Patents Assigned to Universiteit Maastricht
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Patent number: 10383732Abstract: An implant, such as a cranial implant, for attachment to a defect in a bone structure having an edge is described. The implant comprises a direction of extension and a rim extending substantially perpendicular to the direction of extension of the implant. The rim is configured to be attached to the edge of the bone structure and comprises at least one mounting portion configured to accommodate a fastener such that at least a portion of the fastener is extendible in a direction extending away from the rim at an angle which is at most acute with respect to the direction of extension of the implant. The implant is configured such that upon placing the implant in the defect, the fastener is extendible into the edge of the bone defect in a controllable manner.Type: GrantFiled: August 22, 2017Date of Patent: August 20, 2019Assignees: ACADEMISCH ZIEKENHUIS MAASTRICHT, UNIVERSITEIT MAASTRICHTInventors: Maikel Michael Adrianus Beerens, Paul Frans Jozef Laeven, Jules Maria Nikolaas Poukens
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Patent number: 10373817Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.Type: GrantFiled: July 23, 2018Date of Patent: August 6, 2019Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universiteit Ultrecht Holding B.V.Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
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Patent number: 10357486Abstract: This invention relates to the treatment of varying degrees of cognitive impairment associated with, for example, aging, Alzheimer's disease, schizophrenia with low dose administration of a PDE4 inhibitor, specifically roflumilast.Type: GrantFiled: August 15, 2014Date of Patent: July 23, 2019Assignee: UNIVERSITEIT MAASTRICHTInventors: Jos Prickaerts, Marlies van Duinen, Anke Sambeth, Arjan Blokland
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Patent number: 10324087Abstract: A device for detecting an analyte includes a thermocouple having an assay polymer over a surface of the thermocouple. The assay polymer is formulated to bind to the analyte, and a heat transfer property of the assay polymer varies responsive to an amount of the analyte bound thereto. A method of forming a sensor includes providing an assay polymer over a thermocouple. A method for detecting an analyte includes passing a liquid containing an analyte adjacent a thermocouple having an assay polymer over a surface thereof, binding an analyte to the assay polymer, detecting a temperature of the thermocouple, and calculating a concentration of the analyte in the liquid based at least in part on the heat transfer property of the assay polymer.Type: GrantFiled: April 11, 2016Date of Patent: June 18, 2019Assignees: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Bart Robert Nicolaas Van Grinsven, Thomas Jan Cleij
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Publication number: 20190170625Abstract: The invention relates to a method of and apparatus for preparing a sample for imaging or diffraction experiments under cryogenic conditions, comprising the steps of applying a sample to sample carrier, such as a film on a support, in particular a grid (3) comprising such a film on a support, or removing residual medium, typically liquid, from an incubated sample on a film on a support (3), and vitrifying the sample. The sample is vitrified by directing a jet (50, 51) of liquid coolant to the center of the film (3) and onto the sample.Type: ApplicationFiled: June 22, 2017Publication date: June 6, 2019Applicant: UNIVERSITEIT MAASTRICHTInventors: Franciscus Johannes Theresia Nijpels, Raimond Ravelli, Jacobus Peter Johannes Peters, Iglesias Carmen Lopez
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Publication number: 20190167845Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: ApplicationFiled: January 31, 2019Publication date: June 6, 2019Applicants: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit MaastrichtInventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Patent number: 10272248Abstract: In some examples, controlling delivery of CRT includes delivering ventricular pacing according to a sequence of different values of at least one of A-V delay or V-V delay, and acquiring one or more electrograms from respective vectors. For each of the different values of the at least one of A-V delay or V-V delay, at least one of a QRS amplitude or a QRS area may be determined based on the one or more electrograms, and a target change in QRS amplitude or QRS area between adjacent ones of the values of the at least one of A-V delay or V-V delay of the sequence may be identified. In response to the identification of the target change, the implantable medical device may deliver the ventricular pacing at a value of the at least one of A-V delay or V-V delay determined based on the identification to provide CRT.Type: GrantFiled: May 31, 2017Date of Patent: April 30, 2019Assignees: Medtronic, Inc., Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Elien B. Engels, Kevin Vernooy, Alfonso Aranda Hernandez, Frits W. Prinzen, Jeffrey M. Gillberg
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Patent number: 10260109Abstract: This disclosure is in the field of molecular biology and medical diagnosis and provides means and methods for determining the prognosis and disease outcome of a subject having a melanoma. More in particular, this disclosure provides a method for determining whether a subject having a melanoma has a poor prognosis, the method comprising the step of determining in a sample from the subject whether the LY75 promoter is methylated and if the LY75 promoter is methylated, classifying the subject as having a poor prognosis.Type: GrantFiled: May 26, 2016Date of Patent: April 16, 2019Assignees: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Manon Van Engeland, Leander Pieter Jo Van Neste, Karin Van Den Hurk
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Patent number: 10232081Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: GrantFiled: June 16, 2015Date of Patent: March 19, 2019Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit MaastrichtInventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Patent number: 10139407Abstract: A method for characterizing bacteria includes passing a liquid containing an analyte comprising a first bacteria and a second bacteria over and in contact with a polymer material on a substrate. The polymer material is formulated to bind to the first bacteria, and the first bacteria binds to the polymer material with a higher affinity than the second bacteria. A heat transfer property of the polymer material varies based on an amount of the analyte bound thereto. The method further includes binding a portion of the first bacteria and the second bacteria of the analyte to the polymer material, removing at least a portion of the second bacteria from the polymer material, detecting a temperature of the substrate, and calculating a concentration of the first bacteria in the liquid based at least in part on the temperature of the substrate.Type: GrantFiled: April 11, 2016Date of Patent: November 27, 2018Assignees: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Bart Robert Nicolaas Van Grinsven, Thomas Jan Cleij
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Publication number: 20180224452Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.Type: ApplicationFiled: February 1, 2018Publication date: August 9, 2018Applicants: The University of Vermont and State Agricultural College, Universiteit MaastrichtInventors: Yvonne M. Janssen-Heininger, Niki Reynaert
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Patent number: 10032618Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detesting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.Type: GrantFiled: December 9, 2015Date of Patent: July 24, 2018Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universitiet Utrecht Holding B.V.Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
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Patent number: 9822336Abstract: A method for making an at least double layered cell aggregate and/or an artificial blastocyst, and/or a further-developed blastoid termed blastoid, by forming a double layered cell aggregate from at least one trophoblast cell and at least one pluripotent and/or totipotent cell, and culturing the aggregate to obtain an artificial blastocyst having a trophectoderm-like tissue that surrounds a blastocoel and an inner cell mass-like tissue. The cell aggregate can be formed from toti- or pluripotent stem cell types, or induced pluripotent stem cell types, in combination with trophoblast stem cells. Formation of a blastoid can be achieved by culturing the cell aggregate in a medium preferably comprising one or more of a Rho/ROCK inhibitor, a Wnt pathway modulator, a PKA pathway modulator, a PKC pathway modulator, a MAPK pathway modulator, a STAT pathway modulator, an Akt pathway modulator, a Tgf pathway modulator and a Hippo pathway modulator.Type: GrantFiled: April 16, 2014Date of Patent: November 21, 2017Assignees: UNIVERSITEIT MAASTRICHT, KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPENInventors: Nicolas Clément Rivron, Clemens Antoni Van Blitterswijk, Niels Geijsen, Erik Jacob Vrij
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Patent number: 9822414Abstract: The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. In particular, the invention provides a method for predicting the in vivo genotoxicity of a compound comprising the steps of performing an Ames test on the compound and determining if the result is positive or negative, followed by a step wherein the gene expression of at least 3 genes is determined in a HepG2 cell, compared to a reference value and predicting that the compound is in vivo genotoxic if the expression level of more than 2 of the genes is above a reference value.Type: GrantFiled: May 19, 2012Date of Patent: November 21, 2017Assignees: UNIVERSITEIT MAASTRICHT, ACADEMISCH ZIEKENHUIS MAASTRICHTInventors: Joseph Henri Marie Van Delft, Joseph Catharina Stephanus Kleinjans, Christina Magkoufopoulou, Danyel Gerardus Jacobus Jennen
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Patent number: 9790545Abstract: This invention is in the field of medical molecular diagnostics. It provides methods and means for the in vitro detection of the neurodevelopmental toxicity of a compound by determining the gene expression of a limited number of genes.Type: GrantFiled: April 17, 2013Date of Patent: October 17, 2017Assignees: UNIVERSITEIT MAASTRICHT, ACADEMISCH ZIEKENHUIS MAASTRICHTInventors: Jeroen Lambertus Antonius Pennings, Petrus Theodorus Theunissen, Aldert Henrick Piersma
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Publication number: 20170292950Abstract: A method for characterizing bacteria includes passing a liquid containing an analyte comprising a first bacteria and a second bacteria over and in contact with a polymer material on a substrate. The polymer material is formulated to bind to the first bacteria, and the first bacteria binds to the polymer material with a higher affinity than the second bacteria. A heat transfer property of the polymer material varies based on an amount of the analyte bound thereto. The method further includes binding a portion of the first bacteria and the second bacteria of the analyte to the polymer material, removing at least a portion of the second bacteria from the polymer material, detecting a temperature of the substrate, and calculating a concentration of the first bacteria in the liquid based at least in part on the temperature of the substrate.Type: ApplicationFiled: April 11, 2016Publication date: October 12, 2017Applicants: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Bart Robert Nicolaas Van Grinsven, Thomas Jan Cleij
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Patent number: 9744042Abstract: An implant, such as a cranial implant, for attachment to a defect in a bone structure having an edge is described. The implant comprises a direction of extension and a rim extending substantially perpendicular to the direction of extension of the implant. The rim is configured to be attached to the edge of the bone structure and comprises at least one mounting portion (6) configured to accommodate a fastener such that at least a portion of the fastener is extendible in a direction extending away from the rim at an angle which is at most acute with respect to the direction of extension of the implant. The implant is configured such that upon placing the implant in the defect, the fastener is extendible into the edge of the bone defect in a controllable manner.Type: GrantFiled: September 21, 2010Date of Patent: August 29, 2017Assignee: ACADEMISH ZIEKENHUIS MAASTRICHT; UNIVERSITEIT MAASTRICHTInventors: Maikel Michael Adrianus Beerens, Paul Frans Jozef Laeven, Jules Maria Nikolaas Poukens
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Publication number: 20170176445Abstract: The invention is in the field of medicine and molecular therapeutics. The invention provides means and measures for diagnosis and treatment, in particular for diagnosis and treatment of tumors, more in particular for determining the level of hypoxia in a tumor and for reducing the risk of metastasis of a tumor in a subject. The invention comprises a method wherein a level of exosome-associated GABARAPL1 is determined in a bodily fluid of the subject and wherein an elevated level of exosome-associated GABARAPL1 is indicative of an increased level of hypoxia of the tumor. The invention also comprises an antibody directed against GABARAPL1 for use in the treatment or prevention of cancer.Type: ApplicationFiled: February 11, 2015Publication date: June 22, 2017Applicants: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Kasper Mathias Antoon ROUSCHOP, Tom Gertrudis Hubertus KEULERS
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Patent number: 9611480Abstract: The invention relates to the fields of molecular biology and medicine, more specifically to treatment and prevention of heart disease. The invention provides alternative methods for counteracting, diminishing, treating, delaying and/or preventing heart disease.Type: GrantFiled: July 16, 2014Date of Patent: April 4, 2017Assignees: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Leon Johannes De Windt, Hamid El Azzouzi
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Patent number: 9528155Abstract: The invention is in the field of molecular diagnostics. More in particular it provides marker genes for determining the immunotoxicity of compounds. A method according to the invention employs samples obtained from a cell exposed to a potentially immunotoxic compound and determines expression levels of a number of marker genes in order to distinguish between immunotoxic compounds and non-immunotoxic compounds. More in particular, the invention relates to an in vitro method for determining whether a compound is immunotoxic wherein the expression level of at least one marker gene is determined in a sample obtained from a nucleated cell exposed to the compound, wherein the at least one marker gene is selected from the group consisting of ABCA1, CHAC1, CRIM1 and HMGCS1, and wherein it is concluded that the compound is immunotoxic if the expression level of said at least one marker gene is below or above a predetermined reference value.Type: GrantFiled: September 16, 2013Date of Patent: December 27, 2016Assignees: Universiteit Maastricht, Academisch Ziekenhuis MaastrichtInventors: Oscar Leonard Volger, Jia Shao, Adrianus Antonius Cornelis Maria Peijnenburg, Hendrik Van Loveren