Abstract: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin.

Abstract: The present invention relates to a novel fusion protein comprising a nitrate reductase (NR) and a truncated hemoglobin N (trHbN) domain. The fusion protein may be used for bioremediation of nitric oxide.

Abstract: An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a first motor output coupled to the first cuff. A second motor is mounted on the third cuff and has a second motor output coupled to the second cuff. A processor is operatively coupled to the first and second motors to manipulate the first cuff and the second cuff relative to the third cuff such that the first cuff and the second cuff are able to move the user's lower limb and upper limb. A method of operating the exoskeleton is also disclosed.

Abstract: Methods according to the invention administering one or more rice rhizosphere isolates to a plant, particularly a rice plant, to the seed of the plant, or to soil surrounding the plant in an amount effective to inhibit infection by a plant pathogen, particularly rice blast, to increase the biomass of the plant, and/or to decrease arsenic uptake by the plant.

Abstract: Provided are methods, systems, and computer readable media for comparing word statistics between a significant amino acid sequence and a significant nucleotide sequence wherein the comparison instructs further research.

Abstract: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin. The hydrogel may contain covalent and non-covalent crosslinks.

Abstract: A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin.

Abstract: Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome.

Abstract: Methods according to the invention administering one or more rice rhizosphere isolates to a plant, particularly a rice plant, to the seed of the plant, or to soil surrounding the plant in an amount effective to inhibit infection by a plant pathogen, particularly rice blast, to increase the biomass of the plant, and/or to decrease arsenic uptake by the plant.

Abstract: A genome-scale metabolic network reconstruction for Clostridium acetobutylicum (ATCC 824) was created using a new semi-automated reverse engineering algorithm. This invention includes algorithms and software that can reconstruct genome-scale metabolic networks for cell-types available through the Kyoto Encyclopedia of Genes and Genomes. This method can also be used to complete partial metabolic networks and cell signaling networks where adequate starting information base is available. The software may use a semi-automated approach which uses a priori knowledge of the cell-type from the user. Upon completion, the program output is a genome-scale stoichiometric matrix capable of cell growth in silico. The invention also includes methods for developing flux constraints and reducing the number of possible solutions to an under-determined system by applying specific proton flux states and identifying numerically-determined sub-systems.

Abstract: Methods and systems for identifying a point of interest on the periphery of an object are disclosed. A system comprises a track, a carriage, an advancement mechanism, a non-contact measurement device, and a processor. The advancement mechanism is configured to advance the carriage along the path defined by the track. The measurement device comprises a transmitter configured to transmit a beam of radiation toward the periphery of the object and a detector configured to detect at least a portion of the radiation reflected from the periphery of the object. The processor is programmed to (i) advance the carriage along the path, (ii) measure a distance between the periphery of the object and the measurement device, (iii) calculate a center of mass of the object from the measured distances, and (iv) determine the point of interest on the periphery of the object using the calculated center of mass of the object.

Abstract: Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.

Abstract: Simulators and methods for simulating an acoustic field of an acoustic waveguide are provided. A sound speed profile of the acoustic waveguide is generated, where the acoustic waveguide has a region of a first fluid within a second fluid, and the first fluid has a different acoustic index of refraction than the second fluid. The sound speed profile and predetermined parameters of a sound source and a receiver are applied to a parabolic equation (PE) model of sound propagation in the acoustic waveguide. The acoustic field of the acoustic waveguide is determined from the PE model. The acoustic field includes an interference pattern from interference between an acoustic signal of the acoustic source and at least one signal refracted by the region of the second fluid.

Abstract: Pelvic orthosis systems and methods are disclosed. An orthosis system comprises a frame for supporting the orthosis system, a hip brace adapted to secured to a hip of a user, and a plurality of elastic members extending from the hip brace to the frame. An orthosis method comprises securing a user to an orthosis system having a frame, a hip brace, and a plurality of elastic members extending from the hip brace to the frame, and enabling the user to walk while secured to the orthosis system.

Abstract: Methods and systems for detecting a plume of a first fluid in a second fluid using an acoustic wave are provided, where the first fluid has a different acoustic index of refraction than the second fluid. A horizontal array having a plurality of receiving elements receives an acoustic signal propagated through the second fluid and at least one refracted signal refracted by the first fluid. The acoustic signal and the at least one refracted signal form a received signal. An interference pattern is detected from the received signal over the plurality of receiving elements. The interference pattern is due to interference between the acoustic signal and the at least one refracted signal. A horizontal angle of refraction is determined between the acoustic signal and the at least one refracted signal from the interference pattern. The horizontal angle of refraction is indicative of a physical characteristic of the first fluid.

Abstract: The invention provides molecular methods for predicting chickens that are more likely to have a lean phenotype, comprising detecting in samples of genetic material obtained from the chickens for the presence of paired single nucleotide polymorphisms (SNPs) in the beta-defensin 9 (DEFB9) gene.

Abstract: The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

Abstract: Substituted 3,4-propylenedioxythiophene monomers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine or 3,3-diallyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a thiol having a hydrocarbyl moiety optionally containing one or more heteroatom-containing functional groups under radical addition conditions under radical addition conditions. Such monomers may be used in homo- or copolymerization processes to obtain thiophene-type polymers containing substituents (which may bear functional groups such as silane, thiol, hydroxyl, carboxylic acid, amine, sugar groups, polyoxyalkylene, and the like). Crosslinkers useful for introducing crosslinking into thiophene-type polymers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a compound having two or more thiol groups under radical addition conditions.

Abstract: A supercapacitor comprising a cathode, an anode, a first single-walled carbon nanotube (SWNT) film electrode adjacent the cathode, a second SWNT film electrode adjacent the anode, and separator disposed between the first and second electrodes. The SWNT film electrodes may be manufactured by a non-filtration process comprising depositing the SWNT film on a foil via CVD; separating the SWNT film from the foil; heating the SWNT film; treating the SWNT film with an acid solution; washing the SWNT film; and excising the electrodes from the SWNT film.

Abstract: A vacuum-induced injection molding apparatus is disclosed. The apparatus includes a tool surface having an injection port extending therethrough. A flexible film extends over and is sealingly coupled to the tool surface. The flexible film comprises an outer surface and an inner surface such that the flexible film inner surface and the tool surface define a volume. A vacuum chamber is sealingly coupled to the outer surface of the flexible film. A vacuum port is in fluid communication with the volume. A method of injection molding a polymer matrix composite is also disclosed.