Patents Assigned to University of Cincinnati
  • Devices capable of fluid sample concentration for extended sensing of analytes
    Patent number: 10506968
    Abstract: The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: December 17, 2019
    Assignees: Eccrine Systems, Inc., University of Cincinnati
    Inventors: Jason Heikenfeld, Jacob A. Bertrand, Michael Brothers, Andrew Jajack
  • Compositions and methods for treating cocaine-related disorders
    Patent number: 10501556
    Abstract: Methods for treating a cocaine-related disorder in an individual include administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In another embodiment, the light chain includes a human kappa light chain at least partially derived from 1B3. Other embodiments are directed toward the antibodies themselves and methods of binding the antibodies.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: December 10, 2019
    Assignees: University of Cincinnati, E. R. Squibb & Sons, L.L.C.
    Inventors: Andrew B. Norman, William J. Ball, Jr., Nils Lonberg, Denise Williams
  • Additive manufacturing by localized electrochemical deposition
    Patent number: 10501857
    Abstract: A method of electrolytic additive manufacturing provides 3-D parts. The method can be used to form parts from particulate material in an electrolytic bath. Metal is electrolytically deposited, binding the particles. Layers of the particles are built up to form the parts. The same process can be used to form parts without the particulate material. Layers of metal are electrolytically deposited in the electrolyte bath to form the parts.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: December 10, 2019
    Assignee: University of Cincinnati
    Inventor: Murali Sundaram
  • Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
    Patent number: 10500227
    Abstract: Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio of about 1:1 by volume, wherein X is greater than or equal to 3, are disclosed, along with methods for treating a patients suffering from cardiovascular disease by administering the ELIP at a site remote from the target diseased section, monitoring presence of the ELIP at the target diseased section, and administering ultrasound upon detection of presence such that bioactive NO is released at the target diseased section.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: December 10, 2019
    Assignee: University of Cincinnati
    Inventors: Christy Holland, Jason Raymond, Jonathan Sutton
  • Devices and methods for analyzing a blood coagulation property
    Patent number: 10488424
    Abstract: A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The analytical membrane (14) includes a porous hydrophilic sample portion (34), a porous hydrophilic analytical portion (36), and a porous hydrophilic wicking portion (38). The porosity of the analytical portion (36) differs from the porosity of the sample portion (34). The method utilizes the device to analyze blood coagulation in a whole blood sample from the distance travelled by the red blood cell leading edge (50) in a predetermined period of time.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 26, 2019
    Assignee: University of Cincinnati
    Inventors: Andrew J. Steckl, Giovanni M. Pauletti, Hua Li
  • Devices for integrated indirect sweat stimulation and sensing
    Patent number: 10485460
    Abstract: A sweat sensing device includes at least one sweat generation unit capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit is located above the indirect stimulation region when the sweat sensing device is placed on skin.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: November 26, 2019
    Assignee: University Of Cincinnati
    Inventors: Zachary Cole Sonner, Jason C. Heikenfeld
  • Enhanced analyte access through epithelial tissue
    Patent number: 10471249
    Abstract: A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 12, 2019
    Assignee: University of Cincinnati
    Inventors: Jason Charles Heikenfeld, Andrew Jajack, Michael Charles Brothers
  • Electrofluidic display and methods for making
    Patent number: 10473914
    Abstract: A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters is less than 25% and a thickness less than 25 micrometers, The film provides a carrier substrate, a photo-curable material, a release agent and deposits a photo-curable material on the substrate, selectively curing the material and leaving uncured material in the pattern of holes, dissolving away the uncured material and removing the cured material from the carrier substrate. Methods and apparatus are described.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: November 12, 2019
    Assignee: University of Cincinnati
    Inventors: Eric Kreit, John David Rudolph, Kenneth A. Dean
  • strains with amplified expression of cellulases and production of biofuel therefrom
    Patent number: 10464974
    Abstract: Transgenic strains of Neurospora crassa engineered to comprise a synthetic positive feedback loop for a transcriptional activator of cellulase expression such that cellulase production is amplified are disclosed, along with compositions thereof. The transgenic strains are particularly useful in methods for generating purified cellulases, fermentable sugars, and cellulosic ethanol for the efficient production of biofuel from cellulose-containing biomass and waste.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: November 5, 2019
    Assignee: University of Cincinnati
    Inventors: Christian Hong, Toru Matsuura
  • Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease
    Patent number: 10456483
    Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: October 29, 2019
    Assignee: University of Cincinnati
    Inventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
  • Stimulation via TLR4/MD-2 to reverse Type 1 diabetes
    Patent number: 10457738
    Abstract: Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed methods and compositions. Also disclosed are methods of restoring adaptive immune T cell tolerance, treating pernicious insulitis, improving immune tolerance, and treating autoimmune diseases using the disclosed methods and compositions.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: October 29, 2019
    Assignee: University of Cincinnati
    Inventor: William Ridgway
  • SYSTEMS AND METHODS FOR GATED-INSULATOR RECONFIGURABLE NON-VOLATILE MEMORY DEVICES
    Publication number: 20190305220
    Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.
    Type: Application
    Filed: March 28, 2019
    Publication date: October 3, 2019
    Applicant: University of Cincinnati
    Inventors: RASHMI JHA, Andrew Rush, Eric Herrmann
  • SYSTEMS AND METHODS FOR GATED-INSULATOR RECONFIGURABLE NON-VOLATILE MEMORY DEVICES
    Publication number: 20190305046
    Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.
    Type: Application
    Filed: March 28, 2019
    Publication date: October 3, 2019
    Applicant: University of Cincinnati
    Inventors: Rashmi Jha, Andrew Rush, Eric Herrmann
  • Silver nanoparticle-enhanced photosensitizers
    Patent number: 10420346
    Abstract: The present invention relates generally to compositions and methods of killing fungi using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). A method of killing fungi may include contacting fungi with a nanostructure (10) including a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16) to form a blend and exposing the blend to light.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 24, 2019
    Assignee: University Of Cincinnati
    Inventors: Peng Zhang, Niranga Wijesiri, Hong Tang
  • Methods of detecting influenza virus
    Patent number: 10408836
    Abstract: Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of neuraminidase (NA) in the sample under one or more differentiating conditions selected from the group consisting of pH, binding to anti-NanA antibody, size exclusion, hemagglutinin (HA) binding, chemical inhibition, and combinations thereof.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: September 10, 2019
    Assignees: University of Cincinnati, MicrobeCapture, LLC
    Inventors: Alison A. Weiss, Karen Melissa Gallegos Villalobos, David Ralph
  • Methods for treating acute myeloid leukemia and nanoparticle complexes of miR-22 utilized therein
    Patent number: 10400242
    Abstract: Compositions and methods for treating acute myeloid leukemia (AML) based on upregulating expression of microRNA-22 (miR-22), and a nanoparticle delivery system that utilizes FLT3-functionalized polyamidoamine (PAMAM) dendromirs for targeted delivery of miR-22 and/or agents that upregulate expression of miR-22 to AML cells.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: September 3, 2019
    Assignee: University of Cincinnati
    Inventors: Jianjun Chen, Xi Jiang
  • Systems, media, and methods for pre-processing and post-processing in additive manufacturing
    Patent number: 10395372
    Abstract: Systems, methods, and media for pre-processing and post-processing in additive manufacturing are provided. A method includes receiving object geometry data. The method may further include generating a sectional snapshot and a bounding box. The method may also include performing a boundary tracing operation on the sectional snapshots. Further still, the method may include executing a contour mapping algorithm. The method may additionally include outputting slice contour points with respect to the object to be fabricated.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: August 27, 2019
    Assignee: University of Cincinnati
    Inventors: Sundararaman Anand, Rohit Vaidya, Sushmit Chowdhury, Kunal Mhapsekar, Matthew McConaha
  • INTEGRATED DEVICES TO CONTINUOUSLY MEASURE BOUND AND UNBOUND ANALYTE FRACTIONS IN BIOFLUIDS
    Publication number: 20190254579
    Abstract: Embodiments of the disclosed invention provide devices for measuring concentrations of bound and unbound fractions of a target analyte in a biofluid sample. Analytes present in biofluid may be found in a free state, or bound to a binding solute, presenting difficulties for wearable analyte sensors to measure physiologically significant concentrations of the analyte in biofluid. The disclosed devices feature sensors configured to measure both the bound and unbound fractions of the analyte, as well as analyte releasers that cause a portion of the bound fraction of analytes to be released to facilitate measurement. Some embodiments include a collector and or a sample conduit. Other embodiments include a plurality of fluid pathways.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Applicants: Eccrine Systems, Inc., University of Cincinnati
    Inventors: Jason Heikenfeld, Hector Wong, Kevin Plaxco, Jacob A. Bertrand
  • DEVICE AND METHODS COMPRISING A FLUIDIC DIVERTER FOR ASSISTING BREATHING
    Publication number: 20190255269
    Abstract: Provided herein is a method for assisting breathing in a subject, the method including passing a pressurized airflow through a fluidic diverter, wherein the fluidic diverter converts the airflow into pulses of pressurized air that are diverted alternately to provide a first and a second train of pulses of pressurized air; and directing the first and second trains of pulses of pressurized air into a nasal passageway of a subject to assist breathing. Also provided herein is a device for assisting breathing, including an airflow source coupled to a fluidic diverter. The devices and methods provided herein generate positive airway pressure in the form of pulsatile vortex airflow for the treatment of obstructive sleep apnea in a subject, without the need for a sealed interface between the subject and the device.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 22, 2019
    Applicant: University of Cincinnati
    Inventors: Ephraim GUTMARK, Liran OREN, Sid KHOSLA
  • Dosing and sealing of fluid-based electro-optical devices and displays
    Patent number: 10386628
    Abstract: A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate; providing a second plate and sealing a second plate onto the first plate forming stacked plates with at least one cavity between the plates, and leaving at least one fill port for a second fluid. Thereafter, the stacked plates are cooled to increase the viscosity of the first fluid so that the first fluid maintains a fixed position as a second fluid is filled into the cavity. Methods are disclosed.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: August 20, 2019
    Assignee: University Of Cincinnati
    Inventors: Kenneth A. Dean, Jason Charles Heikenfeld, Kaichang Zhou, Hari Mukunda Atkuri, Wyatt Austin Black Rodgers