Abstract: Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.

Abstract: According to at least one embodiment, a method of fabricating a micro electro-mechanical systems (MEMS) structure is disclosed. The method involves causing an etchant to remove a portion of a sacrificial layer of the MEMS structure, the sacrificial layer between a structural layer of the MEMS structure and a substrate of the MEMS structure. In this embodiment, causing the etchant to remove the portion of the sacrificial layer involves causing a target portion of the substrate to be released from the MEMS structure. According to another embodiment, another method of fabricating a MEMS structure is disclosed. The method involves causing an etchant including water to remove a portion of a sacrificial layer of the MEMS structure, the sacrificial layer between a structural layer of the MEMS structure and a substrate of the MEMS structure. In this embodiment, the sacrificial layer and the substrate are hydrophobic.

Abstract: The current invention features a rod screw for medical application that can be configured and used to fixate fracture of bones varying in shape and dimension, and treating maladies such as scoliosis, and securing an implanted device, to tissue such as bone. This is achieved by designing a flexible rod screw with a mechanism to lock the configuration in a rigid state. In an embodiment, a bone-fracture fixation device, such as a rod screw, includes a flexible body, a plurality of flexible members, and first and second interfaces. The flexible members are disposed longitudinally within the flexible body, such that the flexible body is rigid when the flexible members are fixed into position. And the first and second interfaces are respectively coupled to the flexible body, each of at least one of the first and second interfaces including a respective at least one hole each configured to receive a respective attachment member configured to engage a bone.

Abstract: The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.

Abstract: A capacitance sensor 1A in which first electrodes 3(1) to 3(4) and a second electrode 4 are arranged on a base material 2 made of a dielectric includes grounded electrostatic shielding members (5(1) to 5(6)). The electrostatic shielding members 5 are arranged, for example, at positions between first wiring portions 6(1)in, 6(2)in, 6(4) in connected to the first electrodes 3(1), 3(2), 3(4) and the second electrode 4, at a position between a second wiring portion 6(5)in connected to the second electrode 4 and the first electrode 3(4), and at a position between the second wiring portion 6(5)in and the first wiring portion 6(4)in.

Abstract: A metal alloy is provided which includes by weight percentage of the metal alloy, 28 to 55 percent copper, 45 to 63 percent nickel, and 4 to 10 percent iron. The metal alloy may be weight percentage 28 percent copper, 62 percent nickel, and 10 percent iron. The metal alloy may be formed into a foil which may have a thickness of 100 ?m or less or 50 ?m or less. A magnetic field instrument may include a magnetometer core body formed from one or more layers of the foil. The magnetometer core body may be a ring core or a racetrack core. The magnetic field instrument may further include a sense winding and may further include a drive winding. The magnetic field instrument may be a fluxgate magnetometer.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: The disclosure pertains to methods of treating or preventing a disease or condition associated with and/or induced by soluble A-beta oligomer such as Alzheimer's disease by administering to a subject in need thereof conformation specific and/or selective antibodies or binding fragments thereof and related products.

Abstract: Apparatuses and methods for producing hydrogen peroxide by performing coupled chemical and electrochemical reactions are disclosed. An electrochemical cell has a chemical reaction chamber configured to hydrogenate a shuttle molecule and an electrochemical chamber configured to electrochemically dissociate water to form hydrogen ions at an anode, and to reduce the hydrogen ions to atomic hydrogen at a cathode. The chemical reaction chamber and the anode chamber are separated by a metallic membrane. The metallic membrane acts as a cathode of the cell, a hydrogen-selective layer and a catalyst. The metallic membrane may comprise a layer of palladium or a palladium alloy. A layer of co-catalyst may optionally be electrodeposited on the layer of palladium or palladium alloy. An ion exchange membrane separates the metallic membrane and the anode chamber. The hydrogenated shuttle molecule may be supplied to a reactor for contacting an oxygen-containing gas to yield hydrogen peroxide.

Abstract: Methods predict candidate epitopes in a protein by: providing a conformational sampling engine; obtaining a model of a protein suitable for use with the conformational sampling engine and comprising a native structure; applying a collective coordinate bias to the protein model, the collective coordinate bias causing the conformational sampling engine to in turn force the protein model to at least partially unfold from its native structure to an updated structure, wherein the collective coordinate bias is applied globally to at least a substantial portion of the protein model and is impartial as to where, within the substantial portion of the protein model, unfolding occurs; and analyzing the updated structure to identify one or more candidate epitopes, where the one or more candidate epitopes exhibit indicia of localized unfolding.

Abstract: Pharmaceutical formulations are provided that include at least two antibiotically active ingredients: a cannabinoid that is one or more of cannabichromene (CBC), cannabidiol (CBD) and/or cannabigerol (CBG); a sesquiterpene that is one or both of a-humulene and/or ?-caryophyllene; and a lipopeptide antibiotic that is daptomycin or an analogue thereof. The antibiotically active ingredients may be provided in relative amounts that amplify their individual activities, including amounts that are synergistically effective in an assay to inhibit growth and/or reproduction of an Enterococcus faecium or an Enterococcus faecalis. Therapies are provided that utilize these formulations as anti-microbials, and provide for the combined use of two or more of the antibiotically active compounds.

Abstract: A triaxial force sensor 1 includes nine first electrodes 11 to 19, and nine second electrodes 21 to 29 attached to an electrode support 10 in such a manner that the electrode support 10 is interposed between the nine first electrodes 11 to 19 and the nine second electrodes 21 to 29. A pair of first electrodes 14 and 16 are arranged such that a straight line connecting the two is orthogonal to a straight line connecting a pair of first electrodes 12 and 18, and the second electrodes 22, 24, 26, and 28 are arranged such that the respective halves overlap the first electrodes 12, 14, 16, and 18 in plan view. The sensor has a number of components and size, thereby allowing a reduction in manufacturing cost, in the case of detecting forces in orthogonal triaxial directions.

Abstract: In an electrostatic capacity sensor 1, first electrodes 11a to 11d are provided on a substrate 10, and an electrode support 14 has dielectric properties and elasticity and is fixed to the substrate 10. A second electrode 12 is provided in the electrode support 14 so as to face the first electrodes 11a to 11d with a distance from the first electrodes 11a to 11d. The electrostatic capacity sensor has improved durability.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: Methods for using compositions comprising a Granzyme B inhibitor and a pharmaceutically acceptable carrier for treating and/or preventing blistering and/or peeling of a skin of a subject are provided. Also provided are methods for using the compositions to improve the healing of a blistered or area of peeled skin of a subject. The compositions can be formulated for oral administration, nasal administration, topical administration, subcorneal administration, intra-epidermal administration, sub-epidermal administration, or for administration by injection.

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: Apparatuses and methods for performing coupled chemical and electrochemical reactions are disclosed. An electrochemical cell has a first reaction chamber configured to perform a chemical reaction and an anode chamber configured to perform an electrochemical reaction. The first reaction chamber and the anode chamber are separated by a first membrane. The first membrane acts as a cathode of the cell, a hydrogen-selective layer and a catalyst. The first membrane may comprise a layer of palladium or a palladium alloy. An ion exchange membrane separates the first membrane and the anode chamber. The chemical and electrochemical reactions may respectively be hydrogenation and dehydrogenation reactions.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.

Abstract: Methods of making a paper product can comprise forming a substrate from a first furnish that comprises a plurality of pulp fibers, at least partially dewatering the substrate, treating a second furnish that comprises a plurality of surface enhanced pulp fibers (SEPF) at least by adding one or more enzymes to the second furnish, and sizing the dewatered substrate at least by depositing the treated second furnish onto at least one of opposing first and second surfaces of the dewatered substrate. The SEPF can have a length weighted average fiber length that is greater than or equal to 0.20 millimeters (mm) and an average hydrodynamic specific surface area that is greater than or equal to 10 square meters per gram (m2/g).