Patents Assigned to University of California
-
Publication number: 20240131079Abstract: The present disclosure provides a composition comprising extracellular vesicles (EVs) derived from induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs). The present EVs possess immunoregulatory functions that are distinct from those of EVs derived from mesenchymal stem cells. The present EVs can be used to treat or modulate immune responses in diseases such as cancer or autoimmune diseases.Type: ApplicationFiled: March 4, 2022Publication date: April 25, 2024Applicant: The Regents of the University of CaliforniaInventors: Jana ZARUBOVA, Mohammad Mahdi HASANI-SADRABADI, Song Li
-
Publication number: 20240131329Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: ApplicationFiled: October 31, 2023Publication date: April 25, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
-
Publication number: 20240132452Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.Type: ApplicationFiled: June 13, 2023Publication date: April 25, 2024Applicant: The Regents of the University of CaliforniaInventors: Charles L. Sawyers, Michael Jung, Charlie D. Chen, Samedy Ouk, Derek Welsbie, Chris Tran, John Wongvipat, Dongwon Yoo
-
Publication number: 20240131463Abstract: A cabin air filtration system and method for regenerating a cabin air filtration system are disclosed. The filtration system includes a frame, and a renewable sorption layer within the frame, the renewable sorption layer configured to clean air from one or more of outside of an automobile and inside an automobile. The cabin air filtration system for an automobile can include a first layer, the first layer configured to particulates, and a second layer, the second layer configured to remove volatile compounds and gases. The method includes placing a renewable sorption layer within a frame in an oven, the renewable sorption layer configured to filter air from one or more of outside of the automobile and inside the automobile; creating a vacuum within the oven; and heating a source of water within the oven to perform a steam regeneration treatment on the renewable sorption layer.Type: ApplicationFiled: October 19, 2023Publication date: April 25, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Heejung Jung, Jacob Swanson
-
Patent number: 11963697Abstract: Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.Type: GrantFiled: April 25, 2023Date of Patent: April 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Timothy L. Hanson, Michel M. Maharbiz, Philip N. Sabes
-
Patent number: 11965840Abstract: An epoxy resin-based embedding media doped with a non-conductive dopant to a predetermined w/w % such that the media is non-charging at 1.8 keV. A preferred dopant is polyethylene glycol at a molecular weight of at least 3350, and having a predetermined w/w % is at least 2% and up to 20%, most preferably from 2% to 10%. Another preferred dopant is polyethylene glycol at a molecular weight of 7000-8000 and a predetermined w/w % of up to ˜40% and more preferably of up to ˜30%.Type: GrantFiled: April 23, 2021Date of Patent: April 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Thomas Deerinck, Mark Ellisman, Steven Peltier
-
Patent number: 11963533Abstract: The disclosure provides stable antimicrobial (e.g., antibacterial or antifungal or both) peptides (SAMPs) that may be used in methods of preventing or treating a bacterial disease (e.g., a Liberibacter disease, such as citrus greening disease (also called Huanglongbing (HLB)) or potato Zebra Chip disease, and other bacterial diseases such as those caused by Agrobacterium tumefaciens (also known as Rhizobium radiobacter) and Pseudomonas syringae) in plants (e.g., citrus plants or potato plants). SAMPs disclosed herein may be heat stable, as well as stable in plant extracts and/or in plant lysates (e.g., citrus lysates).Type: GrantFiled: October 23, 2018Date of Patent: April 23, 2024Assignee: The Regents of The University of CaliforniaInventors: Hailing Jin, Chien Yu Huang
-
Patent number: 11968311Abstract: In a Byzantine computing environment in which a database is sharded or partitioned among multiple clusters of computing nodes, consensus for and execution of data transactions (e.g., transactions that require and/or affect data of one or more shards) are achieved in a resilient manner. Within some clusters, multiple primary replicas concurrently propose transactions for processing in parallel by all replicas. For some multi-shard transactions, shards involved in the transactions may be logically ring-ordered; each shard in turn achieves consensus among its nodes to commit the transactions, and then executes its portion of the operation after consensus is obtained among all shards. For some other multi-shard transactions, involved shards first determine whether local data constraints are satisfied, after which data modifications are made in parallel.Type: GrantFiled: November 1, 2021Date of Patent: April 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Mohammad Sadoghi Hamedani, Jelle Antonius Johannes Hellings, Suyash Gupta, Sajjad Rahnama
-
Patent number: 11965159Abstract: Compositions and methods for conditionally regulating activities of CRISPR-Cas systems. In some embodiments, the methods comprise providing an inactive guide RNA comprising a regulatory domain bound by a lock nucleic acid different from the guide RNA; and displacing the lock nuclei acid from the regulatory domain by a trigger nucleic acid, thereby activating the guide RNA, wherein the activated guide RNA forms a complex with a Cas enzyme.Type: GrantFiled: January 29, 2020Date of Patent: April 23, 2024Assignees: The Broad Institute, Inc., The Brigham and Women's Hospital, Inc., The Regents of the University of CaliforniaInventors: Amit Choudhary, Kurt Cox, Hari Subramanian, Elisa Franco
-
Patent number: 11968073Abstract: Aspects of quadrature phase shift keying for quadrature amplitude modulation are described. In some examples, quadrature phase shift keying signals are generated using quadrature phase shift keying modulators. The quadrature phase shift keying signals are combined in a combiner circuit to generate a quadrature amplitude modulation signal for wireless transmission.Type: GrantFiled: June 17, 2020Date of Patent: April 23, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Hossein Mohammadnezhad, Huan Wang, Payam Heydari
-
Patent number: 11963764Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.Type: GrantFiled: November 23, 2020Date of Patent: April 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Yasser Khan, Donggeon Han, Adrien Pierre, Jonathan Ting, Xingchun Wang, Claire Meyer Lochner, Ana Arias
-
Publication number: 20240124538Abstract: Glaucoma or pathogenic intraocular pressure is treated by locally administering to an eye in need thereof formulations of a Wnt5a inhibitor.Type: ApplicationFiled: November 28, 2023Publication date: April 18, 2024Applicant: The Regents of the University of CaliforniaInventor: Lu Chen
-
Publication number: 20240125599Abstract: A dual-shell architecture and methods of fabrication of fused quartz resonators is disclosed. The architecture may include two encapsulated and concentric cavities using plasma-activated wafer bonding followed by the high-temperature glassblowing. The dual-shell architecture can provide a protective shield as well as a “fixed-fixed” anchor for the sensing element of the resonators. Structures can be instrumented to operate as a resonator, a gyroscope, or other vibratory sensor and for precision operation in a harsh environment. Methods for fabricating a dual-shell resonator structure can include pre-etching cavities on a cap wafer, pre-etching cavities on a device wafer, bonding the device wafer to a substrate wafer to form a substrate pair and aligning and bonding the cap wafer to the substrate pair to form a wafer stack with aligned cavities including a cap cavity and a device cavity. The wafer stack may be glassblown to form a dual-shell structure.Type: ApplicationFiled: July 6, 2023Publication date: April 18, 2024Applicant: The Regents of the University of CaliforniaInventors: Andrei M. SHKEL, Mohammad H. ASADIAN ARDAKANI, Yusheng WANG
-
Publication number: 20240125952Abstract: A detector module is provided that can be used as part of a time-of-flight positron emission tomography (TOF-PET) system. The detector module comprises a plurality of emitter elements, each emitter element including an emitter composed of a substance that produces scintillation light and/or Cherenkov radiation in response to gamma photons and, coupled to each of two opposing ends of the emitter, a plurality of photodetectors. The height or thickness of the emitters between their coupled photodetectors is less than 20 mm (e.g., 5-15 mm). The photomultipliers may be silicon photomultipliers or SiPMs that have surface areas less than approximately 9 mm2. Due to the quantity of photodetectors, their operating locations at both ends of each emitter, and the relative thinness of the emitters, the emitter elements and the detector module provide a timing resolution better (lower) than 100 ps full width at half maximum.Type: ApplicationFiled: March 29, 2022Publication date: April 18, 2024Applicant: The Regents of the University of CaliforniaInventor: Gerard Ariño Estrada
-
Publication number: 20240128864Abstract: A switched-capacitor (SC) network in an SC converter is controlled to operate at varying resonant modes to achieve high conversion ratio efficiency, at a low circuit component count. These power converters are suited to numerous application areas including improving energy efficiency of data centers. A family of resonant switched capacitor (SC) converters with multiple operating phases are presented “Multi-Resonant SC Converters”. Described in detail are an 8-to-1 Multi-Resonant-Doubler (MRD) converter and a 6-to-1 Cascaded Series-Parallel (CaSP). The topology of these converters make them amenable to combining like units in parallel toward reaching higher power levels.Type: ApplicationFiled: May 19, 2023Publication date: April 18, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Zichao Ye, Robert Pilawa-Podgurski
-
Publication number: 20240125948Abstract: A single photon radiation detector is designed for a particular radiation source fluence, such that an incident radiation photon strikes a scintillator monolith, creating scintillation photons, which are amplified by appropriately sized channels of photomultipliers optically coupled to the scintillator monolith. The photomultiplier output is electronically shaped into a corresponding stream of scintillation pulses (otherwise referred to as scintillation photons) that pass through a comparator to produce a bitstream of the detected scintillation photons, which is sampled into a field programmable gate array (FPGA) acting as a giga-sample transceiver to produce time-to-digital conversions, capable of producing an output data stream of 10's-of-giga-samples per second or more. Appropriate design ensures sparsity of scintillation photon arrival, so that each photon in the bitstream corresponds to a single incident scintillation photon.Type: ApplicationFiled: October 12, 2023Publication date: April 18, 2024Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, National Technology & Engineering Solutions of Sandia, LLCInventors: Joshua W. Cates, Woon-Seng Choong, Erik Brubaker
-
Publication number: 20240124903Abstract: The present disclosure provides methods for producing fuels, such as biofuels, and commodity chemicals. In some embodiments, the methods comprise pretreating cellulosic biomass with a sugar acid. In some embodiments, the methods further comprise recycling sugar acids that are produced during fermentation for use in the subsequent pretreatment of cellulosic biomass. In some embodiments, the methods further comprise utilizing one or more components produced during pretreatment for subsequent fermentation. Fuels and commodity chemicals produced according to the methods of the present invention are also provided herein.Type: ApplicationFiled: May 16, 2023Publication date: April 18, 2024Applicant: The Regents of the University of CaliforniaInventor: Zhiliang Fan
-
Publication number: 20240123088Abstract: Disclosed herein are systems, compositions and methods for using a split dCas protein system to modify the epigenetic profile of a gene of interest. The systems, compositions, and methods are useful for modifying the epigenetic profile of a particular gene within a cell, based on the discovery that effective expression of a larger-sized recombinant protein can be successfully achieved using two separate expression cassettes each encoding a half of the protein fused with a half of an intein, utilizing the unique feature of an intein system to ultimately rejoin the two halves to form one larger fusion protein with the intein spliced out.Type: ApplicationFiled: October 19, 2023Publication date: April 18, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Julian Halmai, Kyle Fink, Jennifer Waldo
-
Publication number: 20240125874Abstract: A magnetic field sensor which can achieve sensitivities competitive with modern sensors while simultaneously maintaining a small size, low power consumption, simplicity of design, and low cost. The magnetic field sensor utilizes nonlinear precession dynamics of subatomic spins to attain parametric amplification of a magnetic field. A preliminary experimental implementation of the proposed concept establishes its feasibility and can already demonstrate significant benefits over existing approaches to sensing.Type: ApplicationFiled: October 15, 2023Publication date: April 18, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yuanxun Ethan Wang, Lap Kun Yeung, Kevin Luong
-
Publication number: 20240124887Abstract: The present disclosure provides methods and compositions for increasing resistance of plants to a disease caused by infection with bacteria of a Liberibacter species.Type: ApplicationFiled: February 9, 2022Publication date: April 18, 2024Applicant: The Regents of the University of CaliforniaInventors: Hailing Jin, Chien Yu Huang