Abstract: A method of transcranial ultrasound thrombolysis comprises the steps of providing a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing the M1 branch and M2 branches of the middle cerebral artery of an individual. A thrombolytic agent is also administered to the individual. A transcranial ultrasound thrombolysis system (10) is also provided that includes a transducer (20). The transducer is adapted to provide a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing at least a substantial portion of the M1 branch and the M2 branches of the middle cerebral artery in one hemisphere of a brain.

Abstract: A simultaneous multianalyte electrochemical assay includes a cell which has a surface and the surface includes analyte binding sites i.e., antibodies or antigens on a solid phase at distinct separate locations. Separate working electrodes are located within proximity to these separate locations. Enzyme labeled antibodies or antigens depending on the assay format are added and the enzyme reaction product measured, by simultaneous amperometric measurement with the independent electrode in each area. The electrodes are spatially separated from adjacent analytes so that a measurement can be taken before cross-interference due to diffusion of product from adjacent analyte areas.

Abstract: The invention relates to antisense oligonucleotides, in particular to antisense oligonucleotides to receptor genes, and the use of such oligonucleotides to regulate reproductive function and as chemopreventive or as a chemotherapeutic for various cancers, especially ovarian cancers. The invention also provides a method for preventing estrogen synthesis, a function of developing ovarian follicles, a therapeutic consideration for the prevention and treatment of some cancers of the breast, endometrium, ovary and cervix and of some endometriosis. The invention also relates to pharmaceutical compositions containing antisense oligonucleotides (ODNs, having 8 to 60 nucleotides) that act by binding to intracellular molecular targets. Optionally, for efficient delivery to a target DNA, RNA or protein, the ODNs may be covalently linked to a carrier moiety, which facilitates delivery of the ODN to the cytosol.

Abstract: This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof, to pharmaceutical compositions containing such Y4 receptor agonists, and to methods for treatment of mammals using the same. The NPY Y4 receptor agonists may be administered to mammals either alone or in combination with NPY Y2 receptor agonists including peptide YY (PYY) (3-36), analogs thereof, and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof, such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.

Abstract: The invention relates generally to the use of pharmaceutical compositions to increase milk production alone or in combination with certain biological active ingredients. Specifically, the method relates to the use of pharmaceutical compositions that will act on the feedback of the intrinsic regulatory pathway in the mammalian mammary gland. The present invention provides for as a method of increasing bovine milk production as well as a method of correcting certain human lactation abnormalities. Preferably, the compounds used in the methods of the present invention are one or more active agents capable of inhibiting peripheral aromatic amino acid decarboxylase (AADC) enzymes, peripheral tryptophan hydroxylase (TPH) enzymes, peripheral serotonin (5-HT) enzymes, or a combination of enzymes thereof.

Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B adrenergic receptor and expressed alpha-2B adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system diseases.

Abstract: The present invention is a MEMS-based two-phase LHP (loop heat pipe) and CPL (capillary pumped loop) using semiconductor grade silicon and microlithographic/anisotrophic etching techniques to achieve a planar configuration. The principal working material is silicon (and compatible borosilicate glass where necessary), particularly compatible with the cooling needs for electronic and computer chips and package cooling. The microloop heat pipes (?LHP™) utilize cutting edge microfabrication techniques. The device has no pump or moving parts, and is capable of moving heat at high power densities, using revolutionary coherent porous silicon (CPS) wicks. The CPS wicks minimize packaging thermal mismatch stress and improves strength-to-weight ratio. Also burst-through pressures can be controlled as the diameter of the coherent pores can be controlled on a sub-micron scale. The two phase planar operation provides extremely low specific thermal resistance (20-60W/cm2).

Abstract: The present invention includes polymorphisms in nucleic acids encoding the alpha-2A adrenergic receptor and expressed alpha-2A adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms and transgenic animals expressing alpha-2A adrenergic receptor molecules. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system diseases.

Abstract: A method of treating a metal surface by application of a solution containing at least one vinyl silane and at least one bis-silyl aminosilane. A solution composition having at least one vinyl silane and at least one bis-silyl aminosilane is also provided, along with a silane coated metal surface.

Abstract: The invention relates to textiles, reservoirs, or films which may be switchably rendered hydrophilic or hydrophobic for liquid wicking, repelling, moving, holding, absorbing, drying, wetting, dispensing, and other means of electrically manipulation of liquids.

Abstract: The present invention relates to a process for the production of substituted 5-isoxazolidinone antibiotics. More specifically the patent relates to the production of compounds that mimic the antibiotic action of ?-lactams, are resistant to ?-lactamase degradation, and inhibit all classes of ?-lactamase.

Abstract: A recombinant nucleic acid is provided having an avian promoter. One embodiment of the present invention contemplates the use of a gut-specific promoter, wherein a promoter can be the chicken intestinal fatty acid binding protein promoter region. A method for making a transgenic bird is also disclosed by transfecting a bird with a vector comprising a recombinant nucleic acid comprising a chicken intestinal fatty acid binding protein promoter region operably linked to a heterologous nucleic acid expressing a desired polypeptide to be expressed in the gut tissue of an avian.

Abstract: A light emissive display having a specular waveguide that propagates short wavelength light and photoluminescent features adjacent to the waveguide that fluoresce, for example, in visible red, green, blue, and mixed colors when selectively coupled with the short wavelength light. The photoluminescent layers emit light primarily and, therefore, efficiently in the direction of an observer only. This light emissive display may be utilized as a planar light source, as patterned information signage, or as a re-configurable information display containing intensity modulated pixels. The light emissive display may be enhanced optically such that only a small portion of ambient light is reflected from the display while preserving the majority of emitted display luminance.

Abstract: Light-emitting devices having a semiconductor phosphor layer formed by metalorganic chemical vapor deposition (MOCVD). The semiconductor phosphor layer may be any Group III nitride semiconductor compound that is in-situ doped during MOCVD deposition with one or more dopants effective to act as luminescent centers. The MOCVD deposition conditions required for the formation of these extrinsic luminescent films differ significantly from the MOCVD deposition conditions utilized to deposit intrinsic GaN luminescent films.

Abstract: Strong authentication of packets sent between nodes of different clusters in a two-tier ad hoc network is provided by the cluster heads. Each cluster head authenticates nodes that enter the cluster. Thereafter, when a sending node requests a session from its cluster head with a receiving node in another cluster, the cluster head negotiates a session secret key (SSK) with the corresponding cluster head of the receiving node. Further, the cluster head provides authentication tags for the sending node to use with each packet. Each authentication tag is time-stamped, digitally signed by the cluster head, encrypted with the SSK, and includes indicators of message integrity, including a sequence number and TCP header field of checksum. The sending node further calculates a check result from a number of the authentication tags, encrypted with the SSK, so that the receiving node can authenticate the number of packets.

Abstract: Abstract of the Disclosure The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the ?1-adrenergic receptor (AR).

Abstract: The DTF optical memory makes use of the property of dielectric thin film interference to create multi-color pixels and serve as a multi-level optical memory device. The fabrication of the device comprises a dielectric thin film deposited on a substrate that is micro-milled utilizing focused ion beam (FIB) technology. Such micro-milling creates pixels of varying depth that when exposed to a broad-band light source create distinct colors caused by the properties of thin film interference and superposition of reflected light from the broad band source, thus creating an effective optical memory device that may be detected using a color CCD camera or a photo-detector array. Accurate creation and detection of discrete colors allows accurate digital encoding and direct storage of color image in a format of sub-micron pixel array. The robustness of the DTF optical memory device allows operation under harsh environmental conditions, including high temperatures and radiation.

Abstract: An actuation system for assisting the operation of a natural heart is disclosed. The actuation system includes a framework for interfacing with the natural heart and a power system that can be coupled to the framework. The framework includes an internal framework element and an external framework element. The power system is configured to engage an exterior surface of the heart wall, and includes an actuator mechanism for exerting force on the heart wall, a driving mechanism for actuating the actuator mechanism, a transmission mechanism coupled between the actuator mechanism and the driving mechanism for transmitting power to the actuator mechanism, and a carrier device coupled between the actuator mechanism and the driving mechanism and configured for housing the transmission mechanism. The modular power system is configured for being freely exchanged and replaced in the actuation system while leaving the framework elements in place and generally undisturbed.

Abstract: Provided is a method for correcting a non-line-of-sight (NLOS) error in a wireless positioning system that enhances the location accuracy of a mobile station by correcting location error caused by NLOS propagation when the mobile station is positioned in a wireless mobile communication environment, and a computer-readable recording medium for recording a program that implements the method. The method checks out the location of the MS in the above environment and provides diverse services by correcting the location error caused by NLOS propagation included in a received signal. That is, a user can enjoy a high-quality location service by receiving the location information only within the radius which user wants, such as traveler's information, vehicle tracking, location service, and location-based advertisements, because the location of the user's MS is detected precisely.

Abstract: A process for the encapsulation of liquid particles within nanometer thick polymer shells utilizes an interfacial free radical alternating copolymerization process. Encapsulating a liquid material includes providing a mixture comprising the liquid material to be encapsulated, a hydrophobic monomer in a non-polar solution and a hydrophilic monomer in a polar solution. The liquid material is compatible in either the polar solution or the non-polar solution. The polar solution and the non-polar solution are not miscible in each other. The mixture is homogenized to form an emulsion, and then polymerized by an initiator which initiates an interfacial free radical alternating copolymerization process. The copolymerization process is optimally constrained to proceed only at the hydrophobic and hydrophilic interface thus forming a polymer around the liquid material.