Patents Assigned to University College Cardiff
  • Method for producing polymers comprising multiple repeat units of bicyclic diamines
    Patent number: 9018270
    Abstract: A method of forming a polymer is provided, the method comprising: Providing a first monomer comprising one or more aromatic moieties, the first monomer comprising at least two amino groups, each of the amino groups being attached to an aromatic moiety; and contacting said first monomer with formaldehyde or a source of methylene. Polymers made by such a method and uses of such polymers are also described.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: April 28, 2015
    Assignee: University College Cardiff Consultants Limited
    Inventors: Neil Bruce McKeown, Mariolino Carta, Matthew James Croad
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9006473
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: April 14, 2015
    Assignees: The UAB Research Foundation, The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • SCREENING METHOD FOR THE DETECTION OF CLOSTRIDIUM DIFFICILE
    Publication number: 20150087542
    Abstract: The invention concerns a screening method for the detection of Clostridium difficile in a sample, wherein said method comprises the detection of conserved target regions in the Clostridium genome through the binding of at least one oligonucleotide probe to said target site.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 26, 2015
    Applicant: University College Cardiff Consultants Limited
    Inventors: Lesley William James Baillie, Lovleen Tina Joshi
  • METHODS AND COMPOUNDS FOR DETECTING CANCER
    Publication number: 20140370520
    Abstract: The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R1, R2, R3, R4, R5 X, Y and z are as defined herein.
    Type: Application
    Filed: December 8, 2011
    Publication date: December 18, 2014
    Applicant: University College Cardiff Constultants Limited
    Inventors: Ian Weeks, Mohammad Jaffar, Richard Knox
  • Selective hydrocarbon oxidation using heterogenous catalysts
    Patent number: 8901028
    Abstract: A process for the complete or partial oxidation of hydrocarbons comprises contacting a C1-C8 hydrocarbon and hydrogen peroxide in the presence of a heterogeneous catalyst under conditions suitable to convert the C1-C8 hydrocarbon to at least one corresponding C1-C8 oxygenate product, wherein the heterogeneous catalyst provides confinement and contains both Brønsted-Lowry and Lewis acid centers. Particularly useful catalysts may include, for example, metal-modified ZSM-5 and other zeolites.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: December 2, 2014
    Assignee: University College Cardiff Consultants Limited
    Inventors: Graham John Hutchings, Jose Antonio Lopez-Sanchez, Ceri Hammond, Nikolaos Dimitratos, Nicholas Fracois Dummer
  • METHOD OF MAKING ALCOHOLS
    Publication number: 20140323774
    Abstract: A method of making one or more alcohols with a single hydroxy group, such as methanol and ethanol, the method comprising contacting a polyol and water with a basic catalyst. The polyol may be glycerol, for example. The '. catalyst may be magnesium oxide.
    Type: Application
    Filed: August 9, 2012
    Publication date: October 30, 2014
    Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Graham John Hutchings, Muhammad Hasnain Haider, Nicholas Francois Dummer, Stuart Hamilton Taylor, David Willliam Knight
  • CRYOPROBE
    Publication number: 20140316399
    Abstract: The invention relates to a medical device, including interchangeable parts thereof, for performing corneal cell freezing wherein said device comprises an elongate member having a flow line system through which a cryogenic fluid flows to cool a cryoprobe tip which tip is fixed and comprises a concave epithelial surface contact member.
    Type: Application
    Filed: September 6, 2012
    Publication date: October 23, 2014
    Applicant: University College Cardiff Consultants Limited
    Inventor: Andrew Quantock
  • Anti-viral pyrimidine nucleoside derivatives
    Patent number: 8859512
    Abstract: A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: October 14, 2014
    Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and Development
    Inventors: Christopher McGuigan, Jan Balzarini, Marco Migliore
  • SELECTIVE OXYGENATION OF ALKANES USING OXYGEN
    Publication number: 20140303400
    Abstract: A process for the complete or partial oxygenation of hydrocarbons comprises contacting a C1-C8 hydrocarbon, molecular oxygen, and hydrogen peroxide, in the presence of water and a heterogeneous catalyst, under conditions suitable to convert the C1-C8 hydrocarbon to at least one corresponding C1-C8 oxygenate product, wherein the heterogeneous catalyst provides confinement and contains both Brønsted-Lowry acid centers and Lewis acid centers. The reaction may be carried out at a temperature ranging from 2° C. to 90° C. The use of molecular oxygen increases the economic attractiveness of the process while also improving yield.
    Type: Application
    Filed: October 3, 2012
    Publication date: October 9, 2014
    Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Graham J. Hutchings, Michael M. Forde, Jose A. Lopez - Sanchez, Nikolaos Dimitratos
  • Substituted Purine Nucleosides, Phosphoramidate and Phosphordiamidate Derivatives for Treatment if Viral Infections
    Publication number: 20140286903
    Abstract: This invention is directed to compounds of Formula (I) having the structure that are useful in the treatment of viral infections in mammals, particularly in humans, mediated, at least in part, by a virus in the Flaviviridae family of viruses.
    Type: Application
    Filed: November 8, 2012
    Publication date: September 25, 2014
    Applicants: INHIBITEX, INC., UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Stanley Chamberlain, John Vernachio, Srinivas K. Battina, Changalvala V.S. Ramamurty, C. Srinivas Rao, Chris McGuigan, Andrea Brancale
  • Therapeutic conjugates
    Patent number: 8835380
    Abstract: The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: September 16, 2014
    Assignee: University College Cardiff Consultants Limited
    Inventors: Elaine Ferguson, David Thomas, Timothy Walsh
  • Surface plasmon four-wave mixing microscopy
    Patent number: 8817261
    Abstract: Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 26, 2014
    Assignee: University College Cardiff Consultants Ltd.
    Inventors: Paola Borri, Wolfgang Langbein, Francesco Masia
  • DISPERSION ANAESTHETIC DEVICE
    Publication number: 20140216456
    Abstract: The invention concerns a cartridge for an inhalation device for delivering anaesthetic to a human or animal wherein anaesthetic in said cartridge is dispersed in an anaesthetic control release medium; an inhalation device for use with said cartridge and a formulation comprising at least one selected anaesthetic and anaesthetic control release medium.
    Type: Application
    Filed: September 18, 2012
    Publication date: August 7, 2014
    Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Judith Hall, Alison Paul, Antony Wilkes
  • MOLECULAR TARGETS FOR HEALING OR TREATING WOUNDS
    Publication number: 20140213629
    Abstract: The invention relates to at least one molecular target for healing or treating wounds and, in particular chronic, human wounds. The molecular target is PTPRK, or a protein 50% homologous therewith, and which retains the same activity as PTPRK protein. Further, the invention concerns a novel therapeutic for treating said wounds and a novel gene therapy approach, involving said molecular target, for treating said wounds.
    Type: Application
    Filed: February 17, 2012
    Publication date: July 31, 2014
    Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Wenguo Jiang, Keith Harding
  • Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
    Patent number: 8759318
    Abstract: Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: June 24, 2014
    Assignees: Inhibitex, Inc., University College Cardiff Consultants Limited
    Inventors: Stanley Chamberlain, Jeff Hutchins, Karolina Madela, Christopher McGuigan, John Vernachio, Mohamed Aljarah, Arnaud Gilles
  • SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140140955
    Abstract: This invention is directed to novel compounds of formula (I) having the structure (I) wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. The compounds of formula (I) and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV).
    Type: Application
    Filed: December 29, 2011
    Publication date: May 22, 2014
    Applicants: UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED, INHIBITEX, INC.
    Inventors: Chris McGuigan, Karolina Madela, Claire Bourdin, John Vernachio, Stanley Chamberlain
  • Sperm factor sequences
    Patent number: 8709774
    Abstract: A nucleic acid sequence, including an isolated, purified or recombinant nucleic acid sequence, includes: (a) a nucleic acid sequence encoding a polypeptide encompassed by the present invention, namely, a PLC-zeta; PLC? amino acid sequence, capable of triggering calcium oscillations in oocytes; (b) a sequence substantially homologous to or that hybridizes to sequence (a) under stringent conditions; (c) a sequence substantially homologous to or that hybridizes to the sequences (a) or (b) but for degeneracy of the genetic code; and (d) an oligonucleotide specific for any of the sequences (a), (b) or (c) above.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 29, 2014
    Assignee: University College Cardiff Consultants Limited
    Inventor: Francis Anthony Lai
  • COMPOSITION BASED ON BACILLUS SPP. AND CORRELATE GENERA AND THEIR USE IN PEST CONTROL
    Publication number: 20140086875
    Abstract: The objective of the current invention is the control of agricultural infestations based on alternative methods that are less aggressive to the environment and that are harmless to other invertebrates and to man; for instance biological control using bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus. A first embodiment of the invention refers to compositions based on the systemic utilization of bacterial strains belonging to species of the genera Bacillus, Brevibacillus and/or Paenibacillus to protect plants by using the composition containing the above referred bacteria in wild-type, conjugated, mutant or transgenic forms and/or the substances produced by them. A second embodiment of the invention refers to a method of bioinsecticide application based on bacteria from the genera Bacillus, Brevibacillus and/or Paenibacillus.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicants: EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA - EMBRAPA, UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED, BTHEK BIOTECNOLOGIA LTDA.
    Inventors: Rose Gomes Monnerat Solon DE PONTES, Carlos Marcelo Silveira SOARES, Colin BERRY
  • Method and system for analyzing calcium transients in coupled cells
    Patent number: 8666676
    Abstract: A system and method are provided for measuring dynamic phenomena in a biological, chemical or physical sample, including the measurement of Ca2+ transients in a living system. The system and method include measuring dynamic phenomena in an in vitro cardiac cell culture system. Computing system environments and computing systems for implementing the method are provided.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: March 4, 2014
    Assignee: University College Cardiff Consultants Limited
    Inventors: Christopher Hugh George, Steven Roger Barberini-Jammaers, Nicole Cherie Silvester
  • Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus
    Patent number: 8658616
    Abstract: Compounds having the general formula (I): are provided which have enhanced inhibitory potency and are thus useful in methods of prophylaxis or treatment of a viral infection such as hepatitis C virus. The compounds are phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine. The glycoside moiety of the nucleoside compound can be substituted at the ss-2? position with methyl and the phosphoramidate group can be 1-naphthyl linked by —O— to the P atom. These compounds can be administered as pharmaceutical compositions, and methods for their preparation are also provided.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: February 25, 2014
    Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and Development
    Inventors: Christopher McGuigan, Plinio Perrone, Johan Neyts