Patents Assigned to University of Central Florida
  • Patent number: 10314813
    Abstract: Clostridium difficile infects and kills 30,000-40,000 people a year in the United States. Provided herein are methods to inhibit growth and reduce the spread of C. difficile using puupehenone, a natural marine product that is excreted from some species of sponges and coral as a defense mechanism.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: June 11, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: William T. Self
  • Patent number: 10316217
    Abstract: A dust resistant and moisture resistant coating composition includes within a solvent that is generally an aqueous solvent: (1) a first component that is chemically condensable with itself and independently cross-linkable; (2) a second component that is chemically condensable with itself and with the first component and includes at least one of a fluorocarbon functionality and a hydrocarbon functionality; and (3) an optional third component that is chemically condensable with the first component and the second component but is neither independently cross-linkable nor includes the at least one of the fluorocarbon functionality and the hydrocarbon functionality. A coated article that results from application of the coating composition to a substrate shows enhanced dust resistance and moisture resistance.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: June 11, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Lei Zhai, Astha Malhotra
  • Patent number: 10312389
    Abstract: An optical detector device may include a substrate, a reflector layer carried by the substrate, and a first dielectric layer over the reflector layer. The optical detector device may include a graphene layer over the first dielectric layer and having a perforated pattern.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Debashis Chanda, Alireza Safaei, Michael Leuenberger
  • Patent number: 10309975
    Abstract: Disclosed herein is a functionalized eyewear device that is adapted for collecting and analyzing disease biomarkers. Specifically, exemplified is a contact lens that has aptamer molecules associated therewith for binding to a specific biomarker (or biomarkers). The eyewear device is useful for detecting and diagnosing medical conditions.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: June 4, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Yoon-Seong Kim
  • Publication number: 20190164317
    Abstract: An apparatus and method are provided for computed tomography (CT) imaging to reduce truncation artifacts due to a part of an imaged object being outside the scanner field of view (FOV) for at least some views of a CT scan. After initial determining extrapolation widths to extend the projection data to fill a truncation region, the extrapolation widths are combined into a padding map and smoothed to improve uniformity and remove jagged edges. Then a hybrid material model fits the measured projection data nearest the truncation region to extrapolate projection data filling the truncation region. Smoothing the padding map is improved by the insight that in general smaller extrapolation widths are more accurate and trustworthy. Further, practical applications often include multiple inhomogeneous materials. Thus, the hybrid material model provides a better approximation than single material models, and more accurate fitting is achieved.
    Type: Application
    Filed: November 30, 2018
    Publication date: May 30, 2019
    Applicants: THE UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, Inc.
    Inventors: Qiulin Tang, Alexander Katsevich, Zhou Yu, Wenli Wang
  • Patent number: 10300089
    Abstract: Disclosed are compositions and methods relating to the expansion of memory NK cells.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: May 28, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Alicja J. Copik, Robert Y. Igarashi, Jeremiah L. Oyer, Deborah Altomare
  • Patent number: 10294184
    Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to oxidative oxidized reaction products made from the mechanocatalytic oxidative depolymerization of lignin. More particularly, but without limitation, the mechanocatalytic oxidative depolymerization of lignin is performed in a non-aqueous/non-solvent based and solvent-free process, i.e., via a solid-solid mechanocatalytic oxidative reaction methodology. In one particular embodiment, the process of making such oxidative oxidized reaction products includes, without limitation, the step of mechanocatalytically reacting an oxidation catalyst with lignin or a lignin-containing material. The oxidative reaction products obtained from the process include, for example, at least one of vanillin, and syringealdehyde, vanillic acid, and syringic acid.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 21, 2019
    Assignee: University of Central Florida Research Foundation Inc
    Inventor: Richard Blair
  • Patent number: 10294531
    Abstract: Disclosed herein are method, materials and kits for detection of B. Burgdorferi infection or determining stage of Lyme disease in a subject. Exemplified is a method of diagnosing an infection in a subject, the method involving exposing a biological sample from the subject to a capture substrate under conditions for an infection marker in said biological sample to associate with the capture substrate to form a capture complex; associating said capture complex with a marker complex, said marker complex comprising an oligonucleotide; and amplifying said oligonucleotide of marker complex associated with said capture complex to produce an amplification signal; wherein an amplification signal above a predetermined signal threshold indicates that said subject is infected.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 21, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mollie Jewett, Micah Halpern
  • Patent number: 10287167
    Abstract: Existing methods of producing high quality graphene/graphite oxides are generally accomplished by exfoliating graphite into flakes and oxidizing the graphite flakes with strong oxidizers under extreme conditions and require careful purification. The oxidizers are typically strong acids used in high concentrations at elevated temperatures requiring complicated purification processes to yield oxidized graphene/sheets. The existing processes can cost up to $12,000/gram. This invention uses a mild oxidant combined with mechanical processing where the sole products are oxidized graphite/graphene and water without the need for further purification.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 14, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Richard Blair
  • Patent number: 10283871
    Abstract: A reconfigurable antenna array capable of utilizing a common antenna aperture which can cover a wide frequency range in a continuous way. With the basic antenna element based on a slot-ring and using a self similar structure approach and RE' switches, the antenna array operates without grating lobes. The antenna array exhibits polarization diversity and single-side radiation capability. When varactors are implemented into the array, the antenna array can cover the frequency range by continuously tuning the center frequency with a relatively narrow instantaneous bandwidth.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: May 7, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Xun Gong, Mahmoud Shirazi, Tianjiao Li
  • Patent number: 10277354
    Abstract: An optical fiber system including an optical fiber and an optical grating is provided. The optical fiber is configured to support M mode groups, where differences in effective refractive index between adjacent mode groups are substantially equal. The optical grating is optically coupled to the optical fiber, and has a period inversely proportional to the difference in effective refractive index between adjacent mode groups. The optical grating is configured to couple all adjacent mode groups in the optical fiber.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: April 30, 2019
    Assignees: Futurewei Technologies, Inc., University of Central Florida Research Foundation, Inc.
    Inventors: Guifang Li, Zhihong Li, Demetrios Christodoulides, Huiyuang Liu, He Wen, Mohammadamin Eftekhar, Bin Huang
  • Patent number: 10269259
    Abstract: A computing device may include a display, a memory to store electronic textbook data comprising a plurality of different images associated with at least one location within the electronic textbook data, a user input device, and a processor coupled to the display, the memory, and the user input device. The processor may be configured to display the electronic textbook data with a primary image from among the plurality of different images at the at least one location on the display, and selectively replace the primary image with at least one secondary image from among the plurality of different images at the at least one location on the display based upon the user input device.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: April 23, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Issa Batarseh, Ghaith Haddad, Rashad Oreifej, Rawad Al-Haddad
  • Patent number: 10266804
    Abstract: The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: April 23, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Mainak Das
  • Patent number: 10268076
    Abstract: Display devices and related methods involving patterned phase retarding are provided. A representative display device includes: a backlight unit, having a light source and a color conversion layer having an alignment direction, the light comprising a first light exhibiting a first upstream polarization ratio, a second light exhibiting a second upstream polarization ratio, and a third light exhibiting a third upstream polarization ratio; and a patterned phase retarder positioned to receive the light, having a plurality of half-wave regions to alter polarization of light passing therethrough, and a plurality of free regions to pass light without altering the polarization; wherein polarization ratio (PR) is defined by PR=(I??I?)/(I?+I?); and wherein the first upstream polarization ratio exhibits a first sign, and both the second upstream polarization ratio and the third upstream polarization ratio exhibit a second sign opposite the first sign.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 23, 2019
    Assignees: A.U. VISTA INC., THE UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Hai-Wei Chen, Shin-Tson Wu, Wei Duan, Ming-Chun Li, Seok-Lyul Lee
  • Patent number: 10263393
    Abstract: A semiconductor vertical resonant cavity light source includes an upper and lower mirror that define a vertical resonant cavity. An active region is within the cavity for light generation between the upper and lower mirror. At least one cavity spacer region is between the active region and the upper mirror or lower mirror. The cavity includes an inner mode confinement region and an outer current blocking region. An index guide in the inner mode confinement region is between the cavity spacer region and the upper or lower mirror. The index guide and outer current blocking region each include a lower and upper epitaxial material layer thereon with an epitaxial interface region in between. At least a top surface of the lower material layer includes aluminum in the interface region throughout a full area of an active part of the vertical light source.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: April 16, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Dennis G. Deppe
  • Patent number: 10261074
    Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: April 16, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath
  • Patent number: 10254090
    Abstract: An energetic material having thin, alternating layers of metal oxide and reducing metal is provided. The energetic material may be provided in the form of a sheet, foil, cylinder, or other convenient structure. A method of making the energetic material resists the formation of oxide on the surface of the reducing metal, allowing the use of multiple thin layers of metal oxide and reducing metal for maximum contact between the reactants, without significant lost volume due to oxide formation. An ignition system for the energetic material includes multiple ignition points, as well as a means for controlling the timing and sequence of activation of the individual ignition points. A gas producing layer is also provided to increase pressure.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: April 9, 2019
    Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, SPECTRE MATERIALS SCIENCES, INC.
    Inventors: Timothy Mohler, Jonathan Mohler, Kevin R. Coffey, Edward Alan Dein
  • Patent number: 10226439
    Abstract: The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: March 12, 2019
    Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDA, UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: James Turkson, Said M. Sebti, Wayne Guida, Man Lun Yip, Nicholas Lawrence, Harshani Rithma Lawrence, Benjamin Greedy
  • Publication number: 20190064629
    Abstract: The present disclosure is directed to systems and methods for omniresonant broadband coherent perfect absorption of incoherent light over large bandwidths. The apparatus and methods that enable 100% effective optical absorption in a structure, irrespective of the material from which it is constructed, over a large, continuous bandwidth (omniresonance) in ultrathin devices. Specifically, we demonstrate achromatic optical absorption (omniresonance) in a planar Fabry-PĂ©rot micro-cavity via angularly multiplexed phase-matching. By assigning each wavelength to an appropriate angle of incidence, the micro-cavity is rendered absorbing with continuous spectral range. For example, the linewidth of a single-order 0.7 nm wide resonance is de-slanted in spectral-angular space to become a 70 nm wide achromatic resonance spanning multiple cavity free spectral ranges. The embodied invention can have important applications in, e.g.
    Type: Application
    Filed: August 31, 2018
    Publication date: February 28, 2019
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Ayman F. Abouraddy, Ali Kazemi Jahromi, Massimo L. Villinger, Ahmed El Halawany, Soroush Shabahang, Hasan Esat Kondakci
  • Patent number: 10213458
    Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: February 26, 2019
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Jesus Manuel Perez, Atul Asati, Santimukul Santra, Charalambos Kaittanis