Patents Assigned to Universite Paris-Saclay
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Patent number: 11590232Abstract: A bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure.Type: GrantFiled: July 18, 2019Date of Patent: February 28, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAYInventors: Patrick Couvreur, Jiao Feng, Sinda Lepetre-Mouelhi
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Patent number: 11560436Abstract: The invention relates to isolated single-domain antibodies (sdAb) directed against von Willebrand Factor (VWF) D?D3 domain and chimeric polypeptides comprising thereof such as blood clotting factors and their uses in therapy such as in the prevention and treatment of hemostatic disorders. The invention also relates to a method of extending or increasing half-life of a therapeutic polypeptide comprising a step of adding to the polypeptide sequence of said therapeutic polypeptide at least one sdAb directed against VWF D?D3 domain.Type: GrantFiled: March 13, 2020Date of Patent: January 24, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS-SACLAYInventors: Petrus Lenting, Gabriel Ayme, Cecile Denis, Olivier Christophe
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Patent number: 11551749Abstract: The present invention relates to a neuromimetic network comprising a set of neurons and a set of synapses, at least one neuron comprising a first stack of superimposed layers, the first stack successively comprising: a first electrode, a first barrier layer made of an electrically insulating material, and a second electrode, the first electrode, the first barrier layer and the second electrode forming a first ferroelectric tunnel junction, at least one synapse comprising a second stack of superimposed layers, the second stack successively comprising: a third electrode, a second barrier layer made of an electrically insulating material, and a fourth electrode, the third electrode, the second barrier layer and the fourth electrode forming a second ferroelectric tunnel junction.Type: GrantFiled: November 30, 2018Date of Patent: January 10, 2023Assignees: UNIVERSITE PARIS-SACLAY, THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Manuel Bibes, Julie Grollier, Vincent Garcia, Nicolas Locatelli
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Publication number: 20230000801Abstract: A freeze-dried powder for preparing a thermogel including: from 1% to 35% of 2-[(3-aminopropyl)amino]ethanethiol or one of its pharmaceutically acceptable salt; from 40% to 85% of one or more poloxamer; and from 0.1% to 20% of one or more carbohydrate compound.Type: ApplicationFiled: November 24, 2020Publication date: January 5, 2023Applicants: CLEVEXEL PHARMA, INSTITUT GUSTAVE ROUSSY, UNIVERSITE PARIS-SACLAYInventors: Denis BRICOUT, Xiuping WANG-ZHANG, Eric DEUTSCH, Céline CLEMENSON
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Publication number: 20220411846Abstract: A method for predicting the pathogenicity and virulence of a strain of Gram-negative bacteria of the Enterobacteriaceae family, wherein the amount of 2-hydroxymyristate and/or 2-hydroxymyristic acid present in the lipopolysaccharides of the bacteria is identified and measured, the amount of 2-hydroxymyristate and/or 2-hydroxymyristic acid is compared with a reference value, and wherein it is concluded that the strain is virulent if the amount of 2-hydroxymyristate is greater than the reference value. Also, the use of the 2-hydroxymyristic acid ester as a marker of pathogenicity and virulence of a Gram-negative bacterial strain and an in vitro diagnosis kit implementing this marker.Type: ApplicationFiled: November 19, 2020Publication date: December 29, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SACLAYInventors: Pierre TISSIERES, Luis AUGUSTO, Nadège BOURGEOIS-NICOLAOS, Richard CHABY, Aude BRETON, Florence DOUCET-POPULAIRE
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Publication number: 20220383083Abstract: This method for training a binarized neural network, also called BNN, including neurons, with a binary weight for each connection between two neurons, is implemented by an electronic circuit and comprises: a forward pass including calculating an output vector by applying the BNN on an input vector; a backward pass including computing an error vector from the calculated output vector, and calculating a new value of the input vector by applying the BNN on the error vector; a weight update including computing a product by multiplying an element of the error vector with one of the new value of the input vector, modifying a latent variable depending on the product; and updating the weight with the latent variable; each weight being encoded using a primary memory component; each latent variable being encoded using a secondary memory component having a characteristic subject to a time drift.Type: ApplicationFiled: May 23, 2022Publication date: December 1, 2022Applicants: Commissariat à l'énergie atomique et aux énergies alternatives, Centre national de la recherche scientifique, UNIVERSITE PARIS-SACLAYInventors: Tifenn HIRTZLIN, Damien QUERLIOZ, Elisa VIANELLO
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Patent number: 11458194Abstract: The inventors have developed a metastatic 4T1 breast tumor model in BALB/c mice. They have shown that the vaccination with xenogeneic embryonic stem cells in combination with valproic acid (VPA) generates a higher anti-tumoral response against breast cancer and inhibits metastasis development. They established that these responses are achieved only by the addition of valproic acid in the therapeutic regimen in comparison to the use ESCs or iPSCs alone. Thus, the inventors provide a new therapeutic strategy to treat cancers expressing embryonic antigens. Accordingly, the present invention relates to i) a population of pluripotent cells and ii) a compound selected from a group which activates MHC expression, as a combined preparation for use in a method for treating a subject suffering from a cancer, comprising a step of administering simultaneously, separately or sequentially to said subject a therapeutically amount thereof.Type: GrantFiled: May 24, 2017Date of Patent: October 4, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), UNIVERSITE PARIS-SACLAY, UNIVERSITE PARIS CITEInventors: Frank Griscelli, Ali Turhan, Annelise Bennaceur Griscelli
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Publication number: 20220175961Abstract: A recombinant adeno-associated virus (AAV) vector that carries a nucleic acid sequence encoding the retinal transcription factor cone-rod homeobox (CRX) for its use in treating CRX-associated IRDs in a subject in need thereof or for use in treating inherited retinal dystrophies caused by hypomorphic mutations in the CRX target genes.Type: ApplicationFiled: March 9, 2020Publication date: June 9, 2022Applicants: UNIVERSITE PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, RETINA FRANCE, VARIANTInventors: Jérôme ROGER, Elodie Kim GRELLIER
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Patent number: 11344586Abstract: The present invention provides methods for determining if a patient is likely to benefit from a cancer treatment, by determining if said patient has a gut dysbiosis with an over representation of certain bacterial species. The present invention also provides probiotic strains to improve the efficacy of a cancer treatment, especially chemotherapy, in patients in need thereof.Type: GrantFiled: April 21, 2020Date of Patent: May 31, 2022Assignees: INSTITUT GUSTAVE ROUSSY, UNIVERSITE PARIS-SACLAY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENTInventors: Laurence Zitvogel, Ivo Gomperts Boneca, Patricia Lepage, Sophie Viaud, Romain Daillere
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Publication number: 20220162266Abstract: The present invention relates to a mutant polypeptide comprising the amino acid sequence of the ectodomain of glycoprotein G of a vesicular stomatitis vims (VSV) strain, wherein said ectodomain comprises the amino acid sequence as set forth in SEQ ID NO: 2 or a sequence having at least 50% of identity with the amino acid sequence as set forth in SEQ ID NO: 2, with at least one substitution of an amino acid residue selected from the group consisting of: a) any amino acid residue located from position 421 to position 429 and any amino acid residue located from position 17 to position 25 of SEQ ID NO:2; or b) any amino acid residue located from a position equivalent to position 421 to a position equivalent to position 429 of SEQ ID NO: 2 and any amino acid residue located from a position equivalent to position 17 to a position equivalent to position 25 of SEQ ID NO: 2, after optimal global alignment with SEQ ID NO:2.Type: ApplicationFiled: March 16, 2020Publication date: May 26, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SACLAYInventors: Aurélie ALBERTINI, Hélène RAUX, Yves GAUDIN, Franck PEREZ
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Patent number: 11332566Abstract: Disclosed are novel polymers that contain monomer units derived from 4-vinylpyridine and monomer units derived from a co-monomer. The polymers may be complexed with a metal, and linear or crosslinked. Also disclosed are methods for preparing these polymers by radical polymerization, as well as to their use for metal capture in aqueous media, particularly uranium capture in seawater or in final nuclear waste from nuclear power plants.Type: GrantFiled: October 2, 2017Date of Patent: May 17, 2022Assignee: UNIVERSITE PARIS-SACLAYInventors: Philippe Gérard Roger, Mohamad Maaz, Bilal Nsouli, Tamara Elzein, Nadine Barroca-Aubry, Bénédicte Lepoittevin
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Publication number: 20220143065Abstract: The present inventors have identified an miRNA capable of greatly modulating the inflammatory response induced by Clostridium difficile. They thus propose incorporating this miRNA into a pharmaceutical composition for preventing or reducing the harmful effects of this infection on the bowels of infected patients. This microRNA is miR-27a-5p. Advantageously, this miRNA can be linked to a matrix, incorporated into particles, or conveyed by a vector. It can be administered to infected subjects for therapeutic purposes.Type: ApplicationFiled: November 8, 2019Publication date: May 12, 2022Applicants: UNIVERSITE PARIS-SACLAY, ASSISTANCE PUBLIQUE - HOPITAUX DE PARISInventors: Imad KANSAU, Hussein KOBEISSY, Cecile LARRAZET, Jean-Christophe MARVAUD
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Patent number: 11320500Abstract: A cryogenic device for cooling an RF coil of a Magnetic Resonance Imaging scanner. The cryogenic device includes: a cryocooler providing a cold source; a solid thermal link; the solid thermal link in thermal contact with the cryocooler; a RF coil holder for holding the RF coil, the RF coil holder being in thermal contact with thermal link; a vacuum chamber enclosing the solid thermal link and the RF-coil holder; a measurement surface, facing the RF coil holder; wherein each one of the cryocooler, the solid thermal link, the RF coil holder and the measurement surface is magnetic material free.Type: GrantFiled: February 14, 2019Date of Patent: May 3, 2022Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, UNIVERSITE PARIS-SACLAYInventors: Gilles Authelet, Marie Poirier-Quinot, Bertrand Baudouy
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Patent number: 11305983Abstract: A hermetic housing is disclosed (10a) for an optoelectronic component (11) or a MEMS device configured to form an enclosure (12) within which a low pressure or vacuum prevails. The hermetic housing includes: an optical window (14) transparent for at least one wavelength of interest (?); and a layer of a getter material (15a) configured to capture gases present in said enclosure and deposited on the optical window opposite the enclosure. This layer of getter material has a thickness (e_t), greater than 60 nanometers, and a porosity (P) in the range from 10 to 70% to satisfy the following relation: (1?P)*e_t<?/2?k with ? corresponding to the at least one wavelength of interest, and k corresponding to the extinction coefficient of the material of the layer of getter material for the at least one wavelength of interest of the optical window.Type: GrantFiled: September 27, 2019Date of Patent: April 19, 2022Assignees: LYNRED, UNIVERSITE PARIS-SACLAY CENTRE NATIONAL DE LA RECHERCHE, SCIENTIFIQUE (CNRS)Inventors: Sylvain Lemettre, David Bunel, Johan Moulin, Alain Bosseboeuf
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Publication number: 20220042926Abstract: A microstrip-type microwave sensor for the measurement of the dielectric properties of a solid or liquid material, constituted by a main line and two connected transmission lines integral at one of their extremities to the main line, the main line and two connected transmission lines being spaced from one another by a slot and being made integral with a substrate. The main line is connected to an electrical circuit by each of its two extremities to inject a sinusoidal signal, and wherein said main line has a width giving it an impedance in the range 50 Ohm, the two connected transmission lines being of the same width and of a length equal to one quarter of the wavelength guided in the substrate, the substrate having a height or thickness giving it flexibility or rigidity, the substrate being applied to a metallic support formed of a layer of metallic material.Type: ApplicationFiled: December 11, 2019Publication date: February 10, 2022Applicants: UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ASSOCIATION YNCRÉA HAUTS-DE-FRANCE, ECOLE CENTRALE DE LILLE, UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCEInventors: Etienne HERTH, Christophe LOYEZ, Laurie CALVET
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Patent number: 11237105Abstract: A system for measuring the absorption of a laser radiation by a sample is provided. The system comprises: •(i) a pulsed laser source, suitable for emitting pulses at a repetition frequency fl and arranged so as to illuminate the sample; •(ii) an AFM probe arranged so as to be able to be placed in contact with the region of the surface of the sample on one side, the AFM probe having a mechanical resonance mode at a frequency fm; and •(iii) a detector configured to measure the amplitude of the oscillations of the AFM probe resulting from the absorption of the laser radiation by the region of the surface of the sample, characterized in that it also comprises a translation system designed to displace the sample at a frequency fp.Type: GrantFiled: September 4, 2019Date of Patent: February 1, 2022Assignees: Centre National De La Recherche Scientifique, Universite Paris-SaclayInventor: Alexandre Dazzi
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Patent number: 11198706Abstract: A Dengue virus Envelope Dimer Epitope (EDE) wherein the EDE: c) spans the polypeptides of a Dengue virus Envelope polypeptide dimer; and/or d) is presented on a dimer of Envelope proteins; and/or c) is formed from consecutive or non-consecutive residues of the envelope polypeptide dimer, wherein the dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from any one or two of DENV-1, DENV-2, DENV-3 and DENV-4.Type: GrantFiled: July 23, 2015Date of Patent: December 14, 2021Assignees: IMPERIAL COLLEGE INNOVATIONS LIMITED, INSTITUT PASTEUR, UNIVERSITE PARIS-SACLAYInventors: Screaton Gavin, Juthathip Mongkolsapaya, Alexander Rouvinski, Pablo Guardado-Calvo, Giovanna Barba-Spaeth, Stéphane Duquerroy, Marie-Christine Vaney, Felix Augusto Rey
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Publication number: 20210380920Abstract: Microfluidic gas exchange devices may include one or more exchange modules (100), wherein each exchange module includes: a first layer comprising: one or more primary inlets (108); a first capillary network connected to the one or more primary inlets, wherein the first capillary network extends radially outward from at least one of the one or more primary inlets, and wherein the first capillary network includes one or more injection branches (104) and a series of microchannels (106); and one or more primary outlets connected to the first capillary network; and a second layer that includes a semipermeable membrane.Type: ApplicationFiled: October 25, 2019Publication date: December 9, 2021Applicants: Centre National de la Recherche Scientifique, UNIVERSITE PARIS-SACLAYInventors: Anne-Marie Haghiri, Lyas Djeghlaf, Julie Lachaux, Alisier Paris, Gilgueng Hwang
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Patent number: 11187705Abstract: The invention relates to a method for labeling specifically living microorganisms in a sample comprising microorganisms, the method comprising the steps of: a) incubating said microorganisms of said sample with at least one modified monosaccharide compound comprising a first reactive chemical group capable to chemically react with a second reactive group, so that a residue bearing said first reactive group is incorporated into such microorganisms, and b) contacting said residue incorporated in the microorganisms, with a labeling molecule comprising a said second reactive group, for generating the chemical reaction of said first reactive group of said residue incorporated within said living microorganisms with said second reactive group of said labeling molecule, resulting in a covalent link, characterized in that the said modified monosaccharide compound has the following formula (I?), or a salt thereof: —X can be O, NH or S, preferably O and NH, and —R1 and R2 can be independently H, OH, NH2, OH and NH2 beinType: GrantFiled: May 3, 2016Date of Patent: November 30, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE PARIS-SACLAYInventors: Sam Dukan, Boris Vauzeilles, Jordi Mas Pons, Aurélie Baron
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Patent number: 11179449Abstract: The invention relates to combinations of peptides carrying T-cell epitopes of the antigen preprocalcitonin, presented by the MHC. These peptides can be used in anti-tumour immunotherapy.Type: GrantFiled: July 4, 2016Date of Patent: November 23, 2021Assignees: Institut Gustave Roussy, Institut National de la Sante et de la Recherche Medicale, Université Paris-SaclayInventors: Fathia Mami-Chouaib, Aurélie Durgeau