Abstract: Provided are novel methods of inhibiting the propagation of pathological forms of tau between cells of the central nervous system by administration of an inhibitor of LRP1. LRP1 was discovered to facilitate the endocytosis of pathological forms of tau which enables the propagation of tau aggregates and resulting neurodegeneration. These methods enable the prevention and treatment of various tauopathies, such as Alzheimer's, chronic traumatic encephalopathy, corticobasal degeneration, and others.

Abstract: The invention described herein provides methods and materials that can impart long-term stability to polyelectrolyte complex coacervate droplets and create complex coacervate emulsions. The methodology described herein is designed to use one or more of a wide variety of comb polyelectrolytes in order to produce stable water-in-water emulsions with precisely controlled droplet size and enhanced stability profiles. The stabilized water-in-water emulsions microdroplets of the invention can further encapsulate active agents such as proteins and the like in a manner that protects them from the surrounding environment, thus allowing the compositions to serve as bio-microreactors and the like.

Abstract: Using a reversed-phase high-performance liquid chromatographic (HPLC) technique, a mixture of antimycins A was separated into eight hitherto unreported subcomponents, Ala, Alb, A2a, A2b, A3a, A3b, Ma, and A4b. Although a base-line resolution of the known four major antimycins Al, A2, A3, and A4 was readily achieved with mobile phases containing acetate buffers, the separation of the new antibiotic subcomponents was highly sensitive to variation in mobile phase conditions. The type and composition of organic modifiers, the nature of buffer salts, and the concentration of added electrolytes had profound effects on capacity factors, separation factors, and peak resolution values. Of the numerous chromatographic systems examined, a mobile phase consisting of methanol-water (70:30) and 0.005 M tetrabutylammonium phosphate at pH 3.0 yielded the most satisfactory results for the separation of the subcomponents.

Abstract: A method and system are disclosed for adaptive cabin air quality control. The method includes: collecting, on a computer processor, data from one or more air quality sensors; calculating, by the computer processor, a pollution level for one or more grid locations; receiving, by the computer processor, a location for a vehicle within the one or more grid locations, the vehicle including an air cabin air recirculation system with a controllable air flap; calculating, by the computer processor, a real-time flap position for the controllable air flap based on the pollution for the one or more grid locations and the location for the vehicle within the one or more grid locations; and sending, by the computer processor, the real-time flap position to the vehicle.

Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is an opportunistic pathogen causing Kaposi's sarcoma. It is capable of establishing latent infection, which can be reactivated to engage lytic infection for progeny production. KSHV contains a ˜165 kilobase DNA genome predicted to encode at least 90 open reading frames (ORFs). In this report, we generated 91 KSHV mutants, each characterized by the disruption of a single viral ORF. The growth of these mutants in cultured cells was examined to systematically investigate the necessity of each ORF for viral latency, reactivation, and lytic replication. Salient aspects are (a) 44 ORFs are essential for viral lytic replication in cultured cells and 47 are nonessential; (b) KSHV reactivation can be positively or negatively regulated by specific viral ORFs; and (c) ORFs identified to regulate viral reactivation encode functions modulating both innate and adaptive immune responses.

Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.

Abstract: Disclosed herein are methods of electrochemically enhanced amine-based CO2 capture and systems for performing the methods of amine-based CO2 capture. The present methods and systems advantageously may be carried out at ambient temperatures and allow for reusing the amine through multiple cycles.

Abstract: The disclosure provides for methods to form compact cross-linked polynucleotide/protein structures that can then be labeled using a barcoded oligonucleotide array in order to reconstruct physical linkage and/or genomic proximity (and phase) of polynucleotide fragments.

Abstract: Systems, methods, and techniques for optofluidic analyte detection and analysis using multi-mode interference (MMI) waveguides are disclosed herein. In some embodiments, spatially and spectrally multiplexed optical detection of particles is implemented on an optofluidic platform comprising multiple analyte channels intersecting a single MMI waveguide. In some embodiments, multi-stage photonic structures including a first stage MMI waveguide for demultiplexing optical signals by spatially separating different wavelengths of light from one another may be implemented. In some embodiments, a second stage may use single-mode waveguides and/or MMI waveguides to create multi-spot patterns using the demultiplexed, spatially separated light output from the first stage.

Abstract: A system and method described herein is effective for generating automated visual analytics and player statistics for videos of sporting events. A dataset of videos is collected that comprises multiple teams. Training the networks on RGB and grayscale images affects the generalization ability of the network learned and augmenting more images using generative adversarial networks to the dataset helps further improves the performance.

Abstract: Described are devices, systems and methods for thermographic imaging of conditions of the ear, nose, and throat (ENT). An example device for thermographic ENT imaging includes an endoscope and a thermal imaging camera that can be either integrated or added as an attachment to the endoscope. The device may also include a mirror configured to direct thermal radiation emitted by a target area to the thermal imaging camera.

Abstract: In certain aspects, the disclosure relates to compositions and methods relating to mutant bacteriophage that target Propionibacterium acnes. In certain aspects, compositions and methods described herein are useful for the treatment of acne.

Abstract: A widely tunable vertical-cavity surface-emitting laser (VCSEL) having a semiconductor cavity followed by an air-gap over which is a movable reflector. Lasing wavelength is controlled by a combination of the resonance of the semiconductor cavity, which is fixed, and the resonance of the air cavity, which can be changed by moving the reflector. Tuning range and slope of the VCSEL are increased by configuring the semiconductor cavity to be antiresonant at the center of the tuning range, which forces electromagnetic energy to be confined more strongly in the air gap than in the semiconductor, thus making emission wavelength more sensitive to the displacement of the tuning mirror.

Abstract: In alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW); and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.

Abstract: A method of removing a substrate, comprising: forming a growth restrict mask with a plurality of striped opening areas directly or indirectly upon a GaN-based substrate; and growing a plurality of semiconductor layers upon the GaN-based substrate using the growth restrict mask, such that the growth extends in a direction parallel to the striped opening areas of the growth restrict mask, and growth is stopped before the semiconductor layers coalesce, thereby resulting in island-like semiconductor layers. A device is processed for each of the island-like semiconductor layers. Etching is performed until at least a part of the growth restrict mask is exposed. The devices are then bonded to a support substrate. The GaN-based substrate is removed from the devices by a wet etching technique that at least partially dissolves the growth restrict mask. The GaN substrate that is removed then can be recycled.

Abstract: Source identification for unknown molecules using mass spectral matching. In an embodiment, a representation of a query mass spectrum is received in a spectrum query. A repository is searched for the query mass spectrum by, for each of a plurality of reference mass spectra, generating a similarity score between the representation of the query mass spectrum and the representation of the reference mass spectrum, when the similarity score exceeds a predetermined threshold value, without utilizing a molecular identity of a molecule represented by the reference mass spectrum, retrieving metadata associated with the reference mass spectrum, and derive context information from the retrieved metadata, and adding the context information to consensus metadata associated with the query mass spectrum, wherein the context information indicates a source of the reference mass spectrum. The consensus metadata is then returned in response to the spectrum query.

Abstract: This disclosure provides a wearable device implemented as a headset such as a virtual reality (VR) headset comprising at least a screen, a gaze tracker, and either one or both the anterior segment or retinal optical coherence tomography and fundus imaging modalities. In some embodiments, the disclosed headset can display a movie on the screen to catch/hold the attention of a patient, and meanwhile capture ocular images of the patient using the ophthalmic imaging modalities in a fully-automated manner. While capturing ophthalmic images, the movie on the screen can cause the patient's gaze to move in various directions in a controllable manner. The gaze tracker can track the movements of the pupils of the patient. The tracked pupil positions can be used to reposition the ophthalmic imaging modalities to refocus and capture images of different regions of the fundus/retina, which allows a widefield-of-view image of the fundus/retina to be reconstructed.

Abstract: A device includes: (1) a boron arsenide substrate; and (2) an integrated circuit disposed in or over the boron arsenide substrate.

Abstract: Methods and systems for treating brackish desalination brine for the recovery of fresh water are disclosed. The method includes treating a source of brackish desalination brine with an ultraviolet-driven persulfate photolysis oxidation pre-treatment; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment to a chemical demineralization process; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment and with the chemical demineralization process to a microfiltration process; and treating the source of brackish desalination brine treated to the ultraviolet-driven persulfate photolysis oxidation pre-treatment, the chemical demineralization process, and the microfiltration process to a reverse osmosis treatment.

Abstract: Systems and methods for a dual-input double-tuned transmitter (Tx) configured to wirelessly power and control a plurality of implantable stimulators using radio frequency (RF) signals in accordance with embodiments of the invention are illustrated. One embodiment includes a transmitter, where the transmitter includes a matching network configured to isolate two input signals of different frequencies, wherein the matching network includes a lumped element frequency trap comprising at least one inductor and a plurality of capacitors. The transmitter further includes a Tx coil, wherein the Tx coil is configured to transmit two RF signals at the frequencies of the input signals with a difference in frequency by a factor of 10% or more.