nucleic acid to the sulfo SMCC molecule, the nucleic acid having been modified beforehand to comprise a thiol function, the electrode being in contact with an aqueous solution, i.e. with a solution in which the solvent is water, during steps (S1), (S2) and (S3).