Abstract: An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a bulk-type all-solid-state iron sulfur cathode, are disclosed. An example all-solid-state lithium battery includes a cathode having a transition metal sulfide mixed with elemental sulfur to increase electrical conductivity. In one example method of in-situ electromechanically synthesis of Pyrite (FeS2) from Sulfide (FeS) and elemental sulfur (S) precursors for operation of a solid-state lithium battery, FeS+S composite electrodes are cycled at moderately elevated temperatures.

Abstract: A double-sided cold plate includes a manifold comprising openings extending from a first surface of the manifold through the manifold to a second surface of the manifold forming recesses within the manifold and an inlet channel and an outlet channel fluidly coupled to the recesses within the manifold, a plurality of first heat sinks coupled to the first surface of the manifold enclosing the openings on the first surface, and a plurality of second heat sinks positioned adjacent each other along a length of the manifold and coupled to the second surface of the manifold, enclosing the openings on the second surface, a width of the plurality of second heat sinks is greater than a width of the manifold thereby forming an overhanging portion on each lengthwise side of the manifold, the overhanging portion configured to mechanically support a plurality of electrical components positioned around a perimeter of the manifold.

Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device or system and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.

Abstract: The present disclosure relates to a compound of Formula (0): a stereoisomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof. The present disclosure also relates to uses of the compound.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patent is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding before, during, and after fluid resuscitation, in some instances, in real-time.

Abstract: Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.

Abstract: Systems and methods for a shape-memory in-ear biosensor for polysomnography and monitoring physiological signals are provided. Various embodiments include an earpiece made from a shape memory or temperature-dependent phase transition material embedded into polydimethylsiloxane elastomer body. The earpiece can use electrodes to detect physiological signals by making direct contact with a user's skin and without the use of electrically conductive gel. When heated above the glass transition temperature of the shape memory polymer, various embodiments of the biosensor may be folded. When cooled, the biosensor will maintain the folded shape. The folded biosensor may then be inserted into the ear canal of a user where, in response to heating by the user's body, it partially unfolds to conform to the shape of the ear canal.

Abstract: Systems and methods for battery-based vehicle diagnostics are provided. Various embodiments include a battery-based diagnostics system that guards vehicles against anomalies with a cyber-physical approach. The diagnostics system can be implemented as an add-on module of commodity vehicles attached to automotive batteries, thus providing vehicles an additional layer of protection. The automotive battery can operate in strong dependency with many physical components of the vehicle, which is observable as correlations between battery voltage and the vehicle's corresponding operational parameters, e.g., a faster revolutions-per-minute (RPM) of the engine, in general, leads to a higher battery voltage. These embodiments exploit such physically induced correlations to diagnose vehicles by cross-validating the vehicle information with battery voltage and may be based on a set of data-driven norm models constructed online.

Abstract: Disclosed is a tongue strengthening device that includes a handle on one end and a bulb structure on the other end. The bulb is resiliently flexible, and enables a user to exercise their tongue by repeatedly compressing and releasing the bulb. Provided is a system or kit that includes multiple tongue strengthening devices having different compression specifications that allow a patient to graduate to devices which are harder to compress as the patient gains tongue strength.

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

Abstract: A method for securing a first interacting element to a second interacting element is provided. The first interacting element includes a lateral surface established by a first surface and a second surface and at least a portion of the lateral surface includes a thread receipt. The second interacting element includes a distal end and a proximal end that establishes a body therebetween. The body has a thread that is configured to at least partially engage with the thread receipt of the first interacting element. The second interacting element is then inserted at least partially through the surface of an object. The thread receipt of the first interacting element is then abutted adjacent to the thread of the second interacting element. Upon rotation of the second interacting element the thread of the second interacting element at least partially engaged with the thread receipt of the first interacting element.

Abstract: The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Abstract: Described herein are systems incorporating a Casimir cavity, such as an optical Casimir cavity or a plasmon Casimir cavity. The Casimir cavity modifies the zero-point energy density therein as compared to outside of the Casimir cavity. The Casimir cavities are paired in the disclosed systems with product generating devices and the difference in zero-point energy densities is used to directly drive the generation of products, such as chemical reaction products or emitted light.

Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.

Abstract: A steady-state microwave conductivity method whereby a light beam is modulated to form an amplitude modulated light having a modulation frequency ?1. The method further includes producing a microwave waveform, exposing a sample to the amplitude modulated light and a first portion of the microwave waveform to produce an amplitude modulation signal on the first portion of the microwave waveform, and mixing a second portion of the microwave waveform and the amplitude modulation signal to produce a first signal and a second signal.

Abstract: The present disclosure discloses a method and apparatus for generating an optical frequency comb. The specific generation method comprises: receiving a pump laser that matches a thermally stable state of a nonlinear optical resonant cavity and causing the pump laser to oscillate in the nonlinear optical resonant cavity, such that a Brillouin gain corresponding to the pump laser coincides with a target longitudinal mode in the nonlinear optical resonant cavity; continuously generating a Brillouin laser at the target longitudinal mode in the case that a pump power of the pump laser exceeds a threshold for generating the Brillouin laser; and generating an optical frequency comb by using the Brillouin laser through a Kerr nonlinear four-wave mixing process. According to the technical solution of the present disclosure, the nonlinear optical resonant cavity with the Brillouin gain can generate an optical frequency comb in its thermally stable region.

Abstract: An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.

Abstract: A driving authentication system is presented for a vehicle. The system includes: a dongle interfaced with a battery of the vehicle and an authenticator configured to receive a discharge current from the battery. The dongle operates to modulate discharge current from the battery with an input code; and the authenticator demodulate the input code from the discharge current, compares the input code to the one or more known authentication codes and, in response to the input code matching one of the one or more known authentication codes, controls power capacity of the battery.