Abstract: Aspects of the disclosure relate to compositions and methods for delivering inhibitory nucleic acids to prokaryotic cells using extracellular vesicles (e.g., exosomes, microvesicles, etc.) derived from mammalian cells. The disclosure provides methods for regulating the expression of one or more genes in a prokaryotic cell. The disclosure further provides methods of treating diseases associated with prokaryotic gene dysregulation.

Abstract: Disclosed are AAV viral-based vector compositions useful in delivering a variety of nucleic segments, including those encoding therapeutic polypetides to selected mammalian host cells for use in therapeutic autoimmune modalities, including, for example, the in vivo induction of immunological tolerance via a liver-directed AAV-based gene therapeutic regimen for treating and/or ameliorating autoimmune disorders such as multiple sclerosis.

Abstract: Described are small molecule embodiments, ALS compounds, that bind with the (G4C2)exp RNA repeat transcription of the chromosome 9 open reading frame 72 involved in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These ALS compounds comprise a pyridocarbazole moiety having at least one substituent. Preferred ALS compounds comprise bridged dimers of the pyridocarbazole moiety in which the bridge between the two pyridocarbazole moieties is a polyoxyethylenyl group or an aminobispolyoxyethylenyl group.

Abstract: Embodiments of the present disclosure provide for coaxial nozzles, capsule fabrication systems comprising coaxial nozzles, and methods of capsule fabrication using capsule fabrication systems. In certain embodiments, coaxial nozzle configurations, capsule fabrication systems, and methods as described herein can be used for multi-layered capsule fabrication.

Abstract: Provided herein are immunotherapy compositions for treating a subject with a glioblastoma, comprising a peptide formulation derived from at least one cancer or stemness factor, nanoparticles containing peptides derived from at least one cancer or stemness factor, dendritic cells containing peptides derived from at least one cancer or stemness factors, RNA coding at least one cancer or stemness factor, nanoparticles containing RNA coding at least one cancer or stemness factor, dendritic cells containing RNA coding at least one cancer factor or stemness factor, or an inhibitor of at least one cancer or stemness factor. Also provided are methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject for glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC) using such immunotherapy compositions.

Abstract: Provided herein are charge complementary peptides coupled to a cargo polypeptide (e.g., a uricase protein) (e.g., uricase) that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein (e.g., to treat gout).

Abstract: Aspects of the disclosure relate to compositions and methods for treating certain (e.g., CD33-positive) cancers. In some aspects, the disclosure provides antibodies that specifically bind to CD33 protein variants that lack an IgV domain. In some aspects, the disclosure provides adaptable cell engagers (ACEs) and recombinant proteins (e.g., BiTEs) comprising an anti-CD33 antibody of the disclosure and an anti-CD3 antibody. In some embodiments, the disclosure provides methods of treating cancer by administering the antibodies, ACEs, or recombinant proteins (e.g., BiTEs) to a subject in need thereof.

Abstract: Provided is an oxidizing composition, in which a liquid medium is substantially inert in the presence of an oxidizing electrophile contained in the liquid medium. The composition comprises (a) an oxidizing electrophile comprising a main group element in oxidized form and at least one conjugate anion of an oxygen acid; (b) a non-oxidizable liquid selected from a fluorinated hydrocarbon, a sulfone, a deactivated arene, a deactivated aliphatic, a deactivated heteroarene, a deactivated heteroaliphatic, and a combination thereof; and (c) optionally one or more salt additives. Further provided are a method of using the oxidizing composition to oxidize a substrate and a method of generating and/or regenerating an oxidizing electrophile comprising a main group element.

Abstract: Provided herein are methods and compositions for treating an eye disorder, for example cone-rod dystrophy type 6 (CORD6). In certain aspects, a therapeutically effective amount of a composition comprising nucleic acids is administered to a subject to treat an autosomal dominant disorder or condition, such as a condition associated with a dominant mutation in a guanylate cyclase 2D (GUCY2D) gene, such as knocking out a dominant mutant form of the gene in the subject. Further provided herein are recombinant AAV particles that comprise one or more recombinant AAV genomes comprising nucleic acids that encode a guide RNA that targets a GUCY2D gene and/or an RNA-guided endonuclease.

Abstract: Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(?CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(?CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(?CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(?CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

Abstract: Provided herein is a method, apparatus, and system for detecting conditions indicative of an attempt to attach a skimming device to a payment device. Methods may include monitoring at least one wire among a plurality of wires between a card reader device and a motherboard; determining voltage consumption; determining current consumption; identifying a change in voltage consumption or current consumption satisfying a predetermined value; and providing for transmission of an alert of a condition indicating possible attachment of a card skimming device. Methods may include generating a status message periodically and transmitting the status message to a remote entity. The change in voltage consumption or current consumption satisfying the predetermined value may include a voltage instability exceeding a predetermined range about an anticipated voltage. The change in voltage consumption or current consumption satisfying the predetermined value may include a decrease in current satisfying the predetermined value.

Abstract: The present disclosure provides compounds of Formula IA and Formula IB and their pharmaceutical compositions as selective agonists of REV-ERB-?: where R1, R2, R3, R4, R5, RX1, RX2, nA, nB, X, Y, and Z are described herein. The compounds are useful in various methods and uses, such as in the treatment of diseases including hyperglycemia, dyslipidemia, atherosclerosis, and autoimmune and inflammatory disorders or diseases, and as cancer therapeutics, such as for the treatment of glioblastoma, hepatocellular carcinoma, and colorectal cancer, and for immune-oncology purposes.

Abstract: Disclosed herein are recombinant AAV variant (e.g., variant serotype 3B (AAV3B)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce hepatic cells. Viral particles containing these capsid variants are capable of evading neutralization by the host humoral immune response. The recombinant AAV3B variant proteins and viral particles disclosed herein were identified from a variant AAV3B capsid library that was engineered by making substitutions in only the variable regions of the capsid. Some embodiments of the AAV3B capsid variants disclosed herein comprise the AAV3B-DE5 variant, which contains 24 mutations relative to wild-type. Compositions of these variant AAV particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as liver cells, and thus treat diseases and disorders pertaining to these cells.

Abstract: The invention is directed towards compounds (e.g., Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof), their mechanism of action, and methods of modulating proliferation activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof).

Abstract: A method of obfuscating a circuit design includes, in part, receiving a netlist of the circuit design, splitting the circuit design into a multitude of partitions, transforming each partitions so as to obfuscate each partition, and stitching the multitude of transformed partitions to form the obfuscated circuit. The netlist may be a register transfer level netlist. The number and the size of partitions may vary. The partitions may be distributed throughout the entirety of the design. The method may further include generating a randomized circuit associated with at least a subset of the partitions, and merging each partition with the partition's associated randomized circuit. The method may further include quantifying the amount of transformation associated with each partition. The method may further include adding a first key to at least one of the obfuscated partitions, and adding a second key to the partition's associated randomized circuit.

Abstract: Methods and systems are directed to enabling CNN operation close to an image sensor and facilitating CNN inference near the image sensor. The system includes, in part, a digital image sensor and a plurality of processing layers that include, in part, an attention-based preprocessing layer (APL), an inference computation layer (ICL), and a fully connected layer. The digital image sensor can include, in part, a plurality of regions and each region can be processed by region processing units disposed in the APL/ICL in parallel. Each region processing unit disposed in the APL can include, in part, an attention module that determines whether the corresponding region is a relevant region. The region processing units disposed in the APL transmit only relevant data to corresponding region processing units in the ICL and only activate the corresponding region processing units in the ICL for relevant regions. The ICL can include, in part, two convolution layers.

Abstract: A digitally tunable acoustic wave resonator includes, in part, a first electrode positioned above a substrate, a composite stack positioned above the first electrode, and a second electrode positioned above the composite stack. The composite stack may include one or more alternate layers of a ferroelectric layer and a transition-metal nitride layer. The transition-metal nitride layer can be positioned above the ferroelectric layer, except the ferroelectric layer at the top of the composite stack. The ferroelectric layer comprises an aluminum scandium nitride layer Al1-xScxN, where 0<x<1.

Abstract: Combined physical unclonable function (PUFs); methods, apparatuses, systems, and computer program products for enrolling combined PUFs; and methods, apparatuses, systems, and computer program products for authenticating a device physically associated with a combined PUF are described. In an example embodiment, a combined PUF includes a plurality of PUFs and one or more logic gates. Each PUF includes a plurality of stages and an arbiter configured to generate a single PUF response based on response portions generated by the plurality of stages. The one or more logic gates are configured to combine the single PUF response for each of the plurality of PUFs in accordance with a combination function to provide a combined response.

Abstract: Provided is a camera system to obtain high resolution imagery on multiple regions of interest even when the regions of interest are ate different focal depths and in different viewing directions. Embodiments include a high speed camera that operates by reflecting a beam of interest corresponding to a scene of interest into a high-speed passive sensor from a dynamic optical modulator. Embodiments described herein provide a foveating camera design that distributes resolution onto regions of interest by imaging reflections off a scanning micro-electromechanical system (MEMS) mirror. MEMS mirrors are used herein to modulate viewing direction. Embodiments include a camera capturing reflections off of a tiny, fast moving mirror.

Abstract: Various examples are provided related to software and hardware architectures that enable lightweight and real-time Denial-of-Service (DoS) and Distributed Denial-of-Service (DDoS) attack detection. In one example, among others, a method for detection and localization of denial-of-service (DoS) attacks includes detecting, by a router of an intellectual property (IP) core in a network-on-chip (NoC) based system-on-chip (SoC) architecture, a compromised packet stream based at least in part upon a packet arrival curve (PAC) associated with the router; identifying, by the IP core, a candidate IP core in the NoC as a potential attacker based at least in part upon a destination packet latency curve (DLC) associated with the IP core; and transmitting, by the router, a notification message indicating that the candidate IP core is the potential attacker to a router of the candidate IP core.