Patents Assigned to University of Cape Town
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Publication number: 20110092728Abstract: A process is described for the production of one or more of linear nitriles, amides and formamides which includes reacting a nitrogen containing compound, such as ammonia or NOx, and a synthesis gas over a catalyst at a temperature of between 160° C. and 400° C. and a pressure of between 1 bar and 50 bar. A further process for the production of one or more of linear phosphorous containing compounds is also described, which includes reacting a phosphorous containing compound, such as a phosphine, and a synthesis gas over a catalyst at a temperature of between 160° C. and 400° C. and a pressure of between 1 bar and 50 bar. A supported cobalt, iron, ruthenium or rhodium catalyst or an unsupported (bulk) promoted iron catalyst, modified with a promoter is used. The synthesis gas is a mixture of hydrogen and carbon monoxide, in a ratio from 0.5:1 to 5:1; or a mixture of hydrogen and carbon dioxide; or a mixture of water and carbon monoxide.Type: ApplicationFiled: April 15, 2009Publication date: April 21, 2011Applicants: THE UNIVERSITY OF CAPE TOWN, CARL VON OSSIETZKY UNIVERSITAT OLDENBURGInventors: Michael Christian Maximilian Claeys, Eric Wilhelmus Josephus Van Steen, Frank Roessner, Tawanda Stephen Sango
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Publication number: 20110080452Abstract: Apparatus for depositing ink on a substrate includes a nozzle defining an outlet for the ink, with at least a portion of the nozzle being electrically conductive. A first voltage source applies a first potential to the outlet nozzle. One or more auxiliary electrodes are located adjacent the outlet nozzle, and a second voltage source applies a second potential to the auxiliary electrodes. The apparatus includes a piezo-electric or thermal actuator for expelling ink from the nozzle towards a target zone on a substrate, the ink comprising a liquid vehicle and pigment particles dispersed in the vehicle. At least the pigment particles are electrically charged, typically due to the applied potentials. In one embodiment, an auxiliary electrode is disposed coaxially around the electrode formed by the nozzle. In another embodiment, an auxiliary electrode located beyond the nozzle, on a common axis with the electrode formed by the nozzle.Type: ApplicationFiled: June 2, 2009Publication date: April 7, 2011Applicant: University of Cape TownInventors: David Thomas Britton, Ekundare Ayodele Odo, Margit Harting
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Patent number: 7910716Abstract: Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.Type: GrantFiled: January 21, 2009Date of Patent: March 22, 2011Assignees: Medical Research Council, University of Cape Town Observatory, University of North Carolina at Chapel Hill, Alphavax, IncorporatedInventors: Robert Edward Johnston, Salim Abdol Karim, Lynn Morris, Ronald Swanstrom, Carolyn Williamson
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Patent number: 7901507Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.Type: GrantFiled: July 14, 2008Date of Patent: March 8, 2011Assignees: University of Bath, University of Cape TownInventors: Ravi Acharya, Edward David Sturrock
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Publication number: 20100303321Abstract: A method is provided for taking electrical impedance tomography measurements using multiple electrodes located at selected positions external to a volume of a subject body. Multiple orthogonal or near-orthogonal signals are introduced simultaneously by way of selected different electrodes and resultant predetermined responses (if any) at receiving electrodes are recorded or determined. The signals are encoded using the technique of code division multiplexing and received signals at each receiving electrode are cross-correlated with original signals to determine the contribution of each original signal to a composite received signal. The invention also relates to apparatus suitable for use in applying a method.Type: ApplicationFiled: November 25, 2008Publication date: December 2, 2010Applicants: THE UNIVERSITY OF CAPE TOWN, THE UNIVERSITY OF SYDNEYInventors: Alistair Lee McEwan, David Simon Holder, Andre van Schaik, Jonathan Craig Tapson
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Publication number: 20100275327Abstract: A method of increasing abiotic stress tolerance in a plant is described, the method comprising transforming the plant with a vector comprising a nucleic acid which is at least 80% identical to SEQ I.D. NO: 10. Plants or plant parts transformed with these sequences are also described.Type: ApplicationFiled: May 4, 2010Publication date: October 28, 2010Applicants: University of Cape Town, The Maize TrustInventors: Jennifer Ann Thomson, Jesse Machuka, Revel Iyer, Richard Okoth
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Patent number: 7813537Abstract: Myocardial tissue tracking techniques are used to project or guide a single manually-defined set of myocardial contours through time. Displacement encoding with stimulated echoes (DENSE), harmonic phase (HARP) and speckle tracking is used to encode tissue displacement into the phase of complex MRI images, providing a time series of these images, and facilitating the non-invasive study of myocardial kinematics. Epicardial and endocardial contours need to be defined at each frame on cine DENSE images for the quantification of regional displacement and strain as a function of time. The disclosed method presents a novel and effective two dimensional semi-automated segmentation technique that uses the encoded motion to project a manually defined region of interest through time. Contours can then easily be extracted for each cardiac phase.Type: GrantFiled: May 14, 2007Date of Patent: October 12, 2010Assignees: Siemens Medical Solutions USA, Inc., University of Virginia Patent Foundation, University of Cape TownInventors: Frederick H Epstein, Ernesta M Meintjes, Bruce S Spottiswoode
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Patent number: 7775257Abstract: The invention concerns a casting apparatus which includes a crucible support and induction heating means (14, 16, 18) arranged to receive and support a crucible (10) containing material which is to be melted and poured from an outlet (38). The outlet is positioned on a vertical axis (40). The support and induction heating means also operates to apply induction heating to the material to melt it in the crucible. There is also a translation mechanism which tilts the crucible while the crucible is still supported and while heat is continuously applied to it. This mechanism operates in such a way that during tilting, the outlet of the crucible is maintained on the vertical axis so that the molten material pours from the outlet on the vertical axis. In the embodiments described, the crucible is simultaneously moved vertically towards the mould into which the melt pours.Type: GrantFiled: May 17, 2005Date of Patent: August 17, 2010Assignee: University of Cape TownInventors: Irshad Khan, Wessel Marthinus Cronje
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Patent number: 7763530Abstract: The invention relates to a method of doping semiconductor material. Essentially, the method comprises mixing a quantity of particulate semiconductor material with an ionic salt or a preparation of ionic salts. Preferably, the particulate semiconductor material comprises nanoparticles with a size in the range 1 nm to 100 ?m. Most preferably, the particle size is in the range from 50 nm to 500 nm. Preferred semiconductor materials are intrinsic and metallurgical grade silicon. The invention extends to a printable composition comprising the doped semiconductor material as well as a binder and a solvent. The invention also extends to a semiconductor device formed from layers of the printable composition having p and n type properties.Type: GrantFiled: August 23, 2006Date of Patent: July 27, 2010Assignee: University of Cape TownInventors: David Thomas Britton, Margit Härting
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Publication number: 20100173977Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.Type: ApplicationFiled: January 10, 2007Publication date: July 8, 2010Applicants: University of Bath, University of Cape TownInventors: Ravi Acharya, Edward David Sturrock
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Publication number: 20100160180Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and the structure co-ordinates thereof.Type: ApplicationFiled: February 26, 2010Publication date: June 24, 2010Applicants: UNIVERSITY OF BATH, University of Cape TownInventors: Ravi Acharya, Edward Sturrock
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Patent number: 7713530Abstract: The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates to a vaccine including two or more of the nucleotide sequences, and nucleotide sequences from the pol and/or gag genes of HIV-1.Type: GrantFiled: July 30, 2008Date of Patent: May 11, 2010Assignees: The South African Medical Research Council, University of Cape TownInventors: Carolyn Williamson, Joanne Heidi van Harmelen, Clive Maurice Gray, William Bourn, Salim Abdool Karim
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Patent number: 7704319Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.Type: GrantFiled: September 12, 2003Date of Patent: April 27, 2010Assignees: University of Bath, University of Cape TownInventors: Ravi Acharya, Edward Sturrock
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Patent number: 7619121Abstract: A method of detecting a member of the taxa actinomycetes is provided. A method also is provided for detecting mycothiol or precursor thereof. An antibody is provided when binds to mycothiol or a mycothiol precursor. A method is further provided for diagnosis of a subject having or at risk of having an actinomycetes-associated disorder. A method is also provided for identifying a sample with altered production of mycothiol or a precursor thereof. A method is provided for detecting mycothiol or precursor thereof in a bacterial colony. Kits are also disclosed which are useful for detecting the presence of mycothiol or precursor thereof in a sample.Type: GrantFiled: August 27, 2004Date of Patent: November 17, 2009Assignee: University of Cape TownInventor: Daniel Jacobus Steenkamp
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Publication number: 20090142822Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.Type: ApplicationFiled: July 14, 2008Publication date: June 4, 2009Applicants: UNIVERSITY OF BATH, UNIVERSITY OF CAPE TOWNInventors: RAVI ACHARYA, EDWARD DAVID STURROCK
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Publication number: 20090092855Abstract: The invention relates to a method of doping semiconductor material. Essentially, the method comprises mixing a quantity of particulate semiconductor material with an ionic salt or a preparation of ionic salts. Preferably, the particulate semiconductor material comprises nanoparticles with a size in the range 1 nm to 100 ?m. Most preferably, the particle size is in the range from 50 nm to 500 nm. Preferred semiconductor materials are intrinsic and metallurgical grade silicon. The invention extends to a printable composition comprising the doped semiconductor material as well as a binder and a solvent. The invention also extends to a semiconductor device formed from layers of the printable composition having p and n type properties.Type: ApplicationFiled: August 23, 2006Publication date: April 9, 2009Applicant: UNIVERSITY OF CAPE TOWNInventors: David Thomas Britton, Margit Harting
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Publication number: 20090076245Abstract: The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates to a vaccine including two or more of the nucleotide sequences, and nucleotide sequences from the pol and/or gag genes of HIV-1.Type: ApplicationFiled: July 30, 2008Publication date: March 19, 2009Applicants: The South African Medical Research Council, University of Cape TownInventors: Carolyn Williamson, Joanne Heidi van Harmelen, Clive Maurice Gray, William Bourn, Salim Abdool Karim
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Publication number: 20090047302Abstract: A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for the L1 polypeptide; introducing the DNA sequence including the sequences for the L1 polypeptide and heterologous peptide into a host cell in which the DNA sequence can be expressed; causing expression of the DNA sequence; and recovering the resulting chimaeric L1 polypeptide which includes the heterologous peptide. The invention also describes a vector for use in the method, a host cell containing the vector, and a vaccine including the chimaeric HPV L1 polypeptide produced according to the method.Type: ApplicationFiled: July 16, 2008Publication date: February 19, 2009Applicant: UNIVERSITY OF CAPE TOWNInventors: Arvind Devshi Varsani, Edward Peter Rybicki
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Patent number: 7479547Abstract: The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates to a vaccine including two or more of the nucleotide sequences, and nucleotide sequences from the pol and/or gag genes of HIV-1.Type: GrantFiled: October 31, 2002Date of Patent: January 20, 2009Assignees: The South African Medical Research Council, University of Cape TownInventors: Carolyn Williamson, Joanne Heidi van Harmelen, Clive Maurice Gray, William Bourn, Salim Abdool Karim
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Patent number: 7407807Abstract: The invention describes a method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide. The method comprises the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for the L1 polypeptide; introducing the DNA sequence including the sequences for the L1 polypeptide and heterologous peptide into a host cell in which the DNA sequence can be expressed; causing expression of the DNA sequence; and recovering the resulting chimaeric L1 polypeptide which includes the heterologous peptide. Typically, the nucleotides encoding the heterologous peptide replace the nucleotides of the L1 polypeptide at the point of insertion. The invention also describes a vector for use in the method, a host cell containing the vector, and a vaccine including the chimaeric HPV L1 polypeptide produced according to the method.Type: GrantFiled: May 19, 2003Date of Patent: August 5, 2008Assignee: University of Cape TownInventors: Arvind Devshi Varsani, Edward Peter Rybicki