Abstract: This invention relates to a method of making N-benzyl indoles, and to intermediates for use in the method, and to certain substantially optically pure N-benzyl indoles obtained by the method.
Type:
Grant
Filed:
August 11, 2000
Date of Patent:
January 21, 2003
Assignees:
The University of East Anglia, Eli Lilly and Company
Inventors:
Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart
Abstract: The use of a calcium intracellular store inactivator for inhibiting cell growth is disclosed; for example, thapsigargin or a derivative may be used to inhibit intraocular lens cell growth. Formulations include an emulsion of the compound for coating an IOL, either ex vivo or in vivo.
Type:
Grant
Filed:
June 29, 1998
Date of Patent:
July 3, 2001
Assignees:
The University of East Anglia, The Norfolk & Norwich Health Care NHS Trust
Inventors:
George Duncan, Michael Wormstone, Peter Davies, Christopher Liu
Abstract: This invention relates to a method of making N-benzyl indoles, and to intermediates for use in the method, and to certain substantially optically pure N-benzyl indoles obtained by the method.
Type:
Grant
Filed:
June 24, 1998
Date of Patent:
December 12, 2000
Assignees:
Eli Lilly and Company, University of East Anglia
Inventors:
Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart
Abstract: A process for producing a compound of the formu5la ##STR1## comprising the step of reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## to form a compound of the formula ##STR4## wherein R.sup.2a is selected from the groups recited above for R.sup.2, or R.sup.2a --X-- is a protected hydroxyl group, and Z is a group of formula --Y--R.sub.5 recited above, or a group that can be converted into a group of said formula --Y--R.sup.5. Intermediates of formula IV and composition containing substantially optically pure enantiomers of Formula (I) are included within the scope of the invention.
Type:
Grant
Filed:
November 19, 1996
Date of Patent:
September 15, 1998
Assignees:
The University of East Anglia, Eli Lilly and Company
Inventors:
Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart
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