Patents Assigned to University of Colorado
  • Precise mechanical disruption for intracellular delivery to cells and small organisms
    Patent number: 11685891
    Abstract: The invention relates to a microfluidic poration device having narrow channels slightly smaller than the width of a target cell, wherein the channels are lined with a plurality of nanospikes in a row extending down the middle of the channel, i.e. in a row parallel to the sides of the channel. In one embodiment, one channel may have 2 nanospikes (or 2 nanolancets). Thus, in particular embodiments, the invention provides microfluidic poration devices capable of simultaneously squeezing cells while piercing holes in their membranes for allowing foreign molecules into cells. The holes in porated cells spontaneously close after exiting the channels, thus entrapping the foreign molecules inside of the target cells. This porated cell population has approximately a 95% viability with greater than 50% containing at least one foreign molecule.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: June 27, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Xiaoyun Ding, Apresio Kefin Fajrial
  • Capacitive Self-Sensing for Electrostatic Transducers with High Voltage Isolation
    Publication number: 20230200250
    Abstract: Transducer systems disclosed herein include self-sensing capabilities. In particular, electrostatic transducers include a low voltage electrode and a high voltage electrode. A low voltage sensing unit is coupled with the low voltage electrode of the electrostatic transducer. The low voltage sensing unit is configured to measure a capacitance of the electrostatic transducer, from which displacement of the electrostatic transducer may be calculated. High voltage drive signals received by the high voltage electrode during actuation may be isolated from the low voltage sensing unit. The isolation may be provided by dielectric material of the electrostatic transducer, a voltage suppression component, and/or a voltage suppression module comprising a low impedance ground path. In the event of an electrical failure of the transducer, the low voltage sensing unit may be isolated from high voltages.
    Type: Application
    Filed: May 29, 2021
    Publication date: June 22, 2023
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Nikolaus Correll, Khoi D. Ly, Nicholas Alexander Kellaris, Christoph Matthias Keplinger
  • Bioprinter and methods of manufacturing an organomimetic device
    Patent number: 11679546
    Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: June 20, 2023
    Assignee: The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Kambez Benam, Alexander Kaiser
  • 2-naphthimidamides, analogues thereof, and methods of treatment using same
    Patent number: 11679093
    Abstract: The present invention relates in certain aspects to the discovery of novel 2-naphthimidamide compounds that are capable of binding Type II Transmembrane Serine Proteases (TTSPs). In certain embodiments, the compounds of the invention can be used to treat or prevent Influenza A viral infection in a mammal.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: June 20, 2023
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Kambez Hajipouran Benam
  • Adjustable loop fiber optic illumination device for surgery
    Patent number: 11672700
    Abstract: The present disclosure provides an adjustable endoscopic surgical device for illuminating a tissue surface with diffuse and oblique light. In some embodiments, light emanates from the sides of an optical fiber, which is optionally formed at least in part into a loop shape.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: June 13, 2023
    Assignee: The Regents of the University of Colorado
    Inventor: Jeffrey L. Olson
  • Optical imaging devices and variable-focus lens elements, and methods for using them
    Patent number: 11675181
    Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: June 13, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Juliet T. Gopinath, Emily A. Gibson, Victor M. Bright, Richard Weir, Diego Restrepo, Baris Ozbay
  • Hi-fidelity bioaerosol condensation capture directly into genomic preservatives
    Patent number: 11662280
    Abstract: This invention relates generally to characterizing bioaerosols and, more particularly, to a system for recovering, quantifying, identifying, and assessing the metabolic activities of bioaerosols based on their major biopolymer profiles (lipids, carbohydrate and protein) and more specific their genetic materials (DNA/RNA), such as airborne viruses, bacteria, fungi and pollens.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: May 30, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, AEROSOL DEVICES, INC.
    Inventors: Mark Hernandez, Patricia B. Keady
  • Machine learning systems and methods for improved localization of image forgery
    Patent number: 11663489
    Abstract: A system for improved localization of image forgery. The system generates a variational information bottleneck objective function and works with input image patches to implement an encoder-decoder architecture. The encoder-decoder architecture controls an information flow between the input image patches and a representation layer. The system utilizes information bottleneck to learn useful residual noise patterns and ignore semantic content present in each input image patch. The system trains a neural network to learn a representation indicative of a statistical fingerprint of a source camera model from each input image patch while excluding semantic content thereof. The system can determine a splicing manipulation localization by the trained neural network.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: May 30, 2023
    Assignees: Insurance Services Office, Inc., The Regents of the University of Colorado
    Inventors: Aurobrata Ghosh, Steve Cruz, Terrance E. Boult, Maneesh Kumar Singh, Venkata Subbarao Veeravarasapu, Zheng Zhong
  • CO-TREATMENT WITH CDK4/6 AND CDK2 INHIBITORS TO SUPPRESS TUMOR ADAPTATION TO CDK2 INHIBITORS
    Publication number: 20230158034
    Abstract: The invention provides a method for treating a disease or disorder, and preferably cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a CDK2 inhibitor, and a therapeutically effective amount of a CDK4/6 inhibitor, wherein the CDK4/6 inhibitor prevents rebound phosphorylation mediated by CDK4 and/or CDK6 in response to the inhibition of CDK2.
    Type: Application
    Filed: April 7, 2021
    Publication date: May 25, 2023
    Applicants: Pfizer Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Mansi Arora, Stephen George Dann, Nichol Lee Goodman Miller, Sabrina Spencer, Todd Lee VanArsdale
  • METHODS FOR THE TREATMENT OF INFLAMMATORY JOINT DISEASE
    Publication number: 20230158114
    Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
    Type: Application
    Filed: January 25, 2023
    Publication date: May 25, 2023
    Applicants: Xalud Therapeutics, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Raymond A. Chavez, Linda May Rothblum Watkins, Robert Landry
  • IOL with drug delivery devices and uninterrupted PCO barrier edge
    Patent number: 11654014
    Abstract: An ophthalmic implant including an IOL with haptics, and drug delivery devices secured to the haptics. The posterior-most extent of the drug delivery device is located anterior to the posterior edge or PCE barrier edge, of the IOL. In other configurations, the drug delivery devices are provided with PCO barrier edges.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: May 23, 2023
    Assignees: SpyGlass Pharma, Inc., The Regents of the University of Colorado
    Inventors: Craig Alan Cable, II, Glenn R. Sussman, James R. Dennewill, Malik Y. Kahook
  • Cardiac and Vascular Access and Closure System and Method
    Publication number: 20230149003
    Abstract: Devices, systems and methods for cardiac and vascular access configured to allow for intracardiac access to conduct medical procedures. The devices, systems and methods are particularly useful in trans-cardiac extra-corporeal membrane oxygenation (ECMO) procedures, ventricular assist procedures, cardiopulmonary bypass, or other medical procedures where intracardiac access may be required.
    Type: Application
    Filed: October 28, 2022
    Publication date: May 18, 2023
    Applicants: Regents of the University of Colorado, ConneX Biomedical, Inc.
    Inventors: Max Bannister Mitchell, Jeremy H. Morgan
  • SYSTEM AND METHOD FOR AUTOMATED OBSERVATION AND ANALYSIS OF INSTRUCTIONAL DISCOURSE
    Publication number: 20230154465
    Abstract: A method of analyzing instructor discourse includes recording an audio signal representing speech of the instructor during a class session, converting the audio signal to a session transcript comprising speech data for the session using an automatic speech recognition tool and segmenting the transcript into utterances, extracting a set of features from the session transcript, filtering student talk out from the utterances, analyzing a first subset of the features to produce a number of local context predictions for each utterance of the session transcript, analyzing a second subset of the features to produce a number of global context predictions for the session transcript, and combining a subset of the number of local context predictions and the number of global context predictions into a classification that attends to differential reliability.
    Type: Application
    Filed: April 14, 2021
    Publication date: May 18, 2023
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate
    Inventors: SEAN P. KELLY, SIDNEY D'MELLO
  • Targeted nanogels for urinary bladder therapies
    Patent number: 11642319
    Abstract: Methods for intravesical administration of a therapeutic agent including application of a photoactive nanogel to the mucosal surfaces of the bladder and/or intravesical application of cell-penetrating peptides. Photoactive nanogels may be aggregated by exposure to ultraviolet light, either in vitro or in vivo, to provide controlled or extended release of a therapeutic agent, such as an antibiotic.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 9, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Devatha P. Nair, Dmitri Simberg, Manju Saraswathy
  • METHOD OF SEQUESTERING GAS-PHASE MATERIALS DURING FORMATION OF HEMPCRETE AND MATERIALS FORMED USING SAME
    Publication number: 20230139941
    Abstract: A method of sequestering gas-phase materials, hempcrete formed using the method, and methods of using hempcrete are disclosed. An exemplary method includes providing a mixture of hempcrete compound material within a chamber and exposing the mixture within the chamber to a gas for a period of time to form hempcrete, wherein the hempcrete exhibits net-negative life cycle carbon emissions. A model to predict net life cycle carbon emission of hempcrete is also disclosed.
    Type: Application
    Filed: April 15, 2021
    Publication date: May 4, 2023
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Wilfred V. Srubar, III, Joseph Hoberg Arehart
  • CRISPR enabled multiplexed genome engineering
    Patent number: 11639511
    Abstract: Described herein are molecules for editing a cell. The molecules described herein generally comprise the following covalently-linked components and a nucleic acid encoding a guide RNA (gRNA) sequence targeting a target region in a cell and a region homologous to the target region comprising a change in sequence relative to the target region.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: May 2, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Andrew Garst, Ryan T Gill
  • High Strain Peano hydraulically amplified self-healing electrostatic (HASEL) transducers
    Patent number: 11635094
    Abstract: High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: April 25, 2023
    Assignee: The Regents of the University of Colorado
    Inventors: Christoph Matthias Keplinger, Xingrui Wang, Shane Karl Mitchell
  • SWELLABLE PHOTOPOLYMERIZED HYDROGELS FOR EXPANSION MICROSCOPY
    Publication number: 20230116191
    Abstract: Compositions and methods for preparing and using a swellable polymer network for expansion microscopy (ExM) applications. The swellable polymer network can be prepared on demand using external stimuli for ExM applications. A variety of external stimuli can be employed, including light irradiation, pH, temperature, and magnetic fields. Network preparation using light irradiation is particularly advantageous, as it allows tuned control over the network properties through the variation of time and dose of light irradiation. In other words, light irradiation can be employed with a wavelength and intensity that enables a polymer network formation.
    Type: Application
    Filed: March 10, 2021
    Publication date: April 13, 2023
    Applicant: The Regents of the University of Colorado, a body
    Inventors: Kristi Anseth, Kemal Arda Gunay, Laura J. Macdougall
  • Remote measurement of shallow depths in semi-transparent media
    Patent number: 11624814
    Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattered medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 11, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, ASTRA LITE, INC.
    Inventors: Jeffrey P. Thayer, Andrew W. Gisler, Steven Mitchell, Matthew Hayman
  • Trans-septal puncture guidance heart repair
    Patent number: 11622745
    Abstract: A controller for displaying a puncture site of an intra-atrial septum for heart repairs includes a memory and a processor (710). The processor (710) executes instructions (784) to perform a process based on image data of a heart that includes a mitral valve and an intra-atrial septum. The process includes defining a mitral valve annulus plane along a mitral valve annulus of the mitral valve and a normal vector perpendicular to the mitral valve annulus plane. The process also includes defining an offset plane that intersects with the intra-atrial septum and that is parallel to the mitral valve annulus plane. A safe zone for the puncture site is identified and displayed on the intra-atrial septum. The safe zone is between a lower boundary plane (456) and an upper boundary plane (455) that are each parallel to the offset plane by specified distances.
    Type: Grant
    Filed: February 2, 2019
    Date of Patent: April 11, 2023
    Assignees: KONINKLIJKE PHILIPS N.V., THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Alexander Haak, Robert Quaife, John Dougher Carroll, Marco Verstege, Niels Nijhof, Onno Wink