Patents Assigned to University of British Columbia
  • Publication number: 20200199595
    Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.
    Type: Application
    Filed: January 7, 2020
    Publication date: June 25, 2020
    Applicant: The University of British Columbia
    Inventors: Amber L. Southwell, Christopher Kay, Michael R. Hayden, Nicholas S. Caron
  • Patent number: 10688456
    Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: June 23, 2020
    Assignee: The University of British Columbia
    Inventors: Andre Wild, Timothy Leaver, Robert James Taylor
  • Patent number: 10677804
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: June 9, 2020
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Wolodymyr Walter Peter Maksymowych, Ruhangiz Taghi Kilani
  • Patent number: 10670429
    Abstract: A sensor unit for detecting bending of the sensor unit comprises: a capacitive upper sensor having an upper capacitance and comprising first and second deformable upper electrodes spaced apart from one another in a Z direction, the first and second upper electrodes respectively having first and second upper shapes; and a capacitive lower sensor having a lower capacitance, spaced apart from the upper sensor in a Z direction and comprising first and second deformable lower electrodes spaced apart from one another in the Z direction, the first and second lower electrodes respectively having first and second lower shapes. For a bend of the sensor unit in a first direction, the first and second upper shapes change such that the upper capacitance decreases and the lower shapes change such that the lower capacitance increases.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: June 2, 2020
    Assignee: The University of British Columbia
    Inventors: John D. W. Madden, Mirza S. Sarwar
  • Patent number: 10667791
    Abstract: The embodiments described herein relate generally to an elastography method and system for obtaining ultrasound images of an excited tissue over a certain time period, then computationally determining one or more mechanical properties of the tissue within a real time refresh rate. This method can perform elastography in real time as only a thin volume of the excited tissue is imaged and processed. The thin volume includes a desired cross-sectional plane of the tissue and at least two adjacent planes that are adjacent to the desired cross-sectional plane. A maximum number of adjacent planes is selected so that a computer system is capable of computationally determining mechanical properties within a real time refresh rate.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: June 2, 2020
    Assignee: The University of British Columbia
    Inventors: Ali Baghani, Hani Eskandari, Robert N. Rohling, Septimu E. Salcudean
  • Patent number: 10660667
    Abstract: Provided is an apparatus, a system and method for use in image guided medical instrument manipulation. Embodiments describe various apparatuses having a mount operable to receive an imaging probe, a body guide and a medical instrument guide. There are also described methods and a systems for using the various apparatuses to position the apparatus and collect data relating to the position of the medical instrument relative to a target within a patient's body. Further methods include using the apparatus and system in epidural anaesthetic procedure or lumbar puncture. The apparatus may include a hand-held ultrasound probe, configured to acquire a volumetric dataset representing a 3-D depiction of a volume, which may include information about a medical instrument's position relative to the target in three dimensions.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 26, 2020
    Assignee: The University of British Columbia
    Inventor: Robert Rohling
  • Patent number: 10663358
    Abstract: A method of sensing a pressure applied to a surface comprises monitoring an electrical signal generated by redistribution of mobile ions in a piezoionic layer under the surface. An externally applied local pressure at a portion of the layer induces redistribution of mobile ions in the piezoionic layer. It is determined that the surface is pressured based on detection of the electrical signal. A piezoionic sensor includes a sensing surface; a piezoionic layer disposed under the sensing surface such that an externally applied local pressure on a portion of the sensing surface causes detectable redistribution of mobile ions in the piezoionic layer; and electrodes in contact with the layer, configured to monitor electrical signal generated by the redistribution of mobile ions in the piezoionic layer.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: May 26, 2020
    Assignee: The University of British Columbia
    Inventors: John Madden, Mirza Sarwar, Yuta Dobashi, Edmond Cretu, Shahriar Mirabbasi, Ettore Glitz, Meisam Farajollahi
  • Patent number: 10653780
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 19, 2020
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • Patent number: 10654811
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: May 19, 2020
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Kunzhong Jian, Marianne Dorothy Sadar, Nasrin R. Mawji, Carmen Adriana Banuelos
  • Publication number: 20200140291
    Abstract: Aspects of exemplary fluid disinfection apparatus and methods are described. One aspect is a disinfection apparatus comprising a body comprising a reflecting chamber, a fluid channel to direct a fluid into reflecting chamber, and radiation source positioned to output a disinfecting radiation into the chamber. The body may include an inlet and outlet. For example, the inlet may extend through the body to receive a fluid at a first velocity; the reflecting chamber may extend along an axis of the body; and the outlet may extend through an end of the reflecting chamber to discharge the fluid from the body. In this example, the fluid channel may direct the fluid from the inlet into the reflecting chamber at a second velocity smaller than the first velocity; and the radiation source may be positioned to output the disinfecting radiation into the reflecting chamber toward the outlet.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 7, 2020
    Applicants: ACUVA TECHNOLOGIES INC., THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Ashkan BABAIE, Babak ADELI-KOUDEHI, Fariborz TAGHIPOUR
  • Patent number: 10640397
    Abstract: A reactor that operates with ultraviolet light emitting diodes (UV-LEDs) to attain UV photoreactions or UV photo-initiated reaction in a fluid flow for various applications, including water purification. The UV-LED reactor is comprised of a conduit means for passing fluid flow, an ultraviolet light emitting diode (UV-LED), and a radiation-focusing element to focus the UV-LED radiation to the fluid in the longitudinal direction of the conduit. The UV-LED reactor may include photocatalysts or chemical oxidants, which are activated by UV emitted by UV-LEDs for photocatalytic and photo-initiated reactions.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: May 5, 2020
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventor: Fariborz Taghipour
  • Publication number: 20200129435
    Abstract: Disclosed herein are embodiments of a composition comprising a matrix, a plurality of microparticles and a therapeutic agent. The therapeutic agent may be encapsulated in the microparticles, and/or the microparticles may be dispersed in the matrix. The composition may be a mesh or a sheet, and may further comprise a second therapeutic agent, and optionally a second microparticle and/or a second matrix. In particular embodiments, the matrix is a hydrogel. Methods for making and using the composition are also disclosed, and in certain embodiments, the composition is useful for treating cancer, such as brain cancer.
    Type: Application
    Filed: October 24, 2018
    Publication date: April 30, 2020
    Applicants: UVic Industry Partnerships Inc., The University of British Columbia
    Inventors: Mohsen Akbari, Brian Toyota
  • Patent number: 10633338
    Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 28, 2020
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, SIMON FRASER UNIVERSITY
    Inventors: Paul Rennie, Artem Tcherkassov, Robert N. Young, Christophe M. Andre
  • Patent number: 10610567
    Abstract: The present invention provides novel nucleic acid sequence compositions and methods relating to minimal human PAX6 promoters. The invention is based in part on the surprising discovery that certain minimal PAX6 promoter elements are capable of expressing in specific cell types in cells eye.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: April 7, 2020
    Assignee: University of British Columbia
    Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Jack Hickmott, Robert Molday
  • Patent number: 10600217
    Abstract: This disclosure provides a computational framework with related methods and systems to enhance the analysis of genomic information. More specifically, the disclosure provides for a graph-based reference genome framework, referred to as a GNOmics Graph Model (GGM), which represents genomic sequence information in edges with nodes representing transitions between edges. The disclosed GGM framework can represent all known polymorphisms simultaneously, including, SNPs, indels, and various rearrangements, in a data-efficient manner. The edges can contain weights to reflect the likelihood of a path within the GGM incorporating any particular edge. The disclosure also provides for systems and methods for using the GGM as a reference model for the rapid assembly of short sequence reads and analysis of DNA sequence variation with enhanced computational efficiency.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: March 24, 2020
    Assignee: The University of British Columbia
    Inventor: Alice Kaye
  • Patent number: 10598632
    Abstract: Methods and techniques for fabricating layered structures, such as capacitive micromachined ultrasound transducers, as well as the structures themselves. The layered structure has a membrane that includes a polymer-based layer and a top electrode on the polymer-based layer. The membrane is suspended over a closed cavity and may be actuated by applying a voltage between the top electrode and a bottom electrode that may be positioned along or be a bottom of the closed cavity. The layered structure may be fabricated using a wafer bonding process.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: March 24, 2020
    Assignee: The University of British Columbia
    Inventors: Carlos D. Gerardo, Robert Rohling, Edmond Cretu
  • Patent number: 10597291
    Abstract: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 24, 2020
    Assignee: The University of British Columbia
    Inventors: Andre Wild, Timothy Leaver, Colin Walsh, Gesine Heuck, Anitha Thomas, Aysha Ansari, Kevin Ou, Robert James Taylor, Euan Ramsay
  • Patent number: 10583167
    Abstract: Provided are methods, uses and pharmaceutical compositions for inhibition of mammalian alpha-amylase in a subject, with a Helianthamide peptide or a derivative thereof in a biologically effective amount. The subject in need of alpha-amylase inhibition, may have or be at risk of developing one or more of the following: Middleton syndrome; a motility disorder of the gastrointestinal tract; postprandial reactive hypoglycemia; postprandial syndrome; irritable bowel syndrome; diabetes mellitus type 1; diabetes mellitus type 2; pre-diabetes; obesity, dumping syndrome; infant dumping syndrome; polycystic ovary syndrome; steatohepatitis; and viral infection.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 10, 2020
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Stephen G. Withers, Andrew Tarling, Raymond J. Andersen, Gary D. Brayer, Robert Keyzers, Christina Rose Tysoe, Leslie Karen Williams
  • Patent number: 10584243
    Abstract: Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deepvein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: March 10, 2020
    Assignees: The University of British Columbia, The Board of Trustees of the University of Illinois
    Inventors: Jayachandran Kizhakkedathu, James H. Morrissey, Richard J. Travers, Rajesh Shenoi, Manu Thomas Kalathottukaren
  • Patent number: 10578618
    Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: March 3, 2020
    Assignee: The University of British Columbia
    Inventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa