Patents Assigned to University of Cincinnati
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Patent number: 10944053Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.Type: GrantFiled: March 28, 2019Date of Patent: March 9, 2021Assignee: UNIVERSITY OF CINCINNATIInventors: Rashmi Jha, Andrew Rush, Eric Herrmann
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Patent number: 10935499Abstract: Described are sensors and methods of detecting hydrogen gas. The sensor includes a polymer matrix and a dye molecule in an amount sufficient such that exposure of the polymer matrix to hydrogen gas causes a change in a spectroscopic property of the dye molecule wherein the spectroscopic property includes at least one of color, absorbance, or luminescence. The polymer matrix may further include a catalyst, such as a transition metal, sulfonated Wilkinson's catalyst, colloidal Pt, sulfonated iridium cyclooctadiene triphenylphosphine, sulfonated rhodium cyclooctadiene triphenylphosphine, sulfonated ruthenium triphenylphosphine, or combinations thereof. Embodiments of the sensor may further include a gas permeable, water impermeable membrane, an outer covering, or combinations thereof.Type: GrantFiled: September 27, 2018Date of Patent: March 2, 2021Assignee: University of CincinnatiInventors: William R. Heineman, John A. Lynch, Daniel P. Rose, Julia Kuhlmann, Daoli Zhao, Peng Zhang, Michael E. Smith
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Patent number: 10933135Abstract: Methods for the treatment of cardiac hypertrophy are described. Additionally, the presently disclosed subject matter relates to the use of small molecule compounds for the inhibition of Human antigen R (HuR)-mRNA interaction, and more particularly for the reduction of nuclear factor of activated T cells (NFAT) transcriptional activity. Novel methods of screening for small molecule compounds for inhibition of RNA binding proteins interaction with their target RNA (such as HuR-mRNA interactions) or for inhibition of DNA binding proteins to their target DNA are also described.Type: GrantFiled: April 5, 2017Date of Patent: March 2, 2021Assignee: University of CincinnatiInventors: Michael Tranter, Sarah Anthony, Samuel Slone
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Patent number: 10934591Abstract: The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to the patient with the cancer. The method includes detecting osteopontin-c (OPN-c), wherein the presence of high amounts of OPN-c in the cancer sample indicates that the subject has a more aggressive form of cancer (e.g., grade 3).Type: GrantFiled: December 13, 2017Date of Patent: March 2, 2021Assignees: VENTANA MEDICAL SYSTEMS, INC., UNIVERSITY OF CINCINNATIInventors: Mana Mirza, Elizabeth Shaughnessy, John K. Hurley, Kristie A. Vanpatten, Gary Pestano, Georg F. Weber
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Patent number: 10932761Abstract: A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220) from outside contaminants when the device (200) is placed on the skin (12). The sweat sensor device (200) may include an absorbing medium (230) to absorb sweat from the skin (12) that is covered by the seal (280). The seal (280) can be permeable to gas, permeable to water and impermeable to at least one aqueous solute, or selectively permeable to at least one aqueous solute. The sweat sensor device (200) may include an artificial sweat stimulation mechanism (345) for stimulating sweat when the device (200) is placed on the skin (12).Type: GrantFiled: May 28, 2015Date of Patent: March 2, 2021Assignee: University of CincinnatiInventor: Jason C. Heikenfeld
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Patent number: 10900965Abstract: Disclosed are kits and methods for determining the presence or absence of an antibody of interest in a biological sample of a subject. In particular, the methods may detect either pathological or beneficial antibodies. The method may include the step of contacting a biological sample from a subject with a substrate conjugated to an antigen and an Fc receptor operatively linked to a detectable label. Detection of the label may indicate the presence or absence of an antibody of interest.Type: GrantFiled: August 24, 2016Date of Patent: January 26, 2021Assignee: University of CincinnatiInventors: E. Steve Woodle, Alin Lucian Girnita
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Patent number: 10888244Abstract: Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume and/or a sweat generation rate, both of which may be measured or predetermined.Type: GrantFiled: November 16, 2018Date of Patent: January 12, 2021Assignee: University of CincinnatiInventor: Jason Charles Heikenfeld
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Publication number: 20210003499Abstract: A sensor for isolating, identifying, and quantifying one or more analytes in a sample is provided, the sensor having a metal substrate base and a polymer waveguide disposed on the metal substrate base, the polymer waveguide including an optical channel and a polymer disposed in the optical channel; wherein the polymer waveguide optically couples a first and a second fiber optic cable. Also provided herein are methods of using the sensor for isolating, identifying, and quantifying one or more analytes in a sample, the method including contacting the polymer waveguide with a sample, sequentially heating the sensor to a plurality of temperature thresholds, obtaining an optical output at each temperature threshold, and analyzing differences in sequentially-obtained optical outputs in order to identify and determine concentrations of individual analytes of interest in the sample.Type: ApplicationFiled: September 17, 2020Publication date: January 7, 2021Applicant: UNIVERSITY OF CINCINNATIInventors: Fred R. Beyette, JR., Geethanga Gayan De Silva
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Patent number: 10857356Abstract: Methods of treating a psychiatric disorder in a subject are provided which include placing at least one anode on an area of the subject's back over the dorsal spinal cord at the level of one or more of: thoracic vertebra 7 (T7), 8 (T8), 9 (T9), 10 (T10), 11 (T11), and 12 (T12) and lumbar vertebra 1 (L1); placing at least one cathode on an area of the subject's back which is generally rostral with reference to the anode; connecting the anode and the cathode to at least one source of direct and/or alternating electrical current; delivering direct current to the anode for a treatment period of time, the treatment period of time defining a tsDCS and/or tsACS treatment session, thereby modulating spinal input to the brain of the subject, decreasing sympathetic activity and reducing one or more symptoms and/or comorbidities associated with the psychiatric disorder.Type: GrantFiled: November 6, 2018Date of Patent: December 8, 2020Assignee: University of CincinnatiInventor: Francisco Romo-Nava
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Patent number: 10849518Abstract: Non-invasive electroencephalogram (EEG)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one channel of a scalp EEG of an injured brain hemisphere of the patient include (a) recording a baseline scalp EEG pattern in the patient at a channel exhibiting high amplitude delta activity; (b) recording a continuous scalp EEG pattern in the patient across a time frame at the at least one channel; and (c) detecting a spreading depolarization during the time frame by observing at least one feature indicative of a spreading depolarization in the continuous scalp EEG recording pattern relative to the baseline scalp EEG pattern at the at least one channel. Scalp EEG recordings are time-compressed prior to analysis. Methods of treating brain-injured patients and triaging brain-injured patients apply the non-invasive EEG methods.Type: GrantFiled: June 30, 2015Date of Patent: December 1, 2020Assignee: University of CincinnatiInventors: Jed A. Hartings, J. Adam Wilson, Jason M. Hinzman, Norberto Andaluz, Vincent DiNapoli, Sebastian Pollandt
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Patent number: 10854812Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.Type: GrantFiled: December 24, 2019Date of Patent: December 1, 2020Assignee: University of CincinnatiInventors: Rashmi Jha, Andrew Rush, Eric Herrmann
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Patent number: 10849627Abstract: A vascular implant device configured to decrease turbulence in blood flow through an arteriovenous fistula is described. The implant includes an arterial section having a straight hollow tube, a venous section having a curved hollow tube divided into an orthogonal portion at the juncture of the arterial section, a curved portion, and a straight extension portion, and having a continual lumen and lumen surface. The curved portion curves approximately 90 degrees with respect to the arterial section, and the extension portion extends substantially parallel to the arterial section. A plurality of flow-conditioning tabs are located along the lumen surface in arrangements precisely designed to convert the turbulent blood flow that enters the venous section into substantially laminar flow, and to minimize oscillatory shear stress on the venous endothelium as the blood flow exits the device and enters the vein.Type: GrantFiled: August 29, 2016Date of Patent: December 1, 2020Assignee: University of CincinnatiInventors: Keith Louis Saum, Prabir Roy-Chaudhury, Begona Campos-Naciff, Diego Celdran-Bonafonte
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Patent number: 10852615Abstract: A laminate which can serve as either a smart window or a smart mirror is formed using first and second substrates coated with transparent first and second electrodes which are separated by foraminous layer and a third grid-like linear electrode insulated from the first and second electrodes. The foraminous layer includes spacers defining a cell space which is filled with a colloidal ink having first and second particles. The first particles have a positive charge and a first color and second particles having a negative charge and a second color different from the first color. By altering the voltages of the first, second and third electrodes, one can achieve different light transmission characteristics which, for example, can alter the color temperature of the light transmitted through the laminate or enhance reflective colors.Type: GrantFiled: December 2, 2015Date of Patent: December 1, 2020Assignees: University of Cincinnati, Crown Electrokinetics Corp.Inventors: Tim R. Koch, Jason C. Heikenfeld, Sayantika Mukherjee
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Patent number: 10835519Abstract: Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or downstream pathway components of S6K1 or mTORC1, in association with administration of at least one inhibitor of PPAR?, PPAR?, or PGC1?. In various embodiments, the compound that inhibits S6K1, mTORC1, or upstream or downstream pathway components of S6K1 or mTORC1 is rapamycin, everolimus, temsirolimus, or imatinib. The inhibitor of PPAR?, PPAR?, or PGC1? can be an antagonist or an inverse agonist selected from GW6471, GSK3787, GSK0660, and ST247.Type: GrantFiled: December 22, 2017Date of Patent: November 17, 2020Assignee: University of CincinnatiInventors: David Plas, Catherine Behrmann
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Patent number: 10823661Abstract: A sensor for isolating, identifying, and quantifying one or more analytes in a sample is provided. Also provided are methods of isolating, identifying, and quantifying one or more analytes in a sample, the method including contacting a polymer waveguide with a sample, sequentially heating the polymer waveguide to a plurality of temperature thresholds, obtaining an optical output at each temperature threshold, and analyzing differences in sequentially-obtained optical outputs in order to identify and determine concentrations of individual analytes of interest in the sample.Type: GrantFiled: August 18, 2016Date of Patent: November 3, 2020Assignee: University of CincinnatiInventors: Fred R. Beyette, Jr., Geethanga Gayan De Silva
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Patent number: 10815526Abstract: Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying one or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of one or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome.Type: GrantFiled: November 25, 2014Date of Patent: October 27, 2020Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATIInventors: Christopher John Lindsell, Hector R. Wong
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Patent number: 10813581Abstract: Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from EEG recordings of confirmed spreading depolarizations (SD) in a reference brain-injured patient cohort; (b) recording an EEG of the brain injured patient to generate recorded EEG waveforms; (c) detecting a slow potential change present in a recorded EEG waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected SPC to a reference database of SD waveform template to identify a candidate SD; and (e) rejecting a candidate SD as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate SD as a detected SD.Type: GrantFiled: June 30, 2015Date of Patent: October 27, 2020Assignee: UNIVERSITY OF CINCINNATIInventors: Jed A. Hartings, Jonathan Adam Wilson
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Publication number: 20200330377Abstract: Novel sustained release biodegradable implants and methods of making and of using the same to treat ocular diseases are provided.Type: ApplicationFiled: May 26, 2020Publication date: October 22, 2020Applicant: University of CincinnatiInventors: Rupak Banerjee, Soumyarwit Manna, James Augsburger
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Patent number: 10806711Abstract: Described are inventions directed to methods of treating a cardiac dysfunction in a subject that includes administering an amount of probenecid effective to treat a symptom of cardiac dysfunction. The probenecid may be administered in at least one of an injection, orally, or transdermally. The amount of probenecid is sufficient to result in an improved performance on a standardized 6 minute walk test, an improved New York Heart Association (NYHA) classification, a lower diuretic dose requirement, a lower serum BNP levels, a normalization of serum sodium concentrations, and combinations thereof. In an embodiment, probenecid is administered over a period of about 8 hours to about 24 hours. Probenecid may be used for short term treatments, i.e., less than a week, or it may be administered in a long term manner, i.e., over a period of weeks, months, or even years.Type: GrantFiled: August 13, 2012Date of Patent: October 20, 2020Assignee: University of CincinnatiInventors: Jack Rubinstein, W. Keith Jones
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Publication number: 20200306565Abstract: Systems and methods for an enhanced ultrasound biofeedback therapy for an improved speech remediation treatment for an individual include transmitting a plurality of ultrasound (US) waves toward a tongue of the individual; receiving a plurality of reflected US waves; converting the plurality of reflected US waves into a plurality of US signals to transmit to an ultrasound machine; and generating one or more enhanced images of the tongue at least partially based on the US signals in real-time, the enhanced images including identified Regions of Interest (ROIs) along tongue sub-parts comprising the tongue root, the tongue dorsum, and the tongue blade and respective ROI points identified therein. An interactive visual story is generated and updated in real-time with a tongue-mapping trajectory of the individual on a display based on the enhanced one or more images to determine a successful or unsuccessful sound production.Type: ApplicationFiled: December 21, 2018Publication date: October 1, 2020Applicant: UNIVERSITY OF CINCINNATIInventors: Suzanne Boyce, Sarah Hamilton Dugan, T. Douglas Mast, Michael Riley