Patents Assigned to University of British Columbia
  • Patent number: 11228232
    Abstract: Displacement devices comprise a stator and a moveable stage. The stator comprises a plurality of coils shaped to provide pluralities of generally linearly elongated coil traces in one or more layers. Layers of coils may overlap in the Z-direction. The moveable stage comprises a plurality of magnet arrays. Each magnet array may comprise a plurality of magnetization segments generally linearly elongated in a corresponding direction. Each magnetization segment has a magnetization direction generally orthogonal to the direction in which it is elongated and at least two of the magnetization directions are different from one another. One or more amplifiers may be connected to selectively drive current in the coil traces and to thereby effect relative movement between the stator and the moveable stage.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 18, 2022
    Assignee: The University of British Columbia
    Inventors: Xiaodong Lu, Irfan-Ur-Rab Usman
  • Publication number: 20220002744
    Abstract: The invention is directed to BAHD acyltransferase enzymes, nucleic acids encoding BAHD acyltransferase enzymes, and inhibitory nucleic acids adapted to inhibit the expression and/or translation of BAHD acyltransferase RNA; expression cassettes, plant cells, and plants that have or encode such nucleic acids and enzymes; and methods of making and using such nucleic acids, enzymes, expression cassettes, cells, and plants.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Steven D. Karlen, Rebecca Anne Smith, John Ralph, Emily Beebe, Craig Bingman, Brian Fox, Shawn Mansfield, Heather Mackay, Hoon Kim, Yaseen Mottiar, Faride Unda
  • Patent number: 11214613
    Abstract: The disclosure pertains to conformational epitopes in TDP-43, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: January 4, 2022
    Assignee: The University of British Columbia
    Inventors: Steven S. Plotkin, Neil R. Cashman, Xubiao Peng
  • Patent number: 11208697
    Abstract: The present invention relates to methods, systems and kits for the diagnosis, prognosis, and treatment of bladder cancer in a subject. The invention also provides biomarkers that define subgroups of bladder cancer, clinically useful classifiers for distinguishing bladder cancer subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of subtyping bladder cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in subtyping bladder cancer in a subject. Classifiers for subtyping a bladder cancer are provided. Methods of treating bladder cancer based on molecular subtyping are also provided.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: December 28, 2021
    Assignees: Decipher Biosciences, Inc., The University of British Columbia
    Inventors: Elai Davicioni, Hussam Al-Deen Ashab, Nicholas Erho, Peter Black
  • Patent number: 11207432
    Abstract: Fluoridated organofluoroborates comprising at least one 18F atom and precursors thereto, for use in PET scanning.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: December 28, 2021
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: David Perrin, Zhibo Liu
  • Patent number: 11196329
    Abstract: Aspects of the invention provide methods and systems for moving moveable stages relative to a stator. A stator is operationally divided into multiple stator tiles. The movement of the one or more moveable stages is controlled by a plurality of controllers (each assigned particular control responsibilities). A controller is provided for each stator sector, where each stator sector comprises a group of one or more stator tiles. Controllers from neighboring sectors share various information to facilitate controllable movement of one or more moveable stages relative to the stator.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: December 7, 2021
    Assignee: The University of British Columbia
    Inventor: Xiaodong Lu
  • Patent number: 11195117
    Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: December 7, 2021
    Assignees: University of Maryland, Duke University, University of British Columbia
    Inventors: Christopher Monroe, Jungsang Kim, Robert Raussendorf
  • Patent number: 11186620
    Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase I and the CMPD is protein transduction domain of the HIV-1 Tat protein.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: November 30, 2021
    Assignee: University of British Columbia
    Inventors: Yu Tian Wang, Xuelai Fan, Jack Wuyang Jin
  • Publication number: 20210353338
    Abstract: The current invention features a rod screw for medical application that can be configured and used to fixate fracture of bones varying in shape and dimension, and treating maladies such as scoliosis, and securing an implanted device, to tissue such as bone. This is achieved by designing a flexible rod screw with a mechanism to lock the configuration in a rigid state. In an embodiment, a bone-fracture fixation device, such as a rod screw, includes a flexible body, a plurality of flexible members, and first and second interfaces. The flexible members are disposed longitudinally within the flexible body, such that the flexible body is rigid when the flexible members are fixed into position. And the first and second interfaces are respectively coupled to the flexible body, each of at least one of the first and second interfaces including a respective at least one hole each configured to receive a respective attachment member configured to engage a bone.
    Type: Application
    Filed: October 17, 2019
    Publication date: November 18, 2021
    Applicant: The University of British Columbia
    Inventors: Robert N. Meek, Carly Anderson Thaler, Steven Charles Dimmer
  • Publication number: 20210345601
    Abstract: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods, uses, associated therewith. In particular, the perfusion fluids comprise two enzymes, GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore, the compositions described herein were found to have activity at temperatures and pH levels suitable for cell viability.
    Type: Application
    Filed: August 16, 2019
    Publication date: November 11, 2021
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, UNIVERSITY HEALTH NETWORK
    Inventors: Marcelo CYPEL, Aizhou WANG, Shafique KESHAVJEE, Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU
  • Patent number: 11168100
    Abstract: A Brønsted-Lowry acid initiator system for cationic polymerization of an ethylenically unsaturated monomer involves an initiator having a structure of Formula (I) in an anhydrous polymerization medium: where: M is tantalum (Ta), vanadium (V) or niobium (Nb); R1, R2, R3 and R4 are the same or different and are independently H, F, Cl, Br, I, alkyl or aryl, or two or more of R2, R3, R4 and R5 on a same benzene ring are taken together to form a bicyclic, tricyclic or tetracyclic moiety with the benzene ring, with the proviso that all of R1, R2, R3 and R4 on the same benzene ring are not H; L is absent or a molecule that coordinates to H+; and, x is 0 when L is absent, or x is 0.5 or more when L is present.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: November 9, 2021
    Assignees: ARLANXEO SINGAPORE PTE. LTD., THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Gilles Arsenault, Hazin Khatera, Derek Gates
  • Patent number: 11167034
    Abstract: This invention provides compositions for controlled localized release of one or more drugs within a subject. More particularly, described herein are compositions comprising a hydrophobic water-insoluble polymer, a low molecular weight biocompatible glycol, and one or more drugs. The compositions described herein may also optionally include a di-block copolymer and/or a swelling agent.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 9, 2021
    Assignee: The University of British Columbia
    Inventors: John K. Jackson, Martin E. Gleave, Veronika Schmitt, Claudia Kesch
  • Patent number: 11154836
    Abstract: A reactor that operates with ultraviolet light emitting diodes (UV-LEDs) to attain UV photoreactions or UV photo-initiated reaction in a fluid flow for various applications, including water purification. The UV-LED reactor is comprised of a conduit means for passing fluid flow, an ultraviolet light emitting diode (UV-LED), and a radiation-focusing element to focus the UV-LED radiation to the fluid in the longitudinal direction of the conduit proportionally to the fluid velocity in the cross section of the conduit.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: October 26, 2021
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventor: Fariborz Taghipour
  • Patent number: 11159090
    Abstract: Synchronous rectification methods and algorithms, and polarity sensing techniques, based on the homopolarity cycle concept for conduction loss reduction in LLC resonant converters are provided. In a half bridge rectifier configuration, one of rectifier switches is switched ON when the polarity of the inverter and rectifier voltages are both positive and the other rectifier switch is switched ON when both polarities are negative.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: October 26, 2021
    Assignees: ALPHA TECHNOLOGIES LTD., The University of British Columbia
    Inventors: Mehdi Mohammadi, Martin Ordonez, Mohammad Mahdavi, Peter Ksiazek, Navid Shafiei, Rahul Khandekar
  • Publication number: 20210325429
    Abstract: A method for the patterning and control of single electrons on a surface is provided that includes implementing scanning tunneling microscopy hydrogen lithography with a scanning probe microscope to form charge structures with one or more confined charges; performing a series of field-free atomic force microscopy measurements on the charge structures with different tip heights, where interaction between the tip and the confined charge are elucidated; and adjusting tip heights to controllably position charges within the structures to write a given charge state. The present disclose also provides a Gibb's distribution machine formed with the method for the patterning and control of single electrons on a surface. A multi bit true random number generator and neural network learning hardware formed with the above described method are also provided.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 21, 2021
    Applicants: Quantum Silicon Inc., National Research Council of Canada, The University of British Columbia
    Inventors: Robert Wolkow, Mohammad Rashidi, Wyatt Vine, Thomas Dienel, Lucian Livadaru, Taleana Huff, Jacob Retallick, Konrad Walus, Jason Pitters, Roshan Achal
  • Publication number: 20210324361
    Abstract: Provided herein are enzymatic compositions for carbohydrate antigen cleavage, methods, uses, apparatuses and systems associated therewith. In particular, the composition comprises two enzymes, GalNAcDeacetylase and Galactosaminidase and the composition may further comprise a crowding agent. Furthermore, the compositions described herein were found to have activity a temperatures and pH levels suitable for cell viability.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 21, 2021
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU
  • Publication number: 20210317497
    Abstract: Provided are transgenic organisms, such as plants and plant parts, cells, and related compositions and methods for producing and monitoring the genotype for enhanced production of montbretin A and/or its precursors. For example, provided is a transgenic organism comprising at least one heterologous nucleic acid operatively linked to a promoter, wherein the heterologous nucleic acid encodes at least one enzyme in a montbretin A (MbA) metabolic pathway. The organisms can be a plant, plant part, or plant cell, or a microorganism such as a yeast. Also provided is a method for producing at least one montbretin A (MbA) precursor and/or MbA, comprising permitting the expression of the at least one heterologous nucleic acid in the transgenic organism. The disclosure also provides isolated nucleic acid molecules that comprise sequence encoding at least one enzyme in a montbretin A (MbA) metabolic pathway and vectors comprising the nucleic acids.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 14, 2021
    Applicant: The University of British Columbia
    Inventors: Carl Joerg BOHLMANN, Sandra IRMISCH, Seohyun JO
  • Patent number: 11142508
    Abstract: Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: October 12, 2021
    Assignees: The University of British Columbia, Provincial Health Services Authority
    Inventors: Raymond J. Andersen, Marianne Dorothy Sadar, Kunzhong Jian, Nasrin R. Mawji, Jun Wang, Carmen Adriana Banuelos, Yu-Chi Yang
  • Patent number: 11142561
    Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the B1SP fusion protein may include a sema domain, a structural stabilization domain; and a half life extending moiety.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: October 12, 2021
    Assignee: The University of British Columbia
    Inventors: Christopher J. Ong, James William Peacock, Martin E. Gleave
  • Patent number: 11131650
    Abstract: A method of facilitating ultrasonic analysis of a subject is provided. The method involves producing signals for causing a set of outgoing ultrasonic signals to be transmitted to the subject, wherein the set of outgoing ultrasonic signals is defined at least in part by a variable imaging parameter that varies over time in accordance with a variable imaging parameter function, the variable imaging parameter function represented or representable at least in part by a function characteristic, receiving signals representing a time dependent representation of the subject generated from a set of received ultrasonic signals scattered by the subject, determining at least one property representation of the subject based on the function characteristic and the time dependent representation of the subject, and producing signals representing the at least one property representation of the subject to facilitate analysis of the subject. Systems, non-transitory computer readable media, and other methods are also provided.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: September 28, 2021
    Assignees: The University of British Columbia, Queen's University at Kingston
    Inventors: Purang Abolmaesumi, Parvin Mousavi