Patents Assigned to University of Florida Research Foundation Incorporated
  • Patent number: 11183068
    Abstract: Various examples are provided related to multi-purpose context-aware bumps (CABs) that can support dynamic adaptation of form factors and functionality. In one example, a CAB system can include sensors distributed in a traffic network and communicatively coupled to a remotely located computing environment; context-aware bumps (CABs) placed in the traffic network and communicatively coupled to the remotely located computing environment; and a CAB application configured to adjust a form factor of a CAB in response to information obtained from the sensors and/or CABs. In another example, a method can include receiving, by a remotely located computing environment, traffic information from sensors distributed in a traffic network or CABs placed in the traffic network; communicating, by the remotely located computing environment, a form factor control to a CAB in response to the traffic information; and adjusting a form factor of the CAB in response to the form factor control.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: November 23, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Swarup Bhunia, Prabuddha Chakraborty, Lili Du, Sandip Ray
  • Patent number: 11179416
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Blanka Sharma, Isaac Adjei, Shreedevi Kumar
  • Patent number: 11176960
    Abstract: A system for distinguishing between a human voice generated command and an electronic speaker generated command is provided. An exemplary system comprises a microphone array for receiving an audio signal collection, preprocessing circuitry configured for converting the audio signal collection into processed recorded audio signals, energy balance metric determination circuitry configured for calculating a final energy balance metric based on the processed recorded audio signals, and energy balance metric evaluation circuitry for outputting a command originator signal based at least in part on the final energy balance metric.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: November 16, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Patrick G. Traynor, Logan E. Blue, Luis Vargas
  • Patent number: 11160488
    Abstract: The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: November 2, 2021
    Assignees: Universty of Washington, University of Florida Research Foundation, Incorporated
    Inventors: Jay Neitz, Maureen Neitz, James A. Kuchenbecker, William W. Hauswirth
  • Publication number: 20210330815
    Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve us of a FXN coding sequence, a truncated FXN 3? UTR, and a prompter.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 28, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Manuela Corti, Barry John Byrne
  • Patent number: 11157675
    Abstract: Methods and apparatus are provided for automatically extracting standard cells to form a standard cell library using raw multi-layer images of an IC. Accordingly, various embodiments involve: extracting the raw contact layer image from the raw multi-layer images; binarizing the raw contact layer image to generate a binarized contact layer image identifying a plurality of contact rows and a plurality of contact columns; determining a plurality of Vcc lines based on a subset of the plurality of contact rows having a periodic nature; extracting a plurality of binarized contact layer image strips from the binarized contact layer image; encoding each binarized contact layer image strip using feature vectors and column distance values; applying a model rule set to each encoded binarized contact layer image strip for detecting cell boundaries; extracting the standard cells based on the cell boundaries; and storing the extracted cells to form a standard cell candidate library.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: October 26, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Damon Woodard, Domenic J. Forte, Ronald Wilson, Navid Asadizanjani
  • Publication number: 20210322571
    Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve use of a FXN coding sequence, a truncated FXN 3? UTR, and a promoter.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 21, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Manuela Corti, PT, Barry John Byrne
  • Patent number: 11152652
    Abstract: Techniques to diagnose internal short circuits (ISCs) of a lithium-ion battery (LIB) are disclosed. The short circuit resistance data can help to detect the ISCs of a LIB as fast as possible. For the proposed detection techniques, a resistor-based circuit and an inductor-based circuit are disclosed for single-cell LIBs as well as for LIBs having multiple cells. Two topologies of the resistor-based circuits are disclosed to detect the ISCs of multi-cell LIBs.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: October 19, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Shuo Wang, Amirhossein Moeini
  • Publication number: 20210317409
    Abstract: Cell-based compositions and methods for targeting and treating human diseases, including cancers and infectious diseases, are provided, wherein exogenous intracellular sarcosine is used for improved delivery of the composition.
    Type: Application
    Filed: March 22, 2017
    Publication date: October 14, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Maryam Rahman, Duane Mitchell, Rolando Lovaton, Hassan Azari
  • Patent number: 11141425
    Abstract: Disclosed herein are compositions of rAAV particles and methods for administrating rAAV particles having enhanced transduction properties.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: October 12, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Shannon E. Boye, Sanford L. Boye
  • Patent number: 11136354
    Abstract: The subject application provides a genetically modified recombinant facultative intracellular invasive bacterial pathogen (RFIIBP) or a recombinant attenuated Salmonella vaccine (RASV) strains encoding Zika virus (ZIKV) antigens. These strains exhibit high immunogenicity, complete safety, and attenuation, and are unable to persist or be shed in an infective or viable form. These RFIIBPs and RASVs also exhibit regulated delayed attenuation in vivo, regulated delayed in vivo synthesis of protective ZIKV antigens. Methods of inducing mucosal, systemic and cellular immunities in hosts are also provided and antibodies produced using the disclosed RFIIBPs and RASVs can comprise neutralizing antibodies against ZIKV that do not crossreact with Dengue virus (DENV).
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: October 5, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventor: Roy Curtiss, III
  • Publication number: 20210300978
    Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof.
    Type: Application
    Filed: June 8, 2021
    Publication date: September 30, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
  • Patent number: 11129576
    Abstract: Various examples are provided for accurate heart rate measurement. In one example, a method includes determining a respiratory rate (RR) and respiration displacement from radar-measured cardiorespiratory motion data; adjusting notch depths of a harmonics comb notch digital filter (HCNDF) based upon the respiration displacement; generating filtered cardiorespiratory data by filtering the radar-measured cardiorespiratory motion data with the HCNDF; and identifying a heart rate (HR) from the filtered cardiorespiratory data. In another example, a system includes radar circuitry configured to receive a cardiorespiratory motion signal reflected from a monitored subject; and signal processing circuitry configured to determine a respiration displacement based upon the cardiorespiratory motion signal; adjust notch depths of a HCNDF based upon the respiration displacement; filter the cardiorespiratory motion data with the HCNDF; and identifying a heart rate (HR) from the filtered cardiorespiratory data.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 28, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Jenshan Lin, Linda Frances Hayward, Tien-yu Haung
  • Patent number: 11130764
    Abstract: The present disclosure provides compounds of any one of Formulae (I?), (I), (IA), (II?), (II), (IIA), (IIIA), (III?), (III?), (III), (IIIA), (IV), (V?), (V), (VI), (VII), (VIII?), (VIII), (IX?), (IX), and (X). The compounds described herein may be useful in treating and/or preventing a broad range of diseases (e.g., proliferative disease (e.g., cancers (e.g., non-small cell lung cancer, or glioma), inflammatory diseases, autoimmune diseases), CNS disorder (e.g., drug addiction), metabolic disorder (e.g., diabetes), or infectious disease (e.g., bacterial infection or parasitic infection (e.g., malaria))). Also provided in the present disclosure are pharmaceutical compositions, methods of synthesis of a compound described herein, kits, methods, and uses including or using a compound described herein.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: September 28, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Robert William Huigens, III, Verrill M. Norwood, IV, Hendrik Luesch
  • Patent number: 11133601
    Abstract: Various examples are provided that are related to fractal-based reactive impedance surfaces. These surfaces allow for miniaturization of antennas. In one example, a fractal rectangular reactive impedance surface (FR-RIS) includes a plurality of fractal rectangular (FR) patches having an outer edge defined by a fractal rectangular pattern that is repeated along each side of inner FR patches of the plurality of FR patches. The fractal rectangular pattern of a FR patch matches with the fractal rectangular pattern of an adjacent FR patch. An antenna can include a planar antenna disposed over the FR-RIS.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 28, 2021
    Assignees: University of Florida Research Foundation, Incorporated, Electronics and Telecommunications Research Institute (ETRI)
    Inventors: Yong Kyu Yoon, Seahee Hwangbo, Hae Yong Yang
  • Publication number: 20210290771
    Abstract: Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date. For example, with respect to the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), both of which hamper delivery of agents to the brain, others have relied on the use of endogenously expressed receptors, like the transferrin receptor, to assist the agent across the barriers.
    Type: Application
    Filed: April 12, 2021
    Publication date: September 23, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Nicholas Muzyczka, Hector Ruben Mendez-Gomez
  • Publication number: 20210292373
    Abstract: Disclosed herein are chimeric recombinant adeno-associated virus (rAAV) capsid proteins comprising a region of VP1? that is replaced by the corresponding amino acids of the VP1? of AAV serotype 1 (AAV1) or AAV serotype 8 (AAV8), and particles comprising them.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 23, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Mavis Agbandje-McKenna, Robert McKenna, Antonette D. Bennett
  • Patent number: 11123682
    Abstract: A liquid desiccant system including a high desorber, a low desorber, and an absorber that are in fluid communication with a working solution, where the high desorber provides rejected water vapor from the working fluid for condensation in a condenser of the low desorber that provides heat for rejection of additional water from the working solution in the low desorber effectively multiplying the heat provided for desorption. The low desorber provided the concentrated working solution to the absorber where water from ambient air is condensed into the concentrated working solution to provide a dilute working solution within a working solution conduit of the absorber that is thermally coupled to an internal cooler of the absorber. In some embodiments, the working solution can be an aqueous solution of at least one ionic liquid.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: September 21, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventor: Saeed Moghaddam
  • Patent number: 11124544
    Abstract: The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: September 21, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Arun Srivastava, George Vladimirovich Aslanidi, Kim M. Van Vliet, Mavis Agbandje-McKenna
  • Publication number: 20210283081
    Abstract: The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit.
    Type: Application
    Filed: October 4, 2017
    Publication date: September 16, 2021
    Applicants: University of Florida Research Foundation Incorporated, Entrinsic Health Solutions, Inc.
    Inventors: Sadasivan Vidyasagar, Reshu Gupta, Lianjie Yin, Astrid Grosche, Paul Gerson Okunieff, Stephen Gatto, Daniel Dennison