Patents Assigned to University of Colorado, A Body Corporate
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Publication number: 20240159942Abstract: A microlens array includes a bottom electrode chip, a sidewall electrode chip, and a top glass chip configured to cooperate to define an array of cavities, each one of the array of cavities containing a fluid. The fluid is a mixture of a polar liquid and a non-polar liquid, in contact with one of the array of sidewalls at a contact angle. The bottom electrode chip includes a plurality of electrical contacts. The sidewall electrode chip includes an array of sidewalls, each including an electrode layer and an insulator layer. When a voltage is applied across the fluid contained a cavity via electrical contacts and the electrode layer of the cavity, the contact angle of the fluid with the sidewall is modified, in embodiments without affecting the contact angle of fluid contained in other ones of the plurality of array of cavities.Type: ApplicationFiled: November 13, 2023Publication date: May 16, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: Juliet T. Gopinath, Samuel D. Gilinsky, Mo Zohrabi, Victor M. Bright, Omkar D. Supekar, Wei Yang Lim
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Patent number: 11981760Abstract: The present invention relates to the unexpected discovery of a cross-linked polymer of 2-hydroxyethyl methacrylate and dipicolylamine-containing monomers that can be used as a therapeutic lens to treat ocular diseases or disorders associated with matrix metalloproteinase (MMP) over-activity and/or over-expression, such as but not limited to corneal melting (or keratolysis).Type: GrantFiled: June 28, 2019Date of Patent: May 14, 2024Assignees: The Regents of the University of Colorado, a body corporate, University of New HampshireInventors: Jung-Jae Lee, Kyung Jae Jeong
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Patent number: 11976328Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.Type: GrantFiled: July 14, 2020Date of Patent: May 7, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: David A. Schwartz, Tasha E. Fingerlin, Weiming Zhang
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Patent number: 11975314Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.Type: GrantFiled: August 19, 2022Date of Patent: May 7, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Staci A. Moulton, Alan W. Weimer
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Patent number: 11971535Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.Type: GrantFiled: April 20, 2020Date of Patent: April 30, 2024Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Juliet T. Gopinath, Emily A. Gibson, Victor M. Bright, Richard Weir, Diego Restrepo, Baris Ozbay
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Patent number: 11965831Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.Type: GrantFiled: March 1, 2019Date of Patent: April 23, 2024Assignee: The Regents of the University of Colorado, a Body CorporateInventors: Juliet T. Gopinath, Brendan M. Heffernan, Robert Niederriter, Stephanie A. Meyer, Diego Restrepo, Emily A. Gibson, Mark E. Siemens
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Patent number: 11964985Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.Type: GrantFiled: May 12, 2020Date of Patent: April 23, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
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Patent number: 11960247Abstract: According to some aspects of the present disclosure, an atomic clock and methods of forming and/or using an atomic clock are disclosed. In one embodiment, an atomic clock includes: a light source configured to illuminate a resonance vapor cell; a narrowband optical filter disposed between the light source and the resonance vapor cell and arranged such that light emitted from the light source passes through the narrowband optical filter and illuminates the resonance vapor cell. The resonance vapor cell is configured to emit a signal corresponding to a hyperfine transition frequency in response to illumination from the light source, and a filter cell is disposed between the light source and the resonance vapor cell and configured to generate optical pumping. An optical detector is configured to detect the emitted signal corresponding to the hyperfine transition frequency.Type: GrantFiled: May 15, 2023Date of Patent: April 16, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Svenja Knappe, Sean Krzyzewski
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Publication number: 20240120091Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.Type: ApplicationFiled: December 4, 2023Publication date: April 11, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: Robin Deterding, Tam Vu
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Patent number: 11952576Abstract: A novel method of diluting the structures in the cell population, such that individual cells, dependent on the activity of the structures, become single measurement devices. This can be applied to all Bacterial Microcomparments (“BMCs”), organelles, and macromolecules, and could provide a universal method for the design of novel ones and understanding of the diverse structures. In one aspect the present invention provides A method of creating a bacterial strain with inducible and detectable carboxysomes. The method includes the steps of incorporating a labeled carbon-fixation enzyme into the genome of a bacterium; deleting all or a portion of the ccm operon from the bacterium; and reintroducing a ccm operon comprising an inducible promoter to create a ?ccm+ strain.Type: GrantFiled: November 16, 2020Date of Patent: April 9, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Jeffrey Carlyle Cameron, Nicholas C. Hill, Jian Wei Tay, Sabina Altus, David Matthew Bortz, Kristin Ann Moore
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Patent number: 11944725Abstract: The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, the at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.Type: GrantFiled: June 28, 2019Date of Patent: April 2, 2024Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Parnaz Boodagh, Wei Tan, Michael Floren
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Patent number: 11946598Abstract: Methods, systems, and devices for ultra or extreme-high vacuum are described. Such systems may comprise a vacuum chamber, a target within the vacuum chamber, two or more overlapping radiation shields arranged within an inner vacuum space of a vacuum chamber, and surrounding at least a portion of the target, a first and a second cooling element unit thermally coupled to a first and second radiation shield of the two or more overlapping radiation shields, wherein the first unit is configured to reduce the first radiation shield's temperature to at least <100K, and the second unit is configured to reduce the second radiation shield's temperature to at least <25K, and a third cooling element unit coupled to the target and isolated from the first and second radiation shield, wherein the third cooling element unit is configured to reduce the target's temperature to at least <4K.Type: GrantFiled: September 12, 2019Date of Patent: April 2, 2024Assignee: The Regents of of the University of Colorado, a body corporateInventors: Daniel Dessau, Justin Griffith
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Publication number: 20240092837Abstract: The present invention describes peptides, peptides carriers, peptide nanobodies, and peptide-drug covalent conjugates having efficient cell and tissue penetration. The peptides and associated configurations can be used in covalent attachments or as complexes or nanoparticles in conjunction with therapeutic agents to enhance their tissue, cellular, and intracellular delivery. Also, the peptides and associated configurations can enhance binding to negatively charged matrices in the body for improved localization or retention of therapeutic carriers and agents.Type: ApplicationFiled: July 26, 2023Publication date: March 21, 2024Applicant: The Regents of the University of Colorado, A Body CorporateInventors: Uday Kompella, Arun Upadhyay
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Patent number: 11932867Abstract: Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.Type: GrantFiled: April 25, 2018Date of Patent: March 19, 2024Assignees: National Jewish Health, The Regents of the University of Colorado, a Body CorporateInventors: Brian Freed, Kirsten Anderson, Christina Roark, Jennifer Matsuda
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Publication number: 20240075189Abstract: A two-component biomaterial and method that replicates both the structural complexity and diverse molecular composition necessary to create a tissue's form and function. It is an objective of the current invention to use the unique combination material and methods herein to provide a pharmaceutical composition, a medical device, a tissue regeneration scaffold, as well as a scaffold for 3D organ culture (tissue on a chip, lab grown meat, research stem cell differentiation) comprising a significant amount of acellular tissue particles packed tightly and held together via crosslinking between the acellular particles and a thiolated protein.Type: ApplicationFiled: December 14, 2021Publication date: March 7, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: Jeanne Barthold, Corey P. Neu
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Publication number: 20240077778Abstract: Surface polarity of a ferroelectric nematic can be configured to generate vectorial control of the orientation of its bulk polarization field. The contact between a surface with in-plane polarity and a ferroelectric nematic liquid crystal generates preferred in-plane orientation of the ferroelectric polarization field at that interface, which can lead to the formation of fluid or glassy monodomains of high polarization without electric field poling.Type: ApplicationFiled: December 30, 2021Publication date: March 7, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: Noel A. Clark, Xi Chen, Joseph E. Maclennan, Matthew A. Glaser
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Patent number: 11916522Abstract: A wideband amplifier includes a first diplexer receiving broadband input signals and divides them by frequency into a low band input signal and a high band input signal. The amplifier has separate high band and low band amplifiers coupled to amplify the low and high band input signals, and a second diplexer coupled to combine outputs of the low and high band amplifiers to form a wideband output. A method of amplification of an input signal includes separating the input signal into high and low band signals, separately amplifying the high and low band signals, and combining amplified high and low band signals into an output signal.Type: GrantFiled: May 20, 2021Date of Patent: February 27, 2024Assignees: The Regents of the University of Colorado, a body corporate, Massachusetts Institute of TechnologyInventors: Philip Zurek, Zorana Popovic
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Patent number: 11911532Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.Type: GrantFiled: March 29, 2018Date of Patent: February 27, 2024Assignee: The Regents Of The University of Colorado, A Body CorporateInventors: Robin Shandas, Steven Lewis, Daewon Park, Omid Jazaeri, Steven Lammers, James Bardill, Brisa Pena-Castellanos
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Publication number: 20240058817Abstract: A system and method for nanoparticle synthesis employing an adhesiveless, deconstructable microfluidic mixing chip and an expandable wireless network of syringe pumps fluidly coupled to one or more microfluidic mixing chips. The wireless network of syringe pumps is controlled by a microprocessor with feedback from each of the syringe pumps in the network to allow for both individual, grouped and multiplexed control over the plurality of syringe pumps in the network.Type: ApplicationFiled: July 26, 2023Publication date: February 22, 2024Applicant: The Regents of the University of Colorado, A Body CorporateInventors: Uday Kompella, Jonathan Taylor
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Patent number: 11905267Abstract: Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid.Type: GrantFiled: January 8, 2021Date of Patent: February 20, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Steven Sartor, Niels Damrauer, Garet Miyake, Cameron Chrisman, Ryan Pearson