Abstract: Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.

Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.

Abstract: This invention provides the use of specialized pro-resolving mediators (SPMs) for use as melanocyte growth promoters and pro-survival factors. More particularly, the SPM compositions are suitable for promoting melanocyte growth and/or survival to prevent depigmentation of melanocytes and/or promoting repigmentation in non-inflammatory depigmentation of melanocytes. Furthermore, the compositions may be used to treat dormant vitiligo lesions, chemically induced vitiligo, vitiligo that is non-responsive to inflammatory therapies, or canities.

Abstract: Disclosed is a peptide including (a) a cell membrane penetration (CMP) sequence; and (b) one or more TDP-43 phosphorylation-blocking (PB) sequences. Also disclosed is a method of reducing the phosphorylation of TDP-43 in a cell, the method including: delivering an effective amount of a peptide to the cell, wherein the peptide comprises: (a) a cell membrane penetration (CMP) sequence; and (b) a TDP-43 phosphorylation-blocking (PB) sequence. Also disclosed is a method of treating a disease or pathological condition, the method comprising administering an effective amount of a peptide to a subject in need thereof; wherein the peptide comprises: (a) a cell membrane penetration (CMP) sequence; and (b) one or more TDP-43 phosphorylation-blocking (PB) sequences. Related uses, peptides for use, vectors, polynucleotide, and pharmaceutical compositions are disclosed.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.

Abstract: This invention provides the use of specialized pro-resolving mediators (SPMs) for use as melanocyte growth promoters and pro-survival factors. More particularly, the SPM compositions are suitable for promoting melanocyte growth and/or survival to prevent depigmentation of melanocytes and/or promoting repigmentation in non-inflammatory depigmentation of melanocytes. Furthermore, the compositions may be used to treat dormant vitiligo lesions, chemically induced vitiligo, vitiligo that is non-responsive to inflammatory therapies, or canities.

Abstract: Methods, circuits, and techniques for reflection cancellation. Laser output is tapped. A tapped portion of the laser output is phase shifted to generate a feedback signal, with the feedback signal being out-of-phase with a parasitic reflection of the laser output. The feedback signal is directed towards the laser such that the parasitic reflection and feedback signal are superpositioned before entering the laser. A magnitude and a phase of the feedback signal are such that superposition of the feedback signal and the parasitic reflection results in a resulting signal of lower magnitude than the parasitic reflection alone. During laser operation, a magnitude of the resulting signal is monitored and, as the parasitic reflection varies, the magnitude of the resulting signal is adjusted by adjusting at least one of the magnitude and the phase of the feedback signal in response to the monitoring of the resulting signal.

Abstract: A method for transporting a material (which may be a viscous fluid) in a conduit defined by a conduit-defining surface comprises: flowing a first fluid and a second fluid in a flow direction within the conduit; contacting the first and second fluids to one another at a contact region to thereby facilitate a reaction creating a reaction product in an interface region that extends downstream from the contact region, wherein the reaction product is an elastic-solid; and transporting the material in the flow direction within the conduit. At locations downstream of interface region, the reaction product creates a barrier between the viscous fluid and the conduit-defining surface.

Abstract: This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

Abstract: The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

Abstract: Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: An electromagnetic wave manipulation apparatus may include a substrate integrated with a liquid crystal. For example, the substrate may include one or more cavities filled with the liquid crystal. Alternatively and/or additionally, the substrate may include one or more layers of material interposed with the liquid crystal. The liquid crystal may be subjected to a voltage bias that alters the dielectric constant of the liquid crystal. Doing so may introduce a corresponding field offset between the input signal and the output signal of the apparatus. Subjecting the liquid crystal to different voltage biases may give rise to a spatial phase gradient that enables the apparatus to perform a variety of electromagnetic wave transformations such as reflection, refraction, retro-reflection, amplification, and cancellation. By performing such transformations, the apparatus may change the radiation pattern of its output signal, thus steering its output signal towards or away from a receiver.

Abstract: A pair of first electrodes 111, 112 is arranged in a state being separated in a direction parallel to a contact surface 102 of a base material 10 made of a dielectric and being at least partially in contact with the base material 10. A pair of second electrodes 121, 122 is arranged in a state of overlapping at least one of the pair of first electrodes and sandwiching the base material 10 at a position farther from the contact surface 102 of the base material 10 than the pair of first electrodes 111 and 112 in a direction perpendicular to the contact surface 102 of the base material 10. The proximity state of an object Q with respect to the contact surface 102 of the base material 10 is detected according to the measurement result of the capacitance C1 between the pair of first electrodes 111 and 112.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).

Abstract: Apparatus for measuring forces on a load-carrying element comprises optical sensors mounted to the load-carrying element. Each optical sensor includes a light source, a photosensor and an opaque mask positioned in a light path between the light source and the photosensor. The mask has a window that is movable relative to the photosensor and is located such that light from the light source that passes through the window forms an illuminated region on the photosensor. Each of the optical sensors has a first part which includes the light source and the photosensor that is coupled to the load-carrying element at a first location and a second part that includes the mask that is attached to the load-carrying element at a second location spaced apart from the first location.

Abstract: A “frequency shifter” is a clock synthesis system, that includes either a multiplexer or a multi-modulus divider (MMD), a fractional frequency divider, a tunable delay element, a sawtooth signal generator, in addition to other synchronization and control circuits. The generated sawtooth signal is used to control the delay of the tunable delay element, which in turn is used to adjust the phase of the signal generated by either M-to-1 multiplexer or the MMD, reducing its timing errors, and improving the spectral purity of the generated clock signal.

Abstract: Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.

Abstract: The present invention provides an in vitro method, and in vitro assay, for staging, classification, screening, monitoring, stratification, selecting treatment for, ascertaining whether treatment is working in, and/or prognostication of cancer in a subject comprising determining allelic imbalance and copy number of target gene-regions in tumor DNA from a subject as set out in the application. The present invention also provides a set of oligonucleotide probes and kits for use in the method, and assay, of the present invention.