Abstract: Disclosed herein are methods for removing acetylene from an ethylene gas stream wherein a catalyst reacts with the acetylene to polymerize said acetylene forming an ethylene gas stream substantially free of acetylene.

Abstract: Provided herein, in some embodiments, are nucleic acid constructs encoding RNA molecules comprising one or more introns that can be regulated (e.g., autoregulated), and that are useful for delivery in a recombinant viral vector. Aspects of the application provide compositions and methods for delivering regulated (e.g., auto-regulated) gem expression constructs to a subject.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation.

Abstract: Systems and methods for a computer-based visual recognition based upon a spatially forked deep learning architecture, including unification of deep learning and reasoning. A method can include a primary learner with an adjacent structured memory bank that can not only predict the output from a given input, but also relate the input to all past memorized instances and help in creative understanding.

Abstract: The instant invention describes compounds having IL-6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by IL-6.

Abstract: The present disclosure includes refactored thaxtomin biosynthetic gene clusters including thaxtomin modules including one or more thaxtomin genes such that the expression of the refactored thaxtomin biosynthetic gene cluster produces at least one thaxtomin compound in the absence of thaxtomin-inducing conditions. Also included are genetically engineered Streptomyces bacterium from a non-pathogenic Streptomyces strain comprising an exogenous, refactored thaxtomin biosynthetic gene cluster of the present disclosure, such that the expression of the refactored thaxtomin biosynthetic gene cluster provides the genetically engineered Streptomyces bacterium with the ability to produce at least one thaxtomin compound in the absence of thaxtomin-inducing conditions. The present disclosure also includes methods of producing thaxtomin compounds, analogs, or intermediate with the refactored thaxtomin biosynthetic gene clusters and genetically engineered bacteria of the present disclosure.

Abstract: Systems and methods for discovering approximations for compilers to apply through genetic programming and deterministic symbolic regression heuristics are provided. A method for discovering approximations for compilers and runtime optimization can include profiling a program to identify performance critical functions, determining appropriate candidates for approximation and developing application and architecture specific approximations through machine learning techniques, genetic programming, and deterministic heuristics. Such approximations can target any optimization goal, with a primary emphasis on parallelism, or can provide a set of Pareto-optimal tradeoffs.

Abstract: There is a need for more effective and efficient printed circuit board (PCB) design. This need can be addressed by, for example, solutions for performing automated PCB component estimation. In one example, a method includes identifying a plurality of initial component estimations for the PCB; performing a shadow detection segmentation using the plurality of initial component estimations, a non-direct-lighting image, and one or more direct-lighting images to generate a first set of detected PCB components; performing a super-pixel segmentation using the plurality of initial component estimations and the non-direct-lighting-image to generate a second set of detected PCB components; and generating a bill of materials for the PCB based at least in part on the first set of detected PCB components and the second set of detected PCB components.

Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: The present invention is directed to a delivery vector for transferring a small peptide coding sequence to a cell for expression of the small peptide coding sequence within the cell. The delivery vector comprises a secretory signal sequence; a sequence encoding a carrier protein operatively associated with the secretory signal sequence; a sequence encoding a cleavage site operatively associated with the sequence encoding a carrier protein; and a sequence encoding a small peptide operatively associated with the sequence encoding a cleavage site.

Abstract: The subject invention pertains to compositions and methods for preparing and using recombinant proteins based on the fungal Coprinus comatus Y3 protein to control plant and animal viruses and microbes, and diagnose, prevent and treat cancers. Methods are disclosed using compositions comprising recombinant Y3 proteins to diagnose, prevent and/or treat cancer diseases based on recombinant Y3 protein interaction with glycans expressed on cancer cells.

Abstract: Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents.

Abstract: The present invention relates to recombinant cyanobacterial cells for the production of a chemical compound of interest. In particular, the present invention relates to genetic modifications that introduce one or more heterologous phosphopantetheinyl transferases (PPTases) into a cyanobacterial cell. These cells can, optionally, further comprise heterologous carrier protein and nucleic acid constructs that provide the cyanobacterial cells with the capability of producing chemicals of interest or compounds of interest, such secondary metabolites polyketides, nonribosomal peptides and their hybrids, the three major families of bioactive natural products, of cyanobacteria and other bacterial phyla, secondary metabolites analogs, and unnatural compounds.

Abstract: A pyramid structure to mitigate optical probing attacks in ICs by scrambling the measurements reflected by a laser pulse is disclosed. The pyramid structure is applied to selected areas at the bottom surface of the metal traces in metal layer to circumvent the extra silicon layer and thus minimize the changes to the conventional device structures. The pyramid structure includes randomized pyramids at nanometer scale. Optical simulation results show the pyramidized metal surface is able to prevent optical probing attacks. The fabrication of pyramids is CMOS compatible as well. Optical simulations are performed to analyze the impact these nano-scaled pyramids in a laser voltage probing attacking model. The nanopyramid can disturb the optical measurements enough to make the attacks practically infeasible. In addition, the nanopyramid structure countermeasure works in a passive mode without consuming any energy.

Abstract: An example system for exciting a selected set of motor neurons of a patient comprises one or more signal generators configured for generating a first electrical signal and a second electrical signal; a first set of wires configured to provide the first electrical signal to a first set of electrodes, wherein the first set of electrodes are configured for being secured to a first set of positions on the patient; a second set of wires configured to provide the second electrical signal to a second set of electrodes, wherein the second set of electrodes are configured for being secured to a second set of positions on the patient; and a controller configured to control operation of the one or more signal generators. The first electrical signal is a periodic signal of a first frequency. The second electrical signal is a periodic signal of a second frequency. The first frequency and the second frequency differ by a non-zero frequency difference.

Abstract: Embodiments of the present invention are directed to lightweight, portable spectrograph systems configured for applications in high-throughput crop phenotyping and plant health assessment, and associated methods.

Abstract: Provided herein are compositions, kits and methods related to permitting a human or non-human primate subject to receive multiple doses of recombinant adeno-associate virus (rAAV) vectors. In some aspects, provided herein are methods comprising administering an anti-CD20 antibody, optionally in combination with an mTOR inhibitor, to the subject to permit multiple doses of an rAAV vector to be administered.

Abstract: Provided herein are modified AAV capsid proteins, particles, nucleic acid vectors, and compositions thereof, as well as methods of their use.

Abstract: Described herein are AAV particles having capsid proteins with amino acid substitutions that confer increased affinity for and transduction of glioma cells. The disclosed capsid proteins may be used in conjunction with any therapeutic transgene for treatment of cancer, including in the manufacture of an AAV particle. Also described are methods of identifying AAV variants having increased affinity for and transduction of specific tumor cell types.