Patents Assigned to University of British Columbia
  • Patent number: 11545892
    Abstract: A power-factor corrected AC/DC converter has three half-bridge legs, electrically coupled with each other in parallel, each leg having a pair of switches. Each switch of the pair is electrically coupled to the other in series via a respective node that is electrically coupled through an inductor to an AC line. The converter has a fourth half-bridge leg electrically coupled with the other legs to form an electrically parallel circuit. The fourth leg has a pair of switches electrically coupled to each other in series via a fourth node, which is selectively electrically coupleable to a neutral or a second AC line. The converter has a controller that operates the three legs as a 3-channel interleaved AC/DC boost converter and couples the fourth node to the neutral or second AC line if the input is single-phase, and as a 3-phase AC/DC boost converter if the input is three-phase.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: January 3, 2023
    Assignees: Delta-Q Technologies Corp., The University of British Columbia
    Inventors: Hamidreza Hafezinasab, Christopher Jon Botting, Wilson Allan Thomas Eberle
  • Patent number: 11529148
    Abstract: Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: December 20, 2022
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Robert Meek, Qingan Zhu, Timothy Schwab, Robin John Noel Coope, Jared Slobodan, Scott Young
  • Publication number: 20220380785
    Abstract: Provided herein are enzymatic compositions for protein O-glycosylation and sialylation, methods and systems associated therewith. In particular, the composition for in vivo sialylation of therapeutic proteins. The composition comprises a polypeptide N-acetylgalactosaminyltransferase; a ?-1,3-galactosyltransferase; an UDP-Glc/GlcNAc 4-epimerase; a disulfide bond isomerase; and an ?-2,3-sialyltransferase or an ?-2,6-sialyltransferase. Furthermore, provided herein are compositions for efficient and complete O-glycosylation and di-sialylation of therapeutic proteins.
    Type: Application
    Filed: November 1, 2020
    Publication date: December 1, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Stephen G. WITHERS, Lyann SIM, Warren William WAKARCHUK
  • Patent number: 11510652
    Abstract: A system useful for performing ultrasound elastography of organs such as the liver allows efficient and robust data acquisition. The system may be applied to perform real-time, noninvasive ultrasound imaging of the liver in humans. Steady-state, shear wave absolute elastography is used to measure the Young's modulus of the liver tissue. This method involves the use of an external exciter or vibrator to shake the tissue and generate a shear wave. Accurate placement of an ultrasound transducer facilitates measurement of the tissue motion due to the shear wave. The stiffness of tissues in the region being imaged may be computed from the measured tissue motions. The following innovations address both vibrator and transducer placement, as well as some specific methods to ensure adequate wave propagation, in order to obtain accurate and consistent measurements.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 29, 2022
    Assignee: The University of British Columbia
    Inventors: Septimiu Salcudean, Robert Rohling, Mohammad Honarvar, Julio Raul Lobo, Caitlin Marie Schneider
  • Patent number: 11504441
    Abstract: A compound comprising a prostate specific membrane antigen (PSMA)-targeting moiety of the following formula or of a salt or a solvate thereof. R0 is O or S. Each of R1a, R1b and R1c may be —CO2H, —SO2H, —SO3H, —PO2H, or —PO3H2, for example. R2 may be methylene or a derivative thereof, propylene or a derivative thereof, or a derivative of ethylene, optionally substituted. R3 is a linker. When the PSMA-targeting moiety is linked to a radiolabeling group, the compound may be used as an imaging agent or therapeutic agent for PSMA-expressing diseases/conditions.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: November 22, 2022
    Assignees: PROVINCIAL HEALTH SERVICES AUTHORITY, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Kuo-Shyan Lin, François Bénard, Hsiou-Ting Kuo, Zhengxing Zhang, David Perrin
  • Publication number: 20220365072
    Abstract: Methods and devices are provided herein for identifying a cell population comprising an effector cell that exerts an extracellular effect. In one embodiment the method comprises retaining in a microreactor a cell population comprising one or more effector cells, wherein the contents of the microreactor further comprise a readout particle population comprising one or more readout particles, incubating the cell population and the readout particle population within the microreactor, assaying the cell population for the presence of the extracellular effect, wherein the readout particle population or subpopulation thereof provides a direct or indirect readout of the extracellular effect, and determining, based on the results of the assaying step, whether one or more effector cells within the cell population exerts the extracellular effect on the readout particle. If an extracellular effect is measured, the cell population is recovered for further analysis to determine the cell or cells responsible for the effect.
    Type: Application
    Filed: July 7, 2021
    Publication date: November 17, 2022
    Applicant: The University of British Columbia
    Inventors: Marketa RICICOVA, Kevin Albert HEYRIES, Hans ZAHN, Oleh PETRIV, Veronique LECAULT, Anupam Singhal, Daniel J. Da Costa, Carl L. G. Hansen, Brad NELSON, Julie NIELSEN, Kathleen Lisaingo
  • Publication number: 20220362326
    Abstract: Disclosed herein are uses of a polypeptide comprising NIMoEsh to treat a disease or condition associated with acute myocardial infarction (AMI) in a subject in need thereof, of a polypeptide comprising NIMoEsh to restore heart function after AMI in a subject in need thereof, of a polypeptide comprising NIMoEsh to reduce or prevent AMI-induced heart function loss in a subject in need thereof, of a polypeptide comprising NIMoEsh to reduce AMI-induced heart tissue infarct in a subject in need thereof, and of a polypeptide comprising NIMoEsh to protect cardiomyocytes against AMI-induced function loss in a subject in need thereof. Disclosed also herein are methods by which such treating, restoring, reducing or preventing, reducing, and/or protecting may be done, and a polypeptide comprising NIMoEsh for use in such treating, restoring, reducing or preventing, reducing, and/or protecting.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 17, 2022
    Applicant: The University of British Columbia
    Inventors: Jack Wuyang Jin, Yu Tian Wang, Max S. Cynader
  • Patent number: 11492400
    Abstract: Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: November 8, 2022
    Assignee: The University of British Columbia
    Inventors: Wilfred Arthur Jefferies, Kyung Bok Choi, Shawna Rose Stanwood, Franz Fenninger, Brett Alexander Eyford, Lonna Munro, Cheryl Gurine Pfeifer, Reinhard Gabathuler
  • Patent number: 11485713
    Abstract: Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: November 1, 2022
    Assignees: ESSA Pharma, Inc., The University of British Columbia, Provincial Health Services Authority
    Inventors: Han-Jie Zhou, Peter Virsik, Raymond John Andersen, Marianne Dorothy Sadar, Kunzhong Jian, Daniel Andrew Golec
  • Patent number: 11466273
    Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: October 11, 2022
    Assignee: The University of British Columbia
    Inventors: Yuzhuo Wang, Stephen Yiu Chuen Choi
  • Patent number: 11467124
    Abstract: Methods for in situ measurement of an oxidation reduction potential (ORP) and pH of a solution comprising iron are provided. The methods comprise measuring a kinetic parameter at an electrode surface of an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode, wherein the kinetic parameter is associated with ferric reduction or both ferric reduction and ferrous oxidation and comparing the kinetic parameter to calibration data for the electrode system to determine the ORP and pH of the solution. Also provided are apparatus and systems for in situ measurement of an ORP and pH of a solution comprising iron. The apparatus and systems comprise an electrode system comprising a working electrode, a counter electrode and a pseudo-reference electrode and a detector for measuring a kinetic parameter at an electrode surface of the electrode system.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 11, 2022
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Edouard Asselin, Hamidreza Zebardast, Jing Liu
  • Patent number: 11459434
    Abstract: Provided herein are compositions comprising: (a) a polymeric catechol binder, such as: polymeric dopamine, polymeric norepinephrine, polymeric epinephrine; polymeric pyrogallol, polymeric tannic acid, polymeric hydroxyhydroquinone, polymeric catechin, polymeric epigallocatechin etc.; and (b) a hydrophilic polymer, methods for using the compositions to coat a substrate, and methods for making the compositions. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: October 4, 2022
    Assignee: The University of British Columbia
    Inventors: Jayachandran N. Kizhakkedathu, Dirk Lange, Joey Lo, Yan Mei, Kai Yu
  • Publication number: 20220290185
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Application
    Filed: October 28, 2021
    Publication date: September 15, 2022
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft
  • Publication number: 20220289915
    Abstract: A method for synthesizing hydrogels comprises dissolving a gelatin in a first solvent to form a first solution, methacrylating the first solution using a methacrylating agent to form a solution containing dissolved gelatin methacryloyl, precipitating the gelatin methacryloyl from the solution by adding a second solvent and isolating the precipitated gelatin methacryloyl. The method may further comprise dissolving the precipitated gelatin methacryloyl in a third solvent to remove the second solvent.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 15, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Mohamed Gamaleldin A. Mohamed, Keekyoung Kim
  • Patent number: 11434530
    Abstract: Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: September 6, 2022
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Carl Lars Genghis Hansen, Hans Zahn, Jens Huft, Marinus Theodorus Johannes Van Loenhout, Kaston Leung, Bill Kengli Lin, Anders Klaus, Samuel Alves Jana Rodrigues Aparicio, Sohrab Prakash Shah, Adi Steif
  • Patent number: 11419645
    Abstract: Implantable devices for fixation of curved bones such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state using a shape locking section. The implantable devices further include a main body and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: August 23, 2022
    Assignees: University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: David Thomas Stinson, Carly Anderson Thaler
  • Publication number: 20220244195
    Abstract: Disclosed is system and method for detecting formation of solid-state water on a surface of a body. The system comprises at least one microwave resonator sensor locatable on the body under the surface and an analyzer operably coupled to the at least one passive microwave resonator; the analyzer configured to measure at least one parameter of the response of the at least one microwave resonator sensor. The at least one parameter varies in relation to at least one of the permittivity and conductivity of the region above the surface calibrated to output a signal indicating and the analyzer is configured to output an indication when the at least one parameter indicates that solid-state water has formed on the surface. The method comprises measuring the at least one parameter at the analyzer and outputting a signal indicating the formation of solid-state water on the surface.
    Type: Application
    Filed: July 23, 2020
    Publication date: August 4, 2022
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Kevin Golovin, Mohammad Zarifi, Benjamin Wiltshire, Kiana Mirshahidi, Ryan Kozak
  • Patent number: 11400419
    Abstract: Methods and apparatuses for adding gas bubbles to a tank containing liquid at locations that allow the bubbles to rise to the top of the tank are disclosed. One embodiment comprises a membrane filtration system connected to a gas source and a drain. The membrane filtration system draws gas into the system from the gas in response to a reduced pressure profile created by opening a drain. The gas may be air supplied at atmospheric pressure.
    Type: Grant
    Filed: December 24, 2018
    Date of Patent: August 2, 2022
    Assignee: The University of British Columbia
    Inventor: Pierre Bérubé
  • Publication number: 20220233432
    Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.
    Type: Application
    Filed: March 4, 2022
    Publication date: July 28, 2022
    Applicants: The University of British Columbia, The General Hospital Corporation
    Inventors: Christian Kastrup, Ju Hun Yeon, James Baylis, Thomas Frederick Burke
  • Patent number: 11396535
    Abstract: The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 26, 2022
    Assignees: PROVINCIAL HEALTH SERVICES AUTHORITY, THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: David Perrin, Mihajlo Todorovic, Francois Bénard, Chengcheng Zhang