Patents Assigned to Universiteit Maastricht
  • Publication number: 20210311057
    Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.
    Type: Application
    Filed: February 22, 2021
    Publication date: October 7, 2021
    Applicants: The University of Vermont and State Agricultural College, Universiteit Maastricht
    Inventors: Yvonne M. Janssen-Heininger, Niki Reynaert
  • Patent number: 11112479
    Abstract: The invention also relates to a MRI apparatus for obtaining images of a target volume of a human and/or animal subject using magnetic resonance imaging (MRI), said MRI apparatus at least comprising: a housing defining a target area for accommodating said human and/or animal subject; at least one main magnet unit and at least one magnetic gradient unit for applying—during use—one or more magnetic field gradients along three independent orthogonal spatial axes in said target area, as well as at least one radiofrequency (RF) pulse generation unit for applying one or more sets of RF pulses towards said target area; a RF receiving unit for acquiring MRI signals possibly having multi-channel spatially sensitive characteristics; and a computer processing unit for processing said acquired MRI signals and for producing said magnetic resonance image data.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: September 7, 2021
    Assignees: UNIVERSITEIT MAASTRICHT, ACADEMISCH ZIEKENHUIS MAASTRICHT
    Inventors: Alard Roebroeck, Benedikt Poser, Francisco Lagos Fritz
  • Patent number: 11078544
    Abstract: This disclosure is in the field of molecular biology and medical diagnosis and provides means and methods for determining the prognosis and disease outcome of a subject having a melanoma. More in particular, this disclosure provides a method for determining whether a subject having a melanoma has a poor prognosis, the method comprising the step of determining in a sample from the subject whether the LY75 promoter is methylated and if the LY75 promoter is methylated, classifying the subject as having a poor prognosis.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 3, 2021
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Manon Van Engeland, Leander Pieter Jo Van Neste, Karin Van Den Hurk
  • Publication number: 20210215716
    Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.
    Type: Application
    Filed: February 22, 2021
    Publication date: July 15, 2021
    Applicants: Roche Diagnostics Operations, Inc., Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Peter Kastner, Manuel Dietrich, André Ziegler, Ursula-Henrike Wienhues-Thelen, Vinzent Rolny, Ulrich Schotten
  • Publication number: 20210161457
    Abstract: A method of processing of electrocardiogram includes the steps of providing an electrocardiogram comprising signals in at least two channels; selecting at least two frequency ranges of the signal in each of the said at least two channels; calculating an envelope for the signal in each frequency range in each channel; dividing the calculated envelope of the signal in each frequency range in each channel into QRS complex segment envelopes; and computing an average or median envelope as an average or mean of QRS complex segment envelopes for each frequency range in each channel.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 3, 2021
    Applicants: Institue of Scientific instruments of the Czech Academy of Sciences, v. v. i., St. Anne's Univeristy Hospital Bmo, Charles University, Universiteit Maastricht, Academisch Ziekenhuis Maastricht, CARDION s.r.o.
    Inventors: Pavel Jurak, Josef Halamek, Ivo Viscor, Filip Plesinger, Vlastimil Vondra, Radovan Smisek, Pavel Leinveber, Magdalena Matejkova, Jolana Lipoldova, Miroslav Novak, Karol Curila, Jana Vesela, Frits W. Prinzen, Ivo Nekuda, Vit Nekuda
  • Patent number: 10993820
    Abstract: The invention relates to stents, in particular to a stent for insertion in a vein of a human or animal body. The invention also relates to a catheter stent insertion device for inserting a stent according to the invention in a vein of a human or animal body. The invention also relates to a method for inserting a stent according to the invention in a vein of a human or animal body using a catheter stent insertion device according to the invention.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 4, 2021
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventor: Cornelis Hendrikus Anna Wittens
  • Patent number: 10933163
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 2, 2021
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Publication number: 20210023123
    Abstract: The present invention relates to dietary fiber compositions that can provide an increased level of acetate in the distal colon. Increase levels of acetate (or other short chain fatty acids; SCFA's) in the distal part of the colon is believed to be beneficial in the treatment of various diseases or conditions, such as being overweight or obese. To accomplish this using dietary intervention, which is clearly the preferred (first-line) option for the treatment and/or prevention of obesity (and related disorders), has been a challenge. It was now surprisingly found that combinations of an inulin-type fructan and resistant starch can be orally consumed to substantially increase the level of acetate in the distal part of the colon in human subjects.
    Type: Application
    Filed: August 6, 2020
    Publication date: January 28, 2021
    Applicants: Coöperatie Koninklijke Cosun U.A., Universiteit Maastricht, Koninklijke Coöperatie Cosun U.A.
    Inventors: Ellen E. Blaak, Emanuel Enzo Canfora, Elaine E. Vaughan
  • Publication number: 20200402761
    Abstract: A sample may be inspected by making particles traverse the sample. The particles that have traversed the sample hit a detector one-by-one. In response thereto, the detector provides a sequence of respective detection outputs. The sequence of respective detection outputs is processed so as to identify respective locations where respective incident particles have hit the detector. An image is generated on the basis of the respective locations that have been identified. In order to determine a location where an incident particle has hit the detector, an evaluation is made with regard to pre-established respective associations between, on the one hand, respective locations where incident particles have hit the detector and, on the other hand, respective detection outputs.
    Type: Application
    Filed: February 13, 2019
    Publication date: December 24, 2020
    Applicant: Universiteit Maastricht
    Inventors: Paul VAN SCHAYCK, Raimond RAVELLI
  • Patent number: 10617739
    Abstract: The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 14, 2020
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Tim Johannes Maria Welting, Marjolein Maria Johanna Caron
  • Publication number: 20190275076
    Abstract: The present invention relates to dietary fiber compositions that can provide an increased level of acetate in the distal colon. Increase levels of acetate (or other short chain fatty acids; SCFA's) in the distal part of the colon is believed to be beneficial in the treatment of various diseases or conditions, such as being overweight or obese. To accomplish this using dietary intervention, which is clearly the preferred (first-line) option for the treatment and/or prevention of obesity (and related disorders), has been a challenge. It was now surprisingly found that combinations of an inulin-type fructan and resistant starch can be orally consumed to substantially increase the level of acetate in the distal part of the colon in human subjects.
    Type: Application
    Filed: March 8, 2019
    Publication date: September 12, 2019
    Applicants: Coöperatie Koninklijke Cosun U.A., Universiteit Maastricht, Koninklijke Coöperatie Cosun U.A.
    Inventors: Ellen E. Blaak, Emanuel Enzo Canfora, Elaine E. Vaughan
  • Patent number: 10383732
    Abstract: An implant, such as a cranial implant, for attachment to a defect in a bone structure having an edge is described. The implant comprises a direction of extension and a rim extending substantially perpendicular to the direction of extension of the implant. The rim is configured to be attached to the edge of the bone structure and comprises at least one mounting portion configured to accommodate a fastener such that at least a portion of the fastener is extendible in a direction extending away from the rim at an angle which is at most acute with respect to the direction of extension of the implant. The implant is configured such that upon placing the implant in the defect, the fastener is extendible into the edge of the bone defect in a controllable manner.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: August 20, 2019
    Assignees: ACADEMISCH ZIEKENHUIS MAASTRICHT, UNIVERSITEIT MAASTRICHT
    Inventors: Maikel Michael Adrianus Beerens, Paul Frans Jozef Laeven, Jules Maria Nikolaas Poukens
  • Patent number: 10373817
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 6, 2019
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universiteit Ultrecht Holding B.V.
    Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
  • Patent number: 10357486
    Abstract: This invention relates to the treatment of varying degrees of cognitive impairment associated with, for example, aging, Alzheimer's disease, schizophrenia with low dose administration of a PDE4 inhibitor, specifically roflumilast.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: July 23, 2019
    Assignee: UNIVERSITEIT MAASTRICHT
    Inventors: Jos Prickaerts, Marlies van Duinen, Anke Sambeth, Arjan Blokland
  • Patent number: 10324087
    Abstract: A device for detecting an analyte includes a thermocouple having an assay polymer over a surface of the thermocouple. The assay polymer is formulated to bind to the analyte, and a heat transfer property of the assay polymer varies responsive to an amount of the analyte bound thereto. A method of forming a sensor includes providing an assay polymer over a thermocouple. A method for detecting an analyte includes passing a liquid containing an analyte adjacent a thermocouple having an assay polymer over a surface thereof, binding an analyte to the assay polymer, detecting a temperature of the thermocouple, and calculating a concentration of the analyte in the liquid based at least in part on the heat transfer property of the assay polymer.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: June 18, 2019
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Bart Robert Nicolaas Van Grinsven, Thomas Jan Cleij
  • Publication number: 20190170625
    Abstract: The invention relates to a method of and apparatus for preparing a sample for imaging or diffraction experiments under cryogenic conditions, comprising the steps of applying a sample to sample carrier, such as a film on a support, in particular a grid (3) comprising such a film on a support, or removing residual medium, typically liquid, from an incubated sample on a film on a support (3), and vitrifying the sample. The sample is vitrified by directing a jet (50, 51) of liquid coolant to the center of the film (3) and onto the sample.
    Type: Application
    Filed: June 22, 2017
    Publication date: June 6, 2019
    Applicant: UNIVERSITEIT MAASTRICHT
    Inventors: Franciscus Johannes Theresia Nijpels, Raimond Ravelli, Jacobus Peter Johannes Peters, Iglesias Carmen Lopez
  • Publication number: 20190167845
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Application
    Filed: January 31, 2019
    Publication date: June 6, 2019
    Applicants: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
  • Patent number: 10272248
    Abstract: In some examples, controlling delivery of CRT includes delivering ventricular pacing according to a sequence of different values of at least one of A-V delay or V-V delay, and acquiring one or more electrograms from respective vectors. For each of the different values of the at least one of A-V delay or V-V delay, at least one of a QRS amplitude or a QRS area may be determined based on the one or more electrograms, and a target change in QRS amplitude or QRS area between adjacent ones of the values of the at least one of A-V delay or V-V delay of the sequence may be identified. In response to the identification of the target change, the implantable medical device may deliver the ventricular pacing at a value of the at least one of A-V delay or V-V delay determined based on the identification to provide CRT.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 30, 2019
    Assignees: Medtronic, Inc., Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Elien B. Engels, Kevin Vernooy, Alfonso Aranda Hernandez, Frits W. Prinzen, Jeffrey M. Gillberg
  • Patent number: 10260109
    Abstract: This disclosure is in the field of molecular biology and medical diagnosis and provides means and methods for determining the prognosis and disease outcome of a subject having a melanoma. More in particular, this disclosure provides a method for determining whether a subject having a melanoma has a poor prognosis, the method comprising the step of determining in a sample from the subject whether the LY75 promoter is methylated and if the LY75 promoter is methylated, classifying the subject as having a poor prognosis.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: April 16, 2019
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Manon Van Engeland, Leander Pieter Jo Van Neste, Karin Van Den Hurk
  • Patent number: 10232081
    Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 19, 2019
    Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit Maastricht
    Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink