Abstract: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
Type:
Application
Filed:
February 13, 2009
Publication date:
September 24, 2009
Applicants:
PERLEGEN SCIENCES, INC., UNIVERSITY OF CAMBRIDGE
Inventors:
David Cox, Dennis Ballinger, Bruce Ponder, Doug Easton
Abstract: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
Type:
Application
Filed:
February 13, 2009
Publication date:
August 20, 2009
Applicants:
PERLEGEN SCIENCES, INC., UNIVERSITY OF CAMBRIDGE
Inventors:
DAVID COX, DENNIS BALLINGER, BRUCE PONDER, DOUG EASTON
Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and a plurality of electronic components mounted on each of the substrates. The substrates are coupled each other at a plurality of bonding regions so that mechanical separation between the substrates is controlled by the number of the bonding regions, an arrangement of the bonding regions, a shape of each bonding region, and a material of the bonding regions. The mechanical separation provides a net axially-directed compressive force in the electronic components.
Type:
Grant
Filed:
August 29, 2006
Date of Patent:
July 7, 2009
Assignees:
DENSO CORPORATION, University of Cambridge, The University of Sheffield
Inventors:
Rajesh Kumar Malhan, C. Mark Johnson, Jeremy Rashid
Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and multiple semiconductor chips and electronic components between the substrates. Each substrate includes multiple electrical insulator layers and patterned electrical conductor layers connecting to the electronic components, and further includes multiple raised regions or posts, which are bonded together so that the substrates are mechanically and electrically connected. The number, arrangement, and shape of the raised regions or posts are adjusted to have mechanical separation between the substrates. The electrical conductor layers are separated and isolated one another so that multiple electric circuits are provided on at least one of the substrates.
Type:
Application
Filed:
August 29, 2006
Publication date:
March 6, 2008
Applicants:
DENSO CORPORATION, University of Cambridge, The University of Sheffield
Inventors:
Rajesh Kumar Malhan, C. Mark Johnson, Cyril Buttay, Jeremy Rashid, Florin Udrea
Abstract: A power electronic package includes: first and second high thermal conductivity insulating non-planar substrates; and a plurality of electronic components mounted on each of the substrates. The substrates are coupled each other at a plurality of bonding regions so that mechanical separation between the substrates is controlled by the number of the bonding regions, an arrangement of the bonding regions, a shape of each bonding region, and a material of the bonding regions. The mechanical separation provides a net axially-directed compressive force in the electronic components.
Type:
Application
Filed:
August 29, 2006
Publication date:
March 6, 2008
Applicants:
DENSO CORPORATION, UNIVERSITY OF CAMBRIDGE, THE UNIVERSITY OF SHEFFIELD
Inventors:
Rajesh Kumar Malhan, C. Mark Johnson, Jeremy Rashid
Abstract: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
Type:
Application
Filed:
November 29, 2006
Publication date:
July 19, 2007
Applicants:
Perlegen Sciences, Inc., University of Cambridge
Inventors:
David Cox, Dennis Ballinger, Bruce Ponder, Doug Easton