Patents Assigned to Universite Paris-SUD
  • Multiplexed homogeneous oligonucleotide detection
    Patent number: 9914959
    Abstract: A new kit is provided for detecting or quantifying the amount of one or multiple nucleic acid targets in a biological sample, and a detection or quantification method using this kit. The present kit is constituted by a universal energy donor probe, a universal energy acceptor probe and a couple of adaptors.
    Type: Grant
    Filed: May 25, 2015
    Date of Patent: March 13, 2018
    Assignees: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, LUMIPHORE INC.
    Inventors: Niko Hildebrandt, Zongwen Jin
  • Conjugated molecules comprising a peptide derived from the CD4 receptor coupled to an anionic polypeptide for the treatment of AIDS
    Patent number: 9907860
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 6, 2018
    Assignees: INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PARIS-SUD, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Francoise Baleux, Hugues Lortat-Jacob, David Bonnaffe, Yves-Marie Coic
  • GERMANIUM-ON-SILICON LASER IN CMOS TECHNOLOGY
    Publication number: 20180048123
    Abstract: A germanium waveguide is formed from a P-type silicon substrate that is coated with a heavily-doped N-type germanium layer and a first N-type doped silicon layer. Trenches are etched into the silicon substrate to form a stack of a substrate strip, a germanium strip, and a first silicon strip. This structure is then coated with a silicon nitride layer.
    Type: Application
    Filed: March 6, 2015
    Publication date: February 15, 2018
    Applicants: STMicroelectronics (Crolles 2) SAS, Centre National de la Recherche Scientifique, Universite Paris SUD
    Inventors: Mathias Prost, Moustafa El Kurdi, Philippe Boucaud, Frederic Boeuf
  • Method for the high-yield production of giant P-(R)calixarenes
    Patent number: 9868809
    Abstract: Giant p-(R)calixarenes, a process for the preparation of giant p-(R)calixarenes with high yields, and their use as the constitution of a material or in the context of the reinforcement of the material.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 16, 2018
    Assignee: UNIVERSITE PARIS-SUD XI
    Inventors: Vincent Germain Huc, Cyril Martini
  • Waveguide for an electro-optic capacitive modulator
    Patent number: 9864255
    Abstract: A waveguide including a substrate, an assembly of semiconductor regions consecutively extending on the substrate along a direction corresponding to a propagation direction of an electromagnetic wave having a wavelength noted ?, the semiconductor regions being electrically alternately doped with a first conductivity type and with a second conductivity type along the propagation direction, a dielectric layer interposed between two consecutive semiconductor regions, at least one pair of consecutive elementary structures having a dimensions along the propagation direction adapted to ? to form a grating where the light propagates with no diffraction effects.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: January 9, 2018
    Assignees: COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SUD
    Inventors: Alexis Abraham, Ségolène Olivier, Diego Perez-Galacho, Delphine Marris-Morini, Laurent Vivien
  • ANTIVIRAL AGENTS DIRECTED AGAINST RESPIRATORY SYNCYTIAL VIRUS
    Publication number: 20170360752
    Abstract: The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.
    Type: Application
    Filed: November 5, 2015
    Publication date: December 21, 2017
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHEAGRONOMIQUE, Institut Pasteur, UNIVERSITÉ PARIS-SUD
    Inventors: Christina Sizun, Stéphane Duquerroy, Jean-François Eleouet, Felix Rey, Anny Slama Schwok, Didier Desmaele, Patrick Couvreur, Bogdan Tarus
  • Frequency converter system conversion cell and frequency conversion system
    Patent number: 9841656
    Abstract: A frequency converter system includes a source that emits a beam having a wide spectral band; and a frequency conversion cell including 1) a birefringent nonlinear crystal having a first phase-matching wavelength, with an input face that receives the beam, an output face that emits at least one frequency-converted beam, and at least two parallel faces different from the input and output faces; 2) means for applying an external mechanical force to at least one of said two parallel faces, resulting in a variation in the birefringence of the nonlinear crystal, the value of the applied external mechanical force being determined so as to obtain phase matching at a second phase-matching wavelength different from the first phase-matching wavelength; and 3) means for adjusting the external mechanical force for wavelength tunability in the frequency conversion cell.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: December 12, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, Institut d'Optique Graduate School, Université Paris-Sud
    Inventors: Loïc Deyra, François Balembois, Patrick Georges
  • Process for the high-yield preparation of P-(R)calix[9-20]arenes
    Patent number: 9809523
    Abstract: A process for the high-yield preparation of p-(R)calix[9-20]arenes.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 7, 2017
    Assignees: UNIVERSITE PARIS-SUD XI, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Germain Huc, Cyril Martini
  • Switchable directional infrared radiation source
    Patent number: 9798218
    Abstract: A source of directional radiation in an IR band comprises at least a substrate and an external layer comprising controllable cells made of a metal insulator transition material that changes phase depending on its temperature relative to a temperature at which the corresponding wavelength is located in the IR band and that possesses a crystalline phase and an amorphous phase, and control means for controlling the phase change of the cells so as to form in this external layer a diffraction grating when the cells are controlled to the amorphous phase, in order thus to obtain a switchable directional source.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: October 24, 2017
    Assignees: Centre National De La Recherche Scientifique, Institut D'Optique Graduate School, Universite Paris SUD
    Inventors: Philippe Ben-Abdallah, Anne-Lise Coutrot, Mondher Besbes, Henri Benisty
  • Multi-target photonic biosensor, and method for manufacturing and preparing same
    Patent number: 9791439
    Abstract: A component or device is provided for the detection or the measurement in parallel of one or more specific types of biological or chemical target products. This component includes a group of nanotubes selected and/or functionalized to interact with the target product, around an optical waveguide. Thus, an optical coupling is produced between the optical waveguide and one or more optical characteristics of these nanotubes, the modifications of which are evaluated in the presence of the target product. In addition, a method is provided for manufacturing and preparing such a component or device, and a detection method using them, as well as a post-manufacture preparation method comprising a specific functionalization for different target products starting from the same type of pluripotent generic component. Also provided is a family of PFO-based functionalization polymers.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: October 17, 2017
    Assignees: UNIVERSITE PARIS SUD 11, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Laurent Vivien, Etienne Gaufres, Nicolas Izard, Eric Doris, Edmond Gravel, Didier Boquet
  • Electromagnetic absorber
    Patent number: 9761953
    Abstract: The invention concerns an electromagnetic absorbent comprising: a metal earth plane, an insulating dielectric substrate, disposed on said metal earth plane, a set of metal resonant elements disposed on said insulating dielectric substrate, the electromagnetic resonant frequency of a resonant element being adjusted by adapting the dimensions of the resonant element, the set of resonant elements comprising resonant elements with different dimensions so as to enable the production, by juxtaposition of different electromagnetic resonant frequencies, of a predetermined electromagnetic absorption band. An elementary pattern formed by a plurality of metal resonant elements can be replaced periodically.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: September 12, 2017
    Assignees: UNIVERSITE PARIS SUD, UNIVERSITE PARIS QUEST NANTERRE LA DEFENSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: André De Lustrac, Alexandre Sellier
  • Multicompartmental lipid nanoparticles
    Patent number: 9757337
    Abstract: The present invention relates to novel multicompartmental lipid nanoparticles (or cellisomes) with excellent stability comprising a first lipophilic compartment (lipid matrix) partly anchored to a second hydrophilic compartment delimited by a phospholipid bilayer (bilayer), as well as the method for preparing same and the use thereof as a vector for administering a wide variety of molecules of interest.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: September 12, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PARIS-SUD
    Inventors: Vincent Faivre, Sylviane Lesieur, Michel Ollivon, Modibo Ouattara, Tri Truong Cong
  • Tetrahydroquinoline derivatives and their use as Epac inhibitors
    Patent number: 9751838
    Abstract: The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: September 5, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paul Sabatier Toulouse III, Universite Paris-Sud, Universite d'Orleans
    Inventors: Frank Lezoualc'h, Rodolphe Fischmeister, Malik Bisserier, Pascal Bouyssou, Jean-Paul Blondeau, Delphine Courilleau
  • Method for welding and for hard surface deposition of metal parts made of aluminium by a MIG method with pulsed current and filler wire
    Patent number: 9731373
    Abstract: A method for hard surface deposition on aluminum metal parts of a turbine engine using MIG welding equipment which includes a pulsed current generator and pulsed filler metal wire feed, wherein the deposition is achieved using a filler metal wire whose composition is of the same nature as the composition of the aluminum alloy of the part to undergo hard surface deposition, with the pulsed metal wire feed and speed of deposition on the metal part of the turbine engine being adapted to carry out deposition without hot fissuring.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: August 15, 2017
    Assignees: SNECMA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD (UPS), UNIVERSITE DE NANTES
    Inventors: Jean-Baptiste Mottin, Jean-François Castagne, Thierry Baudin, Alexandre Yann Michel Benoit, Pascal Paillard
  • Cytological method using the auto fluorescence of white corpuscles for the early diagnosis and the monitoring of infections
    Patent number: 9709501
    Abstract: The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic microorganism of said individual, comprising at least the following two steps: i) measuring the mean cellular intensity of the autofluorescence of said sample, and ii) comparing the intensity measured in step i) with a control value, so as to determine the infectious state of said individual. The diagnostic method of the invention uses a routine optical material making it possible to work in wavelength regions which are compatible with the cellular autofluorescence, and thus constitutes a rapid, reliable and inexpensive aid for the diagnosis or monitoring of an infection in an individual.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: July 18, 2017
    Assignees: UNIVERSITE DE NANTES, UNIVERSITE PARIS-SUD 11, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Karim Asehnoune, Marie-Pierre Fontaine-Aupart, Sandrine Lecart, Antoine Monsel, Antoine Roquilly
  • Mutant human and simian immunodeficiency virus ENV proteins with reduced immunosuppressive properties
    Patent number: 9682137
    Abstract: A pharmaceutical composition includes, as active substance a mutated lentiviral ENV protein, substantially devoid of immunosuppressive properties or a variant of the mutated lentiviral ENV protein or a fragment of the above proteins, in association with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 20, 2017
    Assignees: VIROXIS SAS, CENTRE NATIONAL DE LA RECHARCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD XI, INSTITUT GUSTAVE ROUSSY
    Inventor: Thierry Heidmann
  • Memory device, comprising at least one element and associated method spintronics
    Patent number: 9653136
    Abstract: A storage device, comprising at least one spintronic element suitable for representing a state among at least n states associated with the spintronic element, n>1, characterized in that each of the n states is associated with at least one characteristic of a group of magnetic skyrmions in the spintronic element, and in that said characteristic associated with a state n oi is different from said characteristic associated with a state n oj when the states n oi and n oj are two different states among the n states.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: May 16, 2017
    Assignees: THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITÉ PARIS-SUD
    Inventors: Vincent Cros, Albert Fert, Joao Sampaio, Pierre Seneor
  • Antenna with resonant cavity
    Patent number: 9647344
    Abstract: The invention relates to an antenna comprising a resonant cavity deliminated by a partially reflecting surface comprising an array of resonant cells, each resonant cell forming a micro-antenna, a totally reflecting surface facing said partially reflecting surface, a radiating source disposed in said resonant cavity and configured so as to radiate a wave between the partially reflecting surface and the totally reflecting surface, said wave illuminating resonant cells of the partially reflecting surface, the partially reflecting surface being curved and resonant cells being individually configured to introduced upon the passage of the incident wave radiated by the source a phase shift dependent on the curvature of the partially reflecting surface at the level of the corresponding resonant cell.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: May 9, 2017
    Assignees: UNIVERSITE PARIS SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PARIS OUEST NANTERRE LA DEFENSE
    Inventors: André De Lustrac, Dylan Germain
  • Mutant human and simian immunodeficiency virus ENV proteins with reduced immunosuppressive properties
    Patent number: 9636396
    Abstract: A pharmaceutical composition includes, as active substance a mutated lentiviral ENV protein, substantially devoid of immunosuppressive properties or a variant of the mutated lentiviral ENV protein or a fragment of the above proteins, in association with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 2, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SUD XI, INSITUT GUSTAVE ROUSSY, VIROXIS S.A.S.
    Inventor: Thierry Heidmann
  • Sodium thiosulphate for the treatment of ectopic calcifications
    Patent number: 9629872
    Abstract: The present invention relates to pharmaceutical compositions comprising sodium thiosulphate dispersed in a hydrophile-in-lipophile emulsion, and the use thereof for topical administration for the treatment of an ectopic calcification and/or of the consequences thereof in an individual, the sodium thiosulphate being in the form of a pharmaceutical composition comprising, in addition, a hydrophile-in-lipophile emulsion. The invention also relates to a method for preparing these pharmaceutical compositions.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: April 25, 2017
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE LIMOGES, CHU DE LIMOGES, UNIVERSITE PARIS-SUD
    Inventors: Voa Ratsimbazafy, Jeremy Jost, Vincent Guigonis, Eric Caudron