Patents Assigned to Universite Paris-SUD
  • Patent number: 10412960
    Abstract: Microparticles and nanoparticles of hydrophobized polysaccharide and an alpha-cyclodextrin, obtained by self-association in an aqueous medium, the hydrophobized polysaccharide being obtained by grafting of alkyl chains derived from fatty acids, by an acylation reaction. These microparticles and nanoparticles constitute systems used for encapsulating substances of interest, in particular in the pharmaceutical field, and vectorization thereof for therapeutic purposes.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: September 17, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD
    Inventor: Kawthar Bouchemal
  • Patent number: 10317656
    Abstract: An optical tomography apparatus comprises: a polychromatic light source, a one-dimensional optical sensor, an interferometric microscope, a one-dimensional confocal spatial filtering system, an actuation system making it possible to perform a one-way scan depthwise of an object to be observed and a processor for reconstructing a two-dimensional image of a section of the object from a plurality of one-dimensional interferential images acquired by the image sensor during the one-way scan. An optical tomography method based on use of such an apparatus is also provided.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 11, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Institut d'Optique Graduate School, UNIVERSITE PARIS SUD 11
    Inventor: Arnaud Dubois
  • Patent number: 10278933
    Abstract: The invention relates to a lipid composition comprising fatty acids mainly in the form of triacylglycerols, in which composition at least 50% of the fatty acids are 14-methyl pentadecanoic acids, and at least 8% of the fatty acids are 12-methyl tetradecanoic acids, the percentages being expressed by weight with respect to the total fatty acids of the composition.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: May 7, 2019
    Assignees: AVRIL, UNIVERSITE PARIS-SUD
    Inventors: France Thevenieau, Sophie Sambou, Marie-Joëlle Virolle, Thierry Dulermo
  • Patent number: 10276302
    Abstract: Process for treating a magnetic structure, wherein it comprises the following steps: providing a magnetic structure comprising one first layer of magnetic material comprising a CoFeB alloy; irradiating the magnetic structure with light low-energy ions; and simultaneously holding the magnetic structure with a preset temperature profile and for a preset time.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: April 30, 2019
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paris SUD (Paris II)
    Inventor: Dafine Ravelosona
  • Patent number: 10272157
    Abstract: A process for preparing a porous solid with an outer surface modified by at least one polymer; the polymer being simultaneously synthetized in solution and grafted on the outer surface of the solid, includes contacting: a porous solid; and a polymer-precursor solution comprising an adhesion primer, and at least one polymerizable monomer; under conditions enabling the formation of radical entities.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 30, 2019
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (CEA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE VERSAILLES SAINT-QUENTIN-EN-YVELINES, UNIVERSITE PARIS-SUD 11
    Inventors: Thomas Berthelot, Elena Bellido Vera, Ruxandra Gref, Patricia Horcajada Cortes, Christian Serre, Patrick Couvreur
  • Patent number: 10240205
    Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: March 26, 2019
    Assignees: Population Bio, Inc., The Universite Paris-Sud, The Assistance Publique—Hopitaux de Paris (APHP), The Institut National de la Sante et de la Recherche Medicale (INSERM), PML Screening, LLC
    Inventors: Eli Hatchwell, Peggy S. Eis, Edward B. Smith, III, Yassine Taoufik
  • Publication number: 20190071438
    Abstract: The invention relates to compounds of formula (I), particularly for the use thereof as a medicament, especially in the treatment or prevention of neurogenerative disorders. The invention also relates to the methods for producing said compounds, and to the pharmaceutical compositions containing same.
    Type: Application
    Filed: October 10, 2016
    Publication date: March 7, 2019
    Applicants: Institut Du Cerveau et de la Moëlle Epiniere, Centre National de la Recherche Scientifique (CNRS (CNRS), Sorbonne Universite, Assistance Publique-Hopitaux de Paris, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris-SUD
    Inventors: Bruno Figadere, Laurent Ferrie, Gael Le Douaron, Rita Raisman-Vozari, Patrick Michel, Julia Sepulveda
  • Patent number: 10213413
    Abstract: The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: February 26, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHEAGRONOMIQUE, Institut Pasteur, UNIVERSITÉ PARIS-SUD
    Inventors: Christina Sizun, Stéphane Duquerroy, Jean-François Eleouet, Felix Rey, Anny Slama Schwok, Didier Desmaele, Patrick Couvreur, Bogdan Tarus
  • Publication number: 20190033324
    Abstract: Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A(SEQ ID NO.1) is determined.
    Type: Application
    Filed: January 16, 2017
    Publication date: January 31, 2019
    Applicants: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre Hospitalier Universitaire, Universite Grenoble Alpes, INSERM, Universite Paris Sud
    Inventors: Virginie Brun, Jérôme Garin, Christophe Bruley, Jamila Faivre, Jean-Pierre Zarski, Vincent Leroy
  • Publication number: 20190023645
    Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 24, 2019
    Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mouâd ALAMI, Abdallah HAMZE, Jean-Daniel BRION, Jérôme BIGNON, Joëlle DUBOIS
  • Patent number: 10172947
    Abstract: A composition including hydrophobized chitosan can be used as an antiparasitic and/or antifungal agent or in the treatment of parasitic and/or fungal infections. The composition may include an antifungal agent and hydrophobized chitosan. The antifungal agent can be in association with the hydrophobized chitosan, with the latter being more preferably in the particle form, or the antifungal agent can be encapsulated in particles including the hydrophobized chitosan. The use of the composition as an antifungal agent or in the treatment of fungal infections, and a method for manufacturing the composition are also described.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: January 8, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIFQUE (CNRS), UNIVERSITE PARIS-SUD 11
    Inventors: Kawthar Bouchemal, Christian Bories, Philippe Loiseau, Christine Vauthier-Holtzscherer, Sebastien Pomel, Benedicte Pradines
  • Patent number: 10174115
    Abstract: The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: January 8, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE MONTPELLIER, CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ PARIS-SUD
    Inventors: Daniel Baty, Jean-Philippe Pin, Patrick Chames, Damien Nevoltris, Philippe Rondard, Pauline Scholler, Gérard Mathis
  • Patent number: 10177541
    Abstract: The invention concerns an aerosol charger having electrical discharge comprising: a body (2); an ion source (3) comprising two electrodes (31, 32); the charger being characterized in that the body (2) and at least a first electrode (32) of the ion source (3) are aligned along a same axis of longitudinal symmetry (AA?) of the charger, the body (2) surrounding the first electrode (32) in such a way as to define an area (5) for an aerosol to flow between a space defined between the body (2) and the first electrode (32); and in that the first electrode (32) comprises a hole (321) in communication with the area (5) for the aerosol (Ae) to flow, the hole (321) being designed to allow ions formed at the ion source (3) to pass therethrough in order for them to mix with an aerosol (Ae) flowing in the area (5) for the aerosol (Ae) to flow.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 8, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD, SONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Jean-Pascal Borra, Manuel Alonso, Nicolas Jidenko
  • Patent number: 10159738
    Abstract: The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: December 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE VERSAILLES-SAINT QUENTIN EN YVELINES, UNIVERSITE PARIS-SUD
    Inventors: Ruxandra Gref, Valentina Agostoni, Samia Daoud-Mahammed, Violeta Rodriguez-Ruiz, Milo Malanga, Laszlo Jicsinszky, Patricia Horcajada-Cortes, Christian Serre
  • Patent number: 10157726
    Abstract: The invention relates to a cathodoluminescence detection system comprising: a collecting optic (112) collecting light radiation (108) from a sample illuminated by a beam of charged particles and reflecting said radiation (108) onto analysis means, said collecting optic (112) being placed in a chamber, called a vacuum chamber, wherein the pressure is below atmospheric pressure; and means (316) for adapting the light radiation, placed downstream of the collecting optic (112) and designed to adapt said light radiation (108) at the inlet of the analysis means. Said system is characterized in that all or part of the adapting means (316) is placed in an environment where the pressure is higher than the pressure in said vacuum chamber.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: December 18, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SUD 11
    Inventors: Mathieu Kociak, Luiz Fernando Zagonel, Marcel Tence, Stefano Mazzucco
  • Patent number: 10111961
    Abstract: Microparticles and nanoparticles of hydrophobized proteins and an alpha-cyclodextrin, obtained by auto-association in an aqueous medium, the hydrophobized protein being obtained by grafting of alkyl chains coming from fatty acids, by an acylation reaction. These microparticles and nanoparticles constitute systems used for encapsulation of active substances of interest, in particular in the pharmaceutical field, and the vectorization thereof for therapeutic purposes.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: October 30, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD XI
    Inventor: Kawthar Bouchemal
  • Patent number: 10093627
    Abstract: The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: October 9, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PAUL SABATIER TOULOUSE III, UNIVERSITE PARIS-SUD, UNIVERSITE D'ORLEANS
    Inventors: Frank Lezoualc'h, Rodolphe Fischmeister, Malik Bisserier, Pascal Bouyssou, Jean-Paul Blondeau, Delphine Courilleau
  • Patent number: 10075006
    Abstract: An electronic device with a circuit for supplying electric power, with a variable capacitor, by alternating mechanical movement. The supply includes, in the form of passive components and without synchronizing structure: generating branch including in series the variable capacitor and a biasing capacitor, connected in parallel to a rectifier circuit and a storage branch, between: a base node, on the variable capacitor side; an output node, on the biasing capacitor side; unidirectional charge return branch: to the generating branch, via a biasing node between the variable capacitor and the biasing capacitor; from the rectifier, receiving a part of the electrical energy produced. A circuit includes a voltage multiplier connected to the biasing node for applying a voltage that is multiplied relative to that existing between the output node; and the base node or one of the ends of the storage branch.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: September 11, 2018
    Assignees: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Elie Lefeuvre
  • Patent number: 10071080
    Abstract: The present invention relates to the use of compounds of general Formula I and pharmaceutically acceptable enantiomers, salts or solvates thereof, for treating pulmonary hypertension in a subject.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 11, 2018
    Assignees: MIFCARE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS-SUD 11
    Inventors: Gaël Jalce, Christophe Guignabert, Morane Le Hiress, Ly Tu, Bernardin Akagah
  • Publication number: 20180215699
    Abstract: The present invention relates to cationic compounds of formula (I) for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicants: Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique-Hôpitaux De Paris, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud
    Inventors: Marc Humbert, Sylvia Cohen-Kaminsky, Sébastien Dumas, Gilles Bru-Mercier, Mouad Alami, Jean-Daniel Brion, Samir Messaoudi, Gilles Galvani