Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
March 8, 2022
Assignee:
University of British Columbia
Inventors:
Guy Dumont, Mark Ansermino, Sara Khosravi, Nicholas West
Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.
Type:
Grant
Filed:
March 7, 2019
Date of Patent:
March 8, 2022
Assignees:
The University of British Columbia, The General Hospital Corporation
Inventors:
Christian Kastrup, Ju Hun Yeon, James Baylis, Thomas Frederick Burke
Abstract: A compound or molecular complex. The compound or molecular complex comprises: a metal chelator configured for chelation with a radioactive isotope or a non-radioactive isotope; and a trifluoroborate (BF3)-containing moiety configured for 19F/18F exchange or a precursor thereof; and optionally a cell-targeting domain.
Type:
Application
Filed:
December 18, 2019
Publication date:
March 3, 2022
Applicants:
Provincial Health Services Authority, The University of British Columbia
Abstract: Methods, systems, and techniques for data compression. A cluster fingerprint of an uncompressed data block is determined to correspond to a cluster fingerprint of a base block stored in a base array. This determining involves looking up the cluster fingerprint of the first base block from the base array using the cluster fingerprint of the first uncompressed data block. The difference between the uncompressed data block and the base block is determined, and a compressed data block is encoded using this difference. The compressed data block is then stored in a data array.
Type:
Grant
Filed:
March 12, 2021
Date of Patent:
February 8, 2022
Assignee:
THE UNIVERSITY OF BRITISH COLUMBIA UNIVERSITY-INDUSTRY LIAISON OFFICE
Abstract: The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.
Type:
Application
Filed:
August 10, 2021
Publication date:
February 3, 2022
Applicant:
The University of British Columbia
Inventors:
Guy Dumont, Klaske Van Heusden, Mark Ansermino
Abstract: Methods for treating inflammatory skin conditions, such as atopic dermatitis and psoriasis, and for promoting skin wound healing and for treating skin wounds, such as thermal and pressure injury, by reducing the activity of Granzyme K.
Type:
Application
Filed:
September 24, 2019
Publication date:
February 3, 2022
Applicant:
THE UNIVERSITY OF BRITISH COLUMBIA
Inventors:
David J. GRANVILLE, Christopher TURNER, Matthew ZEGLINSKI, Katlyn RICHARDSON, Sho HIROYASU
Abstract: A device and algorithm for controlling an autonomic function in an individual. In particular, a controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. In particular, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.
Type:
Grant
Filed:
February 16, 2018
Date of Patent:
February 1, 2022
Assignee:
THE UNIVERSITY OF BRITISH COLUMBIA
Inventors:
Aaron Phillips, Andrei Krassioukov, Jordan Squair
Abstract: Displacement devices comprise a stator and a moveable stage. The stator comprises a plurality of coils shaped to provide pluralities of generally linearly elongated coil traces in one or more layers. Layers of coils may overlap in the Z-direction. The moveable stage comprises a plurality of magnet arrays. Each magnet array may comprise a plurality of magnetization segments generally linearly elongated in a corresponding direction. Each magnetization segment has a magnetization direction generally orthogonal to the direction in which it is elongated and at least two of the magnetization directions are different from one another. One or more amplifiers may be connected to selectively drive current in the coil traces and to thereby effect relative movement between the stator and the moveable stage.
Abstract: The invention is directed to BAHD acyltransferase enzymes, nucleic acids encoding BAHD acyltransferase enzymes, and inhibitory nucleic acids adapted to inhibit the expression and/or translation of BAHD acyltransferase RNA; expression cassettes, plant cells, and plants that have or encode such nucleic acids and enzymes; and methods of making and using such nucleic acids, enzymes, expression cassettes, cells, and plants.
Type:
Application
Filed:
November 8, 2019
Publication date:
January 6, 2022
Applicants:
WISCONSIN ALUMNI RESEARCH FOUNDATION, THE UNIVERSITY OF BRITISH COLUMBIA
Inventors:
Steven D. Karlen, Rebecca Anne Smith, John Ralph, Emily Beebe, Craig Bingman, Brian Fox, Shawn Mansfield, Heather Mackay, Hoon Kim, Yaseen Mottiar, Faride Unda
Abstract: The disclosure pertains to conformational epitopes in TDP-43, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
January 4, 2022
Assignee:
The University of British Columbia
Inventors:
Steven S. Plotkin, Neil R. Cashman, Xubiao Peng
Abstract: The present invention relates to methods, systems and kits for the diagnosis, prognosis, and treatment of bladder cancer in a subject. The invention also provides biomarkers that define subgroups of bladder cancer, clinically useful classifiers for distinguishing bladder cancer subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. The methods, systems and kits can provide expression-based analysis of biomarkers for purposes of subtyping bladder cancer in a subject. Further disclosed herein, in certain instances, are probe sets for use in subtyping bladder cancer in a subject. Classifiers for subtyping a bladder cancer are provided. Methods of treating bladder cancer based on molecular subtyping are also provided.
Type:
Grant
Filed:
January 19, 2018
Date of Patent:
December 28, 2021
Assignees:
Decipher Biosciences, Inc., The University of British Columbia
Inventors:
Elai Davicioni, Hussam Al-Deen Ashab, Nicholas Erho, Peter Black
Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.
Type:
Grant
Filed:
December 15, 2017
Date of Patent:
December 7, 2021
Assignees:
University of Maryland, Duke University, University of British Columbia
Inventors:
Christopher Monroe, Jungsang Kim, Robert Raussendorf
Abstract: Aspects of the invention provide methods and systems for moving moveable stages relative to a stator. A stator is operationally divided into multiple stator tiles. The movement of the one or more moveable stages is controlled by a plurality of controllers (each assigned particular control responsibilities). A controller is provided for each stator sector, where each stator sector comprises a group of one or more stator tiles. Controllers from neighboring sectors share various information to facilitate controllable movement of one or more moveable stages relative to the stator.
Abstract: In one aspect, the invention provides a peptide comprising a chaperone-mediated autophagy (CMA)-targeting signal domain; a protein-binding domain that selectively binds to a target cytosolic protein; and a cell membrane penetrating domain (CMPD). In another aspect, the invention provides methods for reducing the intracellular expression level of an endogenous target protein in vitro and in an animal, wherein the method involves administration of the peptide. Methods are also provided for treating a pathological condition in an animal, the methods comprising administering the peptide to the animal. In one embodiment, the pathological condition is a neurodegenerative disease. In another embodiment of the invention, the target cytosolic protein is death associated protein kinase I and the CMPD is protein transduction domain of the HIV-1 Tat protein.
Type:
Grant
Filed:
March 27, 2019
Date of Patent:
November 30, 2021
Assignee:
University of British Columbia
Inventors:
Yu Tian Wang, Xuelai Fan, Jack Wuyang Jin
Abstract: The current invention features a rod screw for medical application that can be configured and used to fixate fracture of bones varying in shape and dimension, and treating maladies such as scoliosis, and securing an implanted device, to tissue such as bone. This is achieved by designing a flexible rod screw with a mechanism to lock the configuration in a rigid state. In an embodiment, a bone-fracture fixation device, such as a rod screw, includes a flexible body, a plurality of flexible members, and first and second interfaces. The flexible members are disposed longitudinally within the flexible body, such that the flexible body is rigid when the flexible members are fixed into position. And the first and second interfaces are respectively coupled to the flexible body, each of at least one of the first and second interfaces including a respective at least one hole each configured to receive a respective attachment member configured to engage a bone.
Type:
Application
Filed:
October 17, 2019
Publication date:
November 18, 2021
Applicant:
The University of British Columbia
Inventors:
Robert N. Meek, Carly Anderson Thaler, Steven Charles Dimmer
Abstract: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods, uses, associated therewith. In particular, the perfusion fluids comprise two enzymes, GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore, the compositions described herein were found to have activity at temperatures and pH levels suitable for cell viability.
Type:
Application
Filed:
August 16, 2019
Publication date:
November 11, 2021
Applicants:
THE UNIVERSITY OF BRITISH COLUMBIA, UNIVERSITY HEALTH NETWORK
Inventors:
Marcelo CYPEL, Aizhou WANG, Shafique KESHAVJEE, Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU
Abstract: A Brønsted-Lowry acid initiator system for cationic polymerization of an ethylenically unsaturated monomer involves an initiator having a structure of Formula (I) in an anhydrous polymerization medium: where: M is tantalum (Ta), vanadium (V) or niobium (Nb); R1, R2, R3 and R4 are the same or different and are independently H, F, Cl, Br, I, alkyl or aryl, or two or more of R2, R3, R4 and R5 on a same benzene ring are taken together to form a bicyclic, tricyclic or tetracyclic moiety with the benzene ring, with the proviso that all of R1, R2, R3 and R4 on the same benzene ring are not H; L is absent or a molecule that coordinates to H+; and, x is 0 when L is absent, or x is 0.5 or more when L is present.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
November 9, 2021
Assignees:
ARLANXEO SINGAPORE PTE. LTD., THE UNIVERSITY OF BRITISH COLUMBIA
Abstract: This invention provides compositions for controlled localized release of one or more drugs within a subject. More particularly, described herein are compositions comprising a hydrophobic water-insoluble polymer, a low molecular weight biocompatible glycol, and one or more drugs. The compositions described herein may also optionally include a di-block copolymer and/or a swelling agent.
Type:
Grant
Filed:
June 13, 2018
Date of Patent:
November 9, 2021
Assignee:
The University of British Columbia
Inventors:
John K. Jackson, Martin E. Gleave, Veronika Schmitt, Claudia Kesch
Abstract: Synchronous rectification methods and algorithms, and polarity sensing techniques, based on the homopolarity cycle concept for conduction loss reduction in LLC resonant converters are provided. In a half bridge rectifier configuration, one of rectifier switches is switched ON when the polarity of the inverter and rectifier voltages are both positive and the other rectifier switch is switched ON when both polarities are negative.
Type:
Grant
Filed:
May 29, 2020
Date of Patent:
October 26, 2021
Assignees:
ALPHA TECHNOLOGIES LTD., The University of British Columbia
Inventors:
Mehdi Mohammadi, Martin Ordonez, Mohammad Mahdavi, Peter Ksiazek, Navid Shafiei, Rahul Khandekar