Abstract: Nitrogen oxides (NOx) storage catalysts comprising cobalt and barium with a lean NOx storage ratio of 1.3 or greater. The NOx storage catalysts can be used to reduce NOx emissions from diesel or gas combustion engines by contacting the catalysts with the exhaust gas from the engines. The NOx storage catalysts can be one of the active components of a catalytic converter, which is used to treat exhaust gas from such engines.

Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington's Disease (HD) protein aggregates.

Abstract: Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.

Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scaffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.

Abstract: Methods and structural defect detectors for detecting a structural defect in composites are presented. An exemplary method includes forming a nanocomposite including a plurality of nanotubes mechanically aligned in a principal direction within a polymer matrix. A voltage is applied to the nanocomposite and a resistance of the nanocomposite is measured using the applied voltage to detect the structural defect. An exemplary structural defect detector includes a nanocomposite including a plurality of mechanically aligned nanotubes within the polymer matrix, electrodes coupled to the nanocomposite, a voltage source for applying a voltage to the electrodes, and a resistance detector for measuring a resistance of the nanocomposite that allows identification of a structural defect. The plurality of nanotubes form a conducting percolating network of sensors.

Abstract: The present invention relates to novel methods for producing a nano-porous gas diffusion media, compositions thereof, and devices comprising the same. The nano-porous gas diffusion media of the invention is produced using photolithographic techniques to create a solid substrate comprising a plurality of nano-scale (1 nm-300 ?m) pores or holes that allow for the diffusion or exchange of molecules, gases, and/or liquids through the substrate. The nano-porous diffusion media of the invention also displays superior electro- and thermal conductivity, and increased durability and performance. In some embodiments, the nano-porous diffusion media of the invention is also coated with a self-assembling monolayer (SAM) of organic molecules to further improve its physical characteristics.

Abstract: The present invention relates generally to sizing compositions for fibers used in composite materials. More specifically, this invention relates to siloxane fiber sizing solutions comprising rubbery-polymers and their use in preparing composite materials. Using the sizings of the present invention not only improves the energy absorption of the composite materials made thereof, but also maintains the interfacial strength of composite materials. Particularly, the rubbery-polymers of the present invention are functionalized with chemical groups that react to the fiber surface and/or to the polymeric resin. In addition, because the rubbery-polymer is incorporated as one block of a block copolymer, it advantageously improves both, the interfacial strength and energy absorption.

Abstract: Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome.

Abstract: A method of detecting leakage from a preform used in a VARTM process includes providing a mold and bagging film suitable for use in the VARTM process; heating air; distributing hot air along an interface between an the bagging film and a surface of the mold; determining a temperature distribution along the interface; and using the temperature distribution to locate one or more leaks in the bagging film.

Abstract: A modulator for modulating an optical signal is disclosed having a substrate, a support mounted to the substrate, and membrane attached to the support and defining an airgap between the substrate and the membrane. The membrane has at least three layers including a central layer having an index of refraction which is the square root of the index of refraction of the substrate. The thickness of the layers and the size of the airgap are optimized to maximize differential reflectivity of light incident on the membrane at a non-normal angle of incidence to the membrane when the membrane is either in an unbiased state or biased state. In one embodiment, the first, central, and third layers have corresponding thicknesses approximately equal to one-quarter, one-quarter, and on-half of a wavelength of the optical signal, respectively.

Abstract: A physical vapor deposition effusion method comprising translating a strip material through a physical vapor deposition zone in a deposition chamber and providing first and second substantially closed vessels located serially along the processing path in the same deposition chamber, each vessel emitting different source materials to produce overlapping plumes and having an array of vapor delivery nozzles distributed uniformly across the vessel along the width of the zone, and configured to expel overlapping plumes to create a fog having a substantially uniform composition across the width and a varying composition across the length of the zone. Also, an elongate vapor deposition effusion vessel having an elongate lid including plural nozzles spaced from each other along its elongate axis, and a continuous heating element in the lid encircling the plural nozzles, the heating element having electrical contacts connected to an electrical source on the same side of the vessel.

Abstract: Methods of remediating soil, sediment or water contaminated with organic compounds such as polychlorinated biphenyls or nitro-aromatic compounds are provided which involve combining the soil, sediment or water with a graphitic carbon and a reducing agent. The contaminants are converted to substances having an increased propensity to enter into an aqueous phase and/or undergo further degradation via biological oxidation.

Abstract: A woven ballistic resistant fabric armor system comprising at least one ply having a yarn-yarn angle between the warp and fill yarns of less than 90°, with each ply oriented relative to an axis along the thickness of the plies such that adjacent plies have a different yarn-yarn angle, a different orientation, or both. The armor system may feature materials of different stiffness, strength, and strain-to-failure in each ply or a filler between selected plies, including a filler comprising discrete pieces of fabric ply that fit within the cell periphery of a stitching pattern.

Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.

Abstract: The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.

Abstract: A controllable brace assembly includes a thigh brace having a thigh gyroscope attached thereto and a shank brace having a shank gyroscope and a shank accelerometer attached thereto. A controllable knee lock couples the thigh brace to the shank brace. The knee lock has an encoder attached thereto. At least one pressure sensor is adapted to be attached to a shoe. A controller is configured to receive signals from the thigh gyroscope, the shank gyroscope, the encoder, the shank accelerometer, and the at least one pressure sensor. The controller transmits a first signal set to engage or disengage the controllable knee lock based on the received signals. A method of controlling the brace is also disclosed.

Abstract: Described herein are electromagnetic traps or tweezers. Desired results are achieved by combining two recently developed techniques, 3D negative refraction flat lenses (3DNRFLs) and optical tweezers. The very unique advantages of using 3DNRFLs for electromagnetic traps have been demonstrated. Super-resolution and short focal distance of the flat lens result in a highly focused and strongly convergent beam, which is a key requirement for a stable and accurate electromagnetic trap. The translation symmetry of 3DNRFL provides translation-invariance for imaging, which allows an electromagnetic trap to be translated without moving the lens, and permits a trap array by using multiple sources with a single lens.

Abstract: An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a first motor output coupled to the first cuff. A second motor is mounted on the third cuff and has a second motor output coupled to the second cuff. A processor is operatively coupled to the first and second motors to manipulate the first cuff and the second cuff relative to the third cuff such that the first cuff and the second cuff are able to move the user's lower limb and upper limb. A method of operating the exoskeleton is also disclosed.

Abstract: A method for fabricating three-dimensional photonic crystal structures includes providing a layer of photosensitive material; introducing a laser beams into the material; reintroducing the laser beams into the photosensitive material during a second exposure; combining results from at least the first and second exposures to produce a three-dimensionally periodic pattern in the photosensitive material. A related system includes a laser source; a grating array having a plurality of diffraction gratings located thereon; a mask plate located on a photoresist layer and arranged in registration with the grating array; a rotating shutter arranged between the grating array and the laser source, said rotating shutter being suitable for periodically blocking light from the laser source; wherein each of the diffraction gratings is positioned and oriented so as to converge all first-order diffracted spots to a common point lying in a plane of a back side of the mask plate.

Abstract: In one embodiment, a method of producing an optoelectronic nanostructure includes preparing a substrate; providing a quantum well layer on the substrate; etching a volume of the substrate to produce a photonic crystal. The quantum dots are produced at multiple intersections of the quantum well layer within the photonic crystal. Multiple quantum well layers may also be provided so as to form multiple vertically aligned quantum dots. In another embodiment, an optoelectronic nanostructure includes a photonic crystal having a plurality of voids and interconnecting veins; a plurality of quantum dots arranged between the plurality of voids, wherein an electrical connection is provided to one or more of the plurality of quantum dots through an associated interconnecting vein.