Patents Assigned to University of Cincinnati
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Patent number: 7705342Abstract: The present invention is a MEMS-based two-phase LHP (loop heat pipe) and CPL (capillary pumped loop) using semiconductor grade silicon and microlithographic/anisotrophic etching techniques to achieve a planar configuration. The principal working material is silicon (and compatible borosilicate glass where necessary), particularly compatible with the cooling needs for electronic and computer chips and package cooling. The microloop heat pipes (?LHP™) utilize cutting edge microfabrication techniques. The device has no pump or moving parts, and is capable of moving heat at high power densities, using revolutionary coherent porous silicon (CPS) wicks. The CPS wicks minimize packaging thermal mismatch stress and improves strength-to-weight ratio. Also burst-through pressures can be controlled as the diameter of the coherent pores can be controlled on a sub-micron scale. The two phase planar operation provides extremely low specific thermal resistance (20-60 W/cm2).Type: GrantFiled: September 8, 2006Date of Patent: April 27, 2010Assignee: University of CincinnatiInventors: H. Thurman Henderson, Ahmed Shuja, Srinivas Parimi, Frank M. Gerner, Praveen Medis
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Patent number: 7704563Abstract: Organofunctional silanes are applied to metal surfaces using an oil bath. Metal is immersed in an oil bath containing approximately 2% silane. In a preferred embodiment, the metal is a tire cord. The silane can either be hydrolyzed or unhydrolyzed. The hydrolyzed silanes can be in combination with a water dispersible resin. When the tire cord is coated with silane using the present method, it allows a tire to be formulated with lower sulfur levels and without cobalt.Type: GrantFiled: March 2, 2006Date of Patent: April 27, 2010Assignees: The University of Cincinnati, Ecosil Technologies LLCInventors: Charles Smith, Max Sorenson, William J. Van Ooij, Ramakrishna Nookala, Kevin Williams
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Patent number: 7700062Abstract: The synthesis of precipitated silica having improved chemical and physical properties of use as a reinforcing filler in polymeric matrices is described. Improvements in the properties result from the synthesis of the silica al a reduced ionic strength. In particular, the use of silicia acid during synthesis, provides a solution of reduced ionic strength, which favors the formation of improved colloidal structure via increased aggregation and reduced agglomeration. In addition, the surface of the silica precipitate formed may be modified by the addition of surface modifying agents, during synthesis to further enhance the desired reinforcing properties of the precipitated silica. The invention also embodies polymeric compositions of improved tensile and elongation strengths, with the compositions including precipitated silica, synthesized at reduced ionic strengths and having modified surfaces, in combination with a polymeric compound.Type: GrantFiled: October 12, 2001Date of Patent: April 20, 2010Assignee: University of CincinnatiInventors: Dale W. Schaefer, Chunyan Chen, Arthur Jing-Min Yang
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Patent number: 7695971Abstract: The use of sucrose polyester containing behenate fatty acid chains as a non-absorbable fat marker to determine total dietary fat absorption by the digestive tract of a subject. A test food for use in measuring fat absorption contains a non-absorbable fat and a dietary fat. The method is useful for diagnostic testing for diagnosing malabsorption of dietary fat by the digestive tract of the subject, and impairment of dietary fat digestion in the subject.Type: GrantFiled: August 5, 2004Date of Patent: April 13, 2010Assignees: Children's Hospital Medical Center, University of CincinnatiInventors: Ronald James Jandacek, Patrick Tso, James E. Heubi
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Patent number: 7642052Abstract: Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha-2C (?2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (?1Arg389) in a sample from the individual. Methods for delaying development of cardiovascular disease in an individual, methods for delaying progression or early death associated with cardiovascular disease in an individual, methods of genetic counseling for cardiovascular disease in an individual are also provided.Type: GrantFiled: September 9, 2003Date of Patent: January 5, 2010Assignee: University of CincinnatiInventors: Kersten M. Small, Stephen B. Liggett
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Patent number: 7608127Abstract: The present invention relates to particle reinforced noble metal matrix composites and a method of making the same. The composites include a noble metal such as silver, gold, and alloys thereof, as a base or matrix, and a particle reinforced filler material, such as a carbide. A pressureless infrared heating, or superheating, process is used to produce the particle reinforced noble metal matrix composites thereby providing a composite with at least sufficient hardness, i.e. wear resistance, and/or low resistivity. The composites may be used in the jewelry industry, such as for making watches, rings, and other jewelry, and/or in the power, automobile, and aircraft industries, such as for making electrical contact materials.Type: GrantFiled: February 22, 2008Date of Patent: October 27, 2009Assignee: The University of CincinnatiInventors: Ray Y. Lin, Donald E. Stafford
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Patent number: 7600410Abstract: A system for optically characterizing an acoustic beam generally includes an immersant, which is an immersion medium seeded with a plurality of seed particles that respond to illumination with fluorescence indicative of at least one parameter of the immersant such as flow or temperature. Optical transmitters illuminate the immersant slicewise, and optical receptors receive the fluorescence in order to generate a three-dimensional map of the parameter over time. A processor back-calculates one or more characteristics of an acoustic beam that results in the map. The processor initially generates a behavior model of an acoustic beam propagating in the immersant by utilizing initial guesses for the characteristics. The initial guess model is compared to the map, and an optimization routine is used to refine the initial guesses. The process repeats iteratively with refined guesses until the difference between the model and the map is minimized.Type: GrantFiled: December 21, 2006Date of Patent: October 13, 2009Assignees: St. Jude Medical, Atrial Fibrillation Division, Inc., The United States of America as represented by the Secretary Department of Health and Human Services, The University of CincinnatiInventors: John W. Sliwa, Jr., Prasanna Hariharan, Ronald A. Robinson, Matthew R. Myers, Subha Maruvada, Rupak K. Banerjee, Gerald R. Harris
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Patent number: 7572603Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system disease.Type: GrantFiled: September 22, 2005Date of Patent: August 11, 2009Assignee: University of CincinnatiInventors: Kersten M. Small, Stephen B. Liggett
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Patent number: 7539580Abstract: A computer implemented method for examining data from a chemical analyzer for artifactual results is provided. A set of rules are established to identify artifactual results based upon experience with the analyzer. Each rule can be associated with a sample collection or testing problem which potentially caused the artifactual result. Using these rules, output data from the analyzer can be tested to see if any of the rules are satisfied. If a rule is satisfied, then an artifactual result can be indicated, as well as the potential cause of the artifactual result. An output file can be created which indicates the artifactual data samples and the potential artifactual causes. The rules file and output file may be provided in a user-friendly format, such as in a spreadsheet or database application format.Type: GrantFiled: August 1, 2005Date of Patent: May 26, 2009Assignee: University of CincinnatiInventors: Amadeo J. Pesce, Marios M. Polycarpou, Zhong Wang, Goce Dimeski, Peter Hickman
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Publication number: 20090124534Abstract: Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click polymers of the present invention provide increased stability in serum as compared with other non-viral vectors, and are particularly useful in protecting nucleic acids against degradation.Type: ApplicationFiled: June 6, 2008Publication date: May 14, 2009Applicant: University of CincinnatiInventor: Theresa Marie Reineke
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Patent number: 7482421Abstract: A silane film that can be used in a wide range of environments, on metals of engineering interest, as a standalone process or as a primer for a top-coating by common paint systems. The film generally comprises: a) at least one bis-silane; b) a water soluble or dispersible polymer; c) nanoparticles; and, d) a water soluble solvent. It is also within the scope of the present invention to include a leachable inhibitor into the silane film. In sum, the present invention teaches a silane composition that may be applied by dipping, wiping, spraying, brushing, or other conventional techniques, whereby the film composition provides a metal treatment that is water soluble and may provide the availability of the coating to “heal” by utilizing a leachable inhibitor whenever damage occurs from scrapes or scratches.Type: GrantFiled: January 24, 2005Date of Patent: January 27, 2009Assignee: The University of CincinnatiInventors: Wim J. van Ooij, Anuj Seth, Matthew B Stacy
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Patent number: 7465710Abstract: This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.Type: GrantFiled: September 13, 2005Date of Patent: December 16, 2008Assignee: University of CincinnatiInventors: Ambikaipakan Balasubramanium, William T. Chance
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Patent number: 7452720Abstract: An apparatus and method of using the apparatus to prepare a biocompatible biodegradable matrix capable of supporting cells to form an implantable or engraftable surgical device. A matrix-forming fluid is contained within a chamber defined by top and bottom surfaces of a thermally conductive material and spacers defining the thickness of the matrix. The chamber is then cooled to freeze the solution at a controlled rate, resulting in a matrix with a desired and uniform thickness having symmetric and uniform reticulations. The apparatus and method reproducibly forms such a matrix, which may be populated with cells for transplantation and engraftment into a wound.Type: GrantFiled: June 2, 2005Date of Patent: November 18, 2008Assignees: University of Cincinnati, Shriners Hospitals for ChildrenInventor: Steven T. Boyce
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Patent number: 7450983Abstract: Brain Magnetic Resonance Imaging (MRI), Computerized Tomotography (CT), or other diagnostic modalities may employ a three-step procedure during initial (“scout”) cranial pre-scans that corrects for patient positioning (i.e., roll, yaw and pitch) to reduce inter- and intra-patient variation, thereby enhancing the diagnostic and comparative value of subsequent detail scans even across different diagnostic platforms. In MRI, for instance, locating the saggital sinus (SS) and optimizing a line to bisect the brain through this SS may be automated to correct for roll and yaw. By then identifying the contour of the corpus callosum in a lateral saggital scout scan, the Talairach anterior commissure (AC)—posterior commissure (PC) reference line may be found for correcting pitch. Prescription of detailed scans are improved, especially when the three-step correction is repeated periodically identifying the need to repeat a detailed scan or to adjust the coordinates of a subsequent scan.Type: GrantFiled: March 18, 2004Date of Patent: November 11, 2008Assignee: University of CincinnatiInventor: Kenneth L. Weiss
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Patent number: 7449292Abstract: Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of ?1-adrenergic receptor are provided. The Gly389 ?1-adrenergic receptor variants are not as responsive to treatment ? blockers such as carvedilol, metoprolol or bisoprol. Thus, genotyping ?1-adrenergic receptor polymorphisms is useful for predicting relative responsiveness to treatment with beta blockers. The Gly389 polymorphism also may be used, alone or in conjunction with other adrenergic receptor polymorphisms, to predict relative risk of developing cardiovascular diseases such as heart failure or to predict relative survival rate in patients with heart failure or other cardiovascular diseases. Also provided are transgenic mice and transgenic cells expressing the ?1-adrenergic receptor polymorphisms, and their use in identifying therapeutic agents.Type: GrantFiled: September 13, 2004Date of Patent: November 11, 2008Assignee: University of CincinnatiInventors: Stephen Bryant Liggett, Lynne Elizabeth Wagoner
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Patent number: 7430355Abstract: A signage device comprising one or more light sources, a waveguide or arrangement of waveguides and photoluminescent features coupled thereto. In one embodiment, a waveguide is adapted to receive light of a first wavelength and the photoluminescent features are adapted to emit light of a second wavelength in response to receiving light of the first wavelength.Type: GrantFiled: September 27, 2006Date of Patent: September 30, 2008Assignee: University of CincinnatiInventors: Jason C. Heikenfeld, Andrew J. Steckl, John D. Rudolph
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Publication number: 20080221038Abstract: This invention relates generally to peptides including tripeptides and to methods for pharmaceutical treatment of mammals using such tripeptides and analogs thereof. More specifically, the invention is directed to neuropeptide Y (“NPY”) receptor antagonists and agonists including O-glycosylated tripeptides, i.e. O-glycopeptides, and extended tripeptides, and their analogs, as well as to PYY analogs, to pharmaceutical compositions containing such tripeptides and PYY analogs, and to methods of treatment of mammals using such tripeptides and PYY analogs. In addition, the invention relates to methods of treatment of mammals using such tripeptides and PYY analogs for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.Type: ApplicationFiled: July 19, 2005Publication date: September 11, 2008Applicant: The University oif CincinnatiInventor: Ambikaipakan Balasubramaniam
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Patent number: 7380224Abstract: A computerized method and system for solving non-linear Boolean equations is disclosed comprising at least partially solving a Boolean function; developing at least one inference regarding said Boolean function and saving said inference to a state machine; and accessing said inference from said state machine to develop at least one heuristic for determining whether said Boolean function is satisfiable.Type: GrantFiled: March 25, 2005Date of Patent: May 27, 2008Assignees: The United States of America as represented by the National Security Agency, The University of CincinnatiInventors: John V. Franco, W. Mark VanFleet, John Schlipf, Michael R. Dransfield
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Patent number: 7378385Abstract: GLP-1 and GLP-1 receptor antagonists have been found to have a sedative or anxiolytic effect on the mammalian central nervous system. Conversely, GLP-1 and GLP-1 receptor agonists increase nervous system activity and the stress response. The invention relates, in one aspect, to the use of GLP-1 agonists and antagonists to modulate the stress response in a mammal. In an aspect GLP-1 and GLP-1 receptor antagonists are used to treat stress-related disorders.Type: GrantFiled: August 6, 2003Date of Patent: May 27, 2008Assignee: University of CincinnatiInventors: Randy John Seeley, David A. D'Alessio, Kimberley P. Kinzig
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Patent number: 7361191Abstract: An actuation system for assisting the operation of the natural heart comprises a framework for interfacing with a natural heart, through the wall of the heart, which includes an internal framework element configured to be positioned within the interior volume of a heart and an external framework element configured to be positioned proximate an exterior surface of the heart. The internal framework is flexibly suspended with respect to the external frame. An actuator system is coupled to the framework and configured to engage an exterior surface of the heart. The actuator system comprises an actuator band extending along a portion of a heart wall exterior surface. The actuator band is selectively movable between an actuated state and a relaxed state and is operable, when in the actuated state, to assume a predetermined shape and thereby indent a portion of the heart wall to effect a reduction in the volume of the heart.Type: GrantFiled: July 14, 2003Date of Patent: April 22, 2008Assignee: The University of CincinnatiInventor: David Boyd Melvin