Abstract: A power-factor corrected AC/DC converter has three half-bridge legs, electrically coupled with each other in parallel, each leg having a pair of switches. Each switch of the pair is electrically coupled to the other in series via a respective node that is electrically coupled through an inductor to an AC line. The converter has a fourth half-bridge leg electrically coupled with the other legs to form an electrically parallel circuit. The fourth leg has a pair of switches electrically coupled to each other in series via a fourth node, which is selectively electrically coupleable to a neutral or a second AC line. The converter has a controller that operates the three legs as a 3-channel interleaved AC/DC boost converter and couples the fourth node to the neutral or second AC line if the input is single-phase, and as a 3-phase AC/DC boost converter if the input is three-phase.

Abstract: Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

Abstract: Provided herein are enzymatic compositions for protein O-glycosylation and sialylation, methods and systems associated therewith. In particular, the composition for in vivo sialylation of therapeutic proteins. The composition comprises a polypeptide N-acetylgalactosaminyltransferase; a ?-1,3-galactosyltransferase; an UDP-Glc/GlcNAc 4-epimerase; a disulfide bond isomerase; and an ?-2,3-sialyltransferase or an ?-2,6-sialyltransferase. Furthermore, provided herein are compositions for efficient and complete O-glycosylation and di-sialylation of therapeutic proteins.

Abstract: A system useful for performing ultrasound elastography of organs such as the liver allows efficient and robust data acquisition. The system may be applied to perform real-time, noninvasive ultrasound imaging of the liver in humans. Steady-state, shear wave absolute elastography is used to measure the Young's modulus of the liver tissue. This method involves the use of an external exciter or vibrator to shake the tissue and generate a shear wave. Accurate placement of an ultrasound transducer facilitates measurement of the tissue motion due to the shear wave. The stiffness of tissues in the region being imaged may be computed from the measured tissue motions. The following innovations address both vibrator and transducer placement, as well as some specific methods to ensure adequate wave propagation, in order to obtain accurate and consistent measurements.

Abstract: A compound comprising a prostate specific membrane antigen (PSMA)-targeting moiety of the following formula or of a salt or a solvate thereof. R0 is O or S. Each of R1a, R1b and R1c may be —CO2H, —SO2H, —SO3H, —PO2H, or —PO3H2, for example. R2 may be methylene or a derivative thereof, propylene or a derivative thereof, or a derivative of ethylene, optionally substituted. R3 is a linker. When the PSMA-targeting moiety is linked to a radiolabeling group, the compound may be used as an imaging agent or therapeutic agent for PSMA-expressing diseases/conditions.

Abstract: Methods and devices are provided herein for identifying a cell population comprising an effector cell that exerts an extracellular effect. In one embodiment the method comprises retaining in a microreactor a cell population comprising one or more effector cells, wherein the contents of the microreactor further comprise a readout particle population comprising one or more readout particles, incubating the cell population and the readout particle population within the microreactor, assaying the cell population for the presence of the extracellular effect, wherein the readout particle population or subpopulation thereof provides a direct or indirect readout of the extracellular effect, and determining, based on the results of the assaying step, whether one or more effector cells within the cell population exerts the extracellular effect on the readout particle. If an extracellular effect is measured, the cell population is recovered for further analysis to determine the cell or cells responsible for the effect.

Abstract: Disclosed herein are uses of a polypeptide comprising NIMoEsh to treat a disease or condition associated with acute myocardial infarction (AMI) in a subject in need thereof, of a polypeptide comprising NIMoEsh to restore heart function after AMI in a subject in need thereof, of a polypeptide comprising NIMoEsh to reduce or prevent AMI-induced heart function loss in a subject in need thereof, of a polypeptide comprising NIMoEsh to reduce AMI-induced heart tissue infarct in a subject in need thereof, and of a polypeptide comprising NIMoEsh to protect cardiomyocytes against AMI-induced function loss in a subject in need thereof. Disclosed also herein are methods by which such treating, restoring, reducing or preventing, reducing, and/or protecting may be done, and a polypeptide comprising NIMoEsh for use in such treating, restoring, reducing or preventing, reducing, and/or protecting.

Abstract: Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.

Abstract: Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.

Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: Methods for in situ measurement of an oxidation reduction potential (ORP) and pH of a solution comprising iron are provided. The methods comprise measuring a kinetic parameter at an electrode surface of an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode, wherein the kinetic parameter is associated with ferric reduction or both ferric reduction and ferrous oxidation and comparing the kinetic parameter to calibration data for the electrode system to determine the ORP and pH of the solution. Also provided are apparatus and systems for in situ measurement of an ORP and pH of a solution comprising iron. The apparatus and systems comprise an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode and a detector for measuring a kinetic parameter at an electrode surface of the electrode system.

Abstract: Provided herein are compositions comprising: (a) a polymeric catechol binder, such as: polymeric dopamine, polymeric norepinephrine, polymeric epinephrine; polymeric pyrogallol, polymeric tannic acid, polymeric hydroxyhydroquinone, polymeric catechin, polymeric epigallocatechin etc.; and (b) a hydrophilic polymer, methods for using the compositions to coat a substrate, and methods for making the compositions. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: A method for synthesizing hydrogels comprises dissolving a gelatin in a first solvent to form a first solution, methacrylating the first solution using a methacrylating agent to form a solution containing dissolved gelatin methacryloyl, precipitating the gelatin methacryloyl from the solution by adding a second solvent and isolating the precipitated gelatin methacryloyl. The method may further comprise dissolving the precipitated gelatin methacryloyl in a third solvent to remove the second solvent.

Abstract: Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.

Abstract: Implantable devices for fixation of curved bones such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state using a shape locking section. The implantable devices further include a main body and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: Disclosed is system and method for detecting formation of solid-state water on a surface of a body. The system comprises at least one microwave resonator sensor locatable on the body under the surface and an analyzer operably coupled to the at least one passive microwave resonator; the analyzer configured to measure at least one parameter of the response of the at least one microwave resonator sensor. The at least one parameter varies in relation to at least one of the permittivity and conductivity of the region above the surface calibrated to output a signal indicating and the analyzer is configured to output an indication when the at least one parameter indicates that solid-state water has formed on the surface. The method comprises measuring the at least one parameter at the analyzer and outputting a signal indicating the formation of solid-state water on the surface.

Abstract: Methods and apparatuses for adding gas bubbles to a tank containing liquid at locations that allow the bubbles to rise to the top of the tank are disclosed. One embodiment comprises a membrane filtration system connected to a gas source and a drain. The membrane filtration system draws gas into the system from the gas in response to a reduced pressure profile created by opening a drain. The gas may be air supplied at atmospheric pressure.

Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.

Abstract: The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.