Patents Assigned to University of Florida Research Foundation Incorporated
  • Publication number: 20190142858
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 16, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu
  • Patent number: 10287611
    Abstract: This invention relates to biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulation and metabolic evolution. More specifically, certain biocatalysts of the present invention produce succinic acid at high titers and yields in mineral salts media during simple pH-controlled batch fermentation without the addition of any exogenous genetic material. The genetic manipulations of the present invention are concerned with energy-conserving strategies coupled with the elimination of alternative routes for NADH oxidation other than the routes for succinic acid production. The biocatalysts contain glucose-repressed gluconeogenic phosphoenolpyruvate carboxykinase (pck) derepressed by genetic modifications and a genetically-inactivated phosphotransferase system.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: May 14, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Xueli Zhang, Kaemwich Jantama, Jonathan C. Moore, Laura R. Jarboe, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
  • Patent number: 10283218
    Abstract: Methods and systems for patient participatory care and monitoring are provided for applications including respiratory care, ECG monitoring, capnography, infusion pump alarm prevention/management, pressure sore prevention, incentive spirometry, consciousness monitoring during sedation, pain management and other care and monitoring modalities. A patient in-the-loop system includes an input interface for receiving data acquired from a monitoring, controlling or sensing device, a storage device for storing the data at a first location, and a processor for analyzing artifacts in the data and determining whether the patient provided a deliberate action with respect to the device as a response to a prompt or query. The processor can further initiate a variety of prompts and/or output queries stored in the storage device at a second location to the patient.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: May 7, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Nikolaus Gravenstein, Samsun Lampotang, David Lizdas, Yashwant Singh Bisht
  • Patent number: 10283459
    Abstract: A semiconductor device can include a first metal trace, a first via disposed on the first metal trace, a second metal trace disposed on the first via, and an insulator interposed between the first metal trace and the first via. The insulator can be configured to lower an energy barrier or redistribute structure defects or charge carriers, such that the first metal trace and the first via are electrically connected to each other when power is applied. The semiconductor device can further include a dummy via disposed on the first metal trace.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: May 7, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Swarup Bhunia, Haoting Shen, Mark M. Tehranipoor, Domenic J. Forte, Navid Asadizanjani
  • Publication number: 20190127424
    Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 2, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Arun Srivastava, George Vladimirovich Aslanidi, Sergei Zolotukhin, Mavis Agbandje-McKenna, Kim M. Van Vliet, Li Zhong, Lakshmanan Govindasamy
  • Publication number: 20190117763
    Abstract: Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 25, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: James B. Flanegan, Robert McKenna, Christopher Daniel Boone, Sushma Abraham Ogram, Barbara Joan Morasco
  • Publication number: 20190119208
    Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the invention to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosures relates to compounds produced by artificial cytochrome P450 enzymes.
    Type: Application
    Filed: October 30, 2018
    Publication date: April 25, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventor: Yousong Ding
  • Patent number: 10269989
    Abstract: A hydrogen sensor can include a substrate, an Ohmic metal disposed on the substrate, a nitride layer disposed on the substrate and having a first window exposing the substrate, a Schottky metal placed in the first window and disposed on the substrate, a final metal disposed on the nitride layer and the Schottky metal and having a second window exposing the Schottky metal, and a polymethyl-methacrylate (PMMA) layer encapsulating the second window. The PMMA layer can fill the second window and be in contact with the Schottky metal.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 23, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Fan Ren, Stephen J. Pearton, Soohwan Jang, Sunwoo Jung
  • Publication number: 20190093111
    Abstract: Aspects of the disclosure relate to methods and compositions for treating retinitis pigmentosa. In some aspects, the disclosure provides compositions and methods for delivering an interfering nucleic acid (for example an interfering RNA) to a subject in order to reduce expression of one or both alleles of an endogenous rho gene (for example a mutant rho allele associated with retinitis pigmentosa) in the subject. In some embodiments, a replacement rho gene that is resistant to the interfering nucleic acid also is delivered to the subject.
    Type: Application
    Filed: March 1, 2017
    Publication date: March 28, 2019
    Applicants: University of Florida Research Foundation, Incorporated, The Trustees of the University of Pennsylvania
    Inventors: Alfred S. Lewin, William W. Hauswirth, MIchael T. Massengill, William Beltran, Gustavo D. Aguirre, Artur Cideciyan, Samuel Jacovson
  • Patent number: 10243446
    Abstract: Methods and apparatuses for selective harmonic current mitigation pulse width modulation (SHCM-PWM) are provided. Low switching frequencies can be utilized for grid connected cascaded H-bridge multilevel rectifiers to meet harmonic requirements within an extended harmonic spectrum. Instead of using voltage references to calculate switching angles for rectifiers as in conventional selective harmonic elimination-PWM (SHE-PWM) and selective harmonic mitigation-PWM (SHM-PWM), current references can be used to compensate for current harmonics and meet current harmonic requirements and total demand distortion (TDD) within the entire harmonic spectrum.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 26, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Shuo Wang, Amirhossein Moeini, Hui Zhao
  • Patent number: 10236460
    Abstract: Photovoltaic cells, methods of fabricating photovoltaic cells, and methods of using photovoltaic cells to capture light energy are provided. A photovoltaic cell can include an electron transporting layer, a photoactive layer, and a hole transporting layer. The electron transporting layer can be ultraviolet ozone treated. The photovoltaic cell can have an inverted configuration.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: March 19, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Franky So, John R. Reynolds, Song Chen, Cephas Small
  • Patent number: 10230240
    Abstract: Techniques for providing ancillary services to a power grid using customer premises such as commercial buildings. The techniques may involve receiving a regulation signal from a grid operator that is specific to a commercial building and modifying power consumption by at least one power consumption component in the building based on the regulation signal. The power consumption component may be a fan and/or a chiller of a Heating, Ventilation, and Air Conditioning (HVAC) system. The regulation signal may be tracked in a at least a portion of a frequency band from about 4 seconds to about 60 minutes, and the control architecture may depend on the portion of the frequency band.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 12, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Prabir Barooah, Sean Meyn
  • Publication number: 20190071681
    Abstract: Disclosed are methods of gene delivery using capsid-modified recombinant adeno-associated viral (rAAV) particles. Exemplary methods are provided employing rAAV particles that have altered affinity for heparin or heparin sulfate. Also provided by the disclosure are methods employing the rAAV vector-based compositions, virus particles, host cells, and pharmaceutical formulations in the expression of selected therapeutic genes, proteins, polypeptides, peptides, antisense oligonucleotides, and/or ribozymes in selected mammals, including organs, tissues, and human host cells.
    Type: Application
    Filed: February 24, 2017
    Publication date: March 7, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Nicholas Muzyczka, Kenneth H. Warrington, Marina Gorbatyuk, Oleg Gorbatyuk
  • Patent number: 10221274
    Abstract: Disclosed herein a composition comprising a urethane of the FIG. 3; where hydroxyl or amine linkages on the urethane of the FIG. 3 are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof. Disclosed herein too is a composition comprising a urethane of the FIG. 3; where hydroxyl or amine linkages of the urethane of the FIG. 3 are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof; and a polymeric resin.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: March 5, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Anthony B. Brennan, Laura M. Villada, Canan Kizilkaya
  • Patent number: 10214713
    Abstract: The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 26, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Zhonghui Hugh Fan, Kirsten Marie Jackson
  • Publication number: 20190043925
    Abstract: A photonic conversion device is provided, comprising a photoactive layer, a dielectric layer, a porous conductor layer, and an electron transport layer in contact with the porous conductor layer. A light emitting device may be in contact with the electron transport layer, forming a conversion device with gain. A method of manufacturing a photonic conversion device may also be provided, comprising forming a photoactive layer, forming a dielectric layer over the photoactive layer, and depositing a conductor layer in contact with the dielectric layer, wherein one or more regions of the dielectric layer are masked during deposition such that the conductor layer includes a plurality of pores that extend through the conductor layer.
    Type: Application
    Filed: September 9, 2016
    Publication date: February 7, 2019
    Applicants: University of Florida Research Foundation, Incorporated, Naoholdings, LLC
    Inventors: Franky So, Do Young Kim, Hyeonggeun Yu, Bhabendra K. Pradhan
  • Patent number: 10198959
    Abstract: A system for use in a lecture environment in which a lecturer delivers a lecture to students. The lecturer can broadcast questions to the students to test their understanding of the subject matter of the lecture, and the students' answers to those question are made available to the lecturer in real time. This makes it possible for the lecturer to adapt the lecture to the students' level of understanding of the subject matter of the lecture.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: February 5, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Walter E. Drane, Susan J. Cardinal
  • Publication number: 20190024150
    Abstract: The invention pertains to an assay that is capable of detecting a mutant polynucleotide in a plurality of polynucleotides. In one embodiment, the assay of the invention is capable of detecting one copy of a mutant polynucleotide in about 50,000 to about 100,000 copies of polynucleotides. The assay of the invention can be used to identify a mutant viral quasispecies or a mutant mRNA encoding an oncogenic protein from a tumor sample. The assay of the invention involves producing the single stranded complements of each of a plurality of polynucleotides containing the target sequence, wherein each of the single stranded complements contain a unique tag sequence and amplifying the single stranded complements by PCR using several sets of primers designed to introduce the sequences appropriate for a paired-end sequencing analysis of the amplified polynucleotides. The invention also pertains to kits for carrying out the assays of the invention.
    Type: Application
    Filed: December 23, 2016
    Publication date: January 24, 2019
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: GARY P. WANG, CHAK KAR (ERIC) LI, LIN LIU
  • Publication number: 20190016759
    Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications.
    Type: Application
    Filed: May 24, 2018
    Publication date: January 17, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Arun Srivastava, George Vladimirovich Aslanidi, Sergei Zolotukhin, Mavis Agbandje-McKenna, Kim M. Van Vliet, Li Zhong, Lakshmanan Govindasamy
  • Patent number: 10181065
    Abstract: Chipless RFID tags and methods of using the same are provided. Each RFID tag provided herein can generate a unique and unclonable (unclonable chipless RFID, or UCR) identifier from its intrinsically random manufacturing process. The UCR device can monitor increase in storage temperature beyond that which is appropriate for a specific commodity to which the device is attached.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 15, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Mark M. Tehranipoor, Haoting Shen, Kun Yang, Domenic J. Forte