Patents Assigned to University of California
  • Publication number: 20240066006
    Abstract: Antiviral compounds can be utilized to mitigate viral activity of enveloped viruses in an infected host. In some instances, a virally infected biological cell is contacted with an antiviral to mitigate viral activity in the biological cell. In some instances, a virally infected animal is administered an antiviral to mitigate viral activity in the animal. In some instances, an animal is prophylactically administered an antiviral to mitigate viral activity in the animal. Therapeutics and treatments involving antiviral compounds are also described.
    Type: Application
    Filed: December 17, 2021
    Publication date: February 29, 2024
    Applicant: The Regents of the University of California
    Inventors: Aimee L. Edinger, Brendan T. Finicle
  • Publication number: 20240069010
    Abstract: The present disclosure describes a high-throughput methodology for rapid and highly personalized screenings to identify efficacious anti-tumor immunotherapy regiments. In one embodiment, therapeutic agents or a combination thereof are screened by co-culturing tumor shaped organoid extrudates with a population of immune cells taken from the same patient. Reduced tumor cell functions or increased immune cell functions in the presence of the therapeutic agents or combination thereof would identify the therapeutic agents or combination thereof for treating the tumor in the patient.
    Type: Application
    Filed: December 7, 2021
    Publication date: February 29, 2024
    Applicant: The Regents of the University of California
    Inventors: Alice SORAGNI, Peyton John TEBON, Luda LIN, Nasrin TAVANAIE, Bowen WANG
  • Patent number: 11912890
    Abstract: The invention relates generally to liquid-repellent coatings, and in particular, to porous liquid-repellent coatings, a method of preparing the porous liquid-repellent coatings, and a method of characterizing a porous surface for the liquid-repellent coatings. The invention further relates to a porous liquid-repellent coating comprising a porous layer of a transition metal oxide and/or hydroxide and a layer of a liquid-repellent compound deposited onto the porous layer of the transition metal oxide and/or hydroxide, wherein the porous layer of the transition metal oxide and/or hydroxide is comprised of a plurality of surface pores of varying angles with an average angle that is re-entrant.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Lance Brockway, Hayden Kingsley Taylor
  • Patent number: 11911619
    Abstract: The present disclosure provides a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventor: Edward F. Chang
  • Patent number: 11911625
    Abstract: Systems and methods for heart stimulation in accordance with embodiments of the invention are illustrated.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: February 27, 2024
    Assignees: The Regents of the University of California, Texas Heart Institute
    Inventors: Aydin Babakhani, Hongming Lyu, Razavi Mehdi, Mathews M. John, Allison Post
  • Patent number: 11912589
    Abstract: Photochemical energy conversion is more efficient when a single light-absorbing unit is split into multiple light-absorbing units (N) that are each 1/N as thick as the single light-absorbing unit and thus use the same amount of material as the single light-absorbing unit. For electrocatalytic parameters relevant to water electrolysis, the maximum efficiency for solar-to-fuel conversion from a 1.75 eV bandgap material increases from approximately 1% for a single light-absorbing unit to greater than 20% for 128 identical stacked light-absorbing units. Alterations in utilization of photons results in a better match of the light-absorber power output to the load of the chemical transformation and in the case of high-quality light-absorbers there is an added benefit from radiative coupling between the light-absorbing units via photon recycling.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Shane Ardo, Samuel Thomas Keene, Gabriel S. Phun
  • Patent number: 11914263
    Abstract: A predistorter for an electro-optical converter includes a plurality of low noise RF amplifiers distributed along a transmission line that receive an RF input. Second order intermodulation injection (IM2) circuitry includes an inductively-degenerated frequency doubler to square and filter IM2 products of the RF input. A Mach-Zehnder Modulator (MZM) is used for electro-optical conversion. Feed forward circuitry injects IM2 to independently propagate RF intermodulation components with velocity matching to the MZM. At least one driver injects the RF input and RF intermodulation components into the MZM.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: James F. Buckwalter, Navid Hosseinzadeh, Aditya Jain, Roger Helkey
  • Patent number: 11913017
    Abstract: A guide RNA comprising: a gRNA spacer sequence at the 5? end of the guide RNA, wherein the spacer sequence is complementary to a target gene, a scaffold sequence that binds to Cas9, and an RNA capture and sequencing domain comprising: a barcode sequence, and a primer binding sequence; nucleic acids and vectors encoding the guide RNA; cells expressing the guide RNA; and a library comprising a plurality of guide RNAs. Also disclosed are methods of introducing a genetic perturbation into a cell, methods of assessing an effect of at least one genetic perturbation on RNA expression in a cell, methods of identifying nucleic acid sequences associated with a disease state and a method of identifying candidate therapeutic agents.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Kun Zhang, Prashant Mali, Yan Wu, Dongxin Zhao
  • Patent number: 11916180
    Abstract: Narrow bandgap n-type small molecules are attracting attention in the near-infrared organic optoelectronics field, due to their easy tunable energy band with a molecular design flexibility. However, only a few reports demonstrate narrow bandgap non-fullerene acceptors (NFAs) that perform well in organic solar cells (OSCs), and the corresponding benefits of NFA photodiodes have not been well investigated in organic photodetectors (OPDs). Here, the ultra-narrow bandgap NFAs CO1-4F, CO1-4Cl and o-IO1 were designed and synthesized for the achieved efficient near-infrared organic photodiodes such as solar cells and photodetectors. Designing an asymmetrical CO1-4F by introducing two different ?-bridges including alkylthienyl and alkoxythienyl units ultimately provides an asymmetric A-D?-D-D?-A molecular configuration. This enables a delicate modulation in energy band structure as well as maintains an intense intramolecular charge transfer characteristic of the excited state.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: February 27, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE MITSUBISHI CHEMICAL CORPORATION
    Inventors: Jaewon Lee, Soe-Jin Ko, Jianfei Huang, Martin Seifrid, Hengbin Wang, Thuc-Quyen Nguyen, Guillermo C. Bazan
  • Patent number: 11912900
    Abstract: Carbon nanotube (CNT) agglomerates can be aligned along the field lines between adjacent electrodes to form conductive bridges. The present invention is directed to a stepwise process of dielectrophoretic deposition of CNTs to form conducting bridges between adjacent electrodes spanning lengths over 50 microns. The CNT bridges are permanently secured using electrodeposition of the conducting polymer polypyrrole. Morphologies of the CNT bridges formed within a frequency range of 1 kHz and 10 MHz are employed and explained as a consequence of interplay between dielectrophoretic and electroosmotic forces. Postdeposition heat treatment increases conductivity of CNT bridges likely due to solvent evaporation and resulting surface tension inducing better contact between CNTs.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lawrence Kulinsky, Tuo Zhou
  • Patent number: 11915870
    Abstract: Capacitors having electrodes made of interconnected corrugated carbon-based networks (ICCNs) are disclosed. The ICCN electrodes have properties that include high surface area and high electrical conductivity. Moreover, the electrodes are fabricated into an interdigital planar geometry with dimensions that range down to a sub-micron scale. As such, micro-supercapacitors employing ICCN electrodes are fabricated on flexible substrates for realizing flexible electronics and on-chip applications that can be integrated with micro-electromechanical systems (MEMS) technology and complementary metal oxide semiconductor technology in a single chip. In addition, capacitors fabricated of ICCN electrodes that sandwich an ion porous separator realize relatively thin and flexible supercapacitors that provide compact and lightweight yet high density energy storage for scalable applications.
    Type: Grant
    Filed: January 4, 2022
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Maher F. El-Kady, Veronica A. Strong, Richard B. Kaner
  • Patent number: 11912986
    Abstract: Understanding the complex effects of genetic perturbations on cellular state and fitness in human pluripotent stem cells (hPSCs) has been challenging using traditional pooled screening techniques which typically rely on unidimensional phenotypic readouts. Here, Applicants use barcoded open reading frame (ORF) overexpression libraries with a coupled single-cell RNA sequencing (scRNA-seq) and fitness screening approach, a technique we call SEUSS (ScalablE fUnctional Screening by Sequencing), to establish a comprehensive assaying platform. Using this system, Applicants perturbed hPSCs with a library of developmentally critical transcription factors (TFs), and assayed the impact of TF overexpression on fitness and transcriptomic cell state across multiple media conditions. Applicants further leveraged the versatility of the ORF library approach to systematically assay mutant gene libraries and also whole gene families.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Prashant Mali, Udit Parekh, Yan Wu, Kun Zhang
  • Patent number: 11915795
    Abstract: Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (HRM), and machine learning within reactions simultaneously.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Stephanie I. Fraley, Sinead Charpentier, Daniel Ortiz Velez, Mridu Sinha, Benjamin Albert Yang
  • Patent number: 11911482
    Abstract: Disclosed herein are self-assembling protein nanoparticles comprising passenger molecules of interest.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Todd Yeates, Yen-Ting Lai, Justin Miller, Phillip Nguyen, Yashes Srinivasan, Nithin Dharmaraj, Scott Taylor, Andrew Liu
  • Patent number: 11915360
    Abstract: A deep learning-based volumetric image inference system and method are disclosed that uses 2D images that are sparsely captured by a standard wide-field fluorescence microscope at arbitrary axial positions within the sample volume. Through a recurrent convolutional neural network (RNN) (referred to herein as Recurrent-MZ), 2D fluorescence information from a few axial planes within the sample is explicitly incorporated to digitally reconstruct the sample volume over an extended depth-of-field. Using experiments on C. elegans and nanobead samples, Recurrent-MZ is demonstrated to increase the depth-of-field of a 63×/1.4 NA objective lens by approximately 50-fold, also providing a 30-fold reduction in the number of axial scans required to image the same sample volume. The generalization of this recurrent network for 3D imaging is further demonstrated by showing its resilience to varying imaging conditions, including e.g.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Aydogan Ozcan, Yair Rivenson, Luzhe Huang
  • Patent number: 11913027
    Abstract: Methods for the efficient isolation and use of pluripotent adipose-derived stem cells (PASCs) are provided. In certain embodiments the methods involve providing an adipose tissue sample from which the stromal vascular fraction is co-cultured with the adipocyte fraction. PASCs can be isolated with a high degree of purification without requiring an additional cell enrichment process (e.g. cell sorting). PASCs and their conditioned media can be used for tissue regeneration within hours of harvesting the adipose tissue, and without requiring cell expansion. PASCs can grow as floating individual cells, as clusters of cells, or attached to surface(s) of the culture vessel. PASCs do not produce teratomas in vivo, nor do they induce immunorejection upon transplantation, and they achieve a high efficiency in grafting. The cells and compositions can be used for cell therapy and to screen new drugs.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Gregorio Chazenbalk
  • Patent number: 11911617
    Abstract: Methods are provided for treating diseases by altering body mass composition in a human subject through application of galvanic vestibular stimulation (GVS) using electrodes placed in electrical contact with the subject's scalp at a location corresponding to each of the subject's left and right vestibular systems. The methods may be used to treat obesity-related diseases such as diabetes, hypertension, type 2 diabetes mellitus and osteoporosis. GVS may be applied for a predetermined period of time at regular intervals.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul Duncan McGeoch, Vilayanur S. Ramachandran
  • Patent number: 11913929
    Abstract: Systems and methods using engineered nanofiltration layers to facilitate acceleration of palladium nanowire hydrogen sensors. The sensors include a metal-organic framework (MOF) assembled on palladium (Pd) nanowires (NWs) for highly selective and ultra-fast H2 molecule detection.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: February 27, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Reginald M. Penner, Won-Tae Koo, Il-Doo Kim
  • Patent number: 11913941
    Abstract: A disclosed system uses modulations of ionic current across a nanopore in a membrane to detect target molecules passing through the nanopore. This principle has been applied mainly to nucleic acid sequencing, but can also be used to detect other molecular targets such as proteins and small molecules. In addition, the system delivers target molecules to a nanopore to provide label-free single molecule analysis using a chip-based system. Target molecules are concentrated on microscale carrier beads, and the beads are delivered and optically trapped in an area within the capture radius of the nanopore. The target molecules are released from the beads and detected using nanopore current modulation. In addition, the disclosed system combines sample preparation (e.g. purification, extraction, and pre-concentration) with nanopore-based readout on a microfluidic chip.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: February 27, 2024
    Assignees: The Regents of the University of California, Brigham Young University
    Inventors: Holger Schmidt, Aaron Roe Hawkins, David W. Deamer
  • Patent number: 11913827
    Abstract: This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventors: Qin Zhou, Alexander K. Zettl