Abstract: Methods for characterizing two-dimensional concept drawings are disclosed. The concept drawings comprise cross-sections intersecting at cross-hairs. The method comprises: determining, for each cross-section: a plane on which the cross-section is located, the plane having a normal vector in a three-dimensional coordinate system; and, for each cross-hair on the cross-section, a tangent vector in the three-dimensional coordinate system which is tangent to the cross-section at the cross-hair. For each cross-hair comprising ith and jth intersecting cross-sections, one or more constraints are satisfied, the constraints comprising: the normal vector ni of the plane on which the ith cross-section is located is at least approximately orthogonal to the normal vector nj of the plane on which the jth cross-section is located; and the tangent vector tij to the ith cross-section at the cross-hair is at least approximately orthogonal to the tangent vector tji to the jth cross-section at the cross-hair.

Abstract: Apparatuses, systems, and methods in which reflective slats are configured to redirect light received from various sun positions are provided. The slats or mirrored array could be coupled to a base of the redirector, such that an adjustment of an angle of the base relative to the horizontal adjusts an angle of each slat relative to the horizontal. In some aspects, an algorithm can be used to determine the angle of tilt that maximizes the transmission efficiency for the mirror array.

Abstract: The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.

Abstract: Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions are provided. The therapeutic effect is achieved via inhibition of viral neuraminidases.

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Abstract: A reactor that operates with ultraviolet light emitting diodes (UV-LEDs) to attain UV photoreactions or UV photo-initiated reaction in a fluid flow for various applications, including water purification. The UV-LED reactor is comprised of a conduit means for passing fluid flow, an ultraviolet light emitting diode (UV-LED), and a radiation-focusing element to focus the UV-LED radiation to the fluid in the longitudinal direction of the conduit. The UV-LED reactor may include photocatalysts or chemical oxidants, which are activated by UV emitted by UV-LEDs for photocatalytic and photo-initiated reactions.

Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

Abstract: A method for generating a polycube segmentation of an input object comprises: providing an input mesh of the object comprising a plurality of surface faces; generating an initial polycube labeling for the faces by assigning, to each face, a label which is one of six directions (±X,±Y,±Z) aligned with a set of Cartesian axes, the initial polycube labeling defining a plurality of charts, and generating the initial polycube labeling comprising effecting a tradeoff between competing objectives of: making the initial polycube labeling relatively compact; and making the initial polycube labeling relatively faithful to the input object. The method further comprises generating an updated polycube segmentation by changing the label assigned to each of one or more surface faces and thereby modifying one or more of the charts to provide the charts with monotonic boundaries.

Abstract: Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber.

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: Provided are cytochrome P450 polypeptides, including cytochrome P450 santalene oxidase polypeptides, cytochrome P450 bergamotene oxidase polypeptides and cytochrome P450 reductase polypeptides. Also provided are nucleic acid molecules encoding the cytochrome P450 polypeptides. Cells containing the nucleic acids and/or the polypeptides are provided as are methods for producing terpenes, such as santalols and bergamotols, by culturing the cells.

Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.

Abstract: A permanently sealed vacuum tube is used to provide the electrons for an electron microscope. This advantageously allows use of low vacuum at the sample, which greatly simplifies the overall design of the system. There are two main variations. In the first variation, imaging is provided by mechanically scanning the sample. In the second variation, imaging is provided by point projection. In both cases, the electron beam is fixed and does not need to be scanned during operation of the microscope. This also greatly simplifies the overall system.

Abstract: A process for the dehydrogenation of alkyl-containing compounds comprises reacting an alkyl-containing compound and a Group VI nitrosyl complex characterized as a transition metal complex having the composition Cp?M(NO)(R1)(R2), wherein Cp? is selected from certain substituted and unsubstituted ?5-cyclopentadienyl groups; M is W or Mo; and R1 and R2 are independently selected from CH2C(CH3)3; CH2Si(CH3)3; CH2(C6H5); CH3; hydrogen; and ?3-allyl; provided that if R1 is hydrogen, R2 is ?3-allyl; under conditions such that the alkyl-containing compound is converted to an olefin, and in particular embodiments, a terminal olefin. The dehydrogenation can be carried out using a neat and/or undried alkyl-containing compound and/or may be conducted under air, and does not require a sacrificial olefin to drive the reaction, thereby increasing convenience and decreasing cost in comparison with some other dehydrogenation processes.

Abstract: A novel constrained peptide epitope derived from A?, related antibody compositions and methods of use. An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric A? is described. An antigenic peptide comprising an epitope having a constrained cyclic configuration, corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric A? is also described. Methods of treating, preventing, and diagnosing Alzheimer's disease are also described.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: A method is described for acquiring 3D quantitative ultrasound elastography volumes. In one embodiment, the method comprises using a 2D ultrasound transducer to scan a volume of tissue through which shear waves are created using an external vibration source, the synchronized measurement of tissue motion within the plane of the ultrasound transducer with the measurement of the transducer location in space, the reconstruction of tissue displacements in time and space over a volume from this synchronized measurement, and the computation of one or several mechanical properties of tissue from this volumetric measurement of displacements. The tissue motion in the plane of the transducer may be measured at a high effective frame rate in the axial direction of the transducer, or in the axial and lateral directions of the transducer. The tissue displacements over the measured volume may be interpolated over a regular grid in order to make the computation of mechanical properties easier.

Abstract: This invention provides the use of a polymer comprising a hyperbranched polyether polyol such as hyperbranched polyglycerol as a serum albumin substitute. Also provided are high molecular weight hyperbranched polyglycerol polymers suitable for a variety of medical and non-medical uses including methods for making such high molecular weight polymers.